viral infections in renal transplant patients

... linear models, linear regression, tacrolimus, renal transplantation Background Tacrolimus, a calcineurin inhibitor, remains the centerpiece of the maintenance treatment scheme in renal transplant ... combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate mofetil or azathioprine) and a steroid (prednizolone). Tacroli- mus was given twice a day in individually ... 7(2):94-100 â Ivyspring International Publisher. All rights reserved Research Paper Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic...

Ngày tải lên: 26/10/2012, 09:32

Ngày tải lên: 13/08/2014, 16:21

... Symptom Rating Scale (GSRS; higher scores = increased severity) and Gastrointestinal Quality of Life Index (GIQLI; higher scores = better GI-specific HRQL)) in renal transplant patients in South ... participating in an international, longitudinal, observational study were analyzed. Patients were ≥ 1 month post transplant and on mycophenolate mofetil (MMF) and a calcineurin inhibitor. Patients ... purposes) tionnaires in a private room at the clinic: the Gastrointestinal Symptom Rating Scale (GSRS), the Gas- trointestinal Quality of Life Index (GIQLI) and the Psy- chological General Well-being Index...

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... prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry certain risk for ... viral mRNAanti-sense oligonucleotideribozymeRNA interferenceviral infectious diseaseblocking antibodysoluble receptorrhinovirus Abstract For two centuries, vaccination has been the dominating ... experi- mental rhinovirus colds by receptor blockade. Antiviral Res 1988, 9:233-247. 25. Casasnovas JM, Springer TA: Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellu- lar...

Ngày tải lên: 18/06/2014, 22:20

... prevent infections by a broad spec- trum of rhinovirus serotypes in human cells in vitro [19- 21]. Administration of soluble ICAM-1 and MAbs in human clinical trials had indeed achieved reduction in symptoms, ... with spe- cific viral mRNA targets. AS-ONs inhibit viral protein pro- duction by both blocking viral mRNA translation and triggering its degradation. Since the discovery of viral inhi- bition effect ... prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry certain risk for...

Ngày tải lên: 20/06/2014, 04:20

... obtain ing therapeutic serum levels and avoiding nephrotoxicity during continu- ous vancomycin infusion in critically ill patients with severe Gram-positive infections and normal baseline renal ... continuous infusion is harming patients. It may indicate that the actual algorithms to adapt vanco- mycin dosing during continuous infusion should be revised. Surprisingly, data on vancomycin ... Continuous infusion of vancomycin is increasingly preferred as an alternative to intermittent administration in critically ill patients. Intermittent vancomycin treatment is associated with an increased occurrence...

Ngày tải lên: 21/06/2014, 01:20

... therapeutic serum levels and avoiding nephrotoxicity during continu- ous vancomycin infusion in critically ill patients with severe Gram-positive infections and normal baseline renal function. AKI is detected ... significant increase in serum creatinine level s, whereas this occurred in only 11 of 91 patients (11.6%) whose vancomycin levels remained below 28 μg/mL. This is in line with our observations that indicated ... believe that aiming at concentrations up to 25 μg/mL with continuous infusion is harming patients. It may indicate that the actual algorithms to adapt vanco- mycin dosing during continuous infusion...

Ngày tải lên: 21/06/2014, 02:20

... sex, concomitant use of a calcineurin inhibitor, hyperbilirubi- nemia, and hypoalbuminemia. The incidence of kidney injury increased with an increase in the number of risk factors. Hypoalbuminemia also was ... creatinine and GFR criteria) Category Criteria Risk (R) Increased creatinine level ì 1.5 or GFR decrease >25% Injury (I) Increased creatinine level ì 2 or GFR decrease >50% Failure (F) Increased ... colistin administration must be adjusted for serum creatinine levels and thus require close monitoring of renal func- tion. Finally, the decision to stop colistin treatment on the basis of renal...

Ngày tải lên: 21/06/2014, 03:20

... splenectomized patients and patients living in endemic areas, including college Should be administered to splenectomized patients and patients living in endemic areas, including college ... meningococcal conjugate d Should be administered to splenectomized patients and patients living in endemic areas, incl uding college Should be administered to splenectomized patients ... wi th acute lymphocytic leukemia. Use in Indicated Patients Vaccine Intensive Chemotherapy Hodgkin's Disease Hematopo ietic Stem Cell Transplantation Diphtheria- tetanus a ...

Ngày tải lên: 07/07/2014, 01:20