to during and after the closure
Báo cáo y học: " Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting" pptx
Ngày tải lên :
12/08/2014, 18:21
... Concentrations of BALF cytokines and serum IgE Concentrations of BALF cytokines and serum IgE (A) BALF cytokine concentrations Four days after the transfer, BAL was performed and then the centrifuged ... proliferated and produced Th2-type cytokines in response to OVA, while the CD62Lhigh subset did not (Figure 9A and 9B) Moreover, transferred CD62Llow subset recruited into the lung, and proliferated there ... recruited into the lung (Figure 9E) Moreover, in the mice that received the CD62Llow subset, some T cells in the lung proliferated there without further antigen stimulation (Figure 9F) These results...
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Báo cáo y học: "Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis" pps
Ngày tải lên :
09/08/2014, 07:20
... A2A receptor knockout mice and A3 receptor knockout mice but, in contrast to the air pouch model, diminishes leukocyte accumulation only in the peritoneal exudates of A3 receptor knockout and wild-type ... (n = 23) Inflammatory exudates were induced in the peritoneum of knockout and wild-type mice, as described After hours the exudates were collected and the leukocytes quantitated The wild-type control ... TNFα, IL-10, and IL-12 [23,25-27,47] In addition to the regulatory effect of adenosine in cytokine secretion, we have further established that Th1 proinflammatory cytokine IL-1 and TNF-α treatment...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
Ngày tải lên :
25/10/2012, 11:40
... used the fixed-effects model and the random-effects model based on the Mantel-Haenszel method and the DerSimonian and Laird method, respectively, to combine values from each of the studies When the ... assumed to be homogenous, the fixed-effects model was then used; otherwise, the random-effects model was more appropriate We also computed the power of the selected studies by using the DSTPLAN4.2 ... study, the OR is plotted on a logarithmic scale against the precision (the reciprocal of the SE) Discussion The GSTP1 gene, which encodes the GST π isoenzyme, is the most important form in the esophagus.[35]...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
Ngày tải lên :
03/11/2012, 10:52
... with its receptor on target cells It is well established that serum levels of TPO are regulated by the binding of the ligand to the receptor and the endocytosis of the ligand-receptor complex [9] ... correlations (p>0.05) between the magnitude of the change of platelet counts, on the one hand, and changes of TPO or sIL-6R concentrations, on the other Neither were there any significant correlations ... value, and treatment failure (F) as a reduction of the platelet count with < 50 % of the baseline value Here, and for the purpose of cytokine levels and platelet counts, we have grouped PR and F together...
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Five stories that are almost true, but not quite
Ngày tải lên :
06/11/2012, 17:33
... gossip or scandal, ridicule this and that and laugh heartily together The theory that opposites attract, did not hold in their case They were, in fact, so attuned to one another that they could ... event and absolutely relished the fact So now and then, they slipped into their own particular interests and carried on a dialogue in which I had no part They would talk of people and events, the ... in the designs to fit a client's personality and after he gained both experience and confidence, started designing his own clothes The business flourished and grew and they began exhibiting their...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
Ngày tải lên :
14/02/2014, 14:20
... in Ab-induced excitotoxicity [11] Furthermore, Fyn sensitizes mice to the toxic effects of Ab [15,16], and tau is required for the Fyn-mediated and Ab-mediated synaptic deficits and network impairments ... [20,21] To determine whether the tyrosine phosphorylation status of tau also affects the binding of tau to Fyn-SH3, CHO cells were cotransfected with Fyn together with either wild-type or the YF ... of the association of these proteins could represent a potential therapeutic strategy for the treatment of AD Here, we used GST fusion proteins of Fyn-SH2 and FynSH3 to further investigate the...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
Ngày tải lên :
18/02/2014, 16:20
... present, the PKA inhibitor H89 further reduced the rate of thrombin generation by another 25%, thus indicating the additional involvement of PKA To assess more directly the role of the P2Y12 ... receptors stimulate the less well understood phosphoinositide 3-kinase (PI3-K) pathway, which leads to aIIbb3 integrin activation and platelet aggregation [18] We and others have shown that both the ... both the extent and duration of the [Ca2+]i increase [9] Platelet pretreatment with AR-C reduced the Ca2+ peak (–9%) and the Ca2+ integral (–34%) after thrombin stimulation (Table 1) Further...
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Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
Ngày tải lên :
18/02/2014, 16:20
... virulence factors and toxins have been found to target Rho GTPases and to induce various chemical modifications interfering with Rho function and resulting in increased invasive properties of the pathogens ... binding and interaction with effectors The positions of the Lys147 residues are almost identical Lys147 of Rac1 is yellow, and the equivalent residue of Rac1b is shown in orange on top There is ... plasmids of 6His–myc–Ub and myc–Rac1L61 Twenty hours after transfection, cells were treated with the JNK-specific inhibitor SP600125 at 10 or 20 lM for or h, and then subjected to the ubiquitination...
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Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
Ngày tải lên :
05/03/2014, 17:20
... into the S phase of the cycle [50], and that signals elicited by the cytoskeleton act independently of ERK1/2 signals to drive the cell cycle machinery through the G1/S boundary and, hence to ... shown that the cytoskeleton orients the cell metabolic and signal transduction machinery, and that mechanical distortion of cells and the cytoskeleton through surface integrin receptors can switch ... rounding These effects have been reported to mimick to some extent the effects of gonadotropins on the cytoskeleton [28,32,34] To our knowledge, our study is the first report of the effects of cytochalasin...
