uncertainty variability and sensitivity analyses in simulation models

... matrix) More importantly, knocking out the expression of gelsolin, an actin-binding protein with filament-severing properties found downregulated in RA, resulted in mild exacerbation of the arthritic ... expression of antiapoptotic proteins Bcl-2 and members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced Dr Brigitte ... cytosis by binding the complement inhibitor factor H (and in some cases, also the factor H-like protein 1) to its surface Binding is mediated by two types of plasmidencoded protein, class I (20...

Ngày tải lên: 09/08/2014, 01:23

... any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores ... proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction ... No Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced...

Ngày tải lên: 09/08/2014, 14:20

... line) between immune and central nervous system [51]: during an injury or infection, brainstem centers receive sensory inputs from the immune system through humoral (circulating cytokines) and ... performed using the Scicos-Scilab and Matlab environments at the French National Institute for Research in Computer Science and Control (INRIA -Sisyphe team) For each 15min recording, the first and last ... high-frequency RR variability [53] In septic shock, baroreflex gain and low-frequency/high-frequency ratio of RR variability were correlated with plasma norepinephrine levels [1] These findings suggest...

Ngày tải lên: 12/08/2014, 11:21

... parameter space in an efficient manner SaSAT provides random sampling, full factorial sampling, and Latin Hypercube Sampling Random sampling The first obvious sampling approach is random sampling whereby ... coefficients) Conclusion In this paper we outlined the purpose and the importance of conducting rigorous uncertainty and sensitivity analyses in mathematical and computational modelling We then presented ... sampling Sensitivity analyses for continuous variables Sensitivity analysis is used to determine how the uncertainty in the output from computational models can be apportioned to sources of variability...

Ngày tải lên: 13/08/2014, 16:21

... following files: Enterprise Beall class: Implements the methods defined in the business interư face and any life cycle callback methods; Business Interfaces: The business interface defines ... facilitate the maintenance and upgrading of systems bv customizing and replacing their components 2.2 C o m p o n e n t-b a s e d s o ftw a re e n g in e e rin g 2.2.2 Com ponent a) D e fin itio n ... Compoiumt are defined by their interfaces, and in tlie most general cases, can be thought of as having two related interfaces, as show in Figure 2.2 A provides interface defines the services...

Ngày tải lên: 25/03/2015, 09:45

... expanding the use of simulations Microsimulation in critical care is no experiment, no hobby; it is present and part of the very near future If intensivists remain at the barrier, they will definitely ... illness The investigators tested eight different algorithms with different sets of input variables, and the ability to predict the clinical course by some of these models is amazing, as seen in Fig ... paper by Saka and colleagues, however, included additional data from the clinical course before they entered the intensive care unit (age, gender, and ethnicity), thus ‘recreating individual patients’...

Ngày tải lên: 13/08/2014, 03:21

... data are in line with previous observations indicating that physiological activators of the p38 and PtdIns 3-kinase pathways including thrombin, dexamethasone, angiotensin II and prostaglandins stimulate ... barbed-end actin and determine the level and distribution of F-actin [34] Therefore, it is tempting to speculate that interactions between monomeric G-actin and actin-binding proteins are a potential ... for 30 and then fixed, permeabilized and stained for F-actin with rhodamine-conjugated phalloidin The effects of toxin B and latrunculin B on the actin filaments was examined by preincubating the...

Ngày tải lên: 19/02/2014, 16:20

... Elsevier Science B.V Michael Elhadad and Kathleen R McKeown 1990 Generating Connectives Proc COLING’97-101 Minqing Hu and Bing Liu 2004 Mining and summarizing customer reviews Proc ACM SIGKDD, ... ClothingType Bottom Linguistic and Ontological Analyses Pants In this section, we discuss linguistic and ontological clues that influence the process of identifying finer-grained polarity For the purpose ... the Ministry of Knowledge Economy in Korea, and in part by the 2nd stage of the Brain Korea 21 project References Ana-Maria Popescu and Oren Etzioni 2005 Extracting Product Features and Opinions...

Ngày tải lên: 20/02/2014, 09:20

... probabilistic models for segmenting and labeling sequence data ICML Nocedal, J and S J Wright 1999 Numerical optimization, Springer-Verlag Povey, D and P C Woodland 2002 Minimum phone error and I-smoothing ... speech recognition IEEE International Conference on Acoustics, Speech, and Signal Processing Collins, M 2002 Discriminative Training Methods for Hidden Markov Models: Theory and Experiments with ... training algorithms for conditional models In most cases, CRF training is more accurate, however, perceptron training is much faster References Bahl, L., P Brown, et al 1986 Maximum mutual information...

Ngày tải lên: 08/03/2014, 02:21

... of chitin into valuable oligosaccharide derivatives for various industrial applications Pf-ChiA has a unique multidomain structure containing two chitin-binding domains (ChBD1 and ChBD2) and two ... in AD2 and carried out mutational and crystallographic analyses in order to clarify their catalytic role Our kinetic study indicated that D2 and E residues play particularly important roles in ... number of amino acid residues contribute to the binding of the substrate by hydrogen bonding and ⁄ or hydrophobic interactions Using the ligplot program [31], we investigated the specific interactions...

Ngày tải lên: 15/03/2014, 11:20

... resources and protecting environment One of typical marine economic models that has been organized and 39 Training technical staff in charge of cultivating and processing Boiling raw material in alkali ... Bleaching alkaliboiled product Supplying material equipment, services of producing consuming and exporting Cooking bar jelly between 200 - 210 minutes Separating product drying, packing and consuming ... marine industry 37 3.3 Processing industry, handicraft and service 3.3.1 Food processing Capacity of processing industry consumed about 50% of aquaculture production output The main processing...

