TONG HOP VA CmiY/^N HOA CAC HOP CHAT TUONG TU'

'.. , ^.KHANCON CO CHtJ*A VONG I N D O L . XL TONG UO? vA

C n U Y H N HOA MOT SO XL/kON n J U R I I O N G NO T U D A N XDAT CUA |, ISOOGH-NOL VA CAC INDOL-3-ANDEHIT.

|, ISOOGH-NOL VA CAC INDOL-3-ANDEHIT.

(SyntJicsis and (ransforiiKUion ofclialconc analogs, eonlaining indole rings. XL Synlhcsi.s and (ransronnaiion of sonic a,P-nnsalnra(c(l

rings. XL Synlhcsi.s and (ransronnaiion of sonic a,P-nnsalnra(c(l

ketones Ironi derivalives of isoeugenole and indolc-3-aldeliydcs.)

• Nguyen Minh Thdo", Trdn Vein Chien, Pham Vdn Phong Khoa JJoii line- Trudng- Dai h.>r K/lTiV, DJ/Qd Ila m'li.

Khoa JJoii line- Trudng- Dai h.>r K/lTiV, DJ/Qd Ila m'li.

\ liy cofuirn.Milion of fi-n. c!v}\.s(H'iiy_rnolr wiih indole-i-aldclwclc.^ the snir.'. cf a,p-iiiis(iUiriJir(l kcfniws. roninintny. tiulnir nnr.s 'have hrrn prcpnrrd. winch have hern (Ichydi oycnntcil in ihc cni ic-pomliny. (irr/inys of flavour or rrndilv irinl with

lihr/iylhyt/nit/ir In };i\'r uidnly![iyni7ohnr.\ > 1 hi' j>niiliicl.\ have han dclcinnncd hv IK-. lJ\e SpfrlKr^roiiv. rlrnn-nln/

nnaly\i.\ niid ihin Invn chi oniniiiyi njihy.

I • '

', Nhu dii bie't. nhieu dim xuAi cua (/gicnol va ksoagicnol co iioai ti'nh sinh hpc dang

I chu y, da <lir(pfc dung lam ihuiV (.liUii ht^nh Uo.\c rli.li kftdi ihlol) sinli IriMnn liitrc vfnl 1.2],

1 NIli(lu,li(7p clul'l chua vOjiig irulol cung dirac diing \hiu lJiui>c chua h6u\\ hni mach, ttiCn ; chinh hoat dung cun he lliAu kinh nung inm^^ lio.lc c6 liic dung ki'ch tln'ch sinh truong

; chinh hoat dung cun he lliAu kinh nung inm^^ lio.lc c6 liic dung ki'ch tln'ch sinh truong

thirc v5l nil gia ni. Vi ihe nt'u glic^p ii6i liai hgp pli.ln n.ay vao lrong cimg niol [iliAn tu ihi

c6 liie lao la cac Uap ch.'il di vdnp, iin'/i \'oi Imai linh sink hoc c() Ih^' da dang vh lliti \d '• han.

'• han.

; Trong mpt thong bao Iriroc dAyl^J cluing I6i (kl giai lliitu sir \6uj\ iiop d/ui xuA'l

• ci-axclykrgicnol roi ngtrng lu. no vol Ciic indol-.l-andchil dc' lao ra ni6l day cac j xeton a,n-kil6ng no va chuy{'a) lioii t Ininp, ih.'uih ( .'n' lii/j> t li.'ll tU{Tnj;'(n flavon ohiia sa'ai):

j xeton a,n-kil6ng no va chuy{'a) lioii t Ininp, ih.'uih ( .'n' lii/j> t li.'ll tU{Tnj;'(n flavon ohiia sa'ai):

indol hoflciciic (I.'iii xuA'l iiKlolylpir.r/oIin.

Trong (lure K-'cac xclon (i.fLklu^n!! no loai nay onng nlur cac 1K;P cli.'U ki(^u lla\'oii

ihocic d^n xuA't cua vong pira/.ohn co chi'ra di vonr, indol cung d6v c6 hoai ifnh sinli hoc ]\'6 nliidu niai- Vi vAy, dc- ii('''p UK hiroii)', nglii(^n ( IP; ii.V/. noni'. c6n|' trinh lii(Mi lai. chiiiif,

]\'6 nliidu niai- Vi vAy, dc- ii('''p UK hiroii)', nglii(^n ( IP; ii.V/. noni'. c6n|' trinh lii(Mi lai. chiiiif,

it6i trinh b.^y sir King lu/p cac xrioii (^(Lkln')ng no iir dan xiiA'i cMixciylksocrgicnol vi'fi nic 'indol-3-andchil va cliuytn hon chiing ih^uili car hop cliri'l lirong tu flavon lioAc cac dAn

'indol-3-andchil va cliuytn hon chiing ih^uili car hop cliri'l lirong tu flavon lioAc cac dAn

jXuA't indolylpira/.ohn Ihco so do dui'ii d.ly;

(.m ' " ' ( ^ • ( H : • l , O H

1 cai^. d- ,,,. ' " ' ' \ : k . ,<iw,,u. " ' ^ \ k " Airi. ow-> J^Cix:t.,

XJ -\:;!^'^- i^^o.'..;- KJ E^^i^Xi

d d a y : Ind = 1) liidolyL3; 2) 2-inciyhndolyL3; 3) N-iiiclyliiuIo!yI-3;Tli - phcuyk

;i' Indol-3-andciiil va 2-inciylindul-3-andcliil nhAn duac bang sir foniyi hoa irvrc {\6\^