tumor response to ca4p as a single agent
Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx
... [30,31] Additionally, irradiation compromises tumor microvasculature by causing endothelial damage at an early stage [32] Endothelial damage may lead to increased transient vascular permeability to ... 188:1001-1008 Marugami N, Tanaka T, Kitano S, Hirohashi S, Nishiofuku H, Takahashi A, Sakaguchi H, Matsuoka M, Otsuji T, Takahama J, et al: Early detection of therapeutic response to hepatic arterial infusion ... changes of mean tumor volumes and mean ADC values of colorectal liver metastases months after treatment with HDR-BT as compared to baseline MRI A decrease in tumor size is inversely associated...
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Báo cáo y học: "Non-small cell lung cancer presenting with choroidal metastasis as first sign and showing good response to chemotherapy alone: a case report" pot
... chemotherapy Thus, chemotherapy alone can be a viable treatment for choroidal metastasis if the primary tumor is responsive to chemotherapy As such, acute radiation damage and its sequelae to vital ... symptom, 58% had lung cancer and 28% had breast cancer [5] Differential diagnosis of choroidal metastasis includes choroidal melanoma, choroidal osteoma, choroidal hemangioma, choroidal neovascularization ... the surface of his choroidal tumor The tumor was on its late phase and it had already accumulated sub-retinal fluid (Figure 1) A B-scan ultrasound revealed a flat-surfaced, elevated choroidal lesion...
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Comparison of the obstetric anesthesia activity index with total delivery numbers as a single denominator of workload demand in Israeli maternity units doc
... Obstetric anesthesia workload demand in Israel has increased due to both an increase in the requests for labor analgesia and a marked increase in the cesarean delivery rate We propose a new workload-driven ... anesthesia workload and that a typical epidural takes about half the time of a typical cesarean Accordingly, the OAAI for each hospital was calculated as ((0.75 * number of epidurals per year) + (1.5 ... this was not the only factor found to determine demands for obstetric anesthesia workload Our data revealed a remarkably wide variation in the rates of epidural labor analgesia and cesarean delivery...
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Bank Behavior in Response to Basel III: A Cross-Country Analysis doc
... a partial adjustment model to a target level of capital to estimate the capital to asset ratio of banks Subsequently, the unanticipated change in the capital to asset ratio is used to estimate ... increases with an increase in RAROC This effect is measured by the optimal capital asset ratio K’ /A as given in (5) above An increase in the demand for loans would raise marginal revenue and the ... noninterest expense ratio and the nonperforming loans to total assets ratio as well as the interaction of each of these variables with the previous period capital -to- asset ratio are assumed to be instruments...
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Báo cáo khoa học: Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX doc
... Immunoprecipitation and SDS/PAGE Materials and cell lines The mAbs V.1 and V.5 against GPV, ALMA.12 against GPIba, ALMA.16 against GPIX and RAM.1 against GPIbb, were developed in our laboratory [19] ... Strassel, C., Baas, M.J., Salamero, J., ChasserotGolaz, S., Cazenave, J.P., De La Salle, C & Lanza, F (2001) Biosynthesis and intracellular post-translational processing of normal and mutant platelet ... band was composed of three or four different molecular mass forms Parallel analysis of the supernatants revealed a positive signal starting at 60 of chase and having a molecular mass (82 kDa) consistent...
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Báo cáo khoa học: RIP1 comes back to life as a cell death regulator in TNFR1 signaling docx
... early after receptor ligation whereas the cell death regulators FAS-associated via death domain (FADD) and caspase are recruited to a pro-apoptotic complex that forms slowly in the cytoplasm This ... cells to necrosis mediated by tumor necrosis factor J Exp Med 187, 1477–1485 62 Sasazuki T, Okazaki T, Tada K, Sakon-Komazawa S, Katano M, Tanaka M, Yagita H, Okumura K, Tominaga N, Hayashizaki ... Schmidt-Supprian M, Ma A, Ogawa M & Sasakawa C (2010) A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO ⁄ IKKgamma to dampen the host NF-kappaB-mediated inflammatory response Nat Cell Biol 12,...
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The Case for Controlled-Atmosphere Killing of Poultry in Transport Containers Prior to Shackling as a Humane Alternative to Electrical Stunning doc
... in-plant Easyload system fitted with gas stunning; washer; automatic drawer loading and unloading is approximately 1.5 million USD” (Burgos 2003) Ian Taylor, sales director of American Autoflow ... Detrimental to Welfare When inhaled, carbon dioxide has been shown to be highly aversive to humans (Gregory and others 1990) and birds Raj (199 8a) states that “[c]arbon dioxide is an acidic gas and ... blood in the carcase meat is low.” Increased Revenue In addition to the carcass- and meat-quality improvements mentioned above, there are additional financial benefits that can be achieved through...
