trunk gastrointestinal stromal tumors and retroperitoneal sarcoma

... Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group: KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumors ... 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and five of ... Research and Treatment of Cancer Page of 30 31 32 33 34 35 36 37 38 39 40 Soft Tissue and Bone Sarcoma Group: For the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma...

Ngày tải lên: 18/06/2014, 19:20

... Tissue and Bone Sarcoma Group; Italian Sarcoma Group; Australasian GastroIntestinal Trials Group: KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumors ... 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and five of ... Research and Treatment of Cancer Page of 30 31 32 33 34 35 36 37 38 39 40 Soft Tissue and Bone Sarcoma Group: For the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma...

Ngày tải lên: 20/06/2014, 03:20

... Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread Radiology 2003, 226:527-532 Duffaud F, Blay JY: Gastrointestinal stromal tumors: biology and ... Stratakis CA, Carney JA: Gastrointestinal stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in ... Weiss SW: Diagnosis of gastrointestinal stromal tumors; a consensus approach Human Pathol 2002, 33:459-465 28 Miettinen M, Lasota J: Gastrointestinal stromal tumors: pathology and prognosis at different...

Ngày tải lên: 09/08/2014, 01:24

... pathway in gastrointestinal stromal tumors Mod Pathol 2007, 20:579-583 27 Pantaleo MA, Nannini M, Di Battista M, Catena F, Biasco G: Combined treatment strategies in gastrointestinal stromal tumors ... Introduction Gastrointestinal Stromal Tumors (GISTs) are a rare malignancy originating from Cajal’s cells of the gastrointestinal tract Most GISTs are caused by mutations in the KIT and PDGFRA ... signalling and therapeutic intervention in a mouse model of gastrointestinal stromal tumors Proc Natl Acad Sci USA 2006, 103:12843-12848 43 Gunawam B: Knock-in murine models of familial gastrointestinal...

Ngày tải lên: 10/08/2014, 10:20

... IGF1R (Santa Cruz antibody) and its ligands IGF1 and IGF2 in 94 patients [40] They found that the IGF1R was strongly expressed in most cases both WT and mutant, but the ligands showed different levels ... with both WT disease and metastases at diagnosis, and was confirmed by WB and IHC SNPs array analysis of the genomic copy number showed that neither of the young patients had tumors with IGF1R amplification ... GIST by WB and IHC (Cell Signaling antibody) Agaram and colleagues evaluated IGF1R in 17 patients as gene expression profiling (mRNA level) and found that it was up-regulated in children and young...

Ngày tải lên: 18/06/2014, 16:20

... risk tumors (31%) and was significantly higher in very low/low- (78.6%) and intermediate-risk tumors (63.6%) than high-risk tumors As low-risk patients have higher maspin overexpression and high-risk ... Polyzou E, Levidou G, Safioleas M: Gastrointestinal stromal tumor World J Surg Oncol 2009, 7:61 Duffaud F, Blay JY: Gastrointestinal stromal tumors: biology and treatment Oncology 2003, 65:187-197 ... The reapraisal of gastrointestinal stromal tumors: from stout to the KIT revolution Virchows Arch 2003, 442:421-428 Connolly EM, Gaffney E, Reynolds JV: Gastrointestinal stromal tumors British Journal...

Ngày tải lên: 09/08/2014, 03:21

... Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors New England Journal of Medicine 2002, 347:472-480 Yantiss R, Spiro I, Compton C, Rosenberg A: Gastrointestinal stromal ... patients with and without previous abdominal surgery Archives of Surgery 2003, 138:1249-1252 Monihan J, Carr N, Sobin L: CD34 immunoexpression in stromal tumors of the gastrointestinal tract and in ... GIST, AF and keloid may overlap Fibromatoses may stain for vimentin, smooth muscle actin, and desmin In some series, fibromatosis did not stain for CD34 or S-100 protein, while CD34 staining and occasional...

Ngày tải lên: 09/08/2014, 04:21

Ngày tải lên: 09/08/2014, 07:21

... of CD34, KIT and BCL-2 characterizes the diagnosis of GISTs and extragastrointestinal stromal tumors (EGISTs) The latter are a small subset (5%) of GISTs that originate outside the gastrointestinal ... Kovatich AJ, Carr NJ, Emory TS, Sobin LH: Gastrointestinal stromal tumors/ smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases ... markers vimentin and CD34 and focally and weak reaction for KIT Cytokeratin and the neuroendocrine marker synaptophysin were not detected Expression of the neural marker S100 protein and smooth muscle...

Ngày tải lên: 11/08/2014, 14:20

... occupied by the tumour and multiple adhesions to other abdominal organs GIST and leiomyosarcomas in the horse are rare occurrences [12], but abdominal leiomyomas and leiomyosarcoma have been reported ... carcinoma [7] and peritoneal mesothelioma [5] without a definite cause being established Hypoglycemia in association with tumours is well recognised in man and dogs, and GIST and leiomyosarcomas causing ... gastric wall and the tumour were fixed in 10% phosphate-buffered formalin, dehydrated and embedded in paraffin About µm sections were cut and stained with hematoxylin-eosin (HE) and van Gieson...

Ngày tải lên: 12/08/2014, 18:22

... staging of retroperitoneal sarcoma Surg Laparosc Endosc Percutan Tech 2003, 13(4):290-291 Scandinavian Sarcoma Group: Recommendations for the Diagnosis and Treatment of Abdominal, Pelvic and Retroperitoneal ... intraabdominal or retroperitoneal sarcoma comparing primary and first recurrence sarcomas undergoing radical (R0) and non-radical (R1 + R2) surgery Radicality, but not whether the sarcoma is primary ... M, Sarlomo-Rikala M, Sobin LH, Lasota J: Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases Am...

