use of neutrons reveals the dynamics of cell surface glycosaminoglycans

... directly on the 3D representations of the foot obtained by surface scanning The software, as well as matching the shape of the foot sole, allows the user to alter the shape and thickness of the orthotic ... density foam box The foam collapses under their weight and when they step out of the box there is a fairly close negative of the shape of their foot left in the foam The box can then either be filled ... form The distance of the sole away from the scanner glass was estimated using the albedo of the sole surface and the pixel intensity of the resulting image, inspired by techniques used in the...

Ngày tải lên: 10/08/2014, 21:24

... with the presence and extend of organ dysfunction, assessed by the SOFA score Furthermore, we evaluated the cell surface expression previously [31] and the oxidative metabolism in monocytes In the ... LPS with regard to the production of inflammatory cytokines [25] In the present study, we evaluated the expression of TLR2, TLR4, CD11b, CD11c and CD66b on the cell surface of neutrophils in patients ... Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study Working group on "sepsis-related problems" of the...

Ngày tải lên: 13/08/2014, 10:20

... Furthermore, the modulation of CCR5 expression by the R5 viruses is at the level of transcription [38] Further experiments will be needed to determine the mechanisms of down-modulation of surface ... between a lack of Env expression and expression of CXCR4 in cells of the induced cultures The distribution of CXCR4 on the minor population of induced Jurkat cells (

Ngày tải lên: 20/06/2014, 01:20

... group may indicate that the cells have recently cycled On the other hand, the upregulation of both CD57 and CD71 in the VIR group may indicate the activation rather than the cell proliferation index ... CD4+ T cells Since these changes were shown to be related to the disease status, we suggest that the use of this technology will facilitate further investigation of the causes and control of HIV ... charts of CD8+ T cells Antibody response charts of CD8+ T cells The bar charts represent the average immunophenotypes, or signatures, for each of the disease categories Asterisks show the antigens...

Ngày tải lên: 13/08/2014, 05:22

... hypothesis is that modulation of cell surface markers occurs during the course of HIV disease and following the initiation of HAART and these cell surface markers may indicate the outcome of antiretroviral ... had similar duration of therapy for each patient were further selected for studying time related changes: (1) the initiation date of the therapy; (2) during the first year of therapy; (3) between ... may be associated with the resting state of T cells [34] The reliability of the antibody microarray technology was further confirmed by the observation that the CD4+ T cell binding density measured...

Ngày tải lên: 13/08/2014, 06:20

... elucidation of specific biosynthetic enzymes, and the identification of end-products The complete genetic makeup of an organism has been generated in the plant sciences as well Because of the success of ... All of these data are then used in the second step to reconstruct the biochemical reaction networks that underlie the cellular function of interest When such data are put into the format of a ... example, the flow of precursors into the disrupted pathway often results in the accumulation of one or more intermediates upstream of the blocked step This is because elevated concentrations of the...

Ngày tải lên: 25/10/2013, 05:20

... infection in many cell types other than epithelial cells of the respiratory tract Although the overall biological significance of such an abortive infection is unclear, biological effects of the individual ... the HRSV F protein AD and RS participated in the design of the experiments, oversight of the conduct of the experiments, and in the interpretation of the results 16 17 18 19 Acknowledgements Recombinant ... encoding the activation domain of NFκB fused to the GAL4 DNA binding domain under the control of the human cytomegalovirus (HCMV) promoter and pFRLuc containing the luciferase reporter gene under the...

Ngày tải lên: 20/06/2014, 04:20

... centres may perform at least some of these tests in routine practice, their usage is not appropriately validated and the impact of the routine use of these tests on the IPI has not been formally ... confirm that the results are valid in Rituximab treated patients The other major limitation is the use of archived rather than fresh trephine tissue for molecular staging due to the logistics of obtaining ... the impact of staging investigations on the IPI in a more homogenously treated DLBCL population Conclusion • The predictive value of the IPI can be improved significantly by the routine use of...

Ngày tải lên: 10/08/2014, 22:20

... Algorithm n can be estimated by treating the position is fixed Using a grid search, we can obtain the MLE of the QTL position from the peak of the profile of the log-likelihood ratio test statistics ... In each case, the peak of the LR landscape (shown by an arrow) beyond the threshold surface (indicated in grey) shows the positions of two epistatic QTLs The names and positions of markers at ... understanding of each of these subcomponent helps to study the genetic basis of heterosis We tested the new multiallelic epistasis model through simulation studies In general, because of a number of Tong...

Ngày tải lên: 11/08/2014, 11:21

... http://www.biomedcentral.com/1471-2229/11/149 Page 15 of 34 Figure Clustering of the expression profiles of the core set of the 7130 modulated genes across three developmental stages of grape ripening (EL 32, EL 35 ... Page 20 of 34 converted to peonidin by the action of 3’-O-methyltransferase [56] Anthocyanins provide the vibrant purple tones of red wines The accumulation of anthocyanins in the skin of red ... updating the annotation performed in [123] following the same protocol as described by the authors to the new genes from the 12X coverage release of the genome assembly The genes were then assigned...

