use of anti infective therapy in critically iii patients

... [10,13,15,32,33,38,39,41], while a combination of IHD and CRRT were used in the remaining studies [21,34-37,40,42] (Table 3) Six studies defined timing of initiation of RRT based on cut-offs in serum urea [15,21,34,35,37,42], ... overall design and quality of studies comparing early versus late initiation of RRT in critically ill patients with AKI is low • Earlier initiation of RRT in critically ill patients with AKI may have ... RIFLE Criteria Risk: Increase in serum Creatinine by 1.5 times or urine output

Ngày tải lên: 14/08/2014, 07:21

... reason to think that ongoing infliximab therapy may be harmful, good data are lacking) Another finding of our study is that discontinuation of infliximab therapy seems justified, since we found ... within 12 weeks after discontinuation of infliximab infusions, 37 within 24 weeks, and 38 within 36 weeks By week 48, of the 42 patients had not needed retreatment and 41 were again receiving infliximab ... An intermittent cessation of anti- TNF therapy may be considered in the case of patients who respond well to infliximab therapy for longer periods of time Since it is unknown how long the patients...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 06:23

... trial of anti- infective prophylaxis in vasculitis As topical mupirocin does not cause serious adverse events [46], it is used in some vasculitis centres during the high risk phase of induction of ... vitamin B supplementation to be the standard of care, with rifampin being a good alternative in case of incompatibility In some PSV, especially in WG, infliximab is used as salvage therapy In such ... infections leading to hospitalisation - of 2.44 in the first months of GC treatment in a large GCA trial and increased infection-related mortality Rising awareness of GC complications, including infections,...

Ngày tải lên: 09/08/2014, 14:22

... availability of fibrinogen to be cleaved into fibrin while in the presence of thrombin If indicated by K and a angle, cryoprecipitate is administered, providing a concentrated form of fibrinogen (150 ... monitoring of coagulation function with tailoring of treatment to the individual patient may improve our ability to administer blood component therapy in the acutely injured patient Monitoring of ... Although the independent effect of acidosis on hemostatic integrity remains unclear, correction of acidosis via resuscitation remains a valuable therapeutic endpoint in terms of minimizing the aforementioned...

Ngày tải lên: 13/08/2014, 23:20

... ≥25% paraprotein increase in two consecutive tests four weeks apart Relapse was defined as reappearance of the paraprotein on immunofixation in CR patients, positive SPE in the nCR patients, and/or ... Page of Figure Impact of advanced (green line) and limited ISS stage (blue line) on OS, showing inferior survival in patients with advanced ISS stage no difference in the proportion of patients ... cycles of VAD (vincristine, adriamycin and dexamethasone) Those achieving ≥ 75% reduction in paraprotein, i.e VAD-chemosensitive patients, proceeded to auto-HSCT Patients with

Ngày tải lên: 18/06/2014, 16:20

... A decline in CCr was followed by an increase in levels of serum creatinine and serum cystatin C (Fig 1) The inverse of the serum cystatin C and serum creatinine levels were plotted against CCr ... Figure The (a) inverse (P serum creatinineP < 0.001) each of patient of = 0.002 versus (1/creatinine) and the (b) inverse of cystatin C (1/cystatin c) were plotted against creatinine clearance ... urine sample was obtained just before the serum sample to calculate the creatinine clearance (CCr) using the following formula: CCr (ml/min) = (urine volume × urine creatinine)/(serum creatinine...

Ngày tải lên: 12/08/2014, 20:21

... Administration of insulin — no (%) Insulin dose — IU/day‡ Median Interquartile range Duration of insulin use — % of ICU stay Median Interquartile range Morning blood glucose — mg/dl§ All patients ... differ in the use of medications other than insulin and antibiotics, the latter most likely a consequence of the effect of intensive insulin therapy on septicemia Second, since the study involved patients ... other than insulin or antibiotics did not differ significantly between the two treatment groups Because intensive insulin therapy reduced the length of stay in the intensive care unit among patients...

Ngày tải lên: 12/08/2014, 20:59

... erythropoietin is increased in patients with severe illness [24] In addition, the studies that found an effect of rHuEPO on erythropoiesis in critically ill patients [15-17] used doses in the range of ... particularly in patients with pre-existing cardiac disease [25,26] Transfusion of RBCs may not be the ideal therapy for these patients because there is a growing body of evidence indicating that ... in critically ill patients is an independent risk factor for increased morbidity and mortality [1,2] In addition, it has been shown that in the majority of critically ill patients the transfused...

Ngày tải lên: 12/08/2014, 22:22

... studies examining this outcome The increase in mortality of patients with infection or acquisition of Acinetobacter in comparison with matched controls without colonization or infection, noted in the ... morbidity of patients with acquisition of or infection with Page of Characteristics and outcomes of matched cases and controls (patients infected and non-infected with A baumannii) Reference Site of infection; ... was made in two of these studies [16,17] Further, the length of stay in the ICU was found to be statistically significantly increased in patients with A baumannii infection in three of five studies...

Ngày tải lên: 12/08/2014, 23:23

... in the course of a disease process) Finally, we used the SOFA score as a comparator with plasma DNA levels in our population group It would be of great interest to use other scoring systems of ... indicators of outcome in patients with severe sepsis Shock 2005, 23:488-493 Pettila V, Hynninen M, Takkunen O, Kuusela P, Valtonen M: Predictive value of procalcitonin and interleukin in critically ... detected by quantitative PCR (Roche Lightcycler; Roche, Lewes, UK), using primers for the β-globin gene, a housekeeping gene involved in the formation of a functioning haemoglobin molecule This...

