vascular liver disease and the liver sinusoidal endothelial cell

... characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells J Ultrastruct ... or brought to the cells via the portal circulation, ii) interaction with other liver cells, and/ or iii) interaction with native extracellular matrix Focusing in the present work on the impact of ... culture of rat liver sinusoidal endothelial cells J Hepatol 2000, 32(5):718-726 de Leeuw AM, Barelds RJ, de Zanger R, Knook DL: Primary cultures of endothelial cells of the rat liver: a model...

Ngày tải lên: 13/08/2014, 13:20

... RS: On the role of the liver endothelial filter in the transport of particulate fat (chylomicrons and their remnants) to parenchymal cells and the influence of certain hormones on the endothelial ... hepatic endothelial cells BMC Cell Biology 2002, 3:7 108 Fraser R, Day WA, Fernando NS: The liver sinusoidal cells, their role in disorders of the liver, lipoprotein metabolism and atherogenesis ... E: The structure and function of the cytoskeleton in sinusoidal endothelial cells in the rat liver In: Cells of the Hepatic Sinusoid (Edited by: Kirn A, Knook DL, Wisse E) Rijswijk, Kupffer Cell...

Ngày tải lên: 13/08/2014, 13:20

... given to the influence of these forces on the surface of liver sinusoids and intactness of the endothelial lining Under normal conditions, liver lobule sinusoids show an intact endothelial lining, ... relationship between liver sinusoidal endothelium (Ec) and neighboring liver parenchymal cells (Pc) Note the patent lumen (L) Inset depicts the intact cytoplasmic processes of endothelial cells bearing ... neuropilin-1 and VEGFR-2 [36] Such a complex was shown to exist on the surface of endothelial cells or between tumor cells and endothelial cells Activation of VEGFR-2 has been shown to be involved in the...

Ngày tải lên: 13/08/2014, 13:20

... functions of the liver endothelial cell Biochem J 1990, 266:313327 Hansen B, Melkko J and Smedsrød B Serum is a rich source of ligands for the scavenger receptor of hepatic sinusoidal endothelial cells ... hepatic sinusoidal Kupffer and endothelial cells Biochem J 1997, 322:567-573 Kawai Y, Smedsrød B, Elvevold K and Wake K Uptake of lithium carmine by sinusoidal endothelial and Kupffer cells of the ... that most vertebrates carry their so-called scavenger endothelial cells (endothelial cells endowed with the same RES-function as rat LSEC) in organs other than liver [9] These findings justify a...

Ngày tải lên: 13/08/2014, 13:20

... get together with others like them because of the supportive and therapeutic aspects They requested that they have lunch together at the end of the sessions During the dance classes, they were ... new people and having the regular opportunity to socialize and ‘work together’ were appreciated They felt the exercises were not boring, and neither did they ‘feel’ like exercise The afternoon ... ongoing basis The touch of others, the rhythm of the music, and the novelty of the experience all contributed to the beneficial effects The sense of community spirit was evident when the tango group...

Ngày tải lên: 28/03/2014, 20:20

... manner on endothelial cells It becomes effective at concentrations that are within the same range as the effective concentrations of other hormones, including the steroid hormones, and, like the latter, ... signals before the start of the ouabain treatment Ouabain was added to the cells at various concentrations in fresh ECGM0.5, and the cells incubated for an additional 12 h For counting, cells were ... investigate whether the observations made thus far are based on a global inhibition of the sodium pump, the uptake of 86Rb+ into endothelial cells was determined as a function of the ouabain concentration...

Ngày tải lên: 30/03/2014, 13:20

... relationships between the biomarkers of endothelial cell activation and sepsis severity, inflammatory response, organ dysfunction, and mortality An improved understanding of the endothelial cell response ... Endothelial cell activation biomarkers and organ dysfunction To assess the association of endothelial cell related biomarkers with organ dysfunction, we analyzed the correlation between the endothelial ... through and/ or between endothelial cells into the underlying tissue (not shown) In sepsis, E-selectin, ICAM-1, and VCAM-1 are cleaved from the cell surface and circulate as a soluble form of the...

