va24 vb11 natural killer t cells

... Our data indicate that NKT cells may be involved in the disease process of RA and that a strategy to boost the regulatory potential of NKT cells might be useful in the treatment of RA Materials ... indicating that this might represent a therapy that can enhance NKT cell numbers in RA patients In the present study we analyzed the frequency, functional characteristics and heterogeneity of NKT cells ... AAC TC-3') or TCR Vβ11 (5'-TCC ACA GAG AAG GGA GAT CTT TCC TCT GAG-3') region, and µmol/l reverse primer specific for TCR constant α (5'ATC ATA AAT TCG GGT AGG ATC C-3') or constant β (5'CTC TTG...

Ngày tải lên: 09/08/2014, 06:22

... characteristics Patient characteristics are shown in Table for the 22 patients treated with IFN-a 2b, the 22 patients not treated with IFN-a 2b, and the 20 healthy subjects Of the 22 treated patients, ... with IFN-a 2b treatment may indeed contribute to the antitumor response A better understanding of the mechanism of action of IFN-a 2b may facilitate the development of treatment strategies to ... with melanoma (22 patients treated in this study and the other 22 patients who were referred to our institution during the study); these data again suggest that Treg values are higher in patients...

Ngày tải lên: 18/06/2014, 16:20

... CD4+CD28– T cells contribute to the cell infiltrate and exhibit increased survival after apoptotic stimuli Resistance to apoptosis in CD28– T cells is due to elevated expression of antiapoptotic protein ... CD4+CD28– T cells with disease status has given rise to the hypothesis that these cells directly contribute to disease manifestations Patients with nodulosis and extra-articular manifestations of ... online http://arthritis-research.com/content/5/4/R210 In the present study we evaluated the correlation between the CD4+CD28– T- cell subset and extra-articular manifestations, magnitude of joint involvement,...

Ngày tải lên: 09/08/2014, 01:22

... AU and IG contributed to the ELISPOT assay analyses GC and AV contributed to interpretation of the data Competing interests The authors declare that they have no competing interests Page of (page ... RA patient with adalimumab For both patients, an EBV-specific T- cell response to latent peptides was detectable at baseline but was not detectable at week 12 Nevertheless, the response to lytic ... (EBV)-specific T- cell treatment IFNγ production in response to high EBV viral load under treatment (a) Spondylarthropathy patient with infliximab + methotrexate (b) Rheumatoid arthritis patient with adalimumab...

Ngày tải lên: 09/08/2014, 14:21

... data management and statistical analysis HP, JCS and CM wrote the manuscript HZ-B was responsible for patient recruitment and management, and participated together with H-DV in the interpretation ... cell cultures after stimulation with TLR ligands Secretion of proinflammatory cytokines in cultures from septic patients was significantly diminished at both time points compared with cultures ... circulating myeloid APC subsets and that these functional alterations are long-lasting Today, it is well established that circulating monocytes represent a heterogeneous cell population Among the...

Ngày tải lên: 13/08/2014, 18:22

... subjects and characterized TCCs specific for this antigen The data obtained suggest that hnRNP-A2 may constitute an important T cell autoantigen in patients with SLE, indicating a potential role ... reports attributing a regulatory function to CD8+CD28- T cells [3840] An increase of these cells in patients with SLE might thus constitute an effort of counter-regulation within the disturbed ... was not statistically significant (16.6 ± 6.6%, p = 0.07) Therefore, the pronounced stimulatory capacity of these supernatants cannot be attributed to IL-10 or IFNγ Unfortunately, the TCCs were...

Ngày tải lên: 09/08/2014, 08:22

... manuscript preparation UW participated in patient recruitment, statistical analysis, and manuscript preparation HH participated in the coordination of the study and helped with patient recruitment and ... death on cytokine production of stimulated T cells upon coincubation with catecholamines was tested After stimulation of T cells for 48 hours with anti-CD3-mAb and anti-CD28-mAb together with ... constant gate that was set on the respective marker The percentage of positive cells was determined with CellQuest Pro software, using twodimensional dot plots Determination of apoptosis The...

Ngày tải lên: 09/08/2014, 08:22

... at each visit to the clinic, the patients were questioned about compliance with the study diet Also, between visits, the nurse made phone calls to the patients and the patients had the opportunity ... intervention period lasted to days for both groups During that period, the patients received instructions in the theory and practical preparation of the diet in question Thereafter, each patient ... compliance The fact that compliance was monitored both via regular contacts between the patients and staff of the project and via dietary intake records made us confident that compliance to diet was...

Ngày tải lên: 09/08/2014, 10:23

... cachexia In the present cohort of patients we did not find that DAS28 or CRP differed between those with cachexia and the rest of the patients, probably related to the fact that most patients had ... not differ between those who were cachectic and those not (data not shown) Discussion This study shows that ambulatory patients with RA of low disease activity were reported to have a diet intake ... normally distributed or not Differences between patient groups were assessed using the Student t test and Mann-Whitney U test, depending on the distribution of the analyzed variable To evaluate the association...

Ngày tải lên: 09/08/2014, 13:22

... interests The authors declare that they have no competing interests Authors' contributions TET participated in the conception and design of the project and in the analysis and interpretation of data ... contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and interpretation of data KMJD contributed to the acquisition of data HRG contributed ... 1.13 (0.62 to 2.04) versus ME 1.64 (0.92 to 2.92)) Thus, a possible limitation of the present study may be that, despite the fact that it is by far the largest to date to assess metabolic syndrome...

