... dicusssion oftheproblemof evil to theproblemof error, or a problem concerning the trustworthiness of clear and distinct ideas Of course, this restriction oftheproblem cannot hold, since error ... his theories of contingency and of individuation His genius is in bringing together in synthesis his own idiosyncratic metaphysical doctrines and the classical themes of Augustinan theodicy, including ... the traditional reading ofthe Tractatus Theologico-Politicus through the lenses ofthe Ethics, and examines Spinoza's dicta inthe Tractatus concerning the spirit of Christ, the essentials of...
... though they may be seeing other specialists The internist has an important role in educating patients about the indications, benefits, risks, and limitations of genetic testing inthe management of ... also influence the severity of infirmity, effect of treatment, and progression of disease The primary care clinician is now faced with the role of recognizing and counseling patients ... in monozygotic twins ranges between 50 and 90% Diabetes or impaired glucose tolerance occurs in 40% of siblings and in 30% ofthe offspring of an affected individual Despite the fact that diabetes...
... the relative risk ranges from two- to fivefold, underscoring the importance of family history for these prevalent disorders Pending further advances in genetic testing, the key to assessing the ... individual will vary depending on the size ofthe pedigree, the number of unaffected relatives, and the types of diagnoses, as well as the ages of disease onset within the family For example, a ... disease-causing mutations are more prevalent in certain ethnic groups For instance, >2% ofthe Ashkenazi population carry one of three specific mutations inthe BRCA1 or BRCA2 genes The prevalence of the...
... cancer, representing another confounding variable inthe pedigree analysis Some ofthe aforementioned features ofthe family history are illustrated in Fig 64-1 In this example, the proband, a ... found, then it is possible to test for this particular alteration inthe proband and other family members, if they so desire Inthe example shown, if the proband's father has the BRCA1 mutation, there ... whether based on family history, characteristic physical findings, or biochemical testing Careful clinical assessment can define the phenotype, thereby preventing unnecessary testing and directing...
... analysis ofthe gene of interest In addition, PCR enables genetic testing on minimal amounts of DNA extracted from a wide range of tissue sources including leukocytes, fibroblasts, epithelial cells in ... established disease, genetic testing for susceptibility to chronic disease is being increasingly integrated into the practice ofmedicineIn most cases, however, the discovery of disease-associated genes ... (Chap 63) Protein truncation tests (PTTs) are used to detect mutations that result inthe premature termination of a polypeptide occurring during protein synthesis In this assay, the isolated complementary...
... of their personal likelihood of disease in preparing pretest educational strategies Often, patients harbor unwarranted fear or denial of their likelihood of genetic risk Genetic testing has the ... concern that testing during childhood violates a child's right to make an informed decision regarding testing upon reaching adulthood On the other hand, testing should be offered in childhood for disorders ... mechanics of testing Most molecular testing for hereditary disease involves DNA-based analysis of peripheral blood Inthe majority of circumstances, test results should be given only to the individual,...
... issues; Assist in determining the role of genetic testing for the individual and family; Ensure that the patient is aware ofthe indications, process, risks, benefits, and limitations ofthe various ... prevention Finally, patients should understand the natural history ofthe disease as well as the potential options for intervention, including screening, prevention, and in certain circumstances— ... understanding of these genetic diseases and as more is learned about the functions ofthe gene products involved Individuals who test negative for a mutation in a disease-associated gene identified in...
... based testing for presymptomatic diagnosis ofthe disorder However, up to onethird of individuals who are homozygous for the HFE mutation not have evidence of iron overload Consequently, inthe absence ... assessment of phenotypic expression awaits further studies In contrast to the issue of population screening, it is important to test and counsel other family members when the diagnosis of hemochromatosis ... inthe absence of a positive family history, current recommendations include phenotypic screening for evidence of iron overload followed by genetic testing Whether genetic screening for hemochromatosis...
... used inthe clinical setting, predictive testing holds the promise of allowing earlier and more targeted interventions that can reduce morbidity and mortality We can expect the availability of ... intensive clinical screening, as it remains very challenging to predict disease penetrance, expression, or clinical course Although genetic diagnosis of these and other disorders is only beginning to ... distinct genetic abnormalities by the time they acquire invasive or metastatic potential (Chaps 79 and 80) Consequently, the major impact of genetic testing in these cases is to allow more intensive...
... 94:389-394 Guidelines for the determination of death Report ofthe medical consultants on the diagnosis of death to the President’s Commission for the Study of Ethical Problems inMedicine and Biomedical ... irrelevant to the diagnosis of life or death because it fails the test of integration The heart’s only purpose is to pump blood to the brain, generally considered the integrator ofthe rest ofthe body ... ofthe atoms that make up the brain are irrevocably destroyed If the atomic structure ofthe brain is disturbed but the structural integrity ofthe brain is maintained, there is no fundamental...
