translational research in head and neck oncology

... Scottish Intercollegiate Guidelines Network (SIGN), Diagnosis and management of head and neck cancer A national clinical guideline, Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network ... means for research and clinical purpose in order to determine the global functional outcome of speech and voice after the treatment of head and neck cancer It allows quantifying the intelligibility ... of Information in Medicine, vol 43, no 1, pp 36–38, 2004 [28] C M Karat, J Vergo, and D Nahamoo, “Conversational interface technologies, IBM Research, ” in The Human-Computer Interaction Handbook:...

Ngày tải lên: 21/06/2014, 20:20

... against infection and invading connective tissue There are still very few studies applying the methods of tissue engineering to produce tracheal replacements and to examine these in vitro and in ... this technique and bearing in mind the contraindications, more than 90% of the children can nowadays be extubated without problems In spite of the progress, in children undergoing single-step surgical ... intubation over several days as an intratracheal splinting An external splinting by metallic microplates in the surgical tracheal reconstruction was described first time by Zalzal and Deutch in...

Ngày tải lên: 25/10/2013, 08:20

... clinics at Cancer Centres (see Topic 2, Structure of services and Topic 3, Initial investigation and diagnosis) Designated head and neck cancer clinicians and clinicians in ENT, maxillofacial and ... from head and neck cancers, are discussed in Improving Outcomes in Haematological Cancers.4 There are marked regional variations in the incidence of head and neck cancers, with rates ranging from ... Association of Otorhinolaryngologists – Head and Neck Surgeons (BAOHNS) set out standards for the treatment and care of patients with head and neck cancer in 1998 These were updated in 2000 and substantially...

Ngày tải lên: 22/03/2014, 16:21

... however, the sole clinical mix journal in the set, maintains links to both the clinical domain and the molecular biology domain This journal plays a key role linking diverse research interests while ... structures, policy initiatives, or clinical concerns? Developments in cancer research in the 1990s, including rapid advances in understanding of cancer genetics and increasing use of surface ... network analysis – to investigate the emergence, structure, and content of translational research in biomedicine by comparing research in cancer and cardiovascular medicine Journal inter-citation is...

Ngày tải lên: 18/06/2014, 19:20

... staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification Takikita et al Journal of Translational Medicine 2011, 9:126 http://www .translational- medicine.com/content/9/1/126 ... no staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of ... (DakoCytomation, Carpinteria, CA) at 95°C, for 10 and 40 min, for Her3 and Her2 staining respectively To minimize non-specific staining, the section was incubated with protein block (DakoCytomation)...

Ngày tải lên: 18/06/2014, 22:20

... strong (3+), and 26% showed no TLR4 staining (Figure 1; Table 3) TLR4 staining (all scores) showed a diffuse and fine granular cytoplasmatic pattern Distinct membrane staining was observed in some ... CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and AS wrote the manuscript All authors read and approved the final ... methods for genotyping (e.g direct sequencing, pyrosequencing or TaqMan-genotyping) were not considered Figure TLR4 immunohistochemistry in head and neck squamous cell carcinomas (A) Strong (score...

Ngày tải lên: 18/06/2014, 22:20

... however, the sole clinical mix journal in the set, maintains links to both the clinical domain and the molecular biology domain This journal plays a key role linking diverse research interests while ... structures, policy initiatives, or clinical concerns? Developments in cancer research in the 1990s, including rapid advances in understanding of cancer genetics and increasing use of surface ... network analysis – to investigate the emergence, structure, and content of translational research in biomedicine by comparing research in cancer and cardiovascular medicine Journal inter-citation is...

Ngày tải lên: 20/06/2014, 03:20

... staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification Takikita et al Journal of Translational Medicine 2011, 9:126 http://www .translational- medicine.com/content/9/1/126 ... no staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of ... (DakoCytomation, Carpinteria, CA) at 95°C, for 10 and 40 min, for Her3 and Her2 staining respectively To minimize non-specific staining, the section was incubated with protein block (DakoCytomation)...

Ngày tải lên: 20/06/2014, 04:20

... strong (3+), and 26% showed no TLR4 staining (Figure 1; Table 3) TLR4 staining (all scores) showed a diffuse and fine granular cytoplasmatic pattern Distinct membrane staining was observed in some ... CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and AS wrote the manuscript All authors read and approved the final ... methods for genotyping (e.g direct sequencing, pyrosequencing or TaqMan-genotyping) were not considered Figure TLR4 immunohistochemistry in head and neck squamous cell carcinomas (A) Strong (score...

Ngày tải lên: 20/06/2014, 04:20

... volume delineation in head- and- neck cancer using CT and PET/CT fusion Int J Radiat Oncol Biol Phys 2006, 65:726-732 Black QC, Grills IS, Kestin LL, Wong CY, Wong JW, Martinez AA: Defining a radiotherapy ... Cummings B, Dawson L, Keller A, Kim J, Ringash J, Yu E, Hendler A, Waldron J: Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers Int ... practicable Schinagl et al compared five methods for determining the BTV using coregistered CT and FDG-PET in HNC patients [26], including visual GTV, 40% and 50% of SUVmax, an absolute SUV of 2.5, and...

Ngày tải lên: 09/08/2014, 09:20

... therapy for head and neck carcinoma The Oncologist 2007, 12:555-564 Lee N, Puri D, Blanco AI, Chao KS: Intensity modulated radiathion therapy in head and neck cancers: an update Head and Neck 2007, ... cohort, indicating that the aim of the study is to report about early experiences in head and neck with RapidArc, not focussing on specific outcome or toxicity in single subgroups It includes ... contoured by the planner and included as follow: spinal cord, brain stem, left and right parotids; larynx and uninvolved oral cavity were outlined whenever not heavily included in the target Whenever...