Ngày tải lên: 09/08/2014, 01:22

... [13] Although there were no data that MCP-1 directly induces T cell activation, it might exert effects indirectly on T cells through the activation of monocytes/macrophages in PBMC cultures As ... Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts Arthritis Rheum 2004, 50:776-784 Arnett FC, Edworthy ... for the future molecular targeting of new therapeutic applications in RA Competing interests The author(s) declare that they have no competing interests Available online http://arthritis-research.com/content/7/1/R139...

Ngày tải lên: 09/08/2014, 06:22

... juxta-articular bone destruction Competing interests The authors declare that they have no competing interests Authors' contributions The initial draft of the report was written by HM and PM Patients ... anti-TNF-α therapy for treatment of persistent active disease, despite treatment with methotrexate Patients were enrolled, starting from when infliximab entered the market, from January 2001 to ... same institution at a time before the advent of anti-TNF-α treatment We first verified that our populations at baseline were representative We were able to confirm the presence of the typical...

Ngày tải lên: 09/08/2014, 10:20

... the new exercises, we presented to the experts the entire hand or foot that included the joint-of-interest from the single joint exercise This allowed us to test whether the presentation of the ... Martin Mola E, Pavelka K, Sany J, Settas J, et al.: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: ... Competing interests The authors declare that they have no competing interests Available online http://arthritis-research.com/content/9/4/R62 Authors' contributions DvdH, RL, SE, and JTS participated...

Ngày tải lên: 09/08/2014, 10:20

... related to study medication All patients with infectious events were treated with antibiotics and recovered fully within the expected time frame None of the patients prematurely discontinued treatment ... patients with active RA, despite ongoing treatment with a stable dose of methotrexate (MTX) of 15 mg/week or more for at least months (CACZ885A2101) It is the first of its kind to be conducted ... study in patients with RA – the first of its kind in humans The study's primary objective was to investigate safety and tolerability; therefore, it was not powered to investigate efficacy or to...

Ngày tải lên: 09/08/2014, 10:23

... interests The authors declare that they have no competing interests Authors' contributions TET participated in the conception and design of the project and in the analysis and interpretation of data ... contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and interpretation of data KMJD contributed to the acquisition of data HRG contributed ... 1.13 (0.62 to 2.04) versus ME 1.64 (0.92 to 2.92)) Thus, a possible limitation of the present study may be that, despite the fact that it is by far the largest to date to assess metabolic syndrome...

Ngày tải lên: 09/08/2014, 13:22

... shown that DMARD treatment increase the cortical bone mass in RA patients [25] The DMARD-treated patients in this study had significantly higher anti-CCP levels than the patients not treated with ... X-rays at all four time points, 29 at three time points and six patients at two time points The patients with and without hand X-rays had similar baseline characteristics (Table 1) Treatment was ... not for citation purposes) Competing interests The authors declare that they have no competing interests Authors' contributions PB performed the statistical analyses and prepared the manuscript...

Ngày tải lên: 09/08/2014, 14:22

... Thirty two patients with RA were recruited One patient withdrew due to time issues during the visit Thirty one patients completed the study There were 24 female and male patients, 12 seronegative ... study participant the RA A MSUS1image ofwith left foot plantar metatarsal area of a A MSUS image of the left foot plantar metatarsal area of a study participant with RA The MSUS image demonstrates ... criteria, [20] and starting anti-TNF-α therapy (infliximab, etanercept, adalimumab) all of whom were attending the Southampton University Hospitals NHS Trust Rheumatology Department Patients...

Ngày tải lên: 10/08/2014, 21:23

... (37%) Ninety-two patients (58%) in the cohort had a history of smoking At the time of the present analysis, 158 patients in the cohort had completed PFT testing: 45 (28%) demonstrated at least one ... In contrast to previous studies, ours is the first study to exclude patients with clinically apparent CVD, thus increasing the likelihood that the reported respiratory symptoms truly reflected ... editing the manuscript JTG performed statistical analyses and edited the manuscript GC participated in data collection and edited the manuscript NL performed statistical analysis and edited the...

Ngày tải lên: 12/08/2014, 14:21

... was blinded to the identity of the patient Sandoo et al Arthritis Research & Therapy 2011, 13:R99 http://arthritis-research.com/content/13/3/R99 Page of Statistical analysis Statistical analysis ... change the findings (data not reported) Another potential limitation of this study is the sample size However, the effect size of the correlations in the current data is small [50] This means that, ... Putte LB, van Riel PL: Modified disease activity scores that include twenty-eightjoint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis...

Ngày tải lên: 12/08/2014, 17:21

... admitted) stayed as inpatients at the hospital after they were admitted The length of hospitalisation for these 32 patients was: a) between one to five days for eight patients (25% of the 32 patients), ... impact on the quality of life of the patient It also associates with very high costs to the health system Hence, it is important to identify strategies that may improve overall management and ... to routine outpatient monitoring appointments or visits for routine day-case therapy Statistical analyses Kolmogorov-Smirnov normality tests were utilised to investigate the normal distribution...

Ngày tải lên: 12/08/2014, 17:22