Ngày tải lên: 11/08/2014, 11:21

... of units of red blood cells 5.3 0.25 Debridement humerus, transfusion of unit of red blood cell 4.4 0.21 General anaesthesia to insertion of central venous line 3.9 0.18 Transfusion of unit of ... Transfusion of units of red blood cells 6.6 0.31 Sequestrectomy humerus, transfusion of unit of red blood cell 5.6 0.27 5.0 0.23 5.4 0.26 4.5 0.23 Debridement humerus, transfusion of unit of red blood cell ... substitution rather than exchange of the blood he lost In the course of surgeries he lost a lot of blood, on the order of his whole blood volume, which was substituted successfully with red blood cells,...

Ngày tải lên: 11/08/2014, 12:20

... attached to the syringe and the required blood sample(s) is drawn Following the collection of the sample, the syringe with the cannula is removed and the shut-off valve is opened The Page of device's ... in the division of respiratory and critical care medicine of the author's hospital LTK is the head of the division of respiratory and critical care medicine of the author's hospital PL is the ... to investigate if the use of a blood conservation device in the presence of a standardised restrictive transfusion practice can reduce the number of units of PRBC transfused The secondary objective...

Ngày tải lên: 13/08/2014, 20:21

... A in terms of another domain B Therefore, once the audience is attracted to the ad, the cross-mapping nature of metaphor lengthens the time they spend on the ads In addition, because metaphors ... conceptual metaphors used in cell phone advertising slogans? The use of metaphors in cellphone advertising slogans 22% use metaphors not use metaphors 78% Chart 1: The use of metaphors in cell phone advertising ... depth on the basis of the language directly observed and tried to model them as mathematics formula; however, the latter tended to study the everyday language of human beings on the basis of the language...

Ngày tải lên: 28/02/2015, 11:54

... slogans of five cell phone brands The last chapter entitled CONCLUSION represents a recapitulation of the main ideas of the study, the limitations of the study, some suggestions for further research ... orientational metaphors Design of the study The thesis consists of four chapters: CHAPTER I: INTRODUCTION, CHAPTER II: THEORETICAL BACKGROUND, CHAPTER III: THE USE OF METAPHORS IN CELL PHONE AND ADVERTISING ... INTRODUCTION, the researcher provides the reason for conducting the research Moreover, readers can find out the objectives of the study as well as the research questions for the thesis The scope,...

Ngày tải lên: 10/08/2015, 19:52

... that the cellular processes that are being modeled often contain poorly understood aspects Further, the temporal dynamics of cell signaling pathway is complex and unintuitive, as the dynamics of ... violation of the ODEs (i.e., the amount by which the right hand side differs from the left hand side of the ODE), subject to the constraint that the model concentrations exactly match the experimentally ... refinement of model parameters and for designing experimental conditions 2.2 ODE model To model the biochemical behavior of the system, we used a system of ODEs to describe the time-evolution of the...

Ngày tải lên: 09/09/2015, 10:18

... integrate pharmacists in the primary care system [20] The role of medical professionals is a dominant factor in defining, controlling and scoping the work of the allied health professionals [21,22] ... indicated the needs for western pharmacists to study Chinese medicine [24] A total of 26.2% of the respondents reported consuming Chinese OTC medication in the previous year The majority of them (19%) ... non-significant (p > 0.05) Use of Chinese OTC medications and consultations with Chinese medicine practitioners A total of 19.0% of the population used Chinese OTC medications only whereas 7.2% used both Chinese...

Ngày tải lên: 25/10/2012, 10:06

... asked how they would rate their general feeling of well-being over the last days on a scale of to 6, with being as bad as it could be Profile P Equals the mean of the scores recorded mental) of a ... latter setting, the W-BQ12 was not found to be responsive The authors of this latter study attributed the lack of responsiveness of the W-QB12 to two possible causes: either the socioeconomically ... prior to this being given to the patient to score Therefore, the patient was aware of the symptoms they had previously nominated, but not the previous score Each of the four items is rated on a...

Ngày tải lên: 25/10/2012, 10:06

... fascial layers of the temporal region 5-6 All these names reflect an anatomical feature of the related fascia The TPF lies just beneath the hair follicles and subcutaneous fat of the temporal region ... located deeper at the level of the ear and approximately 10 cm above the crus helix, they take a more superficial course entering the subdermal plexus.8 The anatomic layers of the temporal region ... extended up to 3-4 cm superior to the origin of the temporal muscle Then, the TPF is elevated from the deep temporal fascia by blunt dissection If lengthening of the pedicle is needed, proximally...

Ngày tải lên: 25/10/2012, 11:00

... artifacts ), the study is confined to the verbal aspects of the act of giving bad news with the use of politeness and hedging In addition, adjacency pairs are beyond the scope of this paper - The study ... weakeners mentioned above in the scope of the study because of the suitability to the topic of the thesis “Hedging before giving bad news” Weakening particles is to use adverbs as: “really, sincerely, ... “hedges” and these hedging devices attenuate or reduce the strength of the utterance or soften/ weaken the effect of the utterance They damp down its force or intensity or directness By giving the notion...

Ngày tải lên: 07/11/2012, 14:44

... agency of the Department of Agriculture The first is the threat of fire and fuel This year, forest fires have burned more than three million hectares of land That is almost two times as much as the ... starts to accelerate in the second half of this century, as many scientists expect, the area of warm air will be much larger during the summer than it is now The impact on the jet stream will be ... SATISFACTION Over the years, the development of different theories of management and different approached to organization has affected the way we view motivation In the 19th century, the writer Federick...

Ngày tải lên: 07/11/2012, 14:58