without breast and prostate cancer

... in the drug combinations Materials and methods Cell culture HCT116 and SW620 colorectal cell lines were obtained from the Cancer Research UK laboratories, and were maintained in Dulbecco’s modified ... alone and into cells treated with VP16 alone was summed, and compared to the extent of BrdU incorporation into cells treated with both CDO and VP16 together Each column represents the mean and ... number, and did not induce significantly more Whole cell lysates from GEO and HCT116 cells treated with drugs were separated by electrophoresis and immunoprobed for p21waf1, cyclin B, cyclin D, CDK and...

Ngày tải lên: 07/03/2014, 15:20

... Mean, standard deviation, and maximum and minimum nicotine values measured in different indoor environments with smoking occupancy 3-23 Mean, standard deviation, and maximum ... lung cancer in some large cohort studies among men smoking cigarettes and other types of tobacco 4-15 Age-adjusted lung cancer mortality ratios for males and females, ... Epidemiologic studies on ETS and lung cancer in this report and tier ranking 5-4 5-2 Studies by location, time, size, and ETS exposure ...

Ngày tải lên: 15/03/2014, 01:20

... usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes Subjects ... treating cancer pain from comparative randomized studies is scanty This study will investigate the epidemiology of cancer pain and of its treatments, the quality of analgesic-drug therapy and the ... pain in advanced cancer is about 70% with ample variations according to the cancer type and disease stage [2] Despite the existence of published and well-known guidelines for cancer pain management...

Ngày tải lên: 20/06/2014, 15:20

... principles and processed by a proprietary technology developed by CK Life Sciences Limited (CKLS) Schisandra chinensis has been shown to suppress the TPA-induced skin tumor formation and prostate ... levels, which helps to prevent and reduce the risk of breast cancer [5] In addition, extracts of soybean suppressed F3II mouse mammary adenocarcinoma cell growth in vivo and in vitro through the G2/M ... tumorigenesis including cell proliferation and apoptosis [7], and also angiogenesis [8] were assessed in gastric tumors after drug treatment Materials and methods Chemicals and reagents CKBM-A01 (Batch no.:...

Ngày tải lên: 08/08/2014, 18:20

... contributions KLC and AH treated the patient and conceived the idea JW performed the literature search and wrote the manuscript KLC reviewed and revised manuscript All authors have read and approved ... affect most organs and tissues with cancer cachexia and hypercalcaemia being common examples [1] This patient had a neurological syndrome experiencing papillitis, myositis and sensory peripheral ... with both the nervous system and the underlying cancer Each of these antibodies is associated with a narrow spectrum of clinical syndromes and a restricted subgroup of cancers [2] Paraneoplastic...

Ngày tải lên: 09/08/2014, 07:22

... are increased in many tumors such as lung cancer [21], esophageal cancer [22], prostate cancer [23], glioma [24], soft tissue sarcoma [25] and breast cancer [5,14] Furthermore, it has been shown ... plays an important role in breast cancer Several studies prove that OPN is overexpressed in breast cancer and that this correlates with high malignancy, poor prognosis and survival [3-5,14,15] ... markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort...

Ngày tải lên: 09/08/2014, 09:20

... eagle medium (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained ... the expression of b1- and b2-ARs was determined at both the mRNA and protein level in SGC-7901 and BGC-823 cells by RT-PCR and western blot Our results showed that b1- and b2-adrenergic receptors ... the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and BGC-823...

Ngày tải lên: 09/08/2014, 09:20

... including prostate cancer and overcoming resistance to standard genotoxic chemo- and radiotherapy Importantly, Akt is embedded into a highly complex network of upstream regulators and downstream ... Cell lines and cell culture The prostate cancer cell lines LNCaP (p53 wild type, androgen-dependent, highly differentiated), PC3 (p53-/-, androgen-independent, poorly differentiated), and DU145 ... Page of 12 Figure Anti-neoplastic effects of ErPC3 and ionizing radiation on prostate cancer cells The prostate cancer cell lines PC3, DU145, and LNCaP, were irradiated (RT) with 2, 5, or 10 Gy...

Ngày tải lên: 09/08/2014, 09:20

... cores from biopsies with normal tissue (sampled cm from the tumour) and cancer, respectively, and one TMA with normal and cancerous tissue from the surgical specimens, whereby Gaber et al Radiation ... the associations between tTATI and s-TATI concentrations, before and after RT, and clinicopathological parameters, including s-CEA and s-creatinine Classification and regression tree (CRT) analysis ... affects t-TATI and s-TATI concentrations in rectal cancer patients, and to assess their prognostic values For this purpose, TATI was analysed in serum, non-malignant rectal mucosa and tumour tissue...

Ngày tải lên: 09/08/2014, 09:21

... DVH and DSH in Fig 1a) 3D-CRT and in Fig 1b) IMRT treatment planning statistically significant between DVH and all other dose parameters, between DWH and DSH but not between DWH and DWH3 and ... DVH, DWH and DSH in 3D-CRT and IMRT treatment planning for prostate cancer A literature review of the association of these dose parameters with late rectal toxicity was conducted Materials and methods ... anatomical anal canal and rectum as the most superior and inferior parts were not included into the OAR Anal canal and rectum were not delineated as different OARs to make the analysis and presentation...

