treatment of neurodegenerative pathologies using undifferentiated mesenchymal stem cells

... As compared with embryonic stems cells and bone marrow-derived mesenchymal stem cells, adiposederived mesenchymal stem cells (ADMSCs) have the distinct advantages of being abundant, easy to obtain ... Ratajczak J, Ratajczak MZ: Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis Stem Cells 2005, 23:879-894 Kee HJ, Sohn ... the treatment of early stages of DCM during disease initiation rather than treatment of the established condition The purposes of this study were to test the hypothesis that early combined treatment...

Ngày tải lên: 18/06/2014, 16:20

... capacity of cells SVV enhanced the survival of Transplanted MSCs Cells were scattered in a number of colony distributions days after planted At day ~ 9, the bottle was covered with long-spindle cells ... Science Foundation of Fujian Province of China (2008J0282) and by the professorial academic Foundation of Fujian Medical University (JS06077) Page of 10 Author details Department of Neurology, Union ... direct inhibitor of caspase-3 and Biochemistry 2001, 40:1117-1123 Zhu W, Chen J, Cong X, Hu S, Chen X: Hypoxia and serum deprivationinduced apoptosis in mesenchymal stem cells Stem Cells 2006, 24:416-425...

Ngày tải lên: 18/06/2014, 19:20

... capacity of cells SVV enhanced the survival of Transplanted MSCs Cells were scattered in a number of colony distributions days after planted At day ~ 9, the bottle was covered with long-spindle cells ... Science Foundation of Fujian Province of China (2008J0282) and by the professorial academic Foundation of Fujian Medical University (JS06077) Page of 10 Author details Department of Neurology, Union ... direct inhibitor of caspase-3 and Biochemistry 2001, 40:1117-1123 Zhu W, Chen J, Cong X, Hu S, Chen X: Hypoxia and serum deprivationinduced apoptosis in mesenchymal stem cells Stem Cells 2006, 24:416-425...

Ngày tải lên: 20/06/2014, 04:20

... evaluate adipogenic potential of amniotic fluid-derived human mesenchymal stem cells Stem Cells Dev 2006, 15:719-726 55 Montaln H, Schichor C, Lah TT: Human mesenchymal stem cells and their use in cell-based ... intracellular detection of a low amount of CD4 in about 20% of MSCs suggests a possible complex regulation of CD4 protein expression in these cells It is noteworthy that this pattern of CD4 expression ... infection of human bone marrow stromal fibroblasts Blood 1990, 76:317-322 40 Wang L, Mondal D, La Russa VF, Agrawal KC: Suppression of clonogenic potential of human bone marrow mesenchymal stem cells...

Ngày tải lên: 13/08/2014, 01:20

... 1.5.2 Adult stem cells 10 1.5.2.1 Bone marrow stem cells 10 1.5.2.1.1 Hematopoietic stem cells 11 1.5.2.1.2 Mesenchymal stem cells 11 1.5.3 Bone marrow stem cell-transplantation ... cardiovascular research 1.5.2.1 Bone marrow stem cells There are most common types of stem cells in bone marrow: (i) hematopoietic stem cells and (ii) mesenchymal stem cells These cell types are believed ... that hematopoietic stem cells may not differentiate into cardiomyocytes45 1.5.2.1.2 Mesenchymal stem cells Mesenchymal stem cells (MSCs) encompass a heterogeneous population of undifferentiated, ...

Ngày tải lên: 12/09/2015, 09:42

... portion of the cells adhered to the cartilage defect Injection of more cells would increase the number of cells that adhered to the defect; however, the injection of a large number of cells would ... Page of 10 (page number not for citation purposes) vial mesenchymal stem cells into cartilage defect Application of low-invasive local adherent technique to transplant synovial mesenchymal stem cells ... 20 21 22 23 24 25 26 Multilineage potential of adult human mesenchymal stem cells Science 1999, 284:143-147 Prockop DJ: Marrow stromal cells as stem cells for nonhematopoietic tissues Science...

