tolerability adverse events and special populations
Poe and the Printed Word - The novel
Ngày tải lên :
01/11/2013, 09:20
... of His Shipwreck, and Consequent Discovery of Certain Islands in the Caribbean Sea: with Details of His Residence There, and of Various Extraordinary and Highly Interesting Events in His Life, ... contemporary society and to provide a utopian alternative to it In other words, they perpetuated the longstanding notion that literature must both delight and instruct For 60 Poe and the printed word ... Travel in Egypt, Arabia Petraea, and the Holy Land, on the other hand, was published Clearly, the Harpers placed great hope in Stephens.12 The ®rm's decision to publish and to promote Stephens's work...
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The State and the Novel
Ngày tải lên :
01/11/2013, 10:20
... effect, and it serves to place attention on preoccupations more pressing for a post-war audience, The State and the Novel 17 such as the changing nature of social and sexual relations, and the ... look parochial and irrelevant to outsiders For writers who have known, and often still live in, a world where torture and deportation, the arbitrary exercise of unlimited power and the familiarity ... ‘a new frankness, openness, and indeed honesty in personal relations and modes of expression’; and, second, the claim that ‘the challenge to established authorities and hierarchies’ has led to...
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Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
Ngày tải lên :
18/02/2014, 16:20
... of Vrp1p and Las17p in yeast and WIP and WASP-family proteins in mammalian cells are direct and result in constitutive and apparently stable complexes [28,29,31,32] In yeast, Vrp1p and Las17p ... functions of Vrp1p in endocytosis, cytokinesis, and growth at elevated temperature, on the one hand, and in cortical actin-patch polarization, on the other hand, are at least partially distinct [23] ... interaction with actin and that GSTC-Vrp1p465)533 binds endogenous actin in yeast lysates and directly binds purified yeast and rabbit skeletal muscle G-actin in vitro (Fig 4B–D and data not shown)...
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Tài liệu Báo cáo khoa học: Characterization of the interaction between the plasma membrane H+-ATPase of Arabidopsis thaliana and a novel interactor (PPI1) doc
Ngày tải lên :
19/02/2014, 07:20
... results The mean Vmax and apparent Km values were, respectively, 1.20 ± 0.04 lmolÆmin)1Æmg protein)1 and 0.35 ± 0.05 mM in the absence and 1.37 ± 0.06 lmolÆmin)1Æmg protein)1 and 0.13 ± 0.02 mM ... kinase and phosphoenolpyruvate and the reaction was carried out for 60 at 30 °C Released Pi was determined as described 5869 Interaction between plasma membrane H+-ATPase and PPI1 in De Michelis and ... PPI1588His6 and GST–AHA1(846–949) bound each other in overlay experiments both when a membrane spotted with GST–AHA1(846–949) was incubated with PPI1588His6 (Fig 1A) and when PPI1588His6 was spotted and...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
Ngày tải lên :
19/02/2014, 07:20
... chromosomes; PDGF-a and -b on chromosomes and 22 [17,18], and PDGF-c and -d on chromosomes and 11 [19], respectively The genomic organization of the pdgf genes is quite similar, although PDGF-c and -d genes ... exons in PDGF-c (exons and 6) and PDGF-d (exons and 7) encoding the cystine knot motifs resemble the corresponding exons in the PDGF-a and -b (exons and 5) genes Both in PDGF-a and -b, exon encodes ... While PDGF-A and -B can form both homo- and heterodimers (PDGF-AA, -AB, -BB), PDGF-C and -D exist only as homodimers (PDGF-CC and -DD) The full-length PDGF-C and -D monomers are 54–55 kDa and 49–56...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
Ngày tải lên :
21/02/2014, 01:21
... immunoreactivity of ERK1/2 and phospho ERK1/2 (A,B), and MEK1/2 and phospho MEK1/2 (C,D) The lower part of each panel reports the quantitative analysis of phospho ERK1/2 (A,B), and phospho MEK1/2 (C,D) ... leupeptin, and 10 lM pepstatin) The samples were sonicated for 10 s (Branson, sonifer B-12, setting 3) and incubated at °C for 15 Lysates were then centrifuged at 10 000 g for 15 (4 °C) and analyzed ... ERK-1/2, phospho-MEK1/2 and phospho-ERK1/2 (New England Biolabs, Inc Beverly, MA, USA) The following dilutions were used for individual antibodies against different proteins: MEK1/2 and ERK1/2 (1 : 1600),...