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Báo cáo hóa học: " Solvothermal synthesis of uniform bismuth nanospheres using poly(N-vinyl-2-pyrrolidone) as a reducing agent" pptx
... ammonia, mannitol, and EG were purchased from Sinopharm Chemical Reagent (China); PVP (with average Mw of 10,000) was purchased from Sigma-Aldrich Inc All the reagents were analytical grade and ... synthesis of platinum nanocrystals for catalytic and electrocatalytic applications Nano Today 2009, 4:81 42 Kaczmarek H, Kamińska A, Światek M, Rabek JF: Photo-oxidative degradation of some water-soluble ... Q, Li Y: A general strategy for nanocrystal synthesis Nature 2005, 437:121 36 Nikolopoulou A, Papoulis D, Komarneni S, Tsolis-Katagas P, Panagiotaras D, Kacandes GH, Zhang P, Yin S, Sato T: Solvothermal...
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Báo cáo khoa học: "Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo" ppsx
... Tumors were irradiated at dose rate of 7.5 Gy/min with a collimated beam in a J.L Shepard Mark I 137Cs irradiator (Pasadena CA USA) Tumor growth delay assay Tumors were established by subcutaneous ... protocols as shown in the legend Data points are the modal values of to 13 tumors Where all tumors did not regrow there is an arrow above the final point that indicates modal value was measured ... Loma Linda Medical Center Author details Radiation Research Laboratories, Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda CA, USA 2Laboratory of Radiobiology,...
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Báo cáo khoa học: "Cystatin C: unsuited to use as a marker of kidney function in the intensive care unit" pot
... issue are warranted Competing interests The author(s) declare that they have no competing interests References 532 Villa P, Jiménez M, Soriano MC, Manzanares J, Casasnovas P: Serum cystatin C as a ... filtration rate in renal transplant recipients Clin Chem 1999, 49:1866-1868 Coll E, Botey A, Alvarez L, Poch E, Quintó LI, Taurina A, Vera M, Piera C, Darnell A: Serum cystatin C as a new marker ... as a marker of acute renal dysfunction in critically ill patients Crit Care 2005, 9:R139-R143 O’Riordan SE, Webb MC, Stowe HJ, Simpson DE, Kandarpa M, Coakly AJ, Newman DJ, Saunders JA, Lamb EJ:...
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Báo cáo y học: "Acute and critically ill peripartum cardiomyopathy and ‘bridge to’ therapeutic options: a single center experience with intra-aortic balloon pump, extra corporeal membrane oxygenation and continuous-flow left ventricular assist devices" pp
... Coronary angio Outcome A, African; APE, acute pulmonary edema; ADHF, acute decompensated heart failure; AFC, Arteria Femoralis Communis; anast, anastomosis; BSA, body surface area; C, Caucasian; ... LVAD was implanted after seven days of ECMO There was a revision at Day because of bleeding at the anastomosis of the aortic cannula During the postoperative course she was treated for ventilator ... initiation of proper heart failure therapy, weaning off the IABP was not possible and the implantation of a LVAD was decided The implantation was complicated by a rupture and large hematoma of...
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Báo cáo khoa học: The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response pptx
... activation of kinases such as Akt has been shown to increase HSF1 activity Enhanced Ras maturation by heat stress was associated with a heightened activation of extracellular signal-regulated kinase ... Immediately after treatment, the cells were cooled to °C and lysed Luciferase activity was measured as described in [48] Statistical analysis All data are expressed as mean ± SD Student’s paired t-test ... stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment J Cell...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... pathway, the PKB pathway and the Janus kinase ⁄ signal transducer and activator of transcription (JAK-STAT) pathway, to promote proliferation, survival and transformation [56,57] The importance ... the mTOR inhibitor, rapamycin, increased BIM expression and overcame RAS-dependent survival signals to promote cell death, arguing that mTOR was an important survival signal that acted, in part, ... pathway modulated by cytokines Cancer Biol Ther 6, 912–919 66 Kuroda J, Kimura S, Strasser A, Andreef A, O’Reilly LA, Ashihara E, Kamitsuji Y, Yokota A, Kawata E, Takeuchi M et al (2007) Apoptosis-based...
