what s in a mouse event

... bedtime Each is loaded with pills.” —Evansville (Ind.) Courier & Press A man who works with his hands is a laborer; a man who works with his hands and his brain is a craftsman; but a man who works with ... English cataracte, from Latin cataracta, from Greek katarraktes (waterfall, portcullis, floodgate), from katarassein (to dash down) The ophthalmological sense derives from figurative portcullis, ... rendering of a verse by Shakespeare, Rilke, Neruda, cummings, Hughes, or Yeats overhead It has also been a chance for me to start to learn a little about Dutch and Belgian poets such as T’Hooft,...

Ngày tải lên: 25/10/2013, 16:20

... has only partial information about the individuals (objects, events, and relations) that are talked about Unless one assumes that the original linguistic analysis can resolve all these uncertainties ... by natural language systems is the ability to reason about whether individuals are equal This issue is often finessed in semantic networks by assuming that each node represents a different individual, ... relations The same problems that arise in representing events arise in representing relations, l:or (try-l) FALL(BALL1), 21 instance, often the analysis of a simple noun-noun phrase such as "the...

Ngày tải lên: 21/02/2014, 20:20

... Fungus Fungus Plant Plant Bacteria Plant Plant Fungus Bacteria Bacteria Bacteria Plant Bacteria Animal Fungus Yeast Yeast Bacteria Bacteria Plant Bacteria Fungus Fungus All Bacteria Animal Animal ... reductase component (ThmD) [64] – Plant VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO GMC GMC GMC Succinate dehydrogenase Succinate dehydrogenase DAAO DAAO DAAO DAAO ... In fact, it is striking that most covalent flavoproteins are oxidases, and only a few reductases and dehydrogenases are known that contain a covalent flavin This is probably because covalent flavinylation...

Ngày tải lên: 16/03/2014, 01:20

... event In humans, neocentromerization is usually initiated by a significant chromosomal rearrangement, such as a translocation that produces an acentric fragment, but neocentromeres can also arise ... CenH3binding domains is open and accessible to the transcriptional machinery In contrast to human [1] and Arabidopsis [2] centromeres, each of which has a large core of nearly homogeneous satellite sequence, ... centromeres, the possibility that active genes and frequent retrotransposon insertions are a common feature of grass centromeres cannot yet be ruled out Also, certain maize centromeres in some lines have...

Ngày tải lên: 14/08/2014, 14:21

... result in small business pools or groups The law enables establishment of state-based nonprofit health insurance cooperatives and funds such efforts with loans Small businesses or small business ... business organizations could presumably establish a health insurance co-op that would allow small businesses across a state to band together to purchase health insurance The law also allows exchanges ... also allows states to create the Small Business Health Options Program (SHOP), a special exchange for small businesses, either within the larger state exchange or as a separate exchange The SHOP...

Ngày tải lên: 17/02/2014, 21:20

... preparative gels [11] or silver nitrate for analytical gels [12] Image capture and analysis Gels were scanned using a UMAX scanner (Amersham Biosciences, Barcelona, Spain) and the images were analyzed ... kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase activities ... cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein name ApoA4 ActB Nsfl1C Acy1...

Ngày tải lên: 23/03/2014, 03:20

... GM-CSF application during vaccination leads to a sustained protection against gastric tumors We observed that this approach (LRAST) increases the systemic anti-tumor immune response and initially ... analyzed using a one way analysis of variance (ANOVA) with a Newman-Keuls post hoc test Tumor sizes were analyzed using the Mann-Whitney-U test Differences in expression of cellular markers as ... (APC)-conjugated antimouse CD25 mAb was obtained from Invitrogen For staining of intracellular Foxp3, a FITC-conjugated antibody and buffers were purchased from eBiosciences (San Diego, CA, USA) and staining...

Ngày tải lên: 18/06/2014, 22:20

... cross-sections of muscle was measured using image analysis software (Bioquant, Nova Version 4.00.8 Advanced Image Analysis, R&M Biometrics, Inc, USA) and expressed as a percentage of the total area ... gap was cropped Image analysis was carried out using image analysis software (Bioquant, Nova Version 4.00.8 Advanced Image Analysis, R&M Biometrics, Inc, USA) The amount of callus, fibrous tissue ... and cartilage in the fracture gap were quantified and compared Statistical analysis All quantitative data were transferred to the statistical program SPSS (Version 14, Chicago IL, USA) Analysis...

Ngày tải lên: 20/06/2014, 01:20

... Operational measures Financial measures Investor / Analyst Capital Markets Event 2010 Operational measures: Cement, aggregates and ready-mix concrete are price inelastic, right sizing has top ... Analyst Capital Markets Event 2010 Reducing financial leverage while seizing investment opportunities • Developments since January 1, 2009 Capex to maintain 3'888 Business portfolio in Australia ... plants © Holcim Ltd 2010 17 Investor / Analyst Capital Markets Event 2010 Africa Middle East crisis resistant & remaining at high level; Reduction in Net Sales due to deconsolidations Africa...

Ngày tải lên: 30/07/2014, 21:32

... fibrosis by inhibiting PDGF signalling is supported by data in idiopathic pulmonary fibrosis, asbestos, bleomycin- and radiation-induced lung fibrosis as well as in fibrosis in other organs such as ... Importantly to us, imatinib treatment starting weeks Figure (a) Kaplan-Meier analysis of mouse survival following thoracic irradiation and imatinib treatment (a) Kaplan-Meier analysis of mouse survival ... fibrosis, ii) if attenuation of the acute inflammation is necessary to block fibrosis and iii) if a late drug administration after radiation insult and after the acute inflammation has subside still...

