waiver of in vivo bioequivalence study

... Biomechanics of the Foot Disorders of the Foot 1980:21-30 Inman VT: Inman's Joints of the Ankle Williams & Wilkins; 2002 Leardini A, Stagni R, O'connor JJ: Mobility of the subtalar joint in the intact ... ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion part I: ankle, hip, and spine International Society of Biomechanics J Biomech ... JE: Using cine phase contrast magnetic resonance imaging to non-invasively study in vivo knee dynamics J Biomech 1998, 31:21-26 Sheehan FT: The Finite Helical Axis of the Knee Joint (a non-invasive...

Ngày tải lên: 10/08/2014, 21:24

... the inguinal lymph node of the mouse by folding back a broad flap of abdominal skin or the popliteal lymph nodes of the feet [25] A rubber ring is glued on the inner surface of the exposed skin ... capacity of DCs and thus certainly influence the way in which they interact with T cells Future directions and challenges for imaging in vivo Future improvements of cell tracking techniques in vivo ... over prolonged times in vivo Finally, it cannot be applied to use in humans Other methods of imaging in vivo might therefore be found useful in the future In general, most of these techniques...

Ngày tải lên: 09/08/2014, 07:20

... obtained during the clinical test that yielded failure of the bone-implant interface was implemented in definition of loading conditions in the finite element analysis In the definition of loading condition, ... properties of the interface, the purpose of this biomechanical study was to quantify failure torque of an osseointegrated implant with severe bone loss and involve the in vivo data in finite element ... surface of the abutment was selected and retained All other nodes resting on the occlusal surface and their degree of freedom (dof) were connected to centrally retained node using RBE link (MSC.Software...

Ngày tải lên: 11/08/2014, 23:22

... analogues in their affinity for binding proteins In view of this, an important practical consequence of our simulations results are that the testing of newly designed hormones in in vivo systems ... M, Franks S: Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome Clin Endocrinol (Oxf) 1995, 43:159-165 Publish ... LM, Mercado M, Baumann G: Influence of high affinity growth hormone binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH J Clin Invest 1993, 91:629-641 Baumann...

Ngày tải lên: 13/08/2014, 22:22

... changed near EGR-1 binding sites, suggesting that EGR-1 binding influences the occupancy of previous binding proteins These observations may help explain why EGR-1 binding results in multiple responses ... SP1 binding occupancies change dramatically EGR-1 binding may influence the occupancy of previous binding proteins, resulting in the reconstruction of the transcription factor complex and the induction ... binding 3.08E-019 GO:0003723 RNA binding 6.44E-018 GO:0005515 Protein binding 5.65E-009 GO:0000166 Nucleotide binding 3.84E-007 GO:0003677 DNA binding 5.69E-007 GO:0051082 Unfolded protein binding...

Ngày tải lên: 14/08/2014, 21:20

... more often unique patterns of miRNA production reflect the lineage-dependence of tumors, relating to their tissues of origin [16–22] Similarly, fundamental processes underlying tumorigenesis, including ... essential nature of this novel mechanism indelibly patterning gene expression in cell-lineage specification [8], in the context of the established model of cancer as a genetic disease in which pathobiology ... miR-16-1, in part, reflects inhibition of the expression of the anti-apoptotic oncogenic protein Bcl-2, which is characteristically overexpressed in CLL, promoting the survival of leukemia cells [31] Indeed,...

Ngày tải lên: 16/03/2014, 01:20

... understanding of the production and function of miRNA in vivo as well as for monitoring the therapeutic potential of miRNAs in cancer Bioimaging of microRNA biogenesis The molecular mechanisms involved ... et al [22] obtained quantitative in vitro images of nine transcripts that were predicted to be miRNA9 targets using the ensemble machinelearning algorithm However, in vivo imaging of miRNA regulation ... the in vitro and in vivo investigations of miRNA production patterns Second, noninvasive monitoring of miRNAs provides useful information of the possible role of miRNAs involving cellular developments...

Ngày tải lên: 16/03/2014, 01:20

... fractions of 2.57 Gy with interfraction intervals of 10 min, (4) fractions Page of of Gy with interfraction intervals of 30 min, (5) fractions of 2.57 Gy with interfraction intervals of Assay Tumor dimensions ... a single dose Gy× at 60min intervals 2.57 Gy×7 at 10min intervals Gy× at 30min intervals 2.57 Gy×7 at 5min intervals control 18 Gy as a single dose Gy× at 60min intervals 2.57 Gy×7 at 10min intervals ... effect of intermittent radiation exposure compared with that of continuous radiation exposure in vivo The results of this in vivo study confirmed a rapid growth of tumor after prolonged intermittent...

Ngày tải lên: 09/08/2014, 09:20

... (right) implants inserted into the tibia of minipigs after 12 weeks of healing time Radiograph Radiograph showing titanium (left) and zirconia (right) implants inserted into the tibia of minipigs after ... drills according to the standard protocol of the manufacturer Implants measuring mm in length and 3.5 mm in diameter were inserted using continuous external sterile saline irrigation to minimize bone ... was induced with an intravenous bolus of 3–5 ml thiopental (Thiopental inresa®, Inresa Arzneimittel, Freiburg, Germany) followed by intubation and maintenance of anaesthesia by inhalation of 1.5%...

Ngày tải lên: 11/08/2014, 20:20

... BoHV-5 strain was isolated from a brain sample after several intracerebral inoculations of calves with brain tissue obtained from an outbreak of meningoencephalitis in calves reported in 1962 in Australia ... strain was isolated from a case Page of of non purulent encephalitis in an outbreak among calves in 1982 in Argentina [19] N569 and A663 BoHV-5 strains were propagated in Madin Darby bovine kidney ... having an impact on the in vitro behavior of both BoHV-5 strains Concerning the in vivo characterization, in spite of the in vitro differences discussed above, we observed that both BoHV-5 strains...

