vaccines for hematological malignancies

... Influenzavirus B/ (flu or influenza*).tw or/3-6 Vaccines/ vaccines, attenuated/ or vaccines, inactivated/ or exp vaccines, subunit/ or exp vaccines, synthetic/ or viral vaccines/ 10 exp Immunization/ 11 (vaccin* ... comprehensive assessment of the effects of influenza vaccines in the elderly The current pandemic has caused a heightened interest in influenza vaccines and Vaccines for preventing influenza in the elderly (Review) ... Trivalent inactivated vaccines are the most commonly used influenza vaccines Due to the poor quality of the available evidence, any conclusions regarding the effects of influenza vaccines for people aged...

Ngày tải lên: 13/02/2014, 18:20

... 134 GENE THERAPY FOR HEMATOLOGICAL DISORDERS FIGURE 6.1 Hierachal model of lymphohemopoiesis A primitive lymphohemopoietic cell is capable of producing lymphoid stem cells for lymphopoiesis ... field forward into real clinical utility REQUIREMENTS FOR GENE TRANSFER INTO HEMATOPOIETIC CELLS Ex Vivo Versus in Vivo Gene Transfer Specific aspects of gene transfer techniques are advantageous for ... transfer is most appropriate for target cells that cannot REQUIREMENTS FOR GENE TRANSFER INTO HEMATOPOIETIC CELLS 135 TABLE 6.1 Relevant Targets and Applications for Gene Therapy of Hematopoietic...

Ngày tải lên: 10/04/2014, 22:10

... tumor volume (GTV) with a 2-3 cm block margin for conformal plans A margin of 1.5-2 cm was added to the GTV to form the planning target volume (PTV) for IMRT plans Radiation therapy was delivered ... Follow-up information was obtained from hospital records and radiation therapy department records Follow-up information was also obtained from the M D Anderson Tumor Registry, which collects information ... hospitalization for days and termination of radiation therapy before completion of the prescribed course No other patient developed grade 3-4 acute toxicity or was hospitalized for acute toxicity...

Ngày tải lên: 09/08/2014, 10:20

... lenalidomide achieves clinical efficacy in hematological malignancies Page of 10 (page number not for citation purposes) Journal of Hematology & Oncology 2009, 2:36 needed for erythroid differentiation The ... decreases the formation of tartrate- resistant acid phosphatase(TRAP)- positive cells which form osteoclasts [11] Additionally, it decreases αVβ3-integrin levels, an adhesion molecule needed for osteoclast ... TNF-α production is implicated in the pathogenesis of various hematologic malignancies and may be partly responsible for stem cell apoptosis and ineffective hematopoiesis seen in MDS [8] TNF-α...

Ngày tải lên: 10/08/2014, 22:20

... and lymphoma Canonical Wnt signaling may act as a potentially useful therapeutic target for hematological malignancies Ultimately, further investigation is needed to interfere with Wnt signaling ... endothelial growth factor and stromal cell-derived factor-1 [38] Role of Wnt canonical pathway in hematological malignancies Hematopoiesis is a continuous process in which stem/ progenitor cells develop ... Wnt/b-catenin signaling pathway for normal B cell development and function [43,44] Frizzled knockout in mice leads to abnormal B-cell development [45] Wnt signaling is required for thymocyte development...

Ngày tải lên: 10/08/2014, 22:21

... the margin for the Fortune 500 drug firms has consistently exceeded the margin for all Fortune 500 companies taken together It is possible that the higher profits are compensation for higher ... US, Europe and Japan account for 77% of the market although they account for less than 15% of the global population [3] In contrast, Sub-Saharan Africa that accounts for almost 25% of the global ... costs Therefore, successful drugs can generate high profits in accounting terms as the R&D costs for such drugs have already been expensed in the past Nevertheless, Table shows that profits for the...

Ngày tải lên: 11/08/2014, 18:20

... Liew Lee Mei, Mdm Wen Hong-Mei for providing me technical assistance I would like to thank the Bioinformatics Group at the Nanyang Polytechnic, Singapore, for performing the statistical analysis ... vaccination against Der p sensitization These data are useful information for the design of safe and efficacious DNA vaccines for allergy in general Taken together, the new findings from this ... Kenny, for showering me with great concern and all those endless motivation in the course of my study I truly appreciate him for being so understanding Also to my dearest baby, Ryan, for adding...