Ngày tải lên: 09/08/2014, 09:20

... swallowing dysfunction after curative radiotherapy in head and neck cancer Radiotherapy and Oncology 2009, 90:189-195 Joke W, Kim De R, Duprez F, et al: Acute Normal Tissue Reactions in Head- and- Neck ... Advanced Head- and- Neck Cancer International Journal of Radiation Oncology* Biology*Physics 2009, 73:410-415 Cooper J, Fleming ID, editors, HD: Head and Neck Cancer AJCC Manual for Staging of Cancer ... KSC, Gokhan O, Wade LT: Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine Seminars in oncology 2003, 30:101-108 26 Denis F, Garaud...

Ngày tải lên: 09/08/2014, 09:20

... head and neck: interdisciplinary collaboration between head and neck surgeons in 305 cases Ann Plast Surg 1996, 36:37-43 Amarante J, Reis J, Costa-Ferreira A, Malheiro E, Silva A: Head and neck ... 2) and patients treated with neoadjuvant chemoradiation (40 Gy and cisplatin or carboplatin and paclitaxel, group3) Intima of the veins (A, * p < 0.05 vs group1 and group 2), media of the veins ... recipient veins of patients suffering from head and neck cancer Although, there was no failure in our patients, the thickening of the intima layer in recipient arteries may influence success of free...

Ngày tải lên: 09/08/2014, 09:20

... Urba S, Lin A, Schipper MJ, Wolf GT: Recurrences near base of skull after IMRT for head- and- neck cancer: implications for target delineation in high neck and for parotid gland sparing Int J Radiat ... failure in patients receiving definitive and postoperative IMRT for head- and- neck cancer Int J Radiat Oncol Biol Phys 2003, 55:312-321 Puri DR, Chou W, Lee N: Intensity-modulated radiation therapy in ... function sparing in patients with head- and- neck cancers receiving intensitymodulated or three-dimensional radiation therapy: initial results Int J Radiat Oncol Biol Phys 2001, 49:907-916 Vineberg...

Ngày tải lên: 09/08/2014, 10:20

... Her-2, Her-3, and Her-4) These receptors are composed of an extra-cellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase domain Binding to EGFR ... regarding overall survival [29] Tyrosine kinase inhibitors (TKI) and RT In preclinical studies, when gefitinib was combined to RT, strikingly greater than additive effects were observed in vivo ... related to the administration of an EGFR inhibitor (cetuximab) when combined to RT in head and neck cancer, confirming the promising results provided by previous phase II clinical studies Enthusiasm...

Ngày tải lên: 09/08/2014, 10:20

... regularly in our joint clinics at the Department of Head and Neck Surgery or Head, Neck and Maxillofacial Surgery Further follow up visits were scheduled every – months in the first years, – monthly in ... has been defined by contouring the anatomic region of the initial primary and nodal GTV, considering the preoperative diagnostics and the clinical and histological findings The PTV1 includes the ... postoperative radiotherapy and weekly cisplatin infusion for locally advanced squamous cell carcinoma of the head and neck: preliminary report of a randomized trial Int J Radiat Oncol Biol Phys...

Ngày tải lên: 09/08/2014, 10:21

... ataxia-telangiectasia-mutated (ATM) improved radiosensitivity in rodent head and neck cancer models [14-16] In addition, superior imaging in head and neck cancers resulted from the use of superparamagnetic ... Harrison PR: Profiling early head and neck cancer Nat Rev Cancer 2005, 5:127-135 Marur S, Forastiere AA: Head and neck cancer: changing epidemiology, diagnosis, and treatment Mayo Clin Proc 2008, ... recurrent/metastatic head and neck cancer Ann Oncol 21(Suppl 7):vii252-vii261 Berrino F, Gatta G: Variation in survival of patients with head and neck cancer in Europe by the site of origin of the tumours...

Ngày tải lên: 11/08/2014, 00:23

... clinical monitoring (92% and 75% respectively) When comparing retrospectively the three monitoring schemes, i.e clinical monitoring alone, bone scans alone and clinical and bone scan monitoring together, ... For bone scintigraphy, 370 MBq 99m-Tc-oxidronate was administered intravenously Static planar scintigramms of 300 seconds were obtained starting to hours after injection in the anterior and both ... ischemia of the skin pedicle and poor scintigraphic findings (score 1), whereas two patients had revision surgery because of poor scintigraphic findings only (score 0) Thrombosis was found in all patients...

Ngày tải lên: 11/08/2014, 23:22

... which included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four ... signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines Int J Cancer 2002, 99:538-548 Yu M, Yeh J, Van Waes C: Protein kinase ... Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res 2004, 10:8204-8213 Ginos...

Ngày tải lên: 14/08/2014, 07:21

... pursuing their research interests at institutions in the US cutting-edge biomedical research This enterprise is attracting, retaining and developing research talent The College’s project is work in ... Translational Research WCMC-Q’s research program aims to a) build a selfsustaining core of top biomedical scientists by recruiting, retaining, and training top talents, and b) establish strong research ... wealthy countries in the region are lacking in their human capacity building but have funding; and four, low and middle income nations are lacking in financial resources despite having welleducated...

Ngày tải lên: 18/06/2014, 19:20