Ngày tải lên: 09/08/2014, 10:20

... expression, whereas RTH is underscored by an inappropriate increase in transcriptional activity in T3 target tissues These data strongly suggest that target-tissue response to T3 administration and the ... analysis of transcriptional response patterns Category Category analysis of transcriptional response patterns Intra-tissue expression patterns of genes showing twofold change or more in iT3 and/ ... cell-cycle/growth-inhibitor genes and WAT In RTH mice this suggests suppression of lipogenesis in the WAT with simultaneous increase in lipogenesis in the heart ing T3 These findings raise the possibility that...

Ngày tải lên: 09/08/2014, 20:20

... Bioscience, CA) Statistical analysis All experiments were repeated at least once The data are expressed as means SEM (standard error of the mean) and differences are considered significant at ... nitrocellulose membranes Western blotting was performed using primary antibodies against extracellular signal-regulated kinase (ERK)1/2 according to the manufacturer 's instructions (Cell Signaling Technology, ... NPRA expression We have reported that NPRA plays a role in airway inflammation Knockout of NPRA in mice resulted in less lung inflammation [11] Inhibition of NPRA by small inferfering RNA against...

Ngày tải lên: 12/08/2014, 14:20

... IFNγ Statistical analysis All data are expressed as mean ± standard error of mean (s. e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general ... aggravates AHR and serum IgE responses in a mouse model of asthma GITR stimulation aggravates AHR and serum IgE responses in a mouse model of asthma A OVA-induced asthma model Sensitization: i.p injection ... research systems, obtained through EMKA Technologies, Paris, France) in response to inhaled methacholine (Sigma-Aldrich) Airway responsiveness was expressed in enhanced pause (Penh), as described...

Ngày tải lên: 12/08/2014, 14:20

... magnification used during the study NADH fluorescence intensity was measured using Sigma Scan (Jandel Scientific Inc., now part of SPSS Inc., Chicago, IL, USA) and was expressed in arbitrary fluorescence ... Hewlett-Packard Co., Mississauga, ON, Canada) The heart rate (HR) was determined from a recording of the arterial pressure trace at time and at 40 minutes post-sc injection Blood samples were also drawn ... made using a repeated measures analysis of variance, with post hoc paired t tests to detect specific differences A p value of less than 0.05 was considered statistically significant Results Table...

Ngày tải lên: 13/08/2014, 03:21

... target usually results in cleavage of the mRNA [8,9], whereas imperfect base pairing leads to translational repression by various mechanisms, including stalling translation, altering mRNA stability ... expression data from Exiqon microarray analysis Additional data file is a table listing retinal miR expression data from Ambion microarray analysis Additional data file is a table listing highly ranked ... profiling All samples and replicates were analyzed on separate miR microarrays Two-step qPCR was performed using ABI 's TaqMan miR Assay (Applied Biosystems, Foster City, CA, USA), in accordance with...

Ngày tải lên: 14/08/2014, 08:20

... mechanisms that are required to regulate degenerative pathways in axons and synapses remains in its infancy One powerful experimental tool that has already yielded novel insights into such pathways is ... cell stress pathways induced by Wlds in vivo and in vitro Changes in cell cycle status in terminally differentiated neurons are often associated with corresponding changes in cell stress pathways ... cerebellar slices and cultured cells were then washed in PBS and incubated in TOPRO (Molecular Probes, Carlsbad, CA, USA) for 10 minutes before mounting in Mowoil Staining was visualised on a laser scanning...

Ngày tải lên: 14/08/2014, 20:22

... Discussion) (a) alterations in ion transport in C rodentium-infected SW mice, including subtle decreases in expression of some apical transporters and compensatory increases in basolateral water ... transformed data A p-value < 0.05 was regarded as statistically significant Abbreviations A/ E, attaching and effacing; AP, activator protein; AQP, aquaporin; CA, carbonic anhydrase; CFTR, cystic ... comparable microbial status and minimize commensal microbiota biases Animals were housed in microisolator cages in a specific pathogen-free facility approved by the Association for Assessment and...

Ngày tải lên: 14/08/2014, 20:22

... assays alone cannot accurately assess the severity or cause of AP After initial diagnosis of AP using serum enzyme activity tests, a series of physiological parameters should be taken and assessed ... biological marker that accurately diagnose AP, initial diagnosis is based on the presence of at least or features, which include abdominal pain, increased serum amylase/lipase/trypsin levels and imaging ... pancreatic digestive enzymes in pancreatic acinar cells The resulting injury causes acute pancreatic inflammation In severe cases, the exaggerated inflammation causes systemic complications accompanied...

Ngày tải lên: 09/09/2015, 17:54

... transducing and encoding noxious stimuli Neuropathic pain Pain arising as a direct consequence of a lesion or disease affecting the somatosensory system Sensitization Increased responsiveness ... peripheral neuropathies (Omoigui, 2007) 1.3.3 Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain Inflammatory pain is ... It mediates facial sensation and plays an important role in pain and temperature senses, including dental pain, and a lesser role in tactile sensation The caudalis nucleus is sometimes called...

Ngày tải lên: 10/09/2015, 08:34