Ngày tải lên: 13/08/2014, 21:21

... control The medium was then withdrawn and the cells were washed twice and harvested by scraping with a rubber policeman into ice-cold NaCl/Pi Lipids were extracted from the cells following the procedure ... on cell toxicity and cell proliferation We observed the toxic effect of hours’ exposure to HePC in proliferating HepG2 cells by measuring the leakage of LDH into the extracellular medium and ... biosynthesis of PC in HepG2 cells at the level of CT activity It interferes with the translocation process of CT from the cytosol to the membrane and finally leads to an inhibition of the biosynthesis...

Ngày tải lên: 17/03/2014, 11:20

... symptoms of IRD There were eight deaths attributable to IRD and the causes of deaths were PTB, EPTB and DTB in 3, 3, and of them, in that order The mean ± SD baseline CD4+ T -cell count for these who ... T -cell count, WBC count and Hgb value of the total 1166 subjects, respectively, were 113.6 ± 71, 47671 ± 1824, 12 ± 2.4 and 28%, 23.6%, and 22.9% of the patients had an elevated AST, ALT, and ... HAART initiation, the patients were also diagnosed for OIs and the majority of the patients had candidiasis (37%) followed by TB (22.1%) (Table 1) Huruy et al AIDS Research and Therapy 2010, 7:46...

Ngày tải lên: 10/08/2014, 05:21

... target cell types of the in vivo infection, endothelial and epithelial cells, occurs via cell- to -cell fusion, and is mediated by NiV glycoproteins expressed a the cell- cell contact sides Nevertheless, ... epithelial cells Results NiV infection of polarized endothelial cells causes syncytia formation and increases transendothelial permeability Primary brain capillary endothelial cells have the ... endothelia [31,32] NiV spread of infection across the lateral junctions of endothelial cells via cell- to -cell fusion was found to be as efficient as in epithelial cells and is, as in epithelia,...

Ngày tải lên: 12/08/2014, 02:20

... cultured at 37°C, 5% CO2 and passaged 2-3 times weekly using trypsin-EDTA The cell line was characterized earlier as endothelial cells by the presence of platelet endothelial cell adhesion molecule ... seen in the cells of a plexiform lesion (P) Inset exhibits prominent luminal staining of GDF-15 in cells lining the vascular channel (arrow) Note the presence of GDF-15 in the endothelial cells ... significant inhibition of endothelial cell proliferation (Figure 11, panel B) Figure Upregulation of GDF-15 by hypoxia in endothelial cells Human pulmonary microvascular endothelial cells (HPMEC) were...

Ngày tải lên: 12/08/2014, 13:22

... endothelial and epithelial cells Surface-volume relationships in endothelial and epithelial cells Surface and Volume densities (Sv and Vv, respectively) are presented for endothelial (A, B) and ... distribution of volume and surface of endothelial and epithelial cells in the air-blood barrier Frequency distribution of volume and surface of endothelial and epithelial cells in the air-blood barrier ... thinning of the endothelial layer but no appreciable changes in the epithelial layer Fig C allows to evaluate the response of endothelial and epithelial cells of the air blood barrier in the cardiogenic...

Ngày tải lên: 12/08/2014, 16:20

... melanoma cells) [15,50,51] Using an in situ liver perfusion system, the cellular origin of the NO release following B16F1 cell arrest in the liver has been identified as periportal endothelial and sinusoidal ... major differences have been noted in the composition of the portal tract and sinusoid with regard to endothelial and parenchymal cell expression of cell- cell and cellmatrix adhesion molecules during ... tumor cells Endothelial- tumor cell interactions induce nitric oxide release from the hepatic endothelium Direct and indirect evidence from the literature has supported the hypothesis that the hepatic...

