1 HOW ALKYL SUBSTITUENTS ARE NAMED

Một phần của tài liệu Preview Essential Organic Chemistry by Bruice P.Y. (2014) (Trang 59 - 62)

Removing a hydrogen from an alkane results in an alkyl substituent (or an alkyl group). Alkyl substituents are named by replacing the “ane” ending of the alkane with

“yl.” The letter “R” is used to indicate any alkyl group.

If a hydrogen of an alkane is replaced by an OH, the compound becomes an alcohol; if it is replaced by an NH2, the compound becomes an amine; if it is replaced by a halogen, the compound becomes an alkyl halide; and if it is replaced by an OR, the compound becomes an ether.

The alkyl group name followed by the name of the class of the compound (alcohol, amine, and so on) yields the common name of the compound. The two alkyl groups in ethers are stated in alphabetical order. The following examples show how alkyl group names are used to build common names:

CH3OH methyl alcohol

CH3CH2NH2 ethylamine

CH3CH2CH2Br propyl bromide

CH3CH2CH2CH2Cl butyl chloride CH3I

methyl iodide

CH3CH2OH ethyl alcohol

CH3CH2CH2NH2 propylamine

CH3CH2OCH3 ethyl methyl ether

R OH

an alcohol

R O R

an ether R NH2

an amine

R X X = F, Cl, Br, or I an alkyl halide

CH3 a methyl group

CH3CH2 an ethyl group

CH3CH2CH2 a propyl group

CH3CH2CH2CH2 a butyl group R

any alkyl group CH3CH2CH2CH2CH2

a pentyl group

Notice that there is a space between the name of the alkyl group and the name of the class of compound, except in the case of amines where the entire name is written as one word.

3-D Molecule:

Isopropyl chloride

PROBLEM 1

Name the following:

a. b. c.

Two alkyl groups—the propyl group and the isopropyl group—have three carbons.

A propyl group is obtained when a hydrogen is removed from a primary carbon of propane. A primary carbon is a carbon bonded to only one other carbon. An iso- propyl group is obtained when a hydrogen is removed from the secondary carbon of propane. A secondary carbon is a carbon bonded to two other carbons. Notice that an isopropyl group, as its name indicates, has its three carbons arranged as an iso structur- al unit.

Molecular structures can be drawn in different ways. Isopropyl chloride, for ex- ample, is drawn here in two ways. Both representations depict the same compound, although, at first glance, the two-dimensional representations appear to be differ- ent: the methyl groups are placed at opposite ends in one structure and at right an- gles in the other. The structures are identical, however, because carbon is tetrahedral. The four groups bonded to the central carbon—a hydrogen, a chlorine, and two methyl groups—point to the corners of a tetrahedron. (If you visit the Molecule Gallery in Chapter 3 of the website (www.chemplace.com), you will be able to actually rotate isopropyl chloride to prove that the two molecules are identical.)

CH3CHCH3

Cl

CH3CHCl CH3

isopropyl chloride isopropyl chloride two different ways to draw isopropyl chloride CH3CH2CH2

a propyl group

CH3CHCH3 an isopropyl group a primary carbon a secondary carbon

CH3CH2CH2Cl propyl chloride

CH3CHCH3 isopropyl chloride

Cl

Mentally rotate the model on the right clockwise until it looks the same as the model on the left.

There are four alkyl groups that contain four carbons. Two of them, the butyl and isobutyl groups, have a hydrogen removed from a primary carbon. A sec-butyl group has a hydrogen removed from a secondary carbon (sec-, often abbreviated s-, stands for secondary), and a tert-butyl group has a hydrogen removed from a tertiary carbon (tert-, sometimes abbreviated t-, stands for tertiary). A tertiary carbon is a carbon that is bonded to three other carbons. Notice that the isobutyl group is the only group with an iso structural unit.

The names of straight-chain alkyl groups sometimes have the prefix “n” (for “nor- mal”), to emphasize that its carbons are in an unbranched chain. If the name does not have a prefix such as “n” or “iso,” we assume that the carbons are in an unbranched chain.

butyl bromide pentyl fluoride

or or

n-butyl bromide n-pentyl fluoride

A chemical name must specify one compound only. The prefix “sec,” therefore, can be used only with sec-butyl. The name “sec-pentyl,” for example, cannot be used because pentane has two different secondary carbons, which means that remov- ing a hydrogen from a secondary carbon of pentane produces one of two different alkyl groups, depending on which hydrogen is removed. As a result, “sec-pentyl chloride” would specify two different alkyl chlorides, and, therefore, it is not a correct name.

If you examine the following structures, you will see that whenever the prefix “iso”

is used, the iso structural unit will be at one end of the molecule and any group replac- ing a hydrogen will be at the other end:

Alkyl group names are used so frequently that you should learn them. Some of the most common alkyl group names are compiled in Table 2 for your convenience.

CH3CHCH2CH2CH2Cl CH3

isohexyl chloride CH3CHCH2CH2OH

CH3

isopentyl alcohol

CH3CHCH2Br CH3 isobutyl bromide

CH3CHCH2NH2

CH3 isobutylamine

CH3CHBr CH3 isopropyl bromide CH3CHCH2CH2OH

CH3

isopentyl alcohol CH3CHCH2CH2CH3

Cl

Both alkyl halides have five carbon atoms with a chlorine attached to a secondary carbon, so both compounds would be named sec-pentyl chloride.

CH3CH2CHCH2CH3

Cl

CH3CH2CH2CH2CH2F CH3CH2CH2CH2Br

CH3CH2CH2CH2 a butyl group

CH3CHCH2

CH3 an isobutyl group

CH3CH2CH CH3 a sec-butyl group

CH3C CH3

CH3

a tert-butyl group a secondary carbon a tertiary carbon

a primary carbon a primary carbon

A primary carbon is bonded to one carbon, a secondary carbon is bonded to two carbons, and a tertiary carbon is bonded to three carbons.

Tutorials:

Common names of alkyl groups

PROBLEM 3

Write a structure for each of the following:

First, determine the number of carbons in the longest continuous chain.

Table 2 Names of Some Alkyl Groups

CH3C CH3

CH3

CH3CH2CH2CH2CH2 pentyl

CH3CHCH2CH2 isopentyl

CH3

CH3 CH3CH2CH sec-butyl

tert-butyl CH3

CH3

methyl

CH3CH2 ethyl

CH3CH2CH2

propyl

CH3CH isopropyl

CH3 CH3CHCH2 isobutyl

CH3CH2CH2CH2 butyl

CH3CH2CH2CH2CH2CH2

hexyl

CH3CHCH2CH2CH2

isohexyl

CH3

a. isopropyl alcohol b. isopentyl fluoride

c. ethyl propyl ether d. sec-butyl iodide

e. tert-butylamine f. n-octyl bromide

PROBLEM 4

Name the following:

c. CH3CH2CHNH2 CH3

e. CH3CHCH2Br CH3

f. CH3CH2CHCl CH3 a. CH3OCH2CH3

b. CH3OCH2CH2CH3 d. CH3CH2CH2CH2OH

PROBLEM 2

Draw the structures and name the four constitutional isomers with molecular formula C4H9Br.

PROBLEM 5

Draw the structure and give the systematic name of a compound with molecular formula C5H12that has

a. one tertiary carbon. c. no secondary or tertiary carbons.

b. three secondary carbons.

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