Ngày tải lên: 22/03/2014, 12:20

... model systems, including lower eukaryotes and invertebrates, in order to obtain clues for building important hypotheses The rapidity and efficiency of in vivo studies in many nonmammal models have ... understanding pathogenic roles Z Yue function [5] LRRK2 also contains armadillo-like repeats, LRR, kinase and WD40 domains [6] In vitro biochemical analysis demonstrates that LRRK2 contains kinase and ... illustration of domain structures and alignment for LRRK2 and LRRK2 structure-related proteins ANK, N-terminal ankyrin repeat domain; DEP, Dishevelled, EGL-10, pleckstrin domain; GEF, guanine-exchange...

Ngày tải lên: 23/03/2014, 04:20

... concentration of microsomal protein Table Accumulation in rat hepatocytes and hepatic protein binding of quinine and quinidine Accumulation of quinine and quinidine (5 lM) in rat hepatocytes is expressed ... is that, in contrast with the human enzyme, they are inhibited by quinine more potently than by quinidine [17,31,37] As shown in Fig 4A, quinine was a more potent inhibitor than quinidine of [O-methyl-14C]dextromethorphan ... microsomes quinine had a lower IC50 than quinidine, and both compounds exhibited slope factors smaller than unity (Fig 4B and Table 1) The IC50 values for quinine and quinidine in rat liver microsomes...

Ngày tải lên: 31/03/2014, 07:20

... Business Economics and Finance with MATLAB®, GIS, and Simulation Models Business Economics and Finance with MATLAB®, GIS, and Simulation Models Patrick L.Anderson Principal, Anderson Economic ... http://www.ebookstore.tandf.co.uk/.” Library of Congress Cataloging -in- Publication Data Anderson, Patrick L Business economics and finance with MATLAB, GIS and simulation models/ Patrick L Anderson p cm Includes index ... Mathematical and Simulation Models in Business Economics 16 MATLAB and Simulink Design Guidelines 26 Importing and Reporting Your Data 53 Library Functions for Business Economics 83 Economic Impact Models...

Ngày tải lên: 08/04/2014, 09:59

... of Engineering and Technology and the Department of Mechanical Engineering at the University of Nebraska at Lincoln References [1] H H€kkinen, U Landman, Superheating, melting, and a annealing ... suppressing the statistical uncertainty and revealing macro-scale phenomena in laser ablation This work emphasizes the evolution and propagation of temperature and thermomechanical waves during and ... distribution in a target with 90 fcc unit cells in both x and y directions, and 15 fcc unit cells in the z direction An interesting phenomenon is observed in Fig where a local temperature minimum appears...

Ngày tải lên: 06/05/2014, 08:54

... uncertain input factors is more important in determining the uncertainty in the output of interest?’ or ‘if we could eliminate the uncertainty in one of the input factors, which factor should we ... the uncertainty of hmin is very small Examples at a glance 33 Figure 2.2 Monte Carlo based uncertainty analysis of Y = Log (PI (Incineration)/PI(Landfill)) obtained by propagating the uncertainty ... to how the uncertainty in Y depends upon the uncertainty in the Pxs A first step in the direction of characterising uncertainty is a normalisation of the derivatives by the factors’ standard deviations:...

Ngày tải lên: 03/06/2014, 02:01

... obtained from Bryan Clary (Duke University) and maintained in supplemented RPMI 1640 containing glutamine (2 mmol/L), pyruvate (1 mmol/L), penicillin (100 IU/ mL), streptomycin (100 IU/mL), and ... pancreatic adenocarcinoma cell lines (Panc-1, AsPC-1, and CFPAC-1) were obtained from ATCC (Bethesda, MD) and maintained in Dulbecco's modified eagle's medium (DMEM) containing glutamine (2 mmol/L), ... split and preincubated for more than 24 hours (Panc-02) and 48 hours (CFPAC-1, AsPC-1, and Panc-1) to maintain their growth conditions SV119 and SW120 were dissolved in DMSO, and gemcitabine and...

Ngày tải lên: 18/06/2014, 15:20

... trunk movements during walking and that are closely related to dynamic balance control during walking and standing The aim of the present study was to examine gait stability and variability of geriatric ... patients with and without cognitive impairment under normal and dual task walking conditions Based on previous studies, showing increased stride-to-stride variability during dual tasking and in elderly ... 0.03) and stride-to-stride variability (z = -2.13, p = 0.03), both implying an increased variability of gait timing in the cognitive impaired elderly (Figure 2) In contrast, walking velocity and...

Ngày tải lên: 19/06/2014, 08:20

... was to examine immediate test-retest reliability of STV while single and dual tasking in CHI and in demented patients with FTD Methods Out of 80 community-dwelling CHI participating in a large ... walking alone (i.e., single tasking) and while counting backward (CB) aloud starting from 50 (i.e., dual tasking) were collected Gait measurements were made according to the guidelines for clinical ... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses; study concept and design: OB and GA; acquisition of data: GA and EF; analysis and interpretation...

Ngày tải lên: 19/06/2014, 08:20

... cumulative dose) to engage in coordinated stepping was not preceded by changes in hind limb gait variability (50 mg/kg cumulative dose) We did not find an increase in gait variability in transgenic SOD1 ... cycle timing in Parkinson's disease and Huntington's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability ... variability in patients with PD, as evidenced by a significant increase in stride length variability of the forelimbs and a significant increase in stance width variability of the forelimbs and...

Ngày tải lên: 19/06/2014, 10:20