Ngày tải lên: 14/09/2015, 14:20

... treatments under development 19 1.3 DNA vaccines for prevention and treatment of allergic asthma 26 1.3.1 History of vaccine and DNA vaccine 26 1.3.2 DNA vaccines for allergic asthma and other allergic ... evaluation of the Der p DNA immunization for potential prophylactic and therapeutic applications for allergic asthma were performed using an experimental mouse model for allergic asthma Results showed ... DEVELOPMENT OF DNA VACCINES FOR ALLERGIC ASTHMA TAOQI HUANGFU (MBBS, SHANGHAI SECOND MEDICAL UNIVERISTY, P R CHINA) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 15/09/2015, 17:09

... 4.5 MAINTAINING CONFORMATION IS IMPORTANT FOR ALLERGY VACCINES DESIGNED FOR ALLERGENS WITH PREDOMINANTLY CONFORMATIONAL EPITOPES .87 4.5.1 Importance of the conformation and implications ... pmole forward or reverse primers Thermocycling profile was set for denaturation at 96° C for 30 seconds, annealing at 50° C for 15 seconds, extension at 60° C for minutes and repeated for 29 ... potentially act as vaccines for immunotherapy against these allergens Materials and Methods 2.1 Genetic engineering of hybrid constructs 2.1.1 Bacteria host strains for transformation Strain Genotype...

Ngày tải lên: 07/10/2015, 10:02

... algorithm Therefore, TPS® additionally offers methods for inverse treatment planning and biological RT treatment optimization for particle therapy In addition, steering parameters for scanned ion ... scanning methods allow generation of highly conformal dose distributions and extremely steep dose gradients Therefore, application of heavy ion therapy for the treatment of paranasal sinus tumours ... contributions ADJ, AVN, MWM were responsible for treatment concepts and patient care, SE, ME for technical treatment planning and quality control, and JD and MWM for conceptual design All authors read...

Ngày tải lên: 09/08/2014, 09:20

... absorption window through the Peyer’s patches [54] Nanoparticles for vaccine/gene delivery: Polynucleotide vaccines/ DNA vaccines/ plasmid vaccines work by delivering genes encoding relevant antigens ... polynucleotide vaccines, DNA, can be produced cheaply and has much better storage and handling properties than the ingredients of the majority of protein-based vaccines Hence, polynucleotide vaccines/ DNA vaccines ... criteria for the preparation of the nanoparticles, the methods can be classified as following 1) dispersion of preformed polymers, 2) polymerization of monomers and 3) ionic gelation method for hydrophilic...

Ngày tải lên: 11/08/2014, 08:20

... importance for DNA vaccines is formulations and adjuvants Adjuvants are common to most licensed vaccines and are included to potentiate the immune responses elicited by vaccination For DNA vaccines, ... x Figure Manufacturing timelines for DNA vaccines compared to egg-based protein vaccines Manufacturing timelines for DNA vaccines compared to egg-based protein vaccines F/F = fill finish Ability ... proteinbased vaccines for pandemic influenza first therapeutic vaccine approved by the U.S government for the treatment of cancer in animals or humans Approved DNA Vaccines Although DNA vaccines...

Ngày tải lên: 11/08/2014, 08:21

... new vaccines, we specifically examined vaccines for anthrax, botulism, toxic-shock syndrome, and plague The following is a brief description of the diseases and vaccines that were developed for ... recommended vaccines for children and adults, plus annual influenza vaccinations Additional vaccines are planned for protection from the nine category A and numerous B-C agents on the Centers for Disease ... stability profiles For example, STEBVax was maintained in a glycine buffer of pH 8, while a phosphate buffer of pH was used for rPA Yet, an advantage associated with the vaccines for anthrax, botulism...

