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Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx

Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx

... peptide. Shown are the summed peak areas P (total area of f + s peaks) divided by the marker peak area M at different time points as a percentage of the initial value of P ⁄ M at the onset of the experiments ... heterogeneity. The proton chemical shifts of the alternative conformer (I 2 ) of cK58-b2m are compared with the corresponding values of the nat- ively folded form of cK58-b2m in the graph. The two conformers ... doubling at the loca- tions and to the extent reported in Fig. 9. The features of the pattern of the second conformer resemble the features of a minor monomeric intermediate occurring along the b2m-refolding...

Ngày tải lên: 23/03/2014, 11:20

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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

... region. Effect of mutations in the C-terminal region of the RmInt1 IEP on RNA splicing in vivo We constructed a series of mutants to identify the functional features of the C-terminal region of the RmInt1 ... resi- due at the N-terminus of a-helix a4, the domain X contains the conserved amino acid residues HKXRA (RmInt1 residues 388–392) carrying a stretch of basic amino acids. Some of the residues of the ... domain X, apparently unrelated to the C-terminal regions of other group II intron-encoded proteins. Multiple sequence alignments identified features of the C-terminal portion of the RmInt1 intron-encoded...

Ngày tải lên: 15/03/2014, 09:20

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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf

Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf

... modulating the catalytic properties of the enzyme [19]. To extend the information about the role of the noncatalytic SBD regions and their effect on the C-terminal CD, we further explored the amino ... Whereas the production of ADPGlc via ADPGlc PPase is the first committed step in starch biosynthe- sis, SS catalyzes the elongation of a-1,4-glucans by the transfer of the glucosyl moiety from the ... of the apparent affinity for the sub- strates and V max of starch synthase III. The results presented here suggest that the interaction of the N-terminal starch-binding domains, particularly the...

Ngày tải lên: 22/03/2014, 21:20

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Tài liệu Integrative Medicine and the Health of the Public: A Summary of the February 2009 Summit docx

Tài liệu Integrative Medicine and the Health of the Public: A Summary of the February 2009 Summit docx

... causes of death (IOM, 1999). Disconnected and uncoordinated care amplifies the economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, ... economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, redundancies, and excesses of the current fragmented system and are considered ... NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of...

Ngày tải lên: 17/02/2014, 14:20

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Tài liệu DIRECTIVE 2004/39/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL ppt

Tài liệu DIRECTIVE 2004/39/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL ppt

... authority of the home Member State of the MTF shall, on the request of the competent authority of the host Member State of the MTF and within a reasonable delay, communicate the identity of the members ... Council on the state of the removal of the obstacles which may prevent the consolidation at the European level of the information that trading venues are required to publish. 5. On the basis of the ... to the competent authority of the host Member State. In the event of a change in the particulars, the competent authority of the home Member State shall inform the competent authority of the...

Ngày tải lên: 17/02/2014, 21:20

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Tài liệu A Compilation of the Messages and Papers of the President pdf

Tài liệu A Compilation of the Messages and Papers of the President pdf

... pursuance of the duties of their appointment they have in the course of the late season performed the following surveys and explorations: 1. The meridian line of the monument at the source of the St. ... remains of the illustrious son should sleep under the same turf with those of his distinguished father, one of the signers of the Declaration of Independence; in the wish of the citizens of his ... United States of America in Congress assembled, That the chairs of the President of the Senate and of the Speaker of the House of Representatives be shrouded in black during the residue of the session,...

Ngày tải lên: 18/02/2014, 08:20

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Tài liệu Report of the Independent Monitoring Board of the Global Polio Eradication Initiative pptx

Tài liệu Report of the Independent Monitoring Board of the Global Polio Eradication Initiative pptx

... indeed, but areas of deep concern persist. The very best news comes from India. For years, many believed that the challenge of stopping polio transmission in India would be the downfall of the Programme; ... healthcare) but fail to meaningfully set out the many ways in which the Polio Programme can contribute. To the generation that follows, the eradication of polio will not be the end of the timeline. ... will be the beginning. What is the polio footprint? What is the legacy that will arm future programmes? This is what the Polio Programme needs to set out. We ask people in the Programme, ‘What...

Ngày tải lên: 18/02/2014, 15:20

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Tài liệu Báo cáo khoa học: An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina pdf

Tài liệu Báo cáo khoa học: An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina pdf

... sub- contract from The Of ce of Biomass Program, within the DOE Of ce of Energy Efficiency and Renewable Energy. Tom Desmet holds a fellowship of the Insti- tute for the Promotion of Innovation through ... presumably, contain the sites of O-glycosylation, but we have not identified the specific site(s) or the form of the O-glycans. The CD spectrum of Cel74A looks a lot like that of an unordered protein ... using savuka software provided by O Bilsel (University of Massachusetts Medical School, N. Worces- ter, MA, USA). The midpoint of the transition (T m )isan apparent value, as the thermal denaturation...

Ngày tải lên: 19/02/2014, 05:20

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Tài liệu Proposal for a DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on Alternative Investment Fund Managers and amending Directives 2004/39/EC and 2009/…/EC ppt

Tài liệu Proposal for a DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on Alternative Investment Fund Managers and amending Directives 2004/39/EC and 2009/…/EC ppt

... protection of the interests of members and others, are required by Member States of companies within the meaning of the second paragraph of Article 58 of the Treaty, in respect of the formation of ... receive the following information before they invest in the AIF, as well as any changes thereof: (a) a description of the investment strategy and objectives of the AIF, all the assets which the ... by the AIFM and communicated in the application. The competent authorities of the home Member State may restrict the scope of the authorisation, in particular as regards the type of AIF the...

Ngày tải lên: 19/02/2014, 09:20

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Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc

Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc

... Figure 5C shows that the spectra of the sample subjected to compression and decompression are similar to the non-treated sample, even in the case of the M88V mutant. The elution of the samples after ... promote significant binding of bis-ANS to any of the particles, with the exception of T 45S, which bound a small amount of bis-ANS, increasing, by twofold, the emission of the probe (Fig. 7B). M88V ... interaction (T 45S) , decrease the stability of the capsid. Our findings illuminate the role of packing in the icosahedral lattice of the virus capsid. Experimental procedures Chemicals All reagents were of...

Ngày tải lên: 19/02/2014, 12:20

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