... peptide. Shown arethe summed peakareas P (total area of f + s peaks) divided by the marker peakarea M at different time points as a percentage ofthe initialvalue of P ⁄ M at the onset ofthe experiments ... heterogeneity. The proton chemical shifts ofthe alternativeconformer (I2) of cK58-b2m are comparedwith the corresponding values ofthe nat-ively folded form of cK58-b2m in the graph. The two conformers ... doubling at the loca-tions and to the extent reported in Fig. 9. The features ofthe pattern ofthe second conformer resemble the featuresof a minor monomeric intermediate occurringalong the b2m-refolding...
... region.Effect of mutations in the C-terminal region of the RmInt1 IEP on RNA splicing in vivoWe constructed a series of mutants to identify the functional featuresofthe C-terminal region of the RmInt1 ... resi-due at the N-terminus of a-helix a4, the domain Xcontains the conserved amino acid residues HKXRA(RmInt1 residues 388–392) carrying a stretch of basicamino acids. Some ofthe residues ofthe ... domain X, apparently unrelated to the C-terminal regions of other group II intron-encoded proteins. Multiplesequence alignments identified featuresofthe C-terminal portion of the RmInt1 intron-encoded...
... modulating the catalytic properties ofthe enzyme [19]. To extend the information about the role ofthe noncatalyticSBD regions and their effect on the C-terminal CD,we further explored the amino ... Whereas the production of ADPGlc via ADPGlcPPase is the first committed step in starch biosynthe-sis, SS catalyzes the elongation of a-1,4-glucans by the transfer ofthe glucosyl moiety from the ... ofthe apparent affinity for the sub-strates and Vmax of starch synthase III. The results presented here suggestthat the interaction ofthe N-terminal starch-binding domains, particularlythe...
... causes of death (IOM, 1999). Disconnected and uncoordinated care amplifies the economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, ... economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, redundancies, and excesses ofthe current fragmented system and are considered ... NOTICE: The project that is the subject of this report was approved by the Governing Board ofthe National Research Council, whose members are drawn from the councils of the National Academy of...
... authority ofthe home Member State of the MTF shall, on the request ofthe competent authority of the host Member State ofthe MTF and within a reasonable delay,communicate the identity ofthe members ... Council on the state of the removal ofthe obstacles which may prevent the consolidation at the European level ofthe information thattrading venues are required to publish.5. On the basis ofthe ... to the competent authority ofthe hostMember State. In the event of a change in the particulars, the competent authority ofthe home Member State shall inform the competent authority of the...
... pursuance ofthe duties of their appointment they have in the course ofthe late season performed the following surveys and explorations:1. The meridian line ofthe monument at the source ofthe St. ... remains ofthe illustrious son should sleep under the same turfwith those of his distinguished father, one ofthe signers ofthe Declaration of Independence; in the wish of the citizens of his ... United States of America in Congress assembled,That the chairs ofthe President ofthe Senate and ofthe Speaker ofthe House of Representatives be shroudedin black during the residue ofthe session,...
... indeed, but areas of deep concern persist. The very best news comes from India. For years, many believed that the challenge of stopping polio transmission in India would be the downfall ofthe Programme; ... healthcare) but fail to meaningfully set out the many ways in which the Polio Programme can contribute. To the generation that follows, the eradication of polio will not be the end ofthe timeline. ... will be the beginning. What is the polio footprint? What is the legacy that will arm future programmes? This is whatthe Polio Programme needs to set out.We ask people in the Programme, ‘What...
... sub-contract from TheOf ce of Biomass Program, within the DOE Of ce of Energy Efficiency and RenewableEnergy. Tom Desmet holds a fellowship ofthe Insti-tute for the Promotion of Innovation through ... presumably, contain the sites of O-glycosylation,but we have not identified the specific site(s) or the form ofthe O-glycans. The CD spectrum of Cel74A looks a lot like that of an unordered protein ... using savuka software provided by O Bilsel(University of Massachusetts Medical School, N. Worces-ter, MA, USA). The midpoint ofthe transition (Tm)isanapparent value, as the thermal denaturation...
... protection ofthe interests of members and others, are required by Member States of companies within the meaning ofthe second paragraph of Article 58 ofthe Treaty, in respect ofthe formation of ... receive the following information before they invest in the AIF, as well as any changes thereof: (a) a description ofthe investment strategy and objectives ofthe AIF, all the assets which the ... by the AIFM and communicated in the application. The competent authorities ofthe home Member State may restrict the scope ofthe authorisation, in particular as regards the type of AIF the...
... Figure 5C shows that the spectra of the sample subjected to compression and decompression are similar to the non-treated sample, even in the case of the M88V mutant. The elution ofthe samples after ... found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured coat proteins to the gel [34,35]. The elution of some D11N ... promote significant binding of bis-ANS to any of the particles, with the exception of T45S, which bound asmall amount of bis-ANS, increasing, by twofold, the emission ofthe probe (Fig. 7B). M88V...
... of revocation shall put an end to the delegation ofthe power specified in that decision. It shall take effect the day following the publication ofthe decision in the Official Journal ofthe ... prepare in relation to the qualifying venture capital funds they manage. The report shall describe the composition ofthe portfolio ofthe fund and the activities ofthe past year. Article ... eligible investors and the use ofthe designation "European Venture Capital Fund" should be sanctioned by the prohibition ofthe use ofthe designation and the removal of the venture capital...