Ngày tải lên: 09/08/2014, 10:23

... may be another critical target for the treatment of inflammatory arthritis [11] Mesenchymal stem cells (MSCs) are cells of stromal origin that can exert profound immunosuppression by modulating ... encouraged a possible use of these cells to modulate autoimmune responses and in the treatment of autoimmue diseases [12,13] To date, the experience of MSCs in the treatment of RA is limited to a ... Yao R, Tuan RS: Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow Stem Cells 2007, 25:1384-1392...

Ngày tải lên: 12/08/2014, 15:22

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... Making use of multiple pathways, in vitro expanded MSCs have been shown to suppress the function of a broad range of immune cells, including T cells, B cells, NK cells and antigen-presenting cells ... Genetic background of stem cells in stem cell transplantation……………93 3.1.1 Characterization of in vitro cultured MSCs……………… …………94 3.1.2 Effect of NFL knockout on the proliferation of MSCs……… …… 95...

Ngày tải lên: 11/09/2015, 09:05

... Types of cells used in bone tissue engineering for osteogenic differentiation 59 2.3.1 Potential of mesenchymal stem cells (MSCs) for bone healing 60 2.3.2 Potential of bone marrow derived mesenchymal ... inflammatory cells, cells of mesenchymal origin Chemotactic effect on other inflammatory cells, stimulation of extracellular matrix synthesis, angiogenesis, recruitment of endogenous fibrogenic cells ... Targeted cells: MSCs, osteoprogenitor cells, osteoblasts, chondrocytes Mitogenic for mesenchymal cells and osteoblasts, chemotactic for inflammatory and mesenchymal cells Targeted cells: mesenchymal...

Ngày tải lên: 11/09/2015, 09:57

... Study on Treatment of Femoral Head Necrosis with Arterial Perfusion of Marrow Stem Cells Chin J Integr Trad West Med 2004,24(11):999-1002 Yan Z, Hang D, Guo C, Chen Z Fate of mesenchymal stem cells ... application of stem cells provides promise for the treatment of ischemic femoral head necrosis When compared with vascular intervention and local drilling for injection, transplantation with stem cells ... intravenous injection of stem cells as a therapeutic strategy is less investigated in the treatment of femoral head necrosis Safety is a critical concern of intravenous transplantation of MSCs Whether...

Ngày tải lên: 25/10/2012, 11:18

... DR (1999) Multilineage potential of adult human mesenchymal stem cells Science 284, 143–147 Porada CD, Zanjani ED & Almeida-Porad G (2006) Adult mesenchymal stem cells: a pluripotent population ... Kitamura S & Nagaya N (2007) Effect of hypoxia on gene expression of bone marrowderived mesenchymal stem cells and mononuclear cells Stem Cells 25, 1166–1177 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan ... antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure Mol Biol Rep 36, 725–731 Li L, Zhang Y, Li Y, Yu B, Xu Y, Zhao S & Guan Z (2008) Mesenchymal stem cell...

Ngày tải lên: 18/02/2014, 04:20

... Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta Stem Cells 22, 1338–1345 Bieback K, Kern S, Kluter H & Eichler H (2004) Critical parameters for the isolation of mesenchymal ... development of in vitro test systems Although primary human hepatocytes are the best source of cells for such systems, their use for this purpose is limited Transcriptome in hepatic induction of AT-MSCs ... process of hepatic differentiation of AT-MSCs No previous report has demonstrated evidence of transdifferentiation of committed adult stem cells In the case of our study, transdifferentiation,...

Ngày tải lên: 30/03/2014, 04:20

... new potential source of pluripotent cells for regenerative medicine The identification of niches of tissue-specific stem cells capable of replacing damaged differentiated cells in the hFTs may ... Prockop D: Mesenchymal stem/ multipotent stromal cells: the state of transdifferentiation and modes of tissue repair – current views Stem Cells 2007, 25:2896-28902 Valtieri M, Sorrentino A: The mesenchymal ... Discussion The possibility of using stem cells for regenerative medicine has opened a new field of investigation to find the best sources for obtaining multipotent stem cells, in particular through...