Ngày tải lên: 11/08/2014, 10:23

... Europe: vaccines and microbicides 21 44 42 30 58 51 72 93 77 USA: vaccines and microbicides 80 86 89 80 92 83 95 99 95 Figure Relative share of funding for vaccines and microbicides vs for integrated ... funding policies Globally, USA government and BMGF account for 79% of the global funding for vaccines and for 59% of the global funding for microbicides [47] The two agencies have a same type of ... financial flows for integrated condom programming used for family planning and reproductive health purposes from those used for HIV prevention, as we will elaborate below The data on funding for research...

Ngày tải lên: 11/08/2014, 14:21

... strain when Page of (page number not for citation purposes) Acta Veterinaria Scandinavica 2006, 48:2 exposed to the vaccines at 1–10 days of age Another reason for the differences in the response ... Acknowledgements Thanks are expressed for a grant for development of new faculty staffs, Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University for supporting this work References Fauquet ... 50% embryo infective dose (EID50)/bird, respectively IOAV (Kimber strain, Chick N-K, Fort Dodge Animal Health, Fort Dodge, Iowa, U.S.A.) was administered subcutaneously at the nape of each chick...

Ngày tải lên: 12/08/2014, 18:21

... IH: Data mining in bioinformatics using Weka Bioinformatics 2004, 20:2479-2481 Gewehr JE, Szugat M, Zimmer R: BioWeka – extending the Weka framework for bioinformatics Bioinformatics 2007, 23:651-653 ... Davies MN, Flower DR: Harnessing bioinformatics to discover new vaccines Drug Discov Today 2007, 12:389-395 Martin W, Sbai H, De Groot AS: Bioinformatics tools for identifying class I-restricted ... conserved across different non-recombinant and recombinant forms of HIV-1 genomes can be considered as ideal candidates for multi-epitope vaccines against HIV-1 Abbreviations HLA: Human Leukocyte...

Ngày tải lên: 12/08/2014, 23:21

... adjuvant for use in recombinant vaccine strategies In addition, LMP1 and LMP1 chimeras could be used as viral vector vaccine adjuvants or adjuvants for DNA or RNA based vaccines Use of LMP1 for Gupta ... Health Service grant AI063982 (for GWS), AI073240 and AI63982 (for RSK), and AI063993, AI071306, and RR000168 (for DTE), and the University of Miami Developmental Center for AIDS Research (AI073961) ... cells in vitro These results are encouraging for the clinical evaluation of LMP1 and LMP1 chimeric constructs as a novel class of adjuvant for HIV vaccines and other immunotherapy strategies Results...

Ngày tải lên: 13/08/2014, 01:20

... or Fisher's exact test, as appropriate, for categorical variables, and independent samples t-tests for continuous variables Multivariate analysis was performed to investigate associations between ... hematologic malignancies, mortality among 22 patients with relapsed malignancies (21 deaths) was significantly higher than among 35 patients at first presentation (26 deaths) [24] Crawford and colleagues ... performed because of the poor clinical condition of the patients, risk of hypoxemia, and potential for opportunistic infection However, cultures of endotracheal aspirates and blood were performed...

Ngày tải lên: 13/08/2014, 19:20

... in order for transduction or transfection procedures to be carried out Most malignancies will not survive in culture in large enough numbers to be utilized However, if the time required for in ... of 95°C for 15 sec., and 62°C for To normalize the number of cells/nuclei, human RNase P was amplified using the TaqMan® RNase P reagents kit (Applied Biosystems, Foster City, CA), or for mouse ... amount of plasmid DNA, therefore these comparisons are relative and not maximized for each method (not shown) We then tested a primary mouse-derived neuroblastoma mass for the ability to be transfected...

Ngày tải lên: 14/08/2014, 19:22

... support highspeed data for multimedia services has been the driving forces for developments in third generation, or 3G, infrastructures Perhaps a more subtle reason for the need for 3G is the growing ... may be different for different users within the cell and between cells It is used for transmitting the forward access channel (FACH) for access grant and the paging channel (PCH) for paging, both ... diversity, the BER performance improved as the chip rate increased For a chip rate of 0.96 Mcps, the BER performance was close to the computer simulated BER performance with L=1 The performance with...

Ngày tải lên: 04/08/2012, 14:24