what is the effect of dna binding domain

... ε icgbt (24) where X is a vector of controls, B the vector of behaviors, ε is the error term, i denotes the individual, c the country, t the year of the interview, g gender, and b is the birth cohort. Following ... males). While the precision of the estimates of the effects of behaviors declines with respect to the micro data, we cannot reject the null hypoth- esis that these effects are jointly statistically ... the case of males the positive effect of education on the number of diseases is driven by the fact that better educated males choose more intensive screening. Turning to the decomposition of the...

Ngày tải lên: 22/03/2014, 14:20

... ring to them. They roll off the tongue and flow with the blog." "I see. And what about this one? This one is long, has five words, and they're even misspelled. Is this a bad domain ... And what about this one? This is a paid theme. What you just said makes it sound like paid themes aren't needed. Is this a bad theme?" "No, it's a wonderful theme," the ... The Matrix by The Wachowski Brothers, The Lord of the Rings by J. R. R. Tolkien, The Legend of Zelda by Nintendo, Star Wars by George Lucas, The Wizard of Oz by L. Frank Baum, The Tragical History...

Ngày tải lên: 14/02/2014, 04:20

... price of a mousetrap? Customers no longer need to know the price of servers, software and the rest of the parts making up the IT service stack. This knowledge is as useful as knowing the price of ... I discuss one functional transformation that has taken placed as a result of cloud services, namely; the impact on the assessment of value. This is a timely discourse as the vast majority of ... mousetrap. Customers, however, must know the price of the equivalent services from other cloud providers. This is the crucial performance measure. It is only this performance measure that constitutes...

Ngày tải lên: 09/03/2014, 02:20

... only these kinds of studies are rigorous, as will be discussed in Section 2 of this report. 2. Synthesise what these studies tell us about: a. The impact of microfinance on the incomes of the ... brings together all these studies, and assesses the nature of the evidence of the impact of microfinance on the poor in SSA. Given this paucity, the particular nature of MFIs in SSA, and the policy ... poor b. The impact of microfinance on wider poverty/ wealth of the poor c. The impact of microfinance on other non-financial outcomes for the poor. The volume and nature of the evidence is varied...

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Ngày tải lên: 13/08/2014, 11:23

... changed either in the presence or absence of the metal cofactor. By contrast, the sub- strate binding affinity of the RNase H domain proba- bly increases in the presence of the metal cofactor compared ... lacking the HBD or RNase H domain. On the basis of the results obtained, we discuss the role of the HBD from Tma-RNase HI. Results Protein preparations The amino acid sequence of Tma-RNase HI is com- pared ... cases, the conformation of the metal binding site is probably slightly changed, so that it becomes unfavor- able for binding of Mg 2+ but is kept favorable for binding of Mn 2+ . The finding that the...

Ngày tải lên: 06/03/2014, 22:21

... the deformability required for the formation of the Early protein 2 C-terminal DNA- binding domain DNA complexes of var- ious types is based not only on the rigidity of the base sequences in the DNA ... For HPV-16, the flexibility of the loop may alter the adaptability of the DNA- binding helices, thus modulating the discrimination of specific versus nonspecific DNA sequences. For both the E2s, we ... 6A), may balance the rigidity of the barrel, facili- tating DNA binding. In this protein, a certain degree of plasticity is also shown by the DNA- binding helices a1, which, in their central part,...

Ngày tải lên: 16/03/2014, 10:20

... transcribed, the affinity of the dA–U base pairs is insufficient to stabil- ize the DNA RNA duplex, and the transcript, together with the RNA polymerase, disassembles from the template. It is expected ... analysis of the puta- tive nucleic acid -binding surface of the cold-shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single-stranded DNA containing the ... A ˚ 2 ). The Bc-Csp domain swap provides insight into the folding and misfolding of the CSP The Bc-Csp domain swap occurs in the middle of loop L 34 and is promoted by a unique combination of torsion...

Ngày tải lên: 23/03/2014, 09:21

Ngày tải lên: 14/08/2014, 14:21

... have named the novel C-terminal actin binding domain the VH2-C domain to distinguish it from the two previously reported N-terminal actin -binding domains [19,21,23]. The second submodule comprises the ... 5A,B). Loss of the LBD abolished the ability of C-Vrp1p 364)817 to restore growth of vrp1D cells at elevated temperature. We next assessed the importance of the LBD for the ability of C-Vrp1p 364)817 to ... domain, and LBD. The fragment C-Vrp1p 364)760 is also known as CABS. The actin -binding domain closest to the N-terminus is also known as the WH2 domain (WH2-1 or D1). The predic- ted WH2 domain (WH2-2...

Ngày tải lên: 18/02/2014, 16:20

... NMR spectroscopy. The global fold of this domain is very simi- lar to that of rat MeCP2 MBD and MBD1 MBD (the methyl-CpG -binding domains of rat MeCP2 and methyl- CpG -binding domain protein 1, ... [or the bulky tryptophan in the case of G162(161)W] is predicted to generate gross structural disturbance of the fold. Likewise, as the side chains of F156(155) and F158(157) contribute to the hydrophobic ... cluster in these two regions. Know- ledge of the structure of a larger portion of MeCP2 including the transcriptional repression domain would resolve these speculations and clarify the role of the helical...

Ngày tải lên: 21/02/2014, 00:20

... to each other, the distribution the scores for the individ- ual questions is different. The histograms of both distributions (Figures 4 and 5) confirm this: the algorithm trained on the Medical ... outperform the other training corpora, and that of the other four, FAQ is the best- performing corpus. Figure 3 also shows a large difference in the sizes of the starting percentiles: The proportion of ... factor that is known to influence the quality of text prediction systems, is training 562 Proceedings of the 13th Conference of the European Chapter of the Association for Computational Linguistics,...

Ngày tải lên: 17/03/2014, 22:20

... understanding of the effect of NPs on the structure of proteins is still in a nascent state. In this work we report the unfolding behavior of the periplasmic domain of the ToxR protein (ToxRp) of Vibrio ... used: a ẳ 3w/ qR ; 10ị where a is the total area of the ZnO NP, w is the mass of ZnO, / is the mass fraction of the NP (0.015), R is the radius (1.25 nm) and q is the density (0.015 gặcm )3 ). Acknowledgements T.C. ... decrease in the a-helical content of the free protein. Isothermal titration calorimetry, used to quantify the thermodynamics of binding of ToxRp with ZnO NPs, showed an exothermic binding isotherm (DH...

Ngày tải lên: 23/03/2014, 03:20

... information about the functionality of the ATPase, they are all interpreted independently of the metallo-chaperone. Indeed, studying the Atx1–Ccc2 route in vivo remains challenging, because of the existence of ... from Atx1 to the core of the copper ATPase. These interactions ensure that no release of free copper occurs in the cytosol during the transfer of the ion to the secretory path- way. The assay designed ... [25]. Therefore, unless another copper -binding site is disclosed in Ccc2, we propose that the copper ion bound to either N-terminal MBD is transferred directly to the membrane transport site, thereby...

Ngày tải lên: 23/03/2014, 05:22