1 cn de tai: '"Nghien cuu phuong phdp tong hpp stavudin, nipt loai thudc chdng HIV
CO hieu qud hien nay''
Ma so': QG-0l'-02
C a q u a n chu tri de tai: Trudng Dai hgc Khoa hgc Tu nhien-Dai hgc Qudc gia Ha ndi Dja chi: 334 NguySn Trai- Quiin Thanh Xuan- Ha ndi
Teh 8588579
Ca quiin quiin ly de tiii: Dili hgc Qudc gia Hii ndi
Dia chi: 144 Dudi.g Xufm Thiiy- Quiin Cfiu Giii'y- Hii ndi Tel: 8340564 ^
Tong kinh phi thuc chi: 60 Iricu ddng Trong dd: - Tu ngiiii siich nhii nudc: -Ti:r kinh phi DHQGHN: - Viiy tfn dung: - Von tu cd: -Thu hdi: 0 60 irieu ddng 0 0 0 Thdi gian nghien ciin: 24 Ihi'mg
Ihdi jii:iii l»a( (l:iu; 05-2001 05-2003 Thoi gian ket thuc
Ten cac can hd phdi hop nghien cuu: - GS.TSKH. Nguydn Dinh Trieu - ThS. Doiin Duy Ticn
Ths. Triin Thi Thanh Van VIOl sd lu)c vien Ciio hoc va sinh vien So dang ki de t;ii
Ngay : 24/05/200
Sd chung nhiin dang ki kel (jiiii nghien ciiu
Biio mat:
a. Phd hicn rgng rai: h. Plid bien han che: c. Biio mat:
•
D
Tom tat ket qua nghien ciiu:
- Da nghien ciiu tdng hgp va tdng hgp thanh cdng thudc chua HIV-AIDS- Stavudin (D4T) di liJ thymin.
- Da nghien cuu ldng hgp va ldng hgp thiinh cdng ihudc chua HIV-AIDS- Zidovudin (AZT) di tu thymin
- Citu liio ciia stavudin (D4) vii zidovudin (AZT) da dugc khiing dinh cpia phuang phiip phd hdng ngoiii vii phd cdng hudng tu hiU nhiin 'H-, '^C-, DEPT, phd hai chieu COSY, HETCOSY, HMBC.
- Dii nghien ciiu tdng hgp mot sd chitt dfiu nhu ihymin, uraxin, 5-melyl uridin chuii'n bi cho vice nghien ciiu ldng hgp thimidin sau uiiy.
- Da tdng hgp dugc mgl sd diln xuitt cua oxiiddiiizol, thiiizol, triazol va ihir hoiit Ifnh sinh hgc ihity cd uic dung ddi vdi mot sd vi khuitn E.Coli, P.iicruginosa, B.subtillis, S.aureus vii mpl sd chiing nain mdc, uitm men. Citu liio cua ciic hgp chiti iiiiy dugc xiic djnh qua phuang phiip phd hdng ngoiii vii phd cdng hudng tu hat nhiin 'H vil ' 'C.
Kien nghi ve qui md va ddi (ugng ap dung nghien cuu:
Suiviulin (D4T) va zidovudin (AZT) hi hiii loiii ihudc dugc sii dung phd bieii Ircn the gidi Vii Viet niim dd dieu iri benh HIV-AIDS mil hicn nay ta phiii nhilp ngoai, neu Siin xuitl dugc irong nudc giii Ihilnh se Ihitp han vil chu ddng. De tai mdi hoiln Ihilnh d miic fim ra phuang phiip dieu che irong phdng thf nghiem. neu cd ngudn kinh phf dugc
Citp han nQ'a se lilm vdi lugng Idn vil tien hanh thu nghiem liim sang.
Chung ldi litl mong dugc su quan Uim ciia ban hinh diio Dili hgc Qudc gia Hii ngi
Vil Ciic Citp cao ho'n giup dd 66 phiit trien hudng nghien cii'u ung dung siin xufil nay lam
Chii nhiem dc tai
Thii truang CO quan chu th de
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Ho ten Nguyin Dinh Trieu Triin Nghi Dang Nhu Tai
Hgc hiim hoc vi
GS. TSKH (iS. TSKH
Kf ten ddng ditu
e. Doan Manh Chat, Nguyen Dinh Trieu
Synthesis and calculation of some molecular structural piirameters for 5-aryl 2-mercapto-1.3.4-oxadiiizoIes.
Proceeding o\ Ihe conrerence on sciences - I liinoi University ol sciences,
pp.86 (2001).
f. Pham Van Chuc, Nguyen Thuy Hang, Nguyen Dinh Trieu
Synthesis and structure study of some deriviUives of aryliden-p- tosysulfonylhidriizones and formiizanes containing arylsunfonyl group. Proceeding of the conference on sciences Hanoi University of sciences, pp.93 (2002).
SCIENTIFIC PROJECT Branch: Chemistry Branch: Chemistry
Project category: special project of Vietniim national University, Hiinoi