Báo cáo y học: "Allele dependent silencing of COL1A2 using small interfering RNAs"

Báo cáo y học: "Allele dependent silencing of COL1A2 using small interfering RNAs"

Ngày tải lên : 03/11/2012, 11:52
... (normalized cDNA peak heights of targeted vs. non-targeted allele of rs1800222) 72 hours post-transfection with three dif- ferent concentrations of siRNA3. Colours of bars indicate the SNP used ... severity of this disease. The principle of allele specific silencing of Collagen type I genes has been explored previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 ... silencing of the Collagen 1 alpha genes, can be tested in clinical trials. The efficiency and specificity of RNA interference using siRNAs is heavily dependent on the base composition of target...
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Tài liệu Accounting Practices and the Market Valuation of Accounting Numbers: Evidence from Indonesia, Korea, Malaysia, the Philippines, Taiwan, and Thailand doc

Tài liệu Accounting Practices and the Market Valuation of Accounting Numbers: Evidence from Indonesia, Korea, Malaysia, the Philippines, Taiwan, and Thailand doc

Ngày tải lên : 17/02/2014, 09:20
... e it 2 where Price it is the stock price per share of firm i at the end of year t, BVPS it is the book value of shareholders' equity of firm i at the end of year t, REPS it is the residual ... for a fiscal year) and stock prices at the end of the fiscal year. Later, we analyze the sensitivity of our results using stock prices lagged 0 to 6 months following the end of the fiscal year. Equation ... time. Focusing on the incremental explanatory power of BVPS, R bjr 2 , we find the incremental power of BVPS ranges widely across the six countries, from a low of .070 in Taiwan to a high of .669...
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Tài liệu Báo cáo khoa học: "Modeling Wisdom of Crowds Using Latent Mixture of Discriminative Experts" docx

Tài liệu Báo cáo khoa học: "Modeling Wisdom of Crowds Using Latent Mixture of Discriminative Experts" docx

Ngày tải lên : 20/02/2014, 05:20
... direction of research appeared in the last decade, taking full advantage of the ”wisdom of crowds” (Surowiecki, 2004). In simple words, wis- dom of crowds enables parallel acquisition of opin- ions ... Linguistics Modeling Wisdom of Crowds Using Latent Mixture of Discriminative Experts Derya Ozkan and Louis-Philippe Morency Institute for Creative Technologies University of Southern California {ozkan,morency}@ict.usc.edu Abstract In ... opinions of multiple an- notators/experts, which is referred to as ”wis- dom of crowds”. In this paper, we propose a new approach for modeling wisdom of crowds based on the Latent Mixture of Discrimina- tive...
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Tài liệu Báo cáo khoa học: "Extracting Semantic Orientations of Words using Spin Model" pdf

Tài liệu Báo cáo khoa học: "Extracting Semantic Orientations of Words using Spin Model" pdf

Ngày tải lên : 20/02/2014, 15:20
... Analysis We investigated a number of errors and concluded that there were mainly three types of errors. One is the ambiguity of word senses. For exam- ple, one of the glosses of “costly”is “entailing ... : ¯x new i =  x i x i exp  βx i  j w ij ¯x old j   x i exp  βx i  j w ij ¯x old j  . (7) 4 Extraction of Semantic Orientation of Words with Spin Model We use the spin model to extract semantic orienta- tions of words. Each spin has a direction taking one of two values: up or ... expressions. For exam- ple, although “brag” means “show off”, neither of “show” and “off” has the negative orientation. Id- iomatic expressions often does not inherit the se- mantic orientation from...
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Valuation of Convertible Bonds pptx

Valuation of Convertible Bonds pptx

Ngày tải lên : 06/03/2014, 08:20
... contracts of European-style. The coupon rate of a mandatory convertible bond is usually higher than the dividend rate of the stock. At maturity it converts mandatorily into a number of stocks if the stock ... 82 7.3.1 Change of measure . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 7.3.2 Valuation of coupons . . . . . . . . . . . . . . . . . . . . . . . . . . 84 7.3.3 Valuation of terminal payment ... maximize the value of the bond by means of optimal exercise of the conversion right. The incentive of the issuer to call a bond is to limit the bondholder’s participation in rising stock prices. The...
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ON THE VALUATION OF CORPORATE BONDS pot

ON THE VALUATION OF CORPORATE BONDS pot

Ngày tải lên : 06/03/2014, 08:20
... and risk- neutral valuation using the definition of risk-neutral probabilities proposed by JLT. We show that the JLT risk-neutral probabilities are independent of estimates of the transition ... to a fraction of the market value of an equal maturity corporate bond in the same risk class plus the same fraction of the coupon, then the risk-neutral valuation gives the same valuation as discounting ... two versions of rating-based models which have been advocated in the literature of Financial Economics and to a comparison of the bond valuations they produce. The simplest version of a rating-based...
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Research " Essays on the Equilibrium Valuation of IPOs and Bonds " pdf