Ngày tải lên: 09/08/2014, 03:22

... Gíslason HG, Magnússon MK, Jónasson JG: Gastrointestinal stromal tumors in Iceland, 1990-2003: the icelandic GIST study, a population-based incidence and pathologic risk stratification study ... Incidence and clinicopathologic features of gastrointestinal stromal tumors A population-based study BMC Cancer 2007, 7:230 Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF: Gastrointestinal stromal ... of surgical management of gastrointestinal stromal tumours (GIST) Eur J Surg Oncol 2006, 32(3):310-4 Miettinen M, Lasota J: Gastrointestinal stromal tumors: Pathology and prognosis at different...

Ngày tải lên: 09/08/2014, 01:24

... Authors' contributions KC and EC and BG performed the operation and together with AG and GM contributed to the conception and design of the manuscript LS, BS, MM, and TI analyzed and interpreted the ... biology and therapy of gastrointestinal stromal tumors Cancer Control 2005, 12:44-56 Casali PG, Jost L, Reichardt P, Schlemmer M, Blay JY, ESMO Guidelines Working Group: Gastrointestinal stromal tumors: ... B, Sobin LH, Weiss SW: Diagnosis of gastrointestinal stromal tumors: a consensus approach Hum Pathol 2002, 33:459-465 Mazur MT, Clark HB: Gastric stromal tumors Reappraisal of histogenesis Am...

Ngày tải lên: 09/08/2014, 04:21

... alpha gene in gastrointestinal stromal tumors Gastroenterology 2003, 125:660-667 DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF: Two hundred gastrointestinal stromal tumors: recurrence ... Kovatich AJ, Carr NJ, Emory TS, Sobin LH: Gastrointestinal stromal tumors/ smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases ... of gastrointestinal stromal tumors: A consensus approach Hum Pathol 2002, 33:459-465 Wardelmann E, Büttner R, Merkelbach-Bruse S, Schildhaus HU: Mutation analysis of gastrointestinal stromal tumors: ...

Ngày tải lên: 09/08/2014, 07:21

... Pediatric gastrointestinal stromal tumors and leiomyosarcoma Cancer 2004, 101:39-50 Miettinen M, Lasota J: Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and ... peritoneum [4-6] Gastrointestinal stromal tumors arise more commonly found in the stomach (40– 70%), small intestine (20–40%), and colon (5–15%) Omental, mesenteric, and retroperitoneal tumors comprise ... all negative for desmin and S-100 protein [4] The reported cases of extra -gastrointestinal stromal tumors (EGIST) have included omental, mesenteric, and retroperitoneal tumors The cellular origin...

Ngày tải lên: 09/08/2014, 07:21

... Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors Science 1998, 279:577-80 Corless CL, Fletcher JA, Heinrich MC: Biology of gastrointestinal stromal tumors J Clin Oncol 2004, 22(18):3813-3825 ... of PET scan in gastrointestinal stromal tumors Gastroenterol Clin Biol 2007, 31(6–7):585-93 Goldstein D, Tan BS, Rossleigh M, Haindl W, Walker B, Dixon J: Gastrointestinal stromal tumors: correlation ... Immunohistochemical comparison of gastrointestinal stromal tumor and solitary fibrous tumor Arch Pathol Lab Med 2002, 126:1189-1192 Miettinen M, Lasota J: Gastrointestinal stromal tumors Review on morphology,...

Ngày tải lên: 09/08/2014, 07:22

... study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group Eur J Cancer 2002, 38(Suppl 5):S83-87 ... References Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM: Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial ... metastatic gastrointestinal stromal tumors responding to treatment with imatinib Int J Cancer 2005, 117:316-325 DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF: Two hundred gastrointestinal...

Ngày tải lên: 10/08/2014, 10:20

... and overlying thrombus Figure Resected specimen Some nuclear variability and tumour giant cells present Positive for CD117 and smooth muscle actin (Figures and 6), negative for S100 protein and ... carcinoid tumour (31.5%), leiomyosarcoma (25.5%), adenocarcinoma (11.4%) and leiomyoma (9.4%) with overall malignancy in 77% of cases [7] The definition of a gastrointestinal stromal tumour (GIST) has ... Conclusion GIST accounts for 0.1% and 3% of all gastrointestinal neoplasms, most commonly occurring in the stomach or small bowel, and is now the most common sarcoma of the small intestine [10]...

Ngày tải lên: 11/08/2014, 17:21

... Daniela Gatta and Sandra Rosini Chapter Treatment Options for Gastrointestinal Stromal Tumors 29 Kai-Hsi Hsu Chapter Molecularly Targeted Therapy: Imatinib and Beyond Andrew Poklepovic and Prithviraj ... for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report ... Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review Hum Pathol 33: 478–483 Miettinen, M., Sobin, L.H & Lasota, J (2005) Gastrointestinal stromal tumors of the stomach:...

Ngày tải lên: 19/02/2014, 23:20

... treat primary and metastatic brain tumors, the incidence and mortality rates of these tumors is increasing Particularly affected are young adults and the elderly The present standard treatment ... iduronacid and N-acethylgalactosa‐ mine polymer and protein core), heparansulphate (glycuronacid and N-sulphoglucosa‐ mine polymer and protein core) and keratansulphate (galactose and Nacethylgalactosamine ... oligoastrocytoma and anaplastic oligodendro‐ glioma These tumors show a higher cellular density and a notable presence of atypia and mitotic cells Grade IV tumors are the most malignant and also the...

Ngày tải lên: 23/03/2014, 10:20