vaccines chemotherapy in the interface with the immune system
Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
Ngày tải lên :
06/08/2014, 19:21
... promoting (though not in initiating) the differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal ... for their suppressive effect in this autoimmune model with a view to future application in treatment of the disease While the role of AhR in the induction of the cytokine IL-22 is now defined in ... functional subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets...
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Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... catenin-like protein 1) as an AID-interacting protein Interestingly, he found that an AID mutant deficient in CTNNBL1 binding retains deamination activity but is impaired in class switching, ... division in cell-fate determination, and provided compelling evidence suggesting that the cell fate determinant Numb is critical in determining lineage commitment in the immune system Tannishtha Reya ... but in the context of an immune response Reiner showed that following antigen triggering, T cells become polarized with respect to the immunological synapse they make with the antigenpresenting...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... affect binding of any of the adherent cell types Binding assays with siglec-expressing COS7 cells Results for COS7 binding experiments are shown in Fig 5C There was a significant increase in binding ... The two spliced regions are indicated in black, the cryptic splice acceptor site is underlined, the transmembrane domain is in bold and amino acids in the ITIM motifs in the cytoplasmic domain ... plasmid and the integrity of the insertion was validated by digesting the plasmid construct with either HindIII/Nco I to check the extracellular domain of siglec or with HindIII/Xba I to check the entire...
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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx
Ngày tải lên :
18/06/2014, 22:20
... antagonize the effects of host cytokines mediating the antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10 ... evidence for an immune escape mechanism that alleviates the host's immune response to viral proteins and therefore generates the possibility of replicating in the host in spite of vaccination Such ... http://www.virologyj.com/content/2/1/22 In this study, sheeppox virus-induced immunomodulating effects were characterized to elucidate the basic mechanisms responsible for understanding the interaction of SPPV with host immune system...
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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc
Ngày tải lên :
20/06/2014, 04:20
... antagonize the effects of host cytokines mediating the antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10 ... evidence for an immune escape mechanism that alleviates the host's immune response to viral proteins and therefore generates the possibility of replicating in the host in spite of vaccination Such ... http://www.virologyj.com/content/2/1/22 In this study, sheeppox virus-induced immunomodulating effects were characterized to elucidate the basic mechanisms responsible for understanding the interaction of SPPV with host immune system...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells remains unknown The balancing act required by the immune ... [56].Yet, in humans, it is impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the ... (TGF-β) These cells can also be distinguished based on where they originate, in the thymus or in the periphery One prevailing model is that a class of regulatory T cells that originate in the thymus,...
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Báo cáo y học: "Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?" pptx
Ngày tải lên :
10/08/2014, 05:21
... protease inhibitor (PI) based HAART regimen, were reported in some studies but not in others [29] Vitamin D and the immune system The main source of vitamin D stems from sun exposure: pre-vitamin D ... no competing interests Authors' contributions ACB wrote the paper CM, RC, RMR, EvE, LL and LK participated in developing the hypothesis and collaborated in the writing and reviewing of the article ... uptake is limited to vitamin D supplementation or consumption of oily fish [31] Vitamin D is transported into the blood by the vitamin D-binding protein (VDBP) is converted in the liver by 25-hydroxylases...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
Ngày tải lên :
10/09/2015, 15:50
... investigate the interactions between tumor cells and immune cells In Chapter 1, I investigate the tumor immune infiltrates in RETAAD mice I find that the immune infiltrates are all different in three ... activated in the immune systems to control these tumors Immunogenic tumor cells are then eliminated from the system while non-immunogenic tumor cells are selected for and remain in equilibrium with the ... of the tumor [8,30] In summary, inflammation and the immune system play critical roles in both tumor suppression and tumor progression Understanding the complex interactions that occur within the...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
Ngày tải lên :
10/09/2015, 15:50
... is the fraction of proliferating cells in the tumor of control mice and k d is the fraction of proliferating cells in the tumor of PMN-MDSC-depleted mice For tumors with ellipsoid shape, the ... expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating cells in the lungs ... time points, the population of melanoma cells in the lung can be described by the following equation (1): (1) 𝑁𝑁 = 𝑁𝑁0 𝑒𝑒 ( 𝜏𝜏 ) 𝑘𝑘𝑘𝑘 Where N is the number of melanoma cells at the end of the experiment,...
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Interaction of burkholderia pseudomallei with cells of the immune system
Ngày tải lên :
08/11/2015, 16:31
... pseudomallei strain KHW invasion of and intracellular replication in T and DC cell lines To examine the interaction of B pseudomallei with T cells, the intracellular replication of the bacteria in a mouse ... cells, with close to % of the inoculum detected in the former at hours after infection However, the numbers of intracellular bacteria increased at later time points after infection, indicating that ... that control the adaptive immune responses Therefore, the entry and persistence of the pathogen within these cells could potentially affect their functions by inhibiting cellular signaling pathways...
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Paradoxical roles of the immune system during cancer development docx
Ngày tải lên :
15/03/2014, 01:20
... are continually fine-tuned as tissue microenvironments are altered Therefore, the immune system is integrally involved in maintaining tissue homeostasis as well as being implicated in the pathogenesis ... characterized by chronic infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant ... However, in these studies deletion of the inhibitor of NFκB kinase (IKKβ) — a key intermediary of NFκB — in intestinal epithelial cells did not decrease intestinal inflammation, as measured by inflammatory...
