what weather is associated with nimbostratus clouds

... region of the NPPB gene was discovered. This poly- morphism was associated with EH in female subjects. However, this finding does not necessarily imply that there is a relationship between the ... accession number AB265677). This VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TTTC (Fig. 1A). There were 8 alleles of this VNTR polymorphism, ranging from 9-repeat to ... a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso- lated a missense mutation of...

Ngày tải lên: 26/10/2012, 10:04

Ngày tải lên: 16/09/2013, 03:10

... be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP M and ASF ⁄ SF2 are associated with TIAR by protein– protein interaction. It is ... molecular processes. However, the physiological existence of ASF ⁄ SF2-TIA complexes is conditioned by the tissue distribution of TIA protein [46], which is clearly more restricted compared to ASF ⁄ ... acting synergistically for optimal interaction with RNA, both RRMs mediate interactions with distinct motifs present in mRNA mol- ecules addressed to SGs upon stress. ASF ⁄ SF2 is a bona fide...

Ngày tải lên: 16/02/2014, 15:20

... HO-2 expression with each of two different siRNAs is consis- tently associated with increased expression of HO-1 mRNA and protein. Moreover, we provide evidence that at least three mechanisms may account ... cells with HO-2 siRNA induced the expres- sion of HO-1 mRNA and protein without affecting the concentration of GAPDH mRNA and b-actin (Fig. 4A,B). Likewise, the selective reduction of HO-2 mRNA with ... underlined is an artificial HindIII site. A full-length HO-2 cDNA fragment was iso- lated from pCR-hHO-2-1 with EcoR1 and subcloned into the pMACS4-IRES vector (Miltenyi Biotec Inc., Bergisch- Gladbach,...

Ngày tải lên: 19/02/2014, 05:20

... iden- tical to those of the unstimulated cells. This view is consistent with a previous report showing that MDP, but not a safe analogue such as MB, is capable of inducing mitochondrial proton leak ... purine nucleotides [4]. UCP2 is widely expressed in many tis- sues with high levels detected in the spleen, thymus, pancreatic b-cells, heart, lung, white and brown adi- pose tissue, stomach, testis and macrophages, ... MDP. The question raised at this stage is whether UCP2 is responsible for the increase in mitochondrial proton permeability (state 4) induced in macrophages after stimulation with MDP. Purine nucleotides...

Ngày tải lên: 05/03/2014, 23:20

... long-term treatment of cells with ST. As the 130 kDa form of GC-C is still on the surface after prolonged ST treatment, it is not clear at this time whether the 130 kDa form alone is recycled, or not ... cells with ST at 4 °C suggest that down-regulation is brought about by selective internalization of the 145 kDa form through endocytosis and subsequent degradation. The mechanisms involved in this ... 20-day-old Caco2 cells were washed with serum-free DMEM/F12 and incubated with or without 10 )7 M SThinDMEM/F12for 9 h. Monolayers were then washed and re-stimulated with fresh STh (10 )7 M ) in the...

Ngày tải lên: 08/03/2014, 08:20

... stereoisomerism). The lower-đeld 1 H NMR signal of 3 belonged to the N-methyl group at N 2 in the E isomer and t he higher-đeld signal t o that in t he Z isomer, in which N 1 is in trans and cis ... stereoisomers, E and Z, with regard to the partial double bond at N 2 , while the NMR spectra showed the presence of only one isomer. Molecular modelling data ( not shown) suggested t hat this isomer ... an (N,N-dimethylacetimidoyl)amino group is presen t (Fig. 8, structure 2). This group is linked to C5 of a legionaminic acid residue, which is substituted with a nonmethylated N-acetimidoyl group...

Ngày tải lên: 08/03/2014, 10:20

... reported that bikunin expression is associated with a less malignant phenotype [24]. There is evidence that bikunin significantly prevented pulmonary metastasis of mouse Lewis lung carcinoma 3LL cells ... sodium vanadate is associated with increased uPAR expression: bikunin has no ability to inhibit overexpression of uPAR in cells treated with sodium vanadate, indicating that bikunin is able to suppress ... analysis. (B) Unstimulated cells were treated with PD098059 (60 l M ) or vehicle for 12 h. C, Cells were pretreated with staurosporin (50 n M ), PD098059 (60 l M ), U0126 (20 l M ), or with a...

Ngày tải lên: 17/03/2014, 11:20

... Whereas substitutions of His15, His36 and His43 did not reduce Lqh3 sensitiv- ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R (Table 3). Unexpectedly, ... onto the oocyte, suggesting that Lqh3 sensitivity to pH is associated with some later stage in the binding process to the channel. This is corrobor- ated by previous binding studies, which demonstrated that ... 6B). Discussion Insight into the molecular basis of preferential interac- tions of scorpion a-toxins with insect or mammalian Na v s was thus far obtained mainly from mutagenesis and comparison...

