... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... therapy twice-weekly for three weeks Therapy was then discontinued and tumor growth was monitored for several weeks Therapy significantly restricted solid tumor growth throughout the course of ... collected at the University of Pennsylvania or the University of Michigan After obtaining informed patient consent, ascites was collected either intraoperatively or at the time of therapeutic...
... advantage for small bowel was observed with IMRT in their study where they defined the CTV as a part ofthe whole GTV Additionally, the presence ofthe tumor shifted small bowel outside ofthe PTV ... maximal dose of 124% inside the PTV This hotspot wouldn’t have been observed if we had covered 95% ofthe volume by 95% ofthe dose Nevertheless, we may wonder whether the presence of these hotspots ... Otto K: Volumetric modulated arc therapyfor delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy Int J Radiat Oncol Biol...
... linear spline with knots at -60 weeks, the start of Apatone therapy and end oftherapy ( ) indicate where patients went off Apatone or started alternative therapy Table PSA Velocity and Doubling ... be demonstrated by further clinical study Additional studies appear warranted forthe use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in thetreatmentof late stage prostate ... stabilization of rising PSA along with no significant side effects led the men to continue therapy Four continued therapyfor months and 11 continued for at least year with one patient continuing for more...
... V20 of 59% and V10 of 73% It is possible that sparing ofthe femoral heads and/ or other organs comes at the cost of increasing dose to the iliac crests The results of our study reinforce the ... M: Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in thetreatmentof locally advanced anal cancer: results of a Page 10 of 11 (page number not for citation purposes) ... Contribution of conformal therapy in thetreatmentof anal canal carcinoma http://www.ro-journal.com/content/2/1/41 24 25 26 27 28 29 with combined chemotherapy and radiotherapy: results of a phase...
... died Therefore, the efficacy rate was 88% The median follow-up time was 35 months (range 13-47 months), and the 3-year overall survival rate was 92% Patients rapidly achieved reconstitution of ... significantly, the hematopoiesis recovery time did not significantly differ between the two groups (Table 1) (P > 0.05 using a ttest) There was no durable donor engraftment nor GVHD Therefore the umbilical ... patient data and samples; FKperformed the statistical analysis All authors have read and approved the final manuscript Conflict of interests The authors declare that they have no competing interests...
... 100% relief of their pain in 86% ofthe patients with a median relief period of months The range of relief varied from zero days to up to 13 months forthe facet injection group None ofthe lumbar ... median period of pain relief being months The range of relief forthe radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Ofthe 14 patients ... that the direct visualization ofthe joint allows better de-innervation ofthe joint and removal ofthe entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...
... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results ofthe study All twelve patients (10 males, females) completed the surgery without...
... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each ofthe samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost ofthe chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...
... with the increased HRT ofthe adsorption tank From an engineering application point of view, the appropriate operational parameters ofthe recycle ratio, HRT ofthe regeneration tank, HRT ofthe ... in the PO43 P removal These results revealed that the selection ofthe operational parameters ofthe CARS process had a great influence on the overall system performance Adsorptive capability of ... technical feasibility of this process was demonstrated The effects of recycle ratio, HRT ofthe regeneration tank, HRT ofthe adsorption tank and SRT ofthe system were evaluated The removal efficiency...
... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival ofthe patients in the cetuximab monotherapy arm ofthe RCT The data from the monotherapy arm NICE ... agreed that fitness, rather than age, is the primary factor when considering whether chemotherapy is appropriate The Committee therefore agreed that the patients included in the NICE technology ... negligible if further active treatment was not available Therefore the results seen in the single-arm cetuximab studies for these outcomes could be interpreted as an effect ofthe drug It also...
... reported on the efficacy and/or effectiveness of hydroxyurea treatmentof hematologic diseases, the toxicity of hydroxyurea in thetreatmentof any disease, and the barriers to thetreatmentof sickle ... reviewer reconciled the results ofthe first two reviewers in the case ofthe randomized trials 29 Forthe other study designs, the results ofthe two reviewers were averaged The quality assessment ... reliability ofthe instruments used A pair of reviewers each performed the quality assessment independently In the case ofthe RCTs, a third reviewer reconciled the results ofthe first two reviewers; for...
