tool for delivery of proteins peptides and nucleic acids

... Prof Feng Si-Shen and co-supervisor Prof Sheu Fwu-Shan for their careful and enthusiastic guidance and assistance in my project z Professor Wang Shih-Chang and Dr Shuter Borys, Department of ... rate of the PLGA copolymers are dependent on the molar ratio of the lactic and glycolic acids in the polymer chain, molecular weight of the polymer, the degree of the crystallinity, and the Tg of ... advantages and limitations Table Structures of biodegradable polymers usually used in drug delivery Table Ideal properties of polymeric-based nanoparticles for drug delivery across the BBB Table Size and...

Ngày tải lên: 26/11/2015, 22:48

... laboratories of several members of the Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseases, using the same substrate and using kits commercially available in Europe, and ... available for comparative diagnostic studies The use of a universal set of RA patients and control sera will allow a direct comparison of the diagnostic performance of current tests and those ... the predictive accuracy for the rate of joint destruction [17] Similar results were reported by Dejaco and colleagues [36], Page of Majka and colleagues [46], and Syversen and colleagues [47] It...

Ngày tải lên: 12/08/2014, 11:22

... Method for the Identification of Signal Peptides constructed out of the known signal peptides at the time and gave results of a sequence level performance of 78% correct classification for eukaryotic ... one training set consisting of 176 background proteins and 291 signal peptides and one validation set consisting of 75 background proteins and 125 signal peptides For every position in the peptide ... subsidiary of Swedish telecom Dr Nordin is a Cofounder of Dacapo AB, a Swedish consulting and research company specialised in the stateof-the-art information technology, and an Inventor of the patented...

Ngày tải lên: 23/06/2014, 01:20

... between Candida albicans viability (%) and zetapotential (mV) Correlation for AmB formulation at low (ᮀ) and high P (l) Correlation between Candida albicans viability (%) and zeta-potential (mV) for ... point of view of reduced nephrotoxicity [22] Furthermore, cationic surfactants and polymers have an effect on integrity of red blood cells [28] Therefore, similar studies should be performed for ... (%) of Candida albicans (1 × 106 cfu/mL) as a function of polyelectrolytes concentration Cells and CMC (A); DODAB/AmB/CMC (B); CMC/PDDA (C) and DODAB/ AmB/CMC/PDDA (D) interacted for h before...

Ngày tải lên: 11/08/2014, 00:22

... plasmid, and less than 0.5 PFU of H5N1 viruses per reaction, and specific for the detection of influenza A of subtype H5 The HA gene of clades 1, 2.1, and 2.3 was amplified from both virus isolates and ... infection and H5N1 subtyping Results Analytical sensitivity and specificity The analytical sensitivity of our LNA Taqman rRT-PCR for the detection of the HA gene of H5N1 was < 0.5 PFU of virus and ... Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia for his support for this work, and Dr Maciej Boni from the Oxford University Clinical Research Unit, Hospital for...

Ngày tải lên: 12/08/2014, 04:21

... carriers for synergistic codelivery of small molecule drugs and nucleic acids /proteins against cancer These particles can encapsulate hydrophobic drugs in the core and bind to biomolecules such as nucleic ... been fabricated and used for the codelivery of various anti-cancer drugs and therapeutic proteins for improved cancer therapy The first part of this thesis focuses on the evaluation of these cationic ... to conceptualize and analyze the entire regulation and signaling networks of different normal and cancer cells The understanding of network system of gene expression profiles and interaction between...

Ngày tải lên: 30/09/2015, 05:59

... all formulation steps of delivery systems and while the drug is released from dosage form at the site of delivery so that 17 their biological activity are retained In addition, peptides and proteins ... backbone of PLA and PLGA to form PLA-TPGS and PLGA-TPGS block copolymers These block copolymers are an example of amphiphiles Their uses as different carriers for delivery of protein and anticancer ... suggests that PLA-TPGS nanoparticles could be of great potential for clinical formulation of proteins and peptides Vitamin E TPGS-folate (TPGS-FOL) conjugate and doxorubicin-poly(lactide-coglycolide)-vitamin...

Ngày tải lên: 26/11/2015, 22:41

... phosphorus for the formation of RNA and DNA, and sulfur for the formation of the amino acids methionine and cysteine Other trace elements, such as metal ions, are required by various enzymes for their ... sparger, and numerous inlets and outlets for removal of samples and medium and for adding various solutions to the growing culture These include nutrients and growth factors to support growth and ... Brevibacterium for amino acids, Clostridium for acetone and butanol, Lactobacillus for organic acids, and Acetobacter for polysaccharides The production principles are similar to those described for recombinant...

Ngày tải lên: 24/04/2016, 10:44

... enough information is provided for judgment Incorporation avoided Yes for all studies Xpert does not form part of the reference standard for studies in this review Were the reference standard results ... or absence of clinical information such as age and presence and severity of symptoms should not affect test performance for the index test (fully automated system) or reference standard Were ... calculations, and non-TB and probable TB patients combined for specificity calculations For review question B, we will sort the studies in RevMan by “year of study” to look for a trend with time, since software...

Ngày tải lên: 06/03/2014, 04:20

... permission and without limitation 31 Office of Chief Counsel Topic NHTSA Office/Internet Telephone No./Link Requests for interpretation of the statutes and regulations administered by NHTSA Office of ... copied and distributed without permission and without limitation 22 submitting the appropriate form to the NHTSA Office of Chief Counsel See Chapter 3, Paragraph B and Appendix of this document for ... 565.15, Table I, entitled “Type of Vehicle and Information Decipherable.” There are two special rules for passenger cars, and for multi-purpose passenger vehicles (MPVs) and trucks with a gross vehicle...