Ngày tải lên: 18/06/2014, 15:20

... marrowderived MSC is the major source of stem cells in these studies [22,24-27], the therapeutic role of adiposederived mesenchymal stem cells (ADMSCs) in acute IR injury of the lung has not been investigated ... Use of Laboratory Animals (NIH publication No Page of 13 85-23, National Academy Press, Washington, DC, USA, revised 1996) Animal Grouping and Isolation of Adipose-Derived Mesenchymal Stem Cells ... scoring system adopted was as follows: = no detectable crowded area; = 75%-100% of crowded...

Ngày tải lên: 18/06/2014, 22:20

... marrow lipid was a consequence of the adipogenesis of marrow mesenchymal stem cells (MSCs) [7] Results of a previous study showed increased number of small size fat cells in the early steroid-associated ... trabecular bone area); fat cells diameter = the total diameter of fat cells in selected field/the number of fat cells in selected field; fat cells area = the area of all fat cells in selected field/(the ... the density of Oil Red Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2007, 2:15 O positive cells were calculated using Image Pro Plus software (Media...

Ngày tải lên: 20/06/2014, 00:20

... Results of Herbert-screw fixation with bone-grafting for the treatment of nonunion of the scaphoid J Bone Joint Surg Am 1999, 81(1):48-52 Trumble TE, Clarke T, Kreder HJ: Non-union of the scaphoid Treatment ... of compression and distraction at the fracture sites which is thought to improve local micro-circulation [20-24] The aim of this study is to examine the efficacy and safety of SNU treatment using ... further soft tissue damage and disruption to the local biology, in less experienced hands A recent systematic review reported union rates of 80% using bone graft without fixation, 85% using bone...

Ngày tải lên: 20/06/2014, 07:20

... delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells Stem Cells 2007, 25(7):1618-26 12 Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT, Pereboeva L: Mesenchymal progenitor cells ... marrow-derived mesenchymal stem cells in the treatment of gliomas Cancer Res 2005, 65(8):3307-18 Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M: Bone marrow-derived mesenchymal stem cells ... phenomenon of MSCs was confirmed in different experimental systems [2,12] Other cell types, such as umbilical cord matrix stem cells (UCMS) [14], neural stem cells [15,16] and endothelial progenitor cells...

Ngày tải lên: 20/06/2014, 07:20

... tnecseroulf gniwollof ehT SBP htiw semit eerht desnir erew selpmas ehT Co73 ta h rof sllec eht htiw detabucni erew seidobitna yramirp ehT ylevitcepser ,PAFG rof 002 : dna ESN rof 002 : ta ares ... 001-X notirT %4.0 neht dna ,nim rof enoteca %001 ,nim 01 rof lonahtem %001 dloc eci htiw detaert neht erew yehT erutarepmet moor ta nim 01 rof SBP ni edyhedlamrof %7.3 htiw dexif neht dna SBP ... llec gnimrofrep dna esu lacinilc rof SBF gnisu tuohtiw oviv xe sCSM dnapxe ot sdohtem dnif ot deen ew dna ,hcraeser ruo rof SBF desu ew ,yduts tneserp ni ,revewoH noitarefilorp sCSM rof noitidnoc...

Ngày tải lên: 07/08/2014, 18:21

... ’slaminA yrotarobaL fo esU dna eraC eht rof ediuG‘ eht fo senilediug eht ot gnidrocca demrofrep saw noitagitsevni sihT yduts yrujni droc lanips latnemirepxe eht rof desu erew ,gk 95.0 ± 77.3 dehgiew ... wef a ,revewoh ;noitamrof ytivac fo egatnecrep tsellams eht detartsnomed puorg PC eht ,noitidda nI spuorg GBCU dna CSM-BCU eht ni noitamrof ytivac fo egatnecrep rellams a dnuof ew ,sllec mets detnalpsnart ... sllec detnalpsnart eht rof troppus reffo yam droc derujni eht ,droc lanips eht fo sdne lamixorp dna latsid eht ot noitcennoc rof ,slairetam ro sllec suoirav fo pu edam dloffacs ro egdirb a htiw...

Ngày tải lên: 07/08/2014, 23:22