what is alzheimer s disease
Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... Importantly, this complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal ... which is about twice as large as the RCAN1- 1S protein This is also much larger that has been described in other tissues (25–29 kDa) There are several possible explanations for this First, there ... FEBS 1717 RCAN1 in Alzheimer s disease C D Harris et al Fig RCAN1-1 is overexpressed in AD RCAN1-1L and RCAN1-4 protein expression was measured via western blot [a representative blot is shown...
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báo cáo hóa học: " Vascular consequences of passive Aβ immunization for Alzheimer''''s disease. Is avoidance of "malactivation" of microglia enough?" docx
... contributor or decorative response to Alzheimer' s disease pathogenesis Neurobiol Aging 2004, 25:599-602; discussion 603-4 Publish with Bio Med Central and every scientist can read your work free ... by Aβ was at least partially responsible for AD-associated degeneration, others had pointed to microglial phagocytosis as a desirable consequence of activation For the purposes of discussion, the ... expression of neurotrophic factors under many of the same conditions in which they show inflammationrelated responses such as phagocytosis, retraction of processes, release of excitotoxins, and...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... the levels of the two extreme groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in ... Clin Invest 1999, 29:643-649 Foy CJ, Passmore AP, Vahidassr MD, Young IS, Lawson JT: Plasma chain-breaking antioxidants in Alzheimer' s disease, vascular dementia and Parkinson 's disease QJM 1999, ... a second cognitive assessment 2.0 (0.2) [median (IQR/2)] years after the initial visit Of the 13 patients who came to autopsy, 12 were Consortium to Establish a Registry for Alzheimer' s disease...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... feelings, vision problems, etc Degenerative diseases like Huntington s disease or other rare, usually genetically transmitted diseases may also cause dementia in adolescents This illness destroys ... in 23 24 Alzheimer s Disease and Other Dementias Ten Warning Signs of Alzheimer s Disease The Alzheimer s Association has come up with a list of 10 warning signs of Alzheimer s disease that may...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... microtubule-associated protein that normally serves to assemble and stabilize microtubules Genetics and risk factors implicated in Alzheimer s disease pathogenesis Familial forms of AD, with an autosomal ... compilation ª 2010 FEBS O Philipson et al Animal models of Alzheimer s disease Fig AD pathogenesis according to the amyloid cascade hypothesis This theory suggests that altered metabolism of Ab, in particular ... models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing animal models discussed, and...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... neurons (Fig 7C), with a similar loss evident for all peptides Discussion Because extensive evidence supports a crucial role for Ab in Alzheimer s disease pathogenesis, there is huge interest in ... urea Mass spectrometry, amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using ... Applied Biosystems Procise 492 cLC sequenator (Applied Biosystems, Framingham, MA, USA) employing standard Edman chemistry, and MS analysis was undertaken using an LCQDECA LC ⁄ MS system (ThermoFinnigan,...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... variability is not associated with the rate of progression of Alzheimer s disease [51,59,67] The study was designed to address a specific question regarding the role of APOE-4 in memory As a prerequisite, ... phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of the Mattis...
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LifeOut of Focus Alzheimer’s Disease and Related Disorders ppt
... characteristics Alzheimer s is a progressive disease; this means that the condition continues to get worse over five to ten years Alzheimer s disease is listed as the cause of more than 100,000 deaths ... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS THE COST OF ALZHEIMER S DISEASE As you can imagine, Alzheimer s disease is very expensive The cost of medical care for its victims is only ... characteristics As the stories above illustrate, the first signs of dementia are slight memory disturbances or subtle changes in personality Alzheimer s is a progressive disease; this means that...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... 18 DeKosky S Early intervention is key to successful management of Alzheimer disease Alzheimer Dis Assoc Disord 2003;17(Suppl 4) :S9 9–104 19 Leifer BP Early diagnosis of Alzheimer s disease: clinical ... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... Mielke R, Heiss WD Positron emission tomography for diagnosis of Alzheimer s disease and vascular dementia J Neural Transm Suppl 1998;53:237–250 108 Alexopoulos GS Vascular disease, depression, and...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... al established, but the role for metal dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of ... di-tyrosine-mediated cross-linking of Ab peptides [16–18] This is consistent with the high di-tyrosine content observed in AD brain tissue [17] Oxidative stress within the AD brain is also closely...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... 