Ngày tải lên: 09/08/2014, 10:21

... According to the ER status and responsiveness to estrogen, breast cancer can be divided into two subtypes: ER+ and ER- The links between miRNA expression and breast cancer have been shown using ... genes between ER+ and ER- breast cancer samples Differential Differential expression of miRNA processing genes between ER+ and ER- breast cancer samples (a) miRNA biogenesis and function pathway ... between ER+ and ER- breast cancer To investigate the difference of a miRNA regulatory effect between ER+ and ER- breast cancer, a two sample t-test was performed to compare RE-scores and determine...

Ngày tải lên: 09/08/2014, 20:20

... mRNA and protein by somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer ... non-small cell lung cancer, bladder cancer and B chronic lymphocytic leukemia [15,32,33] Human prostate epithelial cells (RWPE-1) and prostate cancer cells (LNCaP, DU145 and PC3), which exhibit ... and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin indicates a promising strategy for prostate cancer therapy Materials and methods Cell lines and...

Ngày tải lên: 10/08/2014, 10:20

... glycosylation and phosphatization of CD44 [34] CD44 and HA mediate the overexpression and activation of integrin as well as the adhesion of tumor cells to epithelia, and enhance the migration and metastasis ... expression of CD44 in RMG-I and RMG-I-H cells detected by immunocytochemistry (×400) Panels and are negative controls; panels and are Lewis y antibody-untreated cells; panels and are Lewis y antibody-treated ... cellular functions and related to some malignant cell behaviors, including adhesion, recognition, and signal transduction, and that the increased fucosylated antigens benefit the invasion and migration...

Ngày tải lên: 10/08/2014, 10:21

... with EPD treatment of normal fibroblasts, OVCAR3 and SKOV3 cancer cells (average (AV) and standard deviation (SD)) % cell viability: average and standard deviation EPD Conc 24 hours 48 hours 72 ... EPD, and to further validate the potential of EPD as an anti -cancer drug in ovarian cancer and other types of cancer Acknowledgements We thank Fred Romijn, Wouter Temmink (LUMC, Leiden) and Alma ... Leiden, The Netherlands Page of Authors’ contributions Data were extracted by CvH and CCD and analyzed by FD and NPMS CCD and AWW contributed substantially to data acquisition and analysis The...

Ngày tải lên: 10/08/2014, 10:21

... docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK Journal of Experimental & Clinical Cancer Research 2011 30:71 Submit your next manuscript to BioMed Central and take full ... volume ≥ 500 mm3 and randomly assigned into groups[6] MCF-7 cell was innoculated into the other 50 nude mice for building the model[7] MDA-MB-231 and MCF-7 cell invasion assay Breast cancer cell invasion ... of uPA, uPAR and ERK in MDA-MB-231 and MCF-7 cells measured by real-time RT-PCR To evaluate the effect of treatments described above on mRNA levels of uPA, uPAR and ERK in breast cancer cells,...

Ngày tải lên: 10/08/2014, 10:21

... high risk of metastasis in colon cancer, gastric carcinoma, lung cancer, and hepatocellular carcinoma [5-8] However, the mechanism of MACC1 implicates in ovarian cancer is still unclear Small interfering ... gene was targeted All single shRNA strands were synthesized at Sangon Biotechnology Co., Ltd (Shanghai, China), and were annealed and ligated into the BglII and HindIII sites of linearized psuper-EGFP ... tumor and ovarian cancer tissues were detected by immunohistochemistry (Table 1) Compared to normal ovary and benign ovarian tumor, expressions of MACC1 were obviously up-regulated in ovarian cancer...

Ngày tải lên: 10/08/2014, 10:21

... tumor suppressor gene ARHI in breast cancer cells Expression of ARHI is markedly down-regulated in breast cancer, and reactivation of ARHI expression in breast cancer cells is associated with ... normal and cancer breast tissue and the mechanism of JMJD2A in breast cancer are required Acknowledgements The work was supported by the National Science Foundation of China (No 81172897 and No ... growth and metastasis may be restrained by silencing JMJD2A, and JMJD2A may be associated with breast cancer cell line MDA-MB-231, thus JMJD2A might be the potential therapeutic target in breast cancer...

Ngày tải lên: 10/08/2014, 10:21

... at 59°C for 35 s and extension at 72°C for min, and followed by the final extension at 72°C for 10 The primers were shown in Table and Table Materials and methods Cell culture and transfection ... demethylation Hela and Siha cells were transfected with siRNA and treated with 1.0 μM 5az-dC (Sigma) respectively, and harvested at 72 h after incubation Genomic DNA was extracted and randomly sheared ... tumor suppressor genes and tumorigenesis in its early status Currently, functions and mechanisms of DNMTs in cervical cancer cells remained unclear, and whether DNMT1 and DNMT3b act synergistically...

Ngày tải lên: 10/08/2014, 10:21

... here the literature and our experience on the in vitro and in vivo animal biological studies of β-glucans, particularly on their immune and anti -cancer mechanisms Physical and chemical properties ... essential if we want to understand and compare the results on how β-glucans act on our immune system and exerting anti -cancer effects A possibly well-defined β-glucan standard is urgently needed in ... JA, Loud JT, Greene MH: Complementary and alternative medicine use among women at increased genetic risk of breast and ovarian cancer BMC complementary and alternative medicine 2008, 8:17 Yang...

Ngày tải lên: 10/08/2014, 22:20