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Báo cáo y học: "Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study" pdf
Ngày tải lên :
12/08/2014, 15:22
... test datasets ACR 20 ACR 50 DAS 28 Table Associations between biomarker levels (baseline and changes from baseline to week 4) and clinical measures (ACR 20, ACR 50, and DAS 28 responses) at week ... independently as predictive markers in the management of patients with RA who are treated with antiTNF -a therapies Abbreviations ACR: American College of Rheumatology; bFGF: basic fibroblast growth factor; ... EC, Hsia EC, Buchanan J, Klareskog L, Murphy F, Wu Z, Parasuraman S, Rahman MU: Golimumab significantly improves physical function, health-related quality of life, and fatigue in rheumatoid arthritis...
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Báo cáo y học: "Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients: a claims-based study" pps
Ngày tải lên :
08/08/2014, 23:21
... concept/design, data analysis/interpretation, statistics, data collection, and project administration GP and RM provided concept/design and data analysis/interpretation JW provided data analysis/interpretation ... tomography; HMO: health maintenance organization; HR: hazard ratio; ICD: International Classification of Diseases; MRI: magnetic resonance imaging; PPAE: potentially prolactin-related adverse ... analysis/interpretation RHW provided data acquisition and organization, data analysis/interpretation, and statistics All authors read and approved the final manuscript Acknowledgements This study was supported by...
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Báo cáo y học: "Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis" pot
Ngày tải lên :
09/08/2014, 08:23
... statistical analysis MH and IG selected and collected samples and interpreted and provided clinical data WZ acquired data MW-H analysed and interpreted data and helped prepare the manuscript CT and ... was performed using GraphPad Prism 3.03 (GraphPad Software, Inc., San Diego, CA, USA) and Statistica 7.1 (StatSoft, Inc., Tulsa, OK, USA) For comparison of paired samples before and after treatment, ... diseases In summary, our data suggest that BAFF and APRIL are differentially regulated in SLE and RA and, in addition, heterogeneously affected by rituximab treatment Competing interests The authors...
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Báo cáo y học: " Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients" potx
Ngày tải lên :
13/08/2014, 05:22
... presented in Table Plasma viral load was measured by a real-time HIV-1 RNA PCR assay (Cobas AmpliPrep/Cobas TaqMan HIV-1 assay; Roche Diagnostics Systems, Meylan, France) The CD4+ T cell count was determined ... 7amino-actinomycin D (7AAD) internalization and nuclear DNA binding, and viable cells were defined as the percentage of 7AAD negative events in the monoparametric histogram 7AAD (all reagents from Beckman-Coulter) ... systems HIV-1 Ag EIA; Bio-Rad, Marnes la Coquette, France) were added and incubated for h at 37°C After three PBS washings, a solution of alkaline phosphatase-labeled streptavidin diluted at 1:1,000...
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Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
Ngày tải lên :
18/06/2014, 16:20
... (5'-AGGCCTGCTGAA AATGACTGAATA-3'), 10 pmol K-ras antisense primer (5'-CTGTATCAAAGAATGGTCCTGCAC-3'), and U of Taq polymerase (Resnova) An additional no-template control containing only mix was run for ... design, acquisition, analysis and interpretation of data; drafting the manuscript All authors read and approved the final manuscript Acknowledgements The authors thank Barbara Vanni, Maurizio ... and k-ras mutation analysis SC: DNA extraction and k-ras mutation analysis MGD: pathological sample evaluation MZ: acquisition of data GP: in acquisition of data FC:drafting the manuscript; CG:...
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Báo cáo y học: "Two-year Outcome of Turkish Patients Treated with Zotarolimus Versus Paclitaxel Eluting Stents in an Unselected Population with Coronary Artery Disease in the Real World: A Prospective Non-randomized Registry in Southern Turk
Ngày tải lên :
25/10/2012, 11:18
... Turkish patients Abbreviations ACC: American College of Cardiology; AHA: American Heart Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse cardiac events; ... primary clinical efficacy end points included major adverse cardiac events (MACE) at two year (MACE: Death, myocardial infarction, target vessel revascularization (TVR) Target vessel revascularization ... 30 days; late, >30 days and very late, >1 year) Myocardial infarction was defined as a creatine kinase (CK) elevation >2 times above the upper limit of normal levels with any associated elevation...
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Tài liệu Differences in 4-Year Health Outcomes for Elderly and Poor, Chronically III Patients Treated in HMO and Fee-for-Service Systems ppt
Ngày tải lên :
14/02/2014, 07:20
... physical and mental health for the average patient HowChronically III Elderly and Poor Patients-Ware et al Table 3.-Physical and Mental Health Outcomes for Patients Treated in Prepaid and Fee-for-Service ... results may not apply to current health care The MOS was not a randomized trial; such trials are rare in health care policy research. 'a' 9 Although quasi-experimental methods2° achieved equivalent average ... data) Mental health Calculated for surviving patients as [(score at 4-year follow-up) -(baseline score)], prorated to adjust for unequal time intervals Categories of change Physical health Each...
