vascular endothelial growth factor in breast cancer

... Firestein GS: Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis J Clin Invest 1999, 103:3-4 Robinson CJ, Stringer SE: The splice variants of vascular endothelial growth factor ... Role of vascular endothelial growth factor in the regulation of angiogenesis Kidney Int 1999, 56:794-814 Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) ... reflects the findings of Felson and coworkers [27], who declared OA to be a disease involving the whole joint In summary, these data support the role of VEGF in mediating destructive processes in articular...

Ngày tải lên: 09/08/2014, 08:23

... 2007, 8:60 Background Vascular endothelial growth factor (VEGF) was originally discovered as a vascular permeability factor in guinea pig skin, and is a mitogen that regulates endothelial cell differentiation, ... using a murine model of http://respiratory-research.com/content/8/1/60 LPS-induced lung injury Using the lung specimens, TUNEL staining and immunostaining of caspase-3, Bax, apoptosis inducing ... examining both endothelial permeability and apoptosis in a single model of lung injury To evaluate the role of VEGF in the apoptosis of endothelial cells and their barrier function in the injured...

Ngày tải lên: 12/08/2014, 15:21

... can stimulate VEGF production include epidermal growth factor (EGF), transforming growth factor β (TGF-β), keratinocyte growth factor (KGF) and insulin like growth factor (IGF) [5,8] These observations ... paracrine or autocrine release of such factors cooperates with local hypoxia in regulating VEGF release in the microenvironment [5] The major cytokines that induce VEGF expression are interleukin ... VEGFs, angiopoietins and ephrins [13] Incorporation of those three different kinds of growth factors in a model of vascular formation has showed that VEGF initiates the formation of vascular vessels...

Ngày tải lên: 12/08/2014, 16:20

... substituting PBS for primary antibody For this study, the intensity of VEGF and COX-2 staining were scored on a scale of 0-3: 0, negative; 1, light staining; 2, moderate staining; and 3, intense staining ... contribute to maintaining a high level of VEGF in NSCLC tissue, thereby playing an important role in tumor-induced angiogenesis Previous reports provide no insight into how up-regulating COX-2 might ... mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner Cancer Res 2005, 65(14):6275-81...

Ngày tải lên: 10/08/2014, 10:20

... vascular endothelial growth factor (VEGF) family members PlGF, placenta growth factor; T.F svVEGF, Trimeresurus flavoviridis, snake-venom vascular endothelial growth factor Ligands Binding activity ... (1994) Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms Int J Cancer ... Flt-1 signaling in macrophages promotes glioma growth in vivo Cancer Res 68, 7342–7351 Lin EY & Pollard JW (2007) Tumor-associated macrophages press the angiogenic switch in breast cancer Cancer Res...

Ngày tải lên: 18/02/2014, 11:20

... conditions [62] Interestingly, we observed that the insulin mRNA PTB binding site has an overlapping consensus CSD binding site PTB, to date, has only been implicated in stability of insulin and VEGF ... recombinant CSD protein binding (B) A comparison of CSD protein RNA binding sites is shown relative to a preferred sequence derived for the mouse MSY1/2/4 CSD proteins [38–40] Bases in binding ... CSD-containing cytoplasmic RNA/protein complex therefore contains at least four different proteins It has been reported that PTB, another single-strand RNA/DNA binding protein [43–46,52–57] can bind...

Ngày tải lên: 19/02/2014, 12:20

... Tonino P, Dinarello CA: Interleukin-1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro ... Factors regulating the growth of metastatic cancer in bone Endocrine-Related Cancer 1999, 6:333-347 Page 13 of 14 10 Mundy GR, Martin TJ: Pathophysiology of skeletal complications of cancer In Handbook ... Upregulation of vascular endothelial growth factor by cobalt chloridesimulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line Clin Exp...

Ngày tải lên: 18/06/2014, 22:20

Ngày tải lên: 19/06/2014, 22:20

... Vascular endothelial growth factor- A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients Journal of Neuroinflammation ... b-actin Basal VEGF-A mRNA expression in normal control group is represented by x-axis in part “A” ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor- A; CCL2, chemokine ... ALS patients could not be ascertained Since elevated CCL2 initiates inflammatory reaction by increasing production of nitric oxide and other inflammatory chemokines from unregulated monocytes/...

Ngày tải lên: 19/06/2014, 22:20

... (two diffusible proteins from mature, monomeric VEGF), but not human placenta-derived growth factor, platelet-derived growth factor, or transforming growth factor Inter- and intra-assay variances ... and controls Several factors contribute to VEGF production, including hypoxic conditions and stimulation by transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative ... residue and vascular endothelial growth Correlation between carbonyl in systemic sclerosis patients at baseline factor (VEGF) concentrations in systemic sclerosis patients at baseline (n = 40;...