Research " Essays on the Equilibrium Valuation of IPOs and Bonds " pdf

Ngày tải lên : 07/03/2014, 02:20
... satisfaction of the requirements for the degree of Doctor of Philosophy in Business Administration in the GRADUATE DIVISION of the UNIVERSITY of CALIFORNIA at BERKELEY Committee in charge: Professor ... sales will become easier (decreasing l). When using the traditional CAPM to measure performance of individual IPO stocks, there are the same three sources of underperformance. The result has a cross-sectional ... a pioneer of the World Wide Web browser, threatened to topple the domination of Microsoft in the software market for personal computers and network computers. Amazon.com, the pioneer of online...
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Báo cáo khoa học: "Determining the Specificity of Terms using Compositional and Contextual Information" pptx

Báo cáo khoa học: "Determining the Specificity of Terms using Compositional and Contextual Information" pptx

Ngày tải lên : 08/03/2014, 04:22
... example, the distribution of co-occurrence words of the terms, the distribution of predicates which have the terms as arguments, and the distribution of modi- fiers of the terms are contextual ... specificity of domain-specific terms. The preci- sion of 82.0% is good performance compared to upper bound of 87.4%. 4.2. Error Analysis One reason of the errors is that the names of some internal ... terms of specificity measuring. A set of journal abstracts was extracted from MEDLINE 2 database using the disease names as quires. Therefore, all the abstracts are related to some of the...
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Báo cáo khoa học: Natriuretic peptide system: an overview of studies using genetically engineered animal models doc

Báo cáo khoa học: Natriuretic peptide system: an overview of studies using genetically engineered animal models doc

Ngày tải lên : 14/03/2014, 23:20
... and suggestions were of inestimable value for our study using GC-A knockout mice, to Professor Misono of the University of Nevada School of Medicine, and to the reviewers of the FEBS Journal, ... pathophysiological roles of the natriuretic peptides ⁄ receptor signaling pathways in the regulation of blood pressure ⁄ volume, maintenance of the cardiovascular system, and devel- opment of the longitudinal ... potential importance of the natriuretic peptide sys- tem in humans. Acknowledgements Our heartfelt appreciation goes to the late Dr Garbers, a former professor of the University of Texas, whose com- ments...
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Valuation Of Environment-Related Health Risks For Children ppt

Valuation Of Environment-Related Health Risks For Children ppt

Ngày tải lên : 15/03/2014, 00:20
... types of altruism in the context of child mortality using a societal perspective. 9. www.oecd.org/dataoecd/16/21/39338429.pdf 1. THE VALUATION OF ENVIRONMENTAL HEALTH RISKS VALUATION OF ENVIRONMENT-RELATED ... provides a summary of the main results of the project. The document concludes with a discussion of policy implications. 1. THE VALUATION OF ENVIRONMENTAL HEALTH RISKS VALUATION OF ENVIRONMENT-RELATED ... on the valuation of health benefits for children. To help fill this gap, a project on the valuation of environmental health risks to children was undertaken: the VERHI project (Valuation of Environment-related...
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The Valuation of Convertible Bonds With Credit Risk ppt

The Valuation of Convertible Bonds With Credit Risk ppt

Ngày tải lên : 15/03/2014, 03:20
... prices and “soft call” provisions, in which the ability of the issuing firm to exercise its option to call is dependent upon the history of its stock price. This paper explores the valuation of convertible ... rate of the stock, s is the spread, and B is the bond component of the convertible. Following the description of this model in Hull (2003), we will assume here that the “growth rate of the stock ... specified period of time (e.g. 30 days), or has been above a level for some specified fraction of time (e.g. 20 out of the last 30 days). The modern academic literature on the valuation of convertibles...
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Valuation of Non-marketed Goods pot

Valuation of Non-marketed Goods pot

Ngày tải lên : 16/03/2014, 01:20
... supply efficient levels of goods or bads which are non-excludable and/or non-rival. Provision of public goods is one of the important activities of governments, and is one of the reasons for social ... BCA at the same time poses one of its major challenges - that of valuation in the absence of market prices. Benefit-Cost Analysis: financial and economic appraisal using spreadsheets, Chapter 12, ... forms of economic activity, such as jobs. The survey results can be used to calculate trade-offs between various types and levels of protection and other economic values. Marginal values of types...
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ON THE VALUATION OF GOODS AND SELECTION OF THE BEST DESIGN ALTERNATIVE docx

ON THE VALUATION OF GOODS AND SELECTION OF THE BEST DESIGN ALTERNATIVE docx

Ngày tải lên : 16/03/2014, 11:20
... price offered. Table 2. Explanation of attribute indices H. E. Cook, A. Wu: On the valuation of goods and selection of the best design alternative 51 On the valuation of goods and selection of ... interac- tions are displayed using additional columns to the right of those shown in the topmost section of Table 1. The H. E. Cook, A. Wu: On the valuation of goods and selection of the best design alternative 49 ... acceleration force of approximately 1 G. Val- ues for fuel economy were computed using a price of fuel of $1.50 and an annual driving distance of 10,000 miles, which yields an annual expenditure of $682...
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