vibrations and friction induced instability in discs

... significant, increase in levels of proMMP-2 and active MMP-2 in the media C2-ceramide -induced regulation of MMP-2 is abrogated by inhibition of PKR R48 To determine a role for PKR in ceramide -induced ... of protein synthesis and increased apoptosis, which may also affect cartilage integrity Increased expression and activation of MMPs, in the absence of a corresponding increase in their inhibitors, ... protein kinase R (PKR)activating protein (PACT) [14] is up-regulated in regions of cartilage that subsequently develop osteoarthritis-like changes in vivo [15] and that PACT and PKR are involved in...

Ngày tải lên: 09/08/2014, 01:23

... [37] In addition, the electrostatic interaction of basic peptides with pectins can increase pectin gelation by reducing pectin charge and hydration [28], indicating that the electrostatic interaction ... that the insolubilisation of GvP1 occurs with an increase in the major amino acids of GvP1 extensin in the saline-insoluble, cell wall structure (Table 1), confirming its incorporation into the ... the nature of the non-extensin EIBMPs involved, heat and DTT-resistant proteins of saline extracts were isolated and assayed in extensin network-containing walls, and found able to reduce hydration...

Ngày tải lên: 11/08/2014, 11:21

... family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin H-type (TRX-H-3) (GIF1) Thioredoxin family protein No classification ... G, Couee I, El Amrani A: Sugar -induced tolerance to atrazine in Arabidopsis seedlings: interacting effects of atrazine and soluble sugars on psbA mRNA and D1 protein levels Plant Sci 2004, 167(4):913-923 ... [52] Atrazine binding to D1 protein of PSII and inhibition of electron feeding to PSI were indeed likely to decrease superoxide radical production by blocking the Mehler reaction The induction...

Ngày tải lên: 12/08/2014, 03:20

... Transcript of TaAGL42 increased, principally in leaf tissue, in the winter varieties and showed no response in Paragon If these two MADS-box genes are involved in cold induced phase transition, ... expressed in spring varieties: it remained low and unchanging in both tissues, however Thus, TaAGL42 might not be involved in phase transition at all A clue that instead it might be involved in cold ... occur during the winter in a northern climate – a gradual decline in temperature, day-length and light intensity In most previous studies, unnaturally high light intensities have been maintained...

Ngày tải lên: 12/08/2014, 03:20

... Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro J Bone Miner Res 1998, 13:688-694 18 Palacio S, Felix R: The role of phosphoinositide 3-kinase in spreading osteoclasts induced ... designed the in vivo and part of the in vitro experiments, and carried out the analysis and interpretation of data; he was also involved in drafting of the manuscript TK participated in the in vitro ... factors, including NF-kB, c-fos, AP-1, PU.1, and CREB, are involved in regulating osteoclastogenesis in its early or late phase, and expression of NFATc1 is specific to the RANKL induced- signaling...

Ngày tải lên: 12/08/2014, 12:20

... motion sickness induced by actual motion in migraineurs, we embarked upon a comparable study of visually -induced motion sickness We were especially interested in replicating and extending research ... created the randomization scheme by drawing treatment assignments from a blinded container The investigator administering the drug, the technicians performing testing, and the subject were blinded to ... http://www.medsci.org Int J Med Sci 2009, may interfere with a previously recognized phenomenon wherein laboratory -induced head pain but not extremity pain potentiates visually -induced motion sickness in migraineurs,...

Ngày tải lên: 26/10/2012, 09:57

... fasting glucose and plasma insulin secretion in obese-diabetic mice Glucose (mmol/l) Treatment with extract fraction Starting point Final Change Plasma insulin (pmol/l) of glucose Starting point ... diabetic STZ induced HFD fed mice were expressed diabetic disease and a insulin resistance However, plasma insulin in HFDfed mice injected STZ was lower as compared to HFD mice without STZ injection ... above results showed that in the ND+STZ mice there are not significant changes in blood fasting glucose, plasma insulin and lipid parameters, such as TC, TG, HDL, and PI, in comparison with untreated...

Ngày tải lên: 12/02/2014, 17:20

... observable Interestingly, the RMI1 mRNA level increased significantly in the liver and intra-abdominal fat of the obese phenotype mice; however, that in the skeletal muscle did not increase, and that in ... in mice fed a high-fat diet In contrast, E2F8 mRNA was strongly induced by highfat feeding (7.1-fold increase over mice fed a normal diet) Interestingly, the expression of E2F8 mRNA induced in ... RMI1+/+ between and h after glucose injection (E) Plasma insulin concentrations during the oral glucose tolerance test (F) AUC for plasma insulin levels between and 0.5 h after glucose injection Values...

Ngày tải lên: 16/02/2014, 09:20

... cooperate in modulating PAI-2 mRNA stability, REMSA analyses were performed to determine the role of the ARE II and ARE IV sites in the binding of proteins to the ‘extended ARE’ Binding of cytoplasmic ... WI, USA) generating pTEasy-Globin and pTEasy-GAPDH For in vitro transcription, 500 ng of SpeI linearized pTEasy-Globin and SacII linearized pTEasy-GAPDH were incubated for h in the presence of ... analysis (10 lg of total RNA) using the intron spanning 32P-labelled globin and GAPDH probes described above The b-globin and GAPDH mRNA band intensities were visualized and quantified with a Phosphorimager...

Ngày tải lên: 16/02/2014, 09:20

... Lysine ⁄ fibrin binding sites of kringles modeled after the structure of kringle of prothrombin Proteins 3, 85–96 20 Thorsen S (1975) Differences in the binding to fibrin of native plasminogen and ... thus indicating accessibility and participation of both K1 and K4 in firmly anchoring plasmin to fibrin and cell surfaces Because the expanded Lys-form of plasminogen may be an intermediary in plasmin ... Lys-Pg as in plasmin, K1- and K4-LBS act as independent and complementary domains both able to support plasminogen binding and activation, and both required to ensure plasmin anchorage and subsequent...