Ngày tải lên: 13/08/2014, 13:20

... problem Therefore, the isolation and maintenance of murine endothelial cells from various developmental stages and locations is important for dissecting molecular and cellular mechanisms of endothelial ... Lyve-1 Liver Heart Yolk sac Brain Embryo A chemistry using antibodies against the pan-EC marker, CD31, the lymphatic endothelial and liver sinusoidal endothelial marker Lyve-1 (lymphatic vessel endothelial ... Lyve-1-positive liver sinusoidal endothelial cells in vitro Intriguingly, almost all of the cell population from the liver were also positive for Lyve-1 (Fig 3C), and Western blot analysis revealed that they...

Ngày tải lên: 18/02/2014, 17:20

... HYDATID DISEASE OF THE LIVER IN CHILDREN ABSTRACT: Twenty one patients with hydatid disease of the liver were operated upon between 1986-1997 There were 10 males and 11 females The mean age of the ... publication in the Journal, the copyright of the paper shall become the property of The Liverpool School of Tropical Medicine who may on request licence me/us to reproduce the paper of any part thereof, ... disease is a major endemic health problem in certain areas of the (1,2) world The most commonly affected organ is the liver( 1,2,3) Children are susceptible to this parasitic infection, and the...

Ngày tải lên: 05/03/2014, 12:20

... with the following: chronic alcoholic liver disease, acute viral liver disease, chronic viral liver disease, mixed liver disease (all chronic), cirrhosis, and alcoholic cirrhosis We adopted the ... Specifically, the meta command was used to compute and graph the randomeffects model estimates,63 the “galbr” command to assess heterogeneity and produce Galbraith plots,62 and the metabias command to ... using over -the- counter “alternative agents” for the therapy of their liver disease The most commonly used nontraditional therapy was milk thistle, and over 50 percent of those patients felt they had...

Ngày tải lên: 18/03/2014, 00:20

... phase reconstitutes the original mass of the liver [1,2] The residual hepatocytes re-enter the cell cycle while the normal homeostatic mechanisms that couple cell cycle re-entry to cell death are ... cristae-rich, and with an electron-dense matrix Quantitation of normal and altered mitochondria in control liver and in liver at 24 and 96 h after PH was performed The majority of liver mitochondria ... succinate and phosphate Mitochondria were suspended in the swelling medium and the absorbance of the mitochondrial suspension as a function of time was monitored either in the absence or in the presence...

Ngày tải lên: 24/03/2014, 04:21

... A) The axial view indicates that the mass is located at the inferior tip of the right liver lobe The surrounding fat tissue does not show any fatstranding B) The coronal view clearly shows the ... the localization with topographic relation to the right liver lobe and the medical history made the diagnosis of a cystic hydatid disease most likely It is worth noting that the sensitivity and ... 80% and 90% and therefore results might be negative despite hydatid disease being present [14] New therapeutic approaches in the treatment of hydatid disease include percutaneous punction of the...

Ngày tải lên: 11/08/2014, 21:22

... preponderance of alcoholic liver disease in the patients with chronic liver failure (n = 13) unrelated to PDT and the patient died 72 hours after tracheostomy insertion Table shows the cumulative incidence ... cirrhosis admitted to a medical ICU The average SOFA score of the patients in this study was 13, and a third of the patients had chronic liver disease as their underlying pathology Incidence ... design, and acquisition of data and were involved with the clinical aspects of the study GA and WB were concerned with analysis and interpretation of data All authors were involved with the clinical...

Ngày tải lên: 13/08/2014, 08:20

... compared this approach with the clinical standard vasopressor treatment, namely norepinephrine infusion The study by Krejci and colleagues therefore raises the question of whether AVP compares favorably ... norepinephrine and epinephrine reduced both superior mesenteric artery flow and capillary perfusion in the small bowel and pancreas [7] Taking these results together, what we learn from the authors’ ... investigation the same group compared the regional macrocirculatory and microcirculatory effects of epinephrine, norepinephrine and phenylephrine In a similar manner to the effects of AVP in the present...

Ngày tải lên: 13/08/2014, 08:21