... one in which the painter is represented inthe act of painting When we look at the painter inthe painting, we are positioned similarly to the model ofthe represented painter We are, on the ... discovering and exposing it, the fascination of seeing it and telling it, of captivating and capturing others by it the specific pleasure ofthe true discourse on pleasure (71) The proliferation of ... function, according to Foucault, are thethe idea ofthework and the notion of writing (écriture)” (11) Without referring to the author, the idea ofthework inevitably implies that it is created...
... all? The difficulty ofthe quest for identity, notably of naming what you consist of inside, is contrasted with the easiness of naming objects in our surrounding at the very beginning ofthe novel ... essence of their own being Finally, the narrator undermines the importance of words and rather highlights the struggle: The story is not inthe words; it‟s inthe struggle” (294) Through gathering ... to their metaphysical questions through writing They are involved inthe process of writing as the act of insight Additionally, all the works question the identity ofthe author and treat the...
... phase clinical studies with the aim of establishing proof of concept in humans The efficacy category includes all research which aims to establish definitive proof of efficacy for an intervention ... reader and the author along the translational medicine pathway Even in this small sample of journals the positioning ofthe journal inthe translational pathway is likely to affect the chance of an ... article falling within the first gap in translation being published inthe journal of choice The general medical journals The Lancet and the NEJM publish a wide range ofresearch that reflects the wide...
... narrow-down close-down The first step in testing this hypothesis was to evaluate the current performance of PARTS in handling the phrasal verb construction To this a set of 94 pairs of Verb+Particle/Preposition ... adjectives This confirms my hypothesis that PARTS will have a problem solving the N/V ambiguity in cases where the lexical probability ofthe word points to a noun These are the very cases that should ... second, and the results of assuming a verbal tag inthe third (The "choice" colunm is explained below.) The average performance of PARTS for this task is 89%, which is lower than the general...
... non-contingent being is intelligible’ seems no more implausible than the thesis ‘If the concept of a thinking being is intelligible, the concept of a non-thinking being is intelligible’.) Of course, ... ‘‘sufficient unto the day is the evil thereof’’ That is to say, the meaning that ‘evil’ has inthe phrase theproblemof evil’ is one of its ordinary meanings ‘‘An evil’’ in this sense ofthe word is ... then, is the relationship of my discussion ofthe apologetic problem to theproblemof evil in its other forms—to personal problems of evil, or pastoral problems of evil? The answer is that the...
... close level of monitoring of therapeutic anticoagulation in dedicated anticoagulation clinics inthe hospital, and of wider awareness ofthe potential for drug interactions with warfarin • Hospital ... Banerjee et al International Journal of Emergency Medicine 2011, 4:22 http://www.intjem.com/content/4/1/22 Page of We extracted the following information, using a structured form, in patients aged ... as the use of five or more prescription medications, as this definition is used inthe North Central London region hospitals as the working definition for identifying risk factors for falls clinic...
... downlink, uplink, and feedback such that the overall system performance in terms ofthe sum ofthe throughputs ofthe downlink and the uplink is maximized In this way, we can also maintain a ... SNR inthe downlink Since the obtainable beamforming gain depends on the quantization resolution, RDL is a function ofthe number b of feedback bits per antenna The original optimization problem ... signal-to-noise ratio (SNR) The index ofthe chosen vector is then fed back to the transmitter There are different ways of designing codebooks for vector quantization [4] By extending theworkin [5], a design...
... associated with the utilization of traditional Chinese medicinein a small town in Hong Kong American Journal of Chinese Medicine 1997:367-373 Pharmacopoeia ofthe People's Republic of China Pharmacopoeia ... those inthe control group On the other hand, a recent study found the popular Echinacea to be ineffective in treating URTI in children age from to 11 years old inthe USA [21] In all these studies, ... extract granules had been formulated into uniform tablets under the supervision ofthe Institute of Chinese Medicine at the Chinese University of Hong Kong The dosage of study drug was tablets (500...
... elements) Another important doctrine in TCM is the Wu Xing Theory (the theory of five elements) According to Wu Xing theory every process in this world is cyclic and is maintained in a kinetic balance ... body and to guide the diagnosis and treatment 1.2.1 The Yin-Yang Theory One ofthe most influential doctrines is the establishment ofthe Yin-Yang theory that had helped inthe use of herbal materials ... Brief Introduction of TCM Principles from Traditional Point of Views 1.2.1 The Yin-Yang theory 1.2.2 The Wu Xing theory (the theory of five elements) .7 1.2.3 The Zhang Fu theory...