... (COX) In these enzymes, the redox potential ofthe metals is harnessed to provide the enzymes with their electron transfer capabilities Paradoxically, it is the same redox potential ofthe metals ... that the interaction between Ab and these metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the ... within the physiological ranges that could be expected within the brain The capacity for metals to facilitate this process may therefore be a critical factor in the Ab mediated pathology of the...
... the inclusion of lysine residues in the protein sequence ofthe A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... altering the rate of internalization ofthe receptor or influencing the intracellular trafficking The proteome ofthe target cell also influences the pathway We have observed large differences in the ... 14) of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs forthetreatment of...
... evidence forthe optimal period oftreatment and number of treatments? We found evidence forthe efficacy of shorter treatment protocols than the 4–6 months recommended by the ICS The basis ofthe ... outcome of physical therapy? What is the optimal period oftreatment and number of treatments? What is the effectiveness of physical therapy in clinical practice settings and can the findings in the ... exercise dosage is the critical factor is unclear The optimal length oftreatment and the number oftreatment episodes could be useful information forthe marketing of physical therapyfor SUI Some...
... upon the peer review comments, the best practice statement was submitted to and approved by the PGC and the Board of Directors ofthe AUA Funding ofthe Panel and ofthe PGC was provided by the ... addressed Placement of a thermosensor to monitor the temperature ofthe external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal ... Cryosurgery fortheTreatmentof Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery forTreatmentof Localized...
... molecules The first is the establishment ofthe relevance ofthe genetic basis of carcinogenesis Second is the determination ofthe specific oncogene to target Third is the determination ofthe specific ... a “combination therapy. ” Cellular uptake ofthe antisense oligodeoxyribonucleotide appears to be the 248 GENE THERAPY IN THETREATMENTOF CANCER limiting factor for effective therapy In animal ... gene delivery to the nucleus In the context of gene therapy, the delivery of therapeutic genes by liposomes can also result in the inhibition of angiogenesis and the observation of an enhanced...
... choice and loading ofthe NM is a compromise between the required efficiency ofthe converter and the market price ofthe NM However, the application of noble metals forthetreatmentof exhaust gas ... are formed in adsorption of reactant molecules on the semi-conducting surface; the formation of these is a function ofthe electronic properties ofthe solid, and the structure and kind of bonds ... mechanism of exhaust treatmentThe aims of this thesis will be then proposed The second chapter introduces basic principles ofthe physico-chemical methods used in the thesis, catalyst synthesis,...
... to improve the effectiveness of systemic chemotherapy The novel strategy that I propose here to improve the effectiveness of systemic chemotherapy in thetreatmentof malignant brain tumors is ... dendrimer The prototype of an imageable nanoparticle bearing chemotherapy within the to 10 nm size range: The Gd-G5-doxorubicin The prototype of an imageable nanoparticle bearing chemotherapy within the ... during the intravenous administration of small molecule chemotherapy drugs such as carboplatin Although the co-administration of labradimil increases the blood half-life of small molecule chemotherapy...
... variation between the two groups of subjects caused not by thetreatment itself but by variation ofthe clinical scale at the beginning ofthetherapy To test the overall effect of adaptive training, ... compared the primary outcome measures (change in the clinical scores) between the baseline (T0) and the end ofthetreatment (T3), irrespective ofthe training mode (treatment) As regards the kinematic ... performance at the end ofthe adaptation phase as compared to the final portion ofthe wash-out phase One subject (S8) did not complete the second half ofthe trial, for reasons unrelated to the study...
... Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2008, 3:9 Statistics The microsoft excel program was used forthe creation ofthe graphs and the SPSS ... minimal loss of physical capacity The technique remains the "gold standard" forthetreatmentof displaced and minimally comminuted olecranon fractures despite the introduction of new Page of (page ... order to improve the biomechanical properties ofthe technique [20] Rowland and Burkhart [21] gave an emphasis on the mathematical need to put the transverse hole forthe figure -of- eight tension...