what are the nonliving components of the biosphere

... in the design of the product, did not properly balance the risks to product users against the utility of the product to society. It is the reasonableness, or lack thereof, of the ... few of the areas where the law can have a significant impact on engineers' discharge of their professional responsibilities. As part of the process of product design, the ... that the breach of duty by the defendant was the cause of the plaintiff's injury. The doctrine of negligence rests on the duty of every person to exercise due care in...

Ngày tải lên: 23/01/2014, 07:20

... late steps of the process. For example, early in the NER process, RPA assists TFIIH in the opening of the DNA helix around the damage site [36]. Further- more, in the presence of the XPA minimal ... sites. Taken together, these findings suggest that the struc- tural properties of DNA-damaged substrates, whether intrinsic or the result of protein binding, function in the recruitment of the XPC–hHR23B ... sequentially at the site of the damage and constitute the pre-incision complex. Endonuclease XPG and the XPF–ERCC1 complex are responsible for the 3¢ and 5¢ DNA inci- sions, respectively. Binding of XPG...

Ngày tải lên: 07/03/2014, 12:20

... been implicated in all but one of the predicted reactions in the GPI pathway. The exception is the addition of the second mannose to the GPI core. We show here that depletion of the essential, multispanning ... Ybr004cp func- tions upstream of Smp3p. Together, these data further support the conclusion that Ybr004cp functions in the yeast GPI assembly pathway. Sequence analysis of the Ybr004cp protein family Database ... cells leads to the bio- chemical defects expected if addition of the second, a-1,6-linked mannose to GPI precursors is prevented. These defects are a block in the incorporation of [ 3 H]inositol...

Ngày tải lên: 07/03/2014, 16:20

... mammalian-specific function of SMO (e.g. nuclear targeting of the mSMOl isoform). Inspection of the mSMOl modelled structure (Fig. 2) indicates that both regions are located on the tip of the FAD-binding domain, ... is localized on the tip of the FAD-binding domain, in close spatial proximity to the protein region encoded by exon VIa of the mSMOl isoform. This observation has led us to hypothesize that these two ... cytosolic. The only structural difference between the two isoforms is the presence of an extra protein domain in mSMO l, encoded by the exon VIa [10]. Comparative analysis of the amino acid sequence of...

Ngày tải lên: 07/03/2014, 17:20

... sites of the tetramer are indicated by the bound CoA molecules. The catalytic site of the yellow domain is marked by an arrowhead. (B) The binding mode of CoA to the thiolase monomer. The three ... contacts to the pantetheine moiety of CoA at the outer edge of the tunnel. Water molecules are also present in the pantetheine binding tunnel, both in the unliganded and liganded states [2,11]. There ... modes of these related compounds. The results show that both the CoA terminal SH group and the side chain SH group of the catalytic Cys89 are crucial for the correct positioning of substrate in the...

Ngày tải lên: 16/03/2014, 04:20

... representing the PSBD of the dihydrosuccinyltransferase chain of the 2-oxoglutarate dehydrogenase complex of E. coli [12] and of the dihydroacetyltransferase chain of the PDH complex of B. stearothermophilus ... 119–171) of the B. stearothermophilus E2p polypeptide chain with the dimer of a protein domain (E3int) representing the interface domain (resi- dues 343–470) of B. stearothermophilus E3. The use of the ... (see above) are probably due to the use of uniformly 15 N-labelled PSBD and the inclusion of additional resi- dues in the construct at the N-terminus of the domain. In particular, the absence of residues...

Ngày tải lên: 16/03/2014, 18:20

... properties of the FeFe protein (Eur. J. Biochem. 269) 1655 Comparison of the turnover signals from enzyme- reduced states of the MoFe protein and the FeFe protein The characteristic EPR signal of the ... identical with the control spectrum in the absence of Rc1 Mo .Furthermore,withthe exception of the classical S ¼ 3/2 signal of the MoFe protein a t l ower temperatures (< 12 K), no other signal was ... assignment of these novel EPR signals to either the cofactor or the P-cluster has proven elusive due to the fact that both of these metal clusters present in the Fe-only n itrogenase are d iamagnetic...

Ngày tải lên: 18/03/2014, 01:20

Ngày tải lên: 21/03/2014, 22:04

Ngày tải lên: 08/04/2014, 01:22

Ngày tải lên: 11/06/2014, 12:49

Ngày tải lên: 18/06/2014, 18:20

Ngày tải lên: 20/06/2014, 20:20

Ngày tải lên: 21/06/2014, 17:20

Ngày tải lên: 11/07/2014, 16:10

... translocation of the internally sequence of PreS1 domain onto the viral surface [62, 63]. This supports the hypothesis that the low pH in the endosome may induce the conformation change of HBV surface ... follows [10]. The assembled HBV virion and sub-viral particles are transported to the Golgi for further modification of its glycans in the surface proteins, and then are secreted out of the host ... target, further confirmed the role of LHBs in the HBV attachment [23]. Recently, the attachment site of LHBs was functionally narrowed down to the amino acids 21–47 of preS1 by employing synthetic...

Ngày tải lên: 03/11/2012, 10:09

... role in the regulation of proliferation, migration, and differ- entiation of the epithelial cells [2,12,18,19] . Following the surgical treatment of adult periodontitis, the epithelial regeneration ... gingivitis grade of 0 or 1. Thanks to the bacteriostatic properties of the tested polymer, a more effective control of the surgical wound no bacterial contamina- tion of the surgical site ... largely responsible for the consistency of the active component that can act as a barrier to the spread of any bacteria penetrating the tissues including those of the periodontium. It is conceivable...

Ngày tải lên: 03/11/2012, 11:35

... clearer and more precise, limiting the chances of the provision being misinterpreted. The participants, therefore, are clearly aware of the circumstances of their rights and obligations. The ... that the function of a text is the application or use which the text has in the particular context of situation” (p.36). There are two components of a text’s function: the ideational and the ... Significance of the study The results of this study will help test the quality of the English translation of the Law on Investment 2005 of Vietnam under the model developed by the German linguist...

Ngày tải lên: 07/11/2012, 14:36

... and there are many other examples around the world. In short, rainwater harvesting has been proven to be successful in many parts of the world. In any buildings in the urban areas, there are ... despite the numerous sources of atmospheric pollution, in most parts of the world, especially in rural and island locations, levels of contamination of rainfall are generally low. Contaminations are ... and the development can become sustainable in terms of water resources. Another added benefit of rainwater harvesting is the potential reduction in flood peaks. If rain that fell on the roof...

Ngày tải lên: 01/04/2013, 22:43

... recommended that the outer harder and shiny part of the palm fronds be used for the fabrication of PFCBB. 4. Other factors like water absorption of the PFCBB be conducted to determine its other properties ... Fabrication of Palm frond cement-bonded blocks Testing of compressive strength of PFCBB using The Universal Testing Machine   1 THE 28 TH CONFERENCE OF THE FEDERATION OF ENGINEERING ... 3,000 hectares per year. Palms are usually pruned every 15 days and the pruned fronds are usually used for “kalakat” and sometimes are burned or left in plantations to rot. The use of chipped...

Ngày tải lên: 01/04/2013, 22:44