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báo cáo hóa học: " Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice" ppt
... embedded in paraffin The other hemi-brain was snap frozen and stored at -80°C for biochemical analysis of A Anti -A antibody ELISA Anti -A antibodies in plasma were measured by ELISA as previously ... ELISAs, and guided or performed image analysis, analyzed data and drafted the manuscript LJ performed tissue preparation, immunohistochemistry, image analysisand ELISAs KT carried out ELISAs and ... has been demonstrated that non-B cell mechanisms may also have a role in clearing cerebral A [8] A multi-center A vaccine human clinical trial (AN1792) was initiated but was suspended when approximately...
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báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf
... potentially serve as a monitor of response to immunomodulatory treatment in MS However, a biological marker of disease activity, as well as response to therapy, must be reliable, noninvasive, and ... by adding O-phenylenediamine as a substrate The color intensity is proportional to sHLA concentration Absorbance was measured at 492 nm Saliva levels of sHLA-II were measured at baseline as well ... response to therapy, with a surrogate marker, may have additional value as particularly effective immunomodulatory activity, such as that observed with natalizumab, may have a potential downside...
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báo cáo hóa học: " F-fluoride PET: changes in uptake as a method to assess response in bone metastases from castrate-resistant prostate cancer patients treated with 223Ra-chloride (Alpharadin)" pdf
... in clinical trials, to the extent that bone metastases are often regarded as a non-measurable disease [4] Criteria exist which use radiographic changes to measure response in bone metastases, but ... biochemical markers including PSA as a tumour marker and ALP as a bone formation marker Methods This imaging study was performed as a pilot substudy of an open-label phase trial of Alpharadin in patients ... K, Nakajima H, Miyazaki T, Yayama T, Kawahara H, Kobayashi S, Tsuchida T, Okazawa H, Fujibayashi Y, Baba H: Effects of Alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured...
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Báo cáo toán học: "SIMWAL: A structural-functional model simulating single walnut tree growth in response to climate and pruning" docx
... observations as far as possible However, data were not analysed statistically for several reasons One was that the model uses probability calculations in several cases Therefore, a statistical analysis ... SIMWAL rather than to validate it in a strict sense RESULTS 2.2 Model inputs and data analysis Initial trees, input parameters and climate As far as possible, initial trees and input parameters ... direct radiation, αi is leaf inclination and Ai is leaf azimuth If T is greater than P0is, the leaf is assumed to be shaded and beam leaf irradiance Iis is equal to zero This simple stochastic...
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Báo cáo khoa học: "Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer" pptx
... Oncologia, Ospedale Cardarelli, Napoli, Italy 2UOC Chirurgia Toracica, Ospedale Cardarelli, Napoli, Italy 3UOC Anatomia Patologica, Ospedale Cardarelli, Napoli, Italy Authors’ contributions FR, GDL and ... regimen in advanced non-small-cell lung cancer: a meta-analysis JAMA 2004, 292:470-84 Mattson KV, Abratt RP, ten Velde G, Krofta K: Docetaxel as neoadjuvant therapy for radically treatable stage III ... January 2009, a CT scan showed an impressive shrinkage of the hilar mass, measuring 35 × 30 mm There also was a marked clinical improvement, as the cough and the dyspnoea had disappeared and...
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Báo cáo y học: "Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulatio" pps
... from animals cannot always be extrapolated to humans Bjelle [36] has analysed the mechanical response of human knees and found an increase in glycosaminoglycan production in loadbearing areas On ... cartilage Ratio II collagen in OF and OA cartilage of aggrecan to type II collagen in the cartilage matrix of OA and OF femoral heads and comparison between areas (SP and IP) Aggrecan and type ... protein analysis The cartilage used for RNA quantification was diced and incubated with RNAlater (Qiagen Inc., Valencia, CA, USA) overnight at 4°C prior to storage Available online http://arthritis-research.com/content/8/5/R149...
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Báo cáo y học: "Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects" pot
... deltoid or the lateral mid-thigh Abatacept and antibody assays Serum samples were used to determine antibody levels The assay to quantify IgG anti-tetanus toxoid antibody levels was based on a ... levels Anti-tetanus and anti-pneumococcal (Danish serotypes 2, 6B, 8, 9V, 14, 19F and 23F) antibody titers were measured by ELISA at 14 and 28 days after vaccination by a central laboratory Abatacept ... Finally, as a normal humoral response to T-cell-dependent antigens peaks at around weeks [12], we also analyzed the impact on humoral response of the timing of vaccination relative to abatacept...
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