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Báo cáo khoa học: Purification and structural analysis of the novel glycoprotein allergen Cyn d 24, a pathogenesis-related protein PR-1, from Bermuda grass pollen pot
Ngày tải lên :
07/03/2014, 12:20
... allergic to BGP require individual diagnosis and therapy, and an understanding of the structure of these allergens is essential to the improvement of diagnosis and the design of adequate therapeutic ... combination of CM-TSK and RP-HPLC The final material was homogenous, as shown by the presence of a single band on SDS ⁄ PAGE, a single sharp peak on RP-HPLC, and a single band on immunoblotting ... Chow et al isoforms and these have high pI values ranging from 9.5 to 10.5 [10–15] Similarly, Cyn d is a calcium-binding protein containing two Ca2+, and its allergenicity and cross-reactivity...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
Ngày tải lên :
15/03/2014, 23:20
... FEBS R V Iozzo and L Schaefer factor jB and results in the synthesis and secretion of tumor necrosis factor a and macrophage inflammatory protein Consequently, additional neutrophils and macrophages ... develop into adenocarcinomas, and this process is accelerated and amplified by subjecting decorin-null mice to a western diet enriched in lipids and low in calcium and FEBS Journal 277 (2010) 3864–3875 ... ligand of innate immunity receptors and interacts with the Tolllike receptors (TLR)-2 and -4 on macrophages, thereby triggering a robust inflammatory response It is intriguing that both TLRs and...
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Báo cáo khoa học: Differential expression pattern of the novel serine⁄threonine kinase, STK33, in mice and men doc
Ngày tải lên :
16/03/2014, 23:20
... disrupted promoter structure and exons I and II, exhibit impaired follicular development and ovulation [25] and impaired spermiogenesis in males [26] On the other hand, mice defective in Camk4 ... hemisphere and between cerebellum primordium and medulla oblongata (Fig 6, A1 and A2) Also border regions between metencephalon and pons with the third ventricle (arrows in Fig 6, A1 and A2) showed ... fetal heart, pituitary gland and kidney Weak but still above background signals were found in interventricular septum of the heart, pancreas, trachea, and thyroid gland (Fig 1B,C) Hybridization...
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of mice and men a comprehensive comparision of the novel and
Ngày tải lên :
21/03/2014, 22:48
... them and the story form the film because I was watching and listening to them, rather than just reading about them John Malkovich's (Lennie), Gary Sinise's (George), and Ray Walton's (Candy) ... pretty but it maybe too pretty I had pictured Candy and Slim to be more dirty and grizzled men I thought Ray Walston looked a little too feeble to play Candy but his acting made up for any shortcomings ... film very worthwhile Malkovich and Sinise are touching and pleasurable to watch together Malkovich uses his baldness with bulky costumes to become convincingly large and stupid He takes the time...
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the chamber a look into the novel and film
Ngày tải lên :
21/03/2014, 22:53
... the governor's mansion -and he'll stand there in the glare of a hundred cameras and deny me clemency And the bastard will have tears in his eyes.' " (Grisham 122) Ruth Kramer and her family are the ... about someone being executed, but about a grandfather dying and his grandson's frightening circumstance of trying to win both a legal victory to save him and an emotional victory to reach him.' " ... father, and if he'd been home with his family instead of riding around at night with his idiot buddies, little Josh and John would not be dead.' " (61) The Chamber is a story about life and death and...
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princeton university press the novel volume 1 history geography and culture may 2006
Ngày tải lên :
11/06/2014, 16:27
... natural and supernatural or between reality and the imagined (which I doubt) Somộ is described in his book, Of Water and the Spirit, as a medicine man and diviner as well as holding a Ph.D from Brandeis ... genealogy, and praises they sing the jeeli of Mandingo origin, who play many instruments, are unattached, and make their living by their profession the nyemakala, wandering singers and guitarists ... Margin, a tale of outlawry and rebellion, was thought to encourage brigands Fiction and reality were merged; the work attacked the abuse of power and misgovernment, and is reformist in tone despite...
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báo cáo khoa học: "Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene" potx
Ngày tải lên :
09/08/2014, 01:24
... ultrasound and Tc99 m Sestamibi-scans both disclosing hyperplasia of the parathyroid glands, abdominal MRI scan and endoscopic ultrasound (EUS) both disclosing a 4.5 × 3.0 cm tumor in the body and tail ... lesion and distal pancreatectomy and splenectomy were performed The incidence of pituitary adenomas in MEN1 patients varies between 10 and 60% [13], while their symptoms depend on the type and the ... neoplastic cells with scant eosinophilic cytoplasm and stippled nuclei, arranged in nests and trabecula There was mild to moderate nuclear atypia and the mitotic figures were less than per 10 HPF...