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Predictors of relapse among pulmonary tuberculosis patients treated in a DOTS programme in South India pot
Ngày tải lên :
06/03/2014, 04:20
... Health Services and all Medical Officers Authors are thankful to S Radhakrishnan (STS), Abdul Kudoos, R Sasidharan, L K Acharya and S Arjunan of the Field Team for collecting data We are thankful ... recaída fueron la resistencia inicial a isoniacida, a rifampicina o a ambas (aOR 4,8 ; IC95% 2,0–11,6) y el tabaquismo (aOR 3,1 ; IC95% 1,6–6,0) La tasa de recaída en los pacientes no fumadores buen ... output The secretarial assistance rendered by A Gopinathan is also acknowledged This report was funded in part by a grant from the United States Agency for International Development (USAID) provided...
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Báo cáo hóa học: " Updated survivals and prognostic factor analysis in myeloma treated by a staged approach use of bortezomib/thalidomide/dexamethasone in transplant eligible patients" pot
Ngày tải lên :
18/06/2014, 16:20
... IgG/kappa from a single IgG/kappa, and two patients had complete change of paraprotein (one from IgA/kappa to IgG kappa, and one from IgD/lambda to IgG/kappa) Statistical analysis OS was defined as ... Garc a- Lara a J, Martínez-Martínez R, Hernández-Garc a MT, Carrera D, Besalduch J, de Arriba F, Ribera JM, Escoda L, Hernández-Ruiz B, Garc a- Frade J, Rivas-González C, Alegre A, Bladé J, San ... Spicka I, Petrucci MT, Palumbo A, Samoilova OS, Dmoszynska A, Abdulkadyrov KM, Schots R, Jiang B, Mateos MV, Anderson KC, Esseltine DL, Liu K, Cakana A, van de Velde H, Richardson PG: VISTA Trial...
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Báo cáo hóa học: "DNA polymeraseh protein expression predicts treatment response and survival of metastatic gastric adenocarcinoma patients treated with oxaliplatin-based chemotherapy" pot
Ngày tải lên :
18/06/2014, 16:20
... Hanaoka F, Moriya M: Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1, N6-ethenodeoxyadenosine J Biol Chem 2001, 276:18717-21 Vaisman A, Masutani C, Hanaoka F, Chaney ... variant) gene encodes human DNA polymerase eta Nature 1999, 399:700-4 Masutani C, Araki M, Yamada A, Kusumoto R, Nogimori T, Maekawa T, Iwai S, Hanaoka F: Xeroderma pigmentosum variant (XP-V) correcting ... with other factors was obtained (data not shown) Relationship between polh expression and survival of metastatic gastric cancer Kaplan-Meier univariate survival analysis revealed that the positive...
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báo cáo hóa học:" Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients" pdf
Ngày tải lên :
20/06/2014, 08:20
... surgical and apoptosis-related parameters Br J Cancer 2005, 92:271-277 Athanassiadou P, Grapsa D, Athanassiades P, Gonidi M, Athanassiadou A- M, Tsipis A, Patsouris E: The prognostic significance ... Cancer 1998, 78:375-381 Ueno Y, Enomoto T, Otsuki Y, Sugita N, Nakashima R, Yoshino K, Kuragaki C, Ueda Y, Aki T, Ikegami H, Yamazaki M, Ito K, Nagamatsu M, Nishizaki T, Asada M, Kameda T, Wakimoto ... Wakimoto A, Mizutani T, Yamada T, Murata Y: Prognostic significance of p53 mutation in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin...
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báo cáo hóa học:" Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs" potx
Ngày tải lên :
20/06/2014, 08:20
... reverse transcriptase and biased dNTP concentrations Proc Natl Acad Sci USA 1994, 91:11787-11791 Abstract Vartanian JP, Meyerhans A, Sala M, Wain-Hobson S: G > A hypermutation of the human immunodeficiency ... reverse G A hypermutations in favor of A G transitions, by increasing the intracellular ratio of dCTP/dTTP.[27] An alternative important cause of G A hypermutation may involve a cellular factor, APOBEC3G, ... substitutions that cause amino-acid changes in HIV-1 favor a guanosine-to-adenosine (G A) transition.[5-8] The G A transition plays an important role in viral evolution as well as in the escape of HIV-1...