Ngày tải lên: 07/03/2014, 11:20

... Foundation for Promotion of Material Science and Technology of Japan (MST Foundation) to KU TO is supported by a Research Fellowship of the Japan Society for the Promotion of Science for Young ... precursor sequence, we performed 3¢ RACE and 5¢ RACE with specific primers for the clone A single product of  0.4 kb for 3¢ RACE or 0.65 kb for 5¢ RACE was obtained and sequenced Figure shows ... al Novel lamprey RFamide peptides Fig Unrooted phylogenetic tree of the precursors of the identified lamprey PQRFamide peptides, and the identified and putative RFamide peptides in other vertebrates...

Ngày tải lên: 07/03/2014, 12:20

... and information from for Energy Regulation historical and expected THE ECONOMIC IMPACTS FOR IRELAND OF HIGH OIL AND GAS PRICES 15 Ireland‘s dependence on Oil and Gas future dominance of oil and ... effect of the oil price shock on the levels of GDP for the US, UK and Euro Area are shown in Figure The THE ECONOMIC IMPACTS FOR IRELAND OF HIGH OIL AND GAS PRICES 09 Economic and Social Impacts of ... and gas and to discuss the drivers and motivators for action in this regard THE ECONOMIC IMPACTS FOR IRELAND OF HIGH OIL AND GAS PRICES 17 Options and actions to reduce exposure to High Oil and...

Ngày tải lên: 08/03/2014, 06:20

... conflicts of interest References US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Guidance for Industry Uncomplicated and complicated ... Practice guidelines for the diagnosis and management of skin and soft-tissue infections Clin Infect Dis 2005;41(10):1373–406 May AK, et al Treatment of Complicaed Skin and Soft Tissue Infections ... daptomycin and standard treatments.55 In summary of clinical trials for the treatment of cSSSI, daptomycin appears to be as efficacious as the comparator standard treatment, namely vancomycin and PRP...

Ngày tải lên: 22/03/2014, 14:20

... characterization of a prototypical thioesterase responsible for the iterative assembly of the quinoline- and quinoxaline-type class of chromodepsipeptides, capable of macrolactonization and macrothiolactonization ... LM (1992) Constrained peptides: models of bioactive peptides and protein substructures Annu Rev Biochem 61, 387–418 10 Davies JS (2003) The cyclization of peptides and depsipeptides J Pept Sci ... on cyclization-efficiency, and to establish TioS T-TE as a general catalyst for the ligation and cyclization of the quinoline- and quinoxaline-type class of chromodepsipeptides, TL11 was synthesized...

Ngày tải lên: 23/03/2014, 06:20

... (c) and A431 (d), respectively (B) Conditioned medium of nontransfected Cos7 cell (a), ng of BNC from the conditioned medium (b), 100 ng of EGFP (c) and a mixture of ng of BNC with 100 ng of EGFP ... between these two bands of I and II should be due to the size of 3654 Fig Secretion of L fusion particles evaluated by enzyme immunoassay and fluorescence The HBsAg immunoreactivity (A) and the fluorescence ... L(D45)-FLAG–EGFP has the potential to form a particle Topology analysis of the C-terminus of L fusion protein Consisting of 56 amino acids, the primary structure of the C-terminus of the S region is rich in...

Ngày tải lên: 23/03/2014, 15:20

Ngày tải lên: 30/03/2014, 01:20

... recommendation for achieving a CVP of 8 mm Hg and an Scvo2 of 70% in the first hrs of resuscitation of sepsis-induced tissue hypoperfusion, although deemed desirable, are not yet the standard of care ... view of the risks for hypoglycemia which can be greater in newborns and children due to a) relative lack of glycogen stores and muscle mass for gluconeogenesis, and b) the heterogeneity of the ... member of the Australia and New Zealand Intensive Care Society Clinical Trials Group for the NICESUGAR Study (no money received); he is a council member of the International Sepsis Forum (as of Oct...

Ngày tải lên: 31/03/2014, 13:20

... founder and former director of the Tissue Engineering and Regenerative Medicine Centre, Imperial College and is now an emeritus professor from the Faculty of Medicine and resides in an office ... development and validation; the development of tools and technologies required to underpin the regenerative medicine sector; and an understanding of the value systems and business models necessary for ... preclinical proof of concept; (2) evidence of safety; and (3) early indications of benefit and efficacy (Phase I/IIA or B human clinical trials) A high level of predictability of a continuing chain of funding...

Ngày tải lên: 03/05/2014, 19:37

... : = [0, 1/2] and C2 : = (1/2, 1] Hence, |T n x − T n y| = kn |x − y| ≤ |x − y| for all x, y ∈ C1 and n ∈ N and |T n x − T n y| = ≤ |x − y| for all x, y ∈ C2 and n ∈ N For x Î C1 and y Î C2, we ... Hu and Cai [3], Sahu et al [4], and Duan [8], the main purpose of this paper is to introduce a new iterative process for finding a common element of the fixed point set of a finite family of ... following notations: ⇀ for the weak convergence and ® for the strong convergence x} denotes the weak ω-limit set of {xn} ωw (xn ) = {x : ∃xnj Preliminaries We need some facts and tools in a real Hilbert...

Ngày tải lên: 21/06/2014, 02:20

... received signal strength We use PDR information for two reasons First of all, the mapping between PDR and received signal strength is not straight forward and noise and interference have a large impact ... PDR-table may contain values for all possible transmission levels or only a subset of them The P values are not dynamic and can be calculated beforehand for each of the transmission power level ... emission or consumption and they are different for different links The minimum energy emission level for each link in Figure 2(c) is 3, and for each link, respectively For the energy consumption,...

Ngày tải lên: 21/06/2014, 11:20