Ngày tải lên: 20/02/2014, 01:20

Ngày tải lên: 05/03/2014, 16:20

... lm) did not maintain Ab42wt -induced toxicity Ab42Arc -induced toxicity was not maintained with either a low or a high concentration of DHA (Fig 7C) DHA in itself did not result in increased toxicity, ... intermediates, i.e protofibrils, and thereby maintaining Ab -induced toxicity in PC12 cells Results Unsaturated fatty acids stabilize Ab42wt protofibrils Fatty acids were incubated with Ab42wt in ... Ab aggregates, indicating a direct interaction Possibly, DHA and AA micelles work as a protective agent and prevent intermolecular interactions and consequent aggregation into insoluble fibrils...

Ngày tải lên: 07/03/2014, 10:20

... curcumin and capsaicin H Manjunatha and K Srinivasan Table Effect of dietary curcumin and capsaicin on iron(II) -induced (in vivo) and copper -induced (in vitro) LDL oxidation in rats Rats were injected ... curcumin and capsaicin H Manjunatha and K Srinivasan Protective effect of dietary curcumin, capsaicin and their combination on iron -induced LDL oxidation in vivo and copper -induced LDL oxidation in ... capsaicin (saline-injected); 6, capsaicin (Fe2+-injected); 7, curcumin + capsaicin (saline-injected); 8, curcumin + capsaicin (Fe2+-injected) 4530 on curcumin, capsaicin or curcumin + capsaicin, the anodic...

Ngày tải lên: 08/03/2014, 08:20

... obligatory role of the protein in steroidogenesis, we detected the protein and its mRNA in all steroidogenic tissues including placenta and brain [32] Inhibition of ACTH release and steroid synthesis ... inactive [49] In our experiments NDGA was effective in inhibiting the activity of purified recombinant MTE-I in an in vitro assay performed in a Hepes-based buffer containing only KCl Information ... performed in triplicate activity in vitro Figure shows that a 5-min preincubation of recombinant protein with NDGA inhibited thioesterase activity Interestingly, NDGA produced only a 20% inhibition...

Ngày tải lên: 08/03/2014, 09:20

... They encode Ssp1 kinase (homolog of calcium–calmodulin-dependent protein kinase kinase) and Sds23 (an inhibitor of type 2A-related protein phosphatases including Ppe1) [30] Ssp1 and Sds23 are functionally ... 3.0 mm remaining glucose) were 3.3 and 4.2 h at 30 and 26 °C, respectively In the 111 mm glucose medium, the doubling times were 2.5 and 3.5 h at 30 and 26 °C (4–8 h, 100 mm remaining glucose), ... role in utilizing glucose through interaction with AMPdependent protein kinase [40], which is implicated in diabetes [41] In S pombe, Ssp2 is the AMP-dependent protein kinase, and Ssp1 and Ssp2,...

Ngày tải lên: 14/03/2014, 23:20

... subsistence farming in uneconomic-sized farms to commercial and market-oriented farms These transformed sometimes happens in improperly ways and induced to change in land use and land covers by ... sensing has been using in several types of works in both government and private agencies As we know, GIS and remote sensing have an important role in linkage and analysis of such data, in particular ... used in countrywide, including agriculture sector did not applied this technique for their agricultural development and land use planning • A meanwhile, in that times agriculture lands in Laos...

Ngày tải lên: 17/03/2014, 11:20

... adhesion complexes consist of integrin proteins, the tyrosine kinases Src and focal adhesion kinase (FAK), actin-binding structural proteins, and the adaptor proteins paxillin and Crk-associated substrate ... [28], MAPK kinase kinase (MEKK-1) [29], MAPK kinase kinase kinase (Raf-1), protein kinase B (Akt) [30,31] and protein kinase C (PKC) [32] PKC is a family of serine ⁄ threonine protein kinases that ... contribute to gaining insight in the growth inhibition and apoptosis induced by this statin in neuroblasts, and additionally it will contribute to establish the role of the mevalonate pathway in the physiological...

Ngày tải lên: 23/03/2014, 11:20

... are shown in (A) and (B) Silver staining is shown in (C) and (D) in blue superimposed with the spots of oxidized proteins shown in red Protein labels: 1, a-tubulin; 2, b-tubulin; 3, actin; 4, PDI; ... acetylTyr-Fluo, resulted in the labeling of cellular proteins, as shown in Fig PDT -induced protein labeling was dependent on the concentration of the photosensitizer (Fig 3, lanes and 4) and the dose of ... tyrosine residues in a target protein In the first experiments, we assessed whether PDT can cause dityrosine (dityramine) formation, and the covalent coupling of the Tyr-Fluo to a model protein...

Ngày tải lên: 23/03/2014, 15:21

... signal-regulated kinases (ERK1/2), stress-activated protein kinases [c-Jun NH2-terminal kinases (JNK)], and p38 mitogen-activated protein kinases (p38MAPK) ERK1/2 are activated mainly by growth factors and ... aspects in the regulation of apoptosis is the involvement of mitogen-activated protein kinases (MAPKs), a family of serine/threonine kinases that mediate intracellular signal transduction in response ... DNA ladder induced by Py/Zn treatment (Fig 1D) To determine the relationship between intracellular Zn levels and induction of apoptosis, we investigate the appearance of a DNA ladder induced by...

Ngày tải lên: 23/03/2014, 21:20

... to increase We observed an increase in HIF-1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia -induced changes in BRCA1 ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer...

Ngày tải lên: 30/03/2014, 03:20