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báo cáo hóa học: " F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin)" pdf
Ngày tải lên :
21/06/2014, 02:20
... K, Nakajima H, Miyazaki T, Yayama T, Kawahara H, Kobayashi S, Tsuchida T, Okazawa H, Fujibayashi Y, Baba H: Effects of Alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured ... PSA as a tumour marker and ALP as a bone formation marker Methods This imaging study was performed as a pilot substudy of an open-label phase trial of Alpharadin in patients with bone metastases ... SUVmax PSA ALP 0.0 6.0 12.0 0.0 6.0 12.0 Figure Mean SUVmax, PSA and ALP changes Mean SUVmax, PSA and ALP changes at and 12 weeks as a percentage of baseline levels in the five subjects (A to...
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Báo cáo y học: "Primary Care Outcomes in Patients Treated by Nurse Practitioners or Physicians" docx
Ngày tải lên :
07/08/2014, 00:20
... Delmy Miranda, BA, Niurka Suero, Hendricks Vanderbilt, Eddy Spies, Ana Sanchez, Tamara Ooms, BSN, Eileen Coloma, BSN, Maricruz Polanco, BA, Hector Caraballo, BS, and Carlos Tejada; research nurses ... rate is comparable to the normal rate of appointments (65%) kept at the participating clinics (P Craig, MA, RN, ©2000 American Medical Association All rights reserved Downloaded from jama.ama-assn.org ... physician patients’ mean ratings of satisfaction with provider attributes was small but statistically significant It may be attributable to the fact that the nurse practitioner practice was moved...
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Báo cáo y học: "Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate" pps
Ngày tải lên :
08/08/2014, 20:23
... anterior cingulate cortex Bipolar Disord 2000, 2:207-216 Hamakawa H, Kato T, Murashita J, Kato N: Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective ... Psychological Med 1999, 29:639-644 Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H, Igarashi Y, Ohara K: Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective ... Bottomley PA: Spatial localization in NMR spectroscopy in vivo Ann NY Acad Sci 1987, 508:333-348 Talairach J, Tournoux P: Co-planar stereotaxic atlas of the human brain New York: Thieme Medical 1988:51-110...
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Báo cáo y học: "Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept" pot
Ngày tải lên :
09/08/2014, 01:21
... joint damage Molecular-marker technology is a tool that may aid in evaluating tissue effects of antirheumatic therapy [12] One promising candidate is COMP (cartilage oligomeric matrix protein, also ... therapy if available were analysed Statistical analyses Comparisons were done by Wilcoxon’s matched-pairs test, the Mann–Whitney U-test, or the chi-square test, where appropriate and correlations ... TS and DH are share-holders in AnaMar Medical Acknowledgements Grants were obtained from the Swedish Medical Research Council, the Gustaf V 80-Year Foundation, the Greta and Johan Kock Foundation,...
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Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot
Ngày tải lên :
09/08/2014, 06:22
... commercial ELISA kits (Biosource, Camarillo, CA, USA), in accordance with the manufacturer's instructions Statistical analysis Statistical analysis was performed using the Statview software (Abacus ... 343:1594-1602 Weinblatt ME, Keystone EC, Furst DE, Moreland LW, Weisman MH, Birbara CA, Teoh LA, Fischkoff SA, Chartash EK: Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, ... ng/ml) was combined with increasing concentrations of plasma from RA patients (0–20%) (a) Four RA plasma samples were obtained before infliximab therapy (b) RA plasma samples (n = 2) were used at...
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Báo cáo y học: "Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs" ppsx
Ngày tải lên :
09/08/2014, 07:20
... sequence variant (LighCycler, Roche Diagnostics, Mannheim, Germany), as was previously reported [10] The primers used were: 5'-ATC CAA GAC AAC ACT ACT AAG GC and 5'-ATG GGG TGG AAG AAG TTG AA for ... ACC-F and LC Red 640-CCC TAC TTC CCC CTC CCA AA for -1,082 IL-10 and AAC CCC GTC CCC ATG CCC C-F and LC Red 640-CCA AAC CTA TTG CCT CCA TTT CTT TTG GGG AC for -308 TNFα Statistical analysis As ... interindividual variations that are genetically regulated by SNP at their promoters [8-12] Our data indicate that antimalarial therapy plays a role Page of (page number not for citation purposes)...
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Báo cáo khoa học: "Randomized controlled trial of live lactobacillus acidophilus plus bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients" pot
Ngày tải lên :
09/08/2014, 08:23
... small intestine Bile acid malabsorption and bacterial contamination by an aerobic and anaerobic bacteria are common causes of diarrhea after the radiation treatment of gynecological cancer Maintaining ... grade In Baughan's study [16], median maximum severity of diarrhea was also grade Although diarrhea usually accompanies rectal mucosal lesions, some authors believe that it is caused by radiation ... two-tailed and an alpha level of 0.05 was used to assess statistical significance Sample size calculation was calculated by the formula: n = (Zα/2 + Zβ)2 σ2/ (X1-X2): n = 29 each group Statistical analyses...
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