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Environmental Injustice and Human Rights Abuse: The States, MNCs, and Repression of Minority Groups in the World System pptx
Ngày tải lên :
15/03/2014, 23:20
... are: the murder of Wilson Pinheiro and Francisco “Chico” Mendes in the Amazon rain forest, the massacre of Father Nery Lito Satur and several others in the Philippines, and the public hanging ... expected In column of the table, the finding concerning the relationship between inequality and freedom is consistent with the extant literature Also consistent with the literature are the relationships ... within a nation Typically, the core exploits the resources of the periphery and maintains economic and political control (Blauner 1972) The core-periphery model is taking a new meaning with the...
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Báo cáo khoa học: Thermal behaviour of cubic phases rich in 1-monooleoyl-rac-glycerol in the ternary system docx
Ngày tải lên :
17/03/2014, 09:20
... another way, with increasing temperature the bilayer gets thinner, with the minimal and the parallel surfaces of the polar/nonpolar interface approaching each other, again resulting in an increased ... A showing (A) without and (B) with the extra peak The dots above the peaks indicate the calculated positions obtained for the Pn3m structure based on the first peak in the diffractogram In samples ... results in a decrease in the size of the unit cell This is interpreted to be an effect of an increase in the curvature of the lipid bilayer affected by the increased mobility of the hydrocarbon chains...
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Báo cáo khoa học: "THE RESOLUTION OF QUANTIFICATIONAL AMBIGUITY IN THE TENDUM SYSTEM" docx
Ngày tải lên :
24/03/2014, 01:21
... denotation of the head noun; I will call it the source of the quantification In the case of an NP without central determiner the source is the denotation of the head noun For the indication of the quantity ... individual boats Assuming that the ambiguous constant BOATS has the single instance BOATS and r that LIFTED has the single instance (Az: LIFTED (z)), the instantiation rules, constrained byrthe ... will now indicate how representations of the form (14) are constructed in the TENDUM system The crane lifted the tubes there is no indication as to whether the tubes were lifted one by one (individual...
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scientific american - 1993 09 - special issue - life, death, and the immune system
Ngày tải lên :
12/05/2014, 14:50
... protein in the body They must be able to distinguish the hemoglobin found in blood from the insulin secreted by the pancreas from the vitreous humor contained in the eye from everything else They ... describe the two main systems by which the body identiÞes foreign material The Þrst is the innate immune system innate in the sense that the body is born with the ability to recognize certain microbes ... immunoglobulin, thereby introducing the genes into the mouse DNA As B cells matured in the developing mice, the introduced genes caused almost all the B cells to produce the specific immunoglobulin on their...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
Ngày tải lên :
06/08/2014, 19:20
... targeting innate immune responses, the parasite is also reducing cytokine-based stimulation of the adaptive immune system Moreover, similar effects were exerted by ectoparasites, in particular the ... asthma [11] Polymorphism in the immune system Immune system genes are exceptionally polymorphic, reflecting in part selection by diverse and rapidly varying pathogens, but also the need to balance ... [3] In an analysis of nearly 100 human interleukin genes, they found the highest single nucleotide polymorphism (SNP) frequencies in geographical areas with the highest number of endemic helminth...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
Ngày tải lên :
07/08/2014, 15:20
... evaluate the immune responses of water buffalo to infectious agents and potential vaccines, it is necessary to characterize the immune system of the water buffalo and elucidate the changes in the immune ... containing either 50 µl of PBS-HS (negative control) or µg of mAb in 50 µl of PBS-HS and incubated for 30 minutes at 4oC Cells were washed times (800 × g/3 min) in PBS-HS, then incubated in the ... noted in cattle following stimulation with Con A [8] mAbs that identify these molecules should prove useful in study of the response to infectious agents and vaccines [8] ACT1 is expressed within...
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Báo cáo khoa học: " Characterization of the Recombinant Proteins of Porcine ircovirus Type 2 Field Isolate Expressed in the Baculovirus System" potx
Ngày tải lên :
07/08/2014, 15:20
... of the Recombinant Proteins of Porcine Circovirus Type2 Field Isolate Expressed in the Baculovirus System 23 novel strain of porcine circovirus in pigs with postweaning multisystemic wasting ... recombinant protein expressed in the baculovirus system did not show any noticeable changes in the molecular mass by tunicamycin treatment This may indicate that the ORF2 of the PCV has minor ... transfected insect cells PCV type2 recombinant proteins were successfully expressed from recombinant virus infected insect cells Expression of the recombinant proteins from recombinant virus infected insect...
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Báo cáo lâm nghiệp: "Morphological and functional variability in the root system of Quercus ilex L. subject to confinement: consequences for afforestation" ppt
Ngày tải lên :
08/08/2014, 00:22
... limitation to the main root growth by shortening its length to the depth of the container and preventing the development of replacement taproots The confining of lateral roots in the container and their ... redundant information according to their partially overlapping position in the biplot, with overall higher values for all these variables characterising the shorter (ST) tube type On the other hand, the ... estimating the following parameters using the software WhinRhizo v.4.1: number of exterior root links (or magnitude, µ); number of root links in the longest unique path from the base link to...
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