2007 The Authors Journal compilation ª 2007 FEBS 3785 Therapy for prion disease and AD T Wisniewski and E M Sigurdsson species Transmissibility of prionoses between different species is generally ... or deposit in the cerebrovasculature A comparable entity in prion diseases consists of the proteinase K resistant scrapie form of the prion protein (PrPSc) that, in certain prion diseases, fibrillizes ... of forming amyloid deposits The presence of amyloid deposits is necessary for making the diagnosis CONFORMATIONAL DISORDERS Alzheimer s Disease Mainly Random Coil Monomers Non-Toxic PrPC Aβ Plaque...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable differences in c-secretase activity We established that the differences in ... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... 50-fold) was the same for both assays This is consistent with previous reports [32–34] and suggests that the same proteolytic machinery produces Ab and the C-terminal cytosolic fragment Differences in...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established with ... from what Alzheimer s Disease 31 neuropathologists are now confirming as Alzheimer s disease (Consensus recommendations for the postmortem diagnosis of Alzheimer s disease The National Institute ... Massachusetts Alzheimer s Disease Research Center Massachusetts General Hospital, Boston, MA USA Preface This book provides a comprehensive review of Alzheimer s disease and other dementias from...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... ELISA in the same set of tissues as dot blots [6] Immunohistochemistry Immunohistochemical staining was performed on 20-lM formalin-fixed frozen sections (two AD cases, and two control cases) ... related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken together with the findings that mTOR phosphorylated at the Ser2481 site has a significant ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
... community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale (ADAS-cog 85 points), clock test, cube copying test and A Quick Test of ... and a specificity of 87% in a large MCI study population [15] Statistics Statistical analysis was performed using the PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., ... dysfunction Abbreviations Ab: b-amyloid; AD: Alzheimer s disease; ADAS-cog: Alzheimer s Disease Assessment Scale; APOE: apolipoprotein E; AQT: A Quick Test of cognitive speed; CSF: cerebrospinal...
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Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer s disease J Neurosci 27, 796–807 Cleary JP, Walsh DM, Hofmeister JJ, Shankar ... models and human disease, it is still interesting and important to reflect upon these observations and to try to provide explanations A comparison between APP transgenic models and the human disease ... laboratory; for specificity, see Fig S3 ), was added and incubated for h at RT Subsequent steps were performed in the same way as for the mAb158 protofibril ELISA Statistical analysis The Morris water maze...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
... Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially in Alzheimer s disease patient s brain [47] ... processes in Alzheimer s disease: role of Ab–AChE complexes and Wnt signaling In Cholinergic Mechanism Function and Dysfunction (Silman I, Soreq H, Anglister L, Michaelson D & Fisher A, eds), ... Mesulam MM (1993) Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima...
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Báo cáo khoa học: Implication of calpain in neuronal apoptosis A possible regulation of Alzheimer’s disease doc
... caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation and functional loss ... astrocytes These findings suggest that calpain is involved in Ca2+-mediated apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is ... isoforms, whereas MAP1A and MAP1B sequential proteolysis results from caspase and calpain activation This work confirms the cross-talk between caspase and calpain and identifies a novel mechanism associated...
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Guideline for Alzheimer’s Disease Management pdf
... presentation or history of depression is atypical or complex (Lyketsos & Lee) Since administering assessment tests for depression to Alzheimer s Disease patients is often challenging (Warshaw, ... University Scale for Psychopathology in Alzheimer s Disease, is brief and effective in assessing psychotic symptoms, but is not appropriate for assessing changes in severity of symptoms (Devanand, ... conditions, functional status, cognitive status, and behavioral symptoms, including possible psychotic symptoms and depression The assessment should also address the patient s support system and decision-making...
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ALZHEIMER’S DISEASE AND RELATED DISORDERS ANNUAL doc
... Alzheimer s disease Donald R Royall Glycosaminoglycan mimetics in Alzheimer s disease 63 Francine Gervais, Denis Garceau, Paul S Aisen, and Serge Gauthier Immunotherapy for Alzheimer s disease ... De Santi S, Zinkowski R, et al MRI and CSF studies in the early diagnosis of Alzheimer s disease J Int Med 2004;256:205–223 Citron M Strategies for disease modification in Alzheimer s disease ... Alzheimer s disease: Correlation with cognitive severity Ann Neurol 1990;27:457–464 Terry RD, Masliah E, Salmon DP, et al Physical basis of cognitive alterations in Alzheimer s disease: synapse loss is...
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