Ngày tải lên: 12/08/2014, 23:23

... determined based on clinical needs Anticoagulation was performed, according to protocol, with an unfractionated pre-filter heparin infusion at a dose of to 10 IU/kg/h No anticoagulant infusion ... infusion was administered if one of the following was present: ongoing bleeding; major hemorrage in the last seven days; an international normalized ratio (INR) or a partial thromboplastin time ratio ... Net UF Clotting/clogging Data are presented as median with interquartile range in parentheses CVVH, continuous veno-venous hemofiltration; CVVHD, continuous venovenous dialysis; INR, international...

Ngày tải lên: 12/08/2014, 23:23

... for MOF and two enriched for infection (Figures and 4) Page of 11 Probability of infection in each cluster Figure Probability of infection in each cluster The baseline infection rate (dashed line) ... 5) Each of the 17 patients spent Probability of multi-organ failure (MOF) in each cluster Figure Probability of multi-organ failure (MOF) in each cluster The baseline MOF rate (dashed line) is ... surrounding scientific examination of a single or small group of adjuncts Indeed, the critical care literature is full of examinations of monitors, scoring systems, measurements and biomarkers, all of...

Ngày tải lên: 13/08/2014, 20:21

... recognition of AKI by the more stringent enrollment criteria employed in PICARD (requiring a 0.5 mg/dL increase in sCr in contrast to an 0.3 mg/dL increase in AKIN) Indeed, underestimation of AKI ... calculate creatinine production in our patients as we did not have urinary creatinine measurements in the majority of these patients Finally, although volume accumulation clearly alters sCr in the 'development' ... determination of AKI severity in critically- ill patients Future studies, including observational cohort studies and randomized clinical trials of patients with AKI, should consider the influence of...

Ngày tải lên: 13/08/2014, 20:22

... levels in vaginal secretions and plasma, determined the V3 genotype of predominant variants found in vaginal secretions, and assessed ART use in a cohort of 43 women attending an HIV outpatient clinic ... more than half of the women in this shedding cohort, demonstrating that vaginal HIV shedding occurs in a number of women taking ART ART use was associated with the presence of predominantly X4-like ... CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV1 isolates: delineation of consensus motif in the V3 domain that predicts CCR-5...

Ngày tải lên: 20/06/2014, 01:20

... controlling the levels of proinflammatory cytokines in acute inflammatory responses The particular role of IL-6 in inflammatory conditions such as RA is presently considered in therapeutic interventions ... Therapeutic response was defined clinically by changes of 28-joint-count Disease Activity Score (DAS28) determined at the beginning of the study (baseline) and months after the start of etanercept treatment ... changes in the expression profile of about 14,500 known genes in peripheral blood mononuclear cells during anti- TNFα therapy reflected a differential response by our patients as evinced by changes in...

Ngày tải lên: 09/08/2014, 10:23

... ApoB Insulin resistance was evaluated from fasting glucose and insulin using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [37] and the Quantitative Insulin Sensitivity Check Index ... sulphasalazine, hydroxyxhloroquine, leflunomide, anti- tumour necrosis factor therapy, glucocorticoid use and NSAID use the odds of having the MetS, independently of any of these factors, suggesting ... demonstrating that the use of glucocorticoids is not associated with the presence of the MetS [44], thus again arguing against a potential anti- inflammatory mechanism of action of methotrexate In view...

Ngày tải lên: 09/08/2014, 14:22

... more than 60% Discussion In 1993, HIV-1 infection of paid blood donors in the central Chinese province of Henan and Anhui provinces constitutes a major epidemic in China[15] In September 2003, the ... analysis of gag and env genes of HIV type circulating in former blood donors of Fuyang city, Anhui province National medical journal of china 2007, 87(22) Wu Z, Liu Z, Detels R: HIV-1 infection in ... genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates[11] Since the first co-receptor antagonist——Maraviroc against HIV-1 was approved in the United States in...

Ngày tải lên: 12/08/2014, 01:22

... cut-off hemofilters, which are characterized by an increased effective pore size Most commercially available hemofilters not permit a substantial elimination of cytokines because of the low cut-off ... from continuous arteriovenous hemofiltration (CAVH) to the last generation of continuous renal replacement therapy machines (a) CAVH machine; (b) the BSM32 machine; (c) the PRISMA machine; (d) ... of dialysis dose, no randomised trial has evaluated the effect of HVHF on clinical outcome, or the effect of different modalities of CRRT on length of stay and recovery of renal function in patients...

Ngày tải lên: 12/08/2014, 23:22

... prophylactic) antimycotic therapy with any antifungal agent Prophylaxis in this review is defined as antifungal therapy without a proven fungal infection Preemptive therapy is defined as antifungal therapy ... participated in designing the study and in collecting and entering data OvR and BL participated in designing the study RW participated in collecting and entering data JR participated in advising on ... failure to decontaminate the gut with polymixin E, gentamicin and amphotericin B in patients in intensive care Eur J Clin Microbiol Infect Dis 1994, 13:165-170 53 Sorkine P, Nagar H, Weinbroum A, Setton...

Ngày tải lên: 13/08/2014, 10:20