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Báo cáo y học: " Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4" pot
Ngày tải lên :
13/08/2014, 05:21
... p30II, and p13II (where I and II denote ORFI and ORFII, respectively), have been identified in the pX region of HTLV-1 and are important in viral infectivity and replication, T-cell activation, and ... Africa and, like HTLV-1 and HTLV-2, potentially could be spread globally through migrations of infected human populations Expanded screening is needed to define the prevalence of HTLV-3 in human populations ... confidence intervals for the origin of HTLV-2 as it migrated out of Africa and Asia and into the Americas via the Bering land bridge and 40,000 – 60,000 ya as confidence intervals for the origin of HTLV-1...
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logico-semantic relations and their realization in chapter 5 white fang and the indians in the novel white fang by jack london
Ngày tải lên :
02/03/2015, 14:32
... and other dogs; and especially between White Fang and Lip-lip The participants of the text include actors (White Fang, Kiche, Grey Beaver, other Indians, Lip-lip, and other puppies and dogs), behavers, ... signaled by a conjunction or a conjunction group such as now, (and) then, (and) afterwards, first…then, and just then, at the same time, and at this time For example: The lights have gone out: now ... means and comparison Means: (and) (in) that way For example: Keep on subtracting the difference, and in that way you will arrive at the correct figure (Halliday, 1994: 234) Comparison: (and) ...
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Logico-semantic relations and their realization in chapter 5 White fang and the Indians in the novel White fang by Jack London
Ngày tải lên :
10/08/2015, 19:51
... of context 1.4 Grammatical rank scale 1.5 Clause and clause complex 1.5.1 Clause and its position in functional grammar 1.5.2 Clause simplex and clause complex 1.6 Logico-semantic relations between ... Abstract iii Notational conventions iv List of figures and tables v Table of contents vi PART A: INTRODUCTION Rationale Aim of the study and Research questions Scope of the study Data collection ... M.A.K (1970), Language Structure and Language Function, (In) New Horizon in Linguistics J Lyons (Ed), Harmonsworth: Penguin Pp 140-165 Halliday, M.A.K (1985), Spoken and Written Language, Deakin...
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The novelty and surface to volume ratio dependent electron band structure in semiconductor nanowire
Ngày tải lên :
09/09/2015, 18:55
... length and band gap on bulk silicon The calculated Si-Si bond length and band gap for bulk silicon are 2.30 Å and 1.29 eV, respectively, which are close to the experimental values (2.35 Å and 1.17 ... properties Going beyond standard DFT, a few studies have calculated the band gap and optical properties of SiNWs using the GW method and time-dependent DFT [25, 26, 27] The GW band gaps were shown ... find the electronic band structure and band gaps [Chapter Modeling and Methodology] 26 References: [1] W Kohn Nobel lecture: Electronic structure of matter—wave functions and density functionals...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
Ngày tải lên :
14/09/2015, 14:04
... technology, especially in genomics and proteomics, and with an annual spending of US$50 million by the pharmaceutical industry on research and development, there have been only a handful of new and successful ... induced by Fas ligand (FasL), tumour necrosis factor alpha (TNFα) and TNF related apoptosis inducing ligand (TRAIL ) where these ligands bind to specific death domain receptors and induce the formation ... inner mitochondrial membrane and the VDAC in the outer mitochondrial membrane and cyclophilin D in the matrix (Green and Kroemer, 2004; Zamzami and Kroemer, 2001) And a sudden increase in permeability...
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The dynamics of literary representation and interpretation in a multilingual environment a study of selected malaysian and singaporean novels in english
Ngày tải lên :
16/09/2015, 08:30
... hands together and placed them under his right cheek and closed his eyes The monk smiled and nodded his head Mr K showed his upturned thumb above his clenched fingers and shook his hand up and ... Taiping and St Paul’s School in Seramban And the first Malay College, an English-medium school, was opened in 1905 at Kuala Kangsar, and only Malay children “of good birth” (Andaya & Andaya 228) and ... Grand Illusion (1961); Johnny Ong’s Sugar and Salt (1964), Run Tiger Run (1965) and The Long White Sands (1977); Lim Thean Soo’s The Siege of Singapore (1971), Destination Singapore (1976) and...
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