Ngày tải lên: 12/08/2014, 18:22

... influence the quality of the determined Kd Major findings include quantitating the fraction of non-fluorescent red fluorescent proteins (mRFP and mCherry) and investigating the relationship of ... development of FCCS to quantitate protein-protein interactions in vivo The thesis contains six chapters and is structured into the following sections: Chapter introduces the basic principles and instrumentation ... parts In the first part, the binding between a small GTPases protein vii Cdc42, and one of its effectors, IQGAP1, is investigated The Kd of the binding in cell culture was compared with that in...

Ngày tải lên: 10/09/2015, 08:38

... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... Nanjing, M.sc National University of Singapore) A THESIS SUBMITTED FOR THE DEGREE OF DORCTOR OF PHILOSOPHY DEPARTMENT OF MEDICINE YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE...

Ngày tải lên: 11/09/2015, 09:06

... as vindesine and vinorelbine can inhibit the assembly of microtubule by reducing the rate of tubulin addition, taxanes have the opposite effect, inhibiting the disassembly of microtubules during ... of tubulin in the microtubules rather than to tubulin dimers The binding site to tubulin differs from the one of vinca-alkaloids and podophyllotoxins While vincas inhibit polymerization and increase ... parts of the body The most common kind of enzyme involved in this degradation of drugs is cytochrome P450 (or CYP), mainly located in liver and intestine CYP is a large family of hemoproteins which...

Ngày tải lên: 09/10/2015, 11:18

... Protein binding displacement interactions has gained prominence as a possible mechanism of drug-drug interaction In the case of plasma protein binding, most displacement of drugs from plasma binding ... proximal small intestine[150] 47 Chapter In Vitro Studies 5.1 PROTEIN BINDING STUDY 5.1.1 Introduction The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution ... provide more information for the future clinical study The main purpose of this investigation was to examine the influence of tamoxifen on the pharmacokinetics of COL-3 administered orally/intravenously...

Ngày tải lên: 09/10/2015, 11:24

... nucleotide including 45 bases was used to connect the 3’ terminus of GLP-1-A gene and 5’ terminus of gAd gene The product of this nucleotide sequence was a glycine-rich short peptide including 15 amino ... in the gene of GLP-1 (7-37) in the present study This mutation resulted in the substitution of glycolamine for alanine at the second site of GLP-1 (7-37) peptide Study has reported that glycine-rich ... glycine-rich linker is flexible, which allows the specific engineering of hinge regions into proteins to achieve desired functional motions [17] We used a glycine-rich short peptide including 15 amino...

Ngày tải lên: 25/10/2012, 11:10

... fixed in 10% phosphate buffered formalin, embedded in paraffin, sectioned, and stained with hematoxylin and eosin (H&E) In vivo pharmacokinetics and bioavailability In vivo pharmacokinetic study ... toxicity of the PANs was found in the experimental animals after i.v at a dose of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI ... drug concentration of EPI and PA/EPI after i.v injection in rats at a single equivalent dose of 10 mg/kg Table 5.  Pharmacokinetic parameters of EPI and PA/EPI i.v injected in rats at the equivalent...

Ngày tải lên: 23/04/2013, 21:38

... Evaluation of ASTER data use in land use study in the Mekong Delta 29 discrimination capacity of ASTER data in land use mapping of such a dynamic area as the Mekong Delta in Vietnam Forest ... combination is the most discriminative Due to the constraints of the spatial resolution of ASTER data in terms of parcel size in the studied area, the physical indexes such as NDVI and VSW will ... digitizing the satellite image This is not an optimal approach (Congalton and Green, 1999), but the digitizing was performed independently from training areas by a well trained person not involved in...

Ngày tải lên: 13/02/2014, 12:20

... Roles of prostaglandin D2 in adipogenesis in vivo Y Fujitani et al indicate that overexpression of H-PGDS increases insulin sensitivity in vivo Adipocyte differentiation ex vivo Finally, we examined ... pancreatic islets to increase insulin secretion Indeed, serum insulin levels were increased after treatment with thiazolidinediones in diabetic mice through regulation of insulin production in pancreatic ... in WAT of TG mice than in WAT of WT mice Serum levels of triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG mice After weeks of normal or HF diet, serum levels of triglyceride,...

Ngày tải lên: 16/02/2014, 09:20

... livers of rats studied at the indicated time points after injection of 30 lg of insulin (four to six rats per time point) (A), or studied after injection of the indicated dose of insulin (two ... The binding of ZIP to Grb14, by recruiting protein kinase Cf, enhances the serine phosphorylation of Grb14 and its inhibitory effect on IR kinase and insulin signaling [10] The interaction of Grb14 ... and ERK insulin signaling pathways and inhibits distal effects of insulin on glycogen and DNA synthesis [6–9], and microinjection of Grb14 into Xenopus laevis oocytes inhibits insulin-induced...

Ngày tải lên: 18/02/2014, 18:20

... doubleringed BchI-BchD structure the ATPase activity of BchI is blocked A conformational transition upon binding to BchH may bring the integrin I domain of BchD into contact with the integrin-binding ... integrin-binding motif of BchH, simultaneously triggering porphyrin metallation This would also lead to a release of the blockade of the ATP-binding site of BchI by the integrin I domain, triggering ATP hydrolysis ... hydrolysis In addition, kinetic analysis had shown binding of Mg2+ to this subunit [21] An integrin I domain, suggested to exist in the C-terminus of the 70 kDa subunit, is a metal binding site (MIDAS...

Ngày tải lên: 19/02/2014, 12:20