Ngày tải lên: 09/08/2014, 01:23

... are induced and outweigh the inhibitors, resulting in the initiation of angiogenesis [4] Among the angiogenesis inducers, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor ... Monson JR, Kerin MJ: Serum vascular endothelial growth factor in breast cancer: its relation with cancer type and estrogen receptor status Clin Cancer Res 2001, 7:3491-3494 Carmeliet P, Jain RK: Angiogenesis ... single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model J Clin Invest 1994, 93:662-670 Takeshita S, Tsurumi Y, Couffinahl...

Ngày tải lên: 09/08/2014, 06:22

... in synovial lining cells and endothelial cells of blood vessels in the sublining layer Immunostained sections were counterstained with hematoxylin Arrows, synovial lining cells; arrowheads, endothelial ... Jesty J: Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A ... synovial lining cells, endothelial cells of blood vessels and macrophage-like cells in the sublining layer of the RA synovium (Fig 5a,b), confirming the findings from in situ hybridization No staining...

Ngày tải lên: 09/08/2014, 07:20

... recombinant PlGF protein Pre-incubation of the PlGF antibody with recombinant PlGF protein (R&D, UK) successfully blocked staining of the tissue therefore indicating that the staining observed is indeed ... 298(6):L768-74 Park JE, et al: Placenta growth factor Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR J ... transcription factors in the in vivo lung Am J Respir Crit Care Med 2008, 178(9):977-83 58 Milkiewicz M, et al: Vascular endothelial growth factor mRNA and protein not change in parallel during non-inflammatory...

Ngày tải lên: 12/08/2014, 13:22

... Several lines of in vitro evidence have pointed to a possible role for VEGF in lung repair and recovery following injury[19,29,35,36] In one LPSinduced murine model of lung injury, intrapulmonary ... 2(1):33-46 Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH: Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury Am J Respir Cell ... characteristics of vascular endothelial growth factor (VEGF), as both an angiogenic and permogenic factor has led to interest in its potential role in this condition[2,3] It is known that VEGF protein is...

Ngày tải lên: 12/08/2014, 14:20

... cells in pulmonary vessels, leading to vascular remodeling Indeed, VEGF has been found to be involved in vascular remodeling in primary pulmonary hypertension, which is characterized by endothelial ... pulmonary endothelial cells [26] In contrast, high levels of VEGF induced airway remodeling in bronchitis-type of COPD [27] These previous findings have promoted a growing interest in clarifying that ... pulmonary vascular remodeling of these common types of COPD With this background in mind, our findings indicate the potential role of VEGF in the pathogenesis of the vascular changes that take place in...

Ngày tải lên: 12/08/2014, 15:20

... The main finding of this study is that cigarette smoking is an important determinant of vascular endothelial growth factor (VEGF) upregulation in the airways, as assessed by VEGF's levels in induced ... volume in one second; DLCO: diffusing lung capacity for carbon monoxide; VEGF: vascular endothelial growth factor; IL-8: interleukin-8; TNF-α: tumor necrosis factor alpha matory mediators in sputum ... of vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema Am J Respir Crit Care Med 2001, 163:737-744 Sakao S, Tatsumi K, Hashimoto T, Igari H, Shino...

Ngày tải lên: 12/08/2014, 15:21

... region encoding the carboxy-terminal propeptide domain; H, encodes the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal ... The binding of VEGFs to NRP1 appears to be mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon and the NRP1/heparin-binding domain encoded ... Christinger HW, Keyt BA, Starovasnik MA: Solution structure of the heparin-binding domain of vascular endothelial growth factor Structure 1998, 6:637-648 The NMR structure of the NRP1/heparin-binding...

Ngày tải lên: 14/08/2014, 14:21

... Charles ST: Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro Microvasc ... stimulating the migration of activated keratinocytes over the wound area what indicates that this growth factor can promote epithelialization independently of its role in recruiting and stimulating endothelial ... mounted in DAPI (4′,6-diamidino-2-phenylindole)-containing medium (a fluorescent stain that strongly binds to DNA) Histology Skin from the healed wound beds surrounded by a margin of normal skin and...

Ngày tải lên: 14/08/2014, 19:22

... activity in HUVEC Increases in cAMP levels and the activation of the cAMP-dependent protein kinase A (PKA) may be involved [44] Indeed, PKA inhibits the MAP kinase pathway by blocking Raf1 activity in ... of platelet factor retain the blocking effect on the receptor binding of basic fibroblast growth factor Jpn J Cancer Res 84, 485–488 12 Gupta, S.K & Singh, J.P (1994) Inhibition of endothelial ... leading to the activation of protein kinase C (PKC), followed by the serine/ threonine kinase, Raf1 and then the threonine/tyrosine kinase, MEK1/2 (MAP kinase kinase 1/2) [28–31] This phosphorylation...

Ngày tải lên: 19/02/2014, 16:20