Ngày tải lên: 23/03/2014, 09:20

... untreated with ADP than in those treated with the nucleotide. This is in line with the experimental findings on Ca 2+ uptake capacity in the presence and absence of adenine nucleotides. Mitochondria isolated ... rotein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms 1 and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms 1, 2, 3, and 4) is shown in Fig. ... failed to inhibit ANT operation as compared with the control (5 mm NH 4 OH, which is the vehicle of BKA, trace c). With the same BKA stocks, this poison fully inhibited ANT operation in rat liver...

Ngày tải lên: 29/03/2014, 00:20

... top). This suggests that this phosphorylation site, in contrast with the others, is phosphorylated during homologous desensitization. Hence, homologous desensitization of GC-A is associ- ated with ... also included in all subsequent purifications. After incubation with lysis buffer for 30 min on ice with vigorous vortexing, the cell debris and nuclei were pelleted by centrifugation at 2000 g for ... by incubation with anti-FLAG IgG coupled to agarose beads (M2 agarose, Sigma-Aldrich) for 2 h at 4 °C, followed by extensive washing with Tris buffer. The protein was eluted in Tris buffer containing...

Ngày tải lên: 29/03/2014, 09:20

... hormone administration. For the tran- scriptional analysis, cells were incubated with 10 nm EGF for 0.5, 1, 2, 4, 6 or 10 h and then washed twice with NaCl ⁄ Pi. Cells not treated with growth ... non- small-cell lung cancer (NSCLC) cell line H1299 with EGFR overexpression (wild-type: EGFR-WT) and with or without the mutation in which Leu858 is substituted with Arg (mutant: L858R), in addition to the ... RALT is known to be a transcriptional feed- back regulator of the ErbB-MAPK signaling pathway [14,15] and its loss is associated with ErbB2 ⁄ HER-2 oncogenic potency leading to Herceptin resistance [16]....

Ngày tải lên: 30/03/2014, 01:20

... function of CD133 is unknown, preliminary evidence proposed that expression of CD133 is associated with the activation of stemness-related signal pathway, resistance to apopto- sis and bioenergetic ... cells is associated with the prognosis of cancer patients, the over- population hypothesis would be substantially supported. By now, the relationship between the percentage of CD133 and prognosis ... tumor cells and the prognosis of colorectal cancer patients. This study showed that the percentage of CD133 + tumor cells was associated with the prognosis among patients with locally advanced colon...

Ngày tải lên: 18/06/2014, 15:20

... Kaczmar- ski EB, Borrow R, Wilson AG: The tumor necrosis factor poly- morphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med 2009, 37:1237-1243. ... characteristics of patients with severe sepsis and patients with abdominal surgery without signs of infection or inflammation (* unpaired t test, ** Fisher's exact test). Severe Sepsis (n ... pol- ymorphism with inflammatory bowel disease in Chinese Han population. Cytokine 2008, 41:44-47. 28. Hizawa N, Yamaguchi E, Takahashi D, Nishihira J, Nishimura M: Functional polymorphisms in the...

Ngày tải lên: 18/06/2014, 15:20

... assisted with the data collection and helped draft the manuscript. IBJ assisted with the statistical analysis. JM assisted with data collection and helped to draft the manuscript. JB assisted with ... expression was associated with a significantly improved OS in uni- variate and multivariate analysis. This is in line with previous findings from two independent breast cancer cohorts where RBM3 was associated ... found to be associated with a good prognosis in both cohorts. RBM3 expression was also examined in vitro using the cisplatin sensitive ovarian cancer cell line A2780 and its cisplatin resistant derivative...

Ngày tải lên: 18/06/2014, 16:20

... was significantly (p = 0.01) lower in comparison to EAC without BE. Normal tissue is considered as one-fold (b). Statistically significant value is indicated with an asterisk. Grimm et al. Journal of Translational ... survival effect [46] but may be associated with neoplastic pro- gression in BE [47]. Therefore, our results may indicate that MMP-1 expression is associated with multistep car- cinogenesis according to clonal ... same as described for immunohistochemistry Table 1 Clinicopathological characteristics of the EAC study population (with and without histological proven BE) Characteristics Patients (n = 60) MMP-1...

Ngày tải lên: 18/06/2014, 16:20

Ngày tải lên: 18/06/2014, 19:20

Ngày tải lên: 18/06/2014, 19:20

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 19/06/2014, 08:20