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Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
Ngày tải lên :
14/03/2014, 16:20
... females moved territories between years once they had bred, and in 15/16 of these cases they moved to an adjacent territory (Magrath, unpublished data) Furthermore, during the breeding season, ... over the whole breeding season or the probability of fledging any young The date the first egg was laid was used as the measure of the beginning of the breeding season for a female The ‘end of the ... birds 1992 Scrubwrens bred both in the Gardens and in the adjacent Canberra Nature Park (c km2 ), and there was dispersal both into and out of the Gardens The Gardens occupy an area of 40 ha,...
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Dangerous But Not Omnipotent pptx
Ngày tải lên :
15/03/2014, 21:20
... Organization Yet the U.S ability to gauge the extent and totality of these challenges is ultimately handicapped by the lack of official relations between the two states since the Islamic Revolution and, ... regarding Iraq These must be simple and easily understood, and the United States must stick to them long enough for them to be taken seriously The United States should reinforce the Status of ... Finally, we wish to express great appreciation to RAND colleagues Bruce Nardulli and James Dobbins and to Shahram Chubin for their insightful technical reviews of the document, and to RAND colleague...
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Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
Ngày tải lên :
16/03/2014, 06:20
... have examined the number of ligands, the geometry of the coordination sphere, and the B-factor of the ion and its environment For example, the distance between ˚ calcium and oxygen atoms should ... may be a good habit to have a look at the atomic coordinate section of the PDB file to see the level of the B-factors of the atoms that are in the most important fragments of the struc˚ ture If ... is the case with other RNase A-like enzymes The orientation of the His97 ring in the deposited structure (PDB code 2i5s) was determined, on the basis of the B-factors of the imidazole atoms, to...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
Ngày tải lên :
17/03/2014, 10:20
... ATP) and in the reverse (V8r, synthesis of ADP) directions were mathematically adjusted, using the MATHEMATICA-3.0 program (to 4000 and 200, respectively) to keep the level of ATP during the application ... times and analyzed by HPLC In (B) application of the theoretical model was performed with the MATHEMATICA-3.0 program, as described in the text and in [3] The V-values, from control cells, and the ... in the yeast cytosol, and grown for 30 in the presence of 1.5 mM H2O2 Ki values of the products were assumed equal to the Km values of the substrate in the cases of enzymes E2, E5, E6, E7 and...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
Ngày tải lên :
17/03/2014, 23:20
... Cbl binding to the P85 subunit: one involves the proline-rich domain of Cbl and the SH3 domain of P85 and while the other implicates a phosphorylated C-terminal tyrosine (Y731) of Cbl and an undefined ... the association between them and the activity of PtdIns-3 kinase The use of in vitro binding and ubiquitination assays will allow us to better understand the mechanism of the interaction between ... P85 ubiquitination and to regulate the recruitment of PtdIns-3 kinase to CD28 and T cell antigen receptor complexes, thereby inhibiting PtdIns-3 kinase activation Two contradictory mechanisms have...
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Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
Ngày tải lên :
23/03/2014, 03:20
... fibrils The key to the properties of amyloid assemblies lies in the regularity and repetitiveness of their underlying molecular architecture of intermolecular b-strands stacked perpendicular to the ... that the exponential growth phase extends through the apparent lag all the way to the beginning of the experiment [23] (Fig 2C), which means that the observed lag time depends inversely on the ... packing of fibrils and it is virtually impossible using these techniques alone to quantify the fraction of the protein that has become converted to fibrils at the given time point The hierarchical...
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Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
Ngày tải lên :
23/03/2014, 04:21
... a plateau after incubation for h and stayed almost the same for the following 66 h In contrast, the inhibitory effects of insulin hardly remained after incubation for 12 h, whereas the promotional ... even after 72 h of incubation This result suggests that the enhanced aggregation could be due to the interaction between amylin and insulin rather than the self-assembly of insulin Considering the ... and carbon, and negatively stained with 1% (w ⁄ v) fresh tungstophosphoric acid The samples were then examined in a JEOL-1200EX electron microscope (JEOL, Tokyo, Japan) at 100 kV To examine the...
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Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
Ngày tải lên :
23/03/2014, 06:20
... On the other hand, the pro-oxidant action of lipoic acid was shown to stimulate mitochondrial permeability transition and apoptosis through the proteins of the mitochondrial contact sites, the ... (Anon-bound E3 ⁄ E1o ⁄ Abound E3 ⁄ E1o) The OGDHC activity yield is the ratio of the total activity of OGDHC in the eluate to the total activity of the OGDHC applied to the column ND, not determined Dissociation ... was applied to the 12 ⁄ 30 column with Sephacryl S-300 The separation varied due to the differences in the sample volume and ⁄ or relative content of the microsomes The interference of the elution...
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Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
Ngày tải lên :
23/03/2014, 21:20
... described by the Stern–Volmer equation, F °/F ¼ + KD · [Q] where F and F ° are the fluorescence intensities in the presence and in the absence of the quencher, Q, respectively, and KD the Stern–Volmer ... with the poor accessibility of the tryptophan suggested by the position of the maximum wavelength of the fluorescence (336 nm at pH 5.7 and 342 at pH 6.8 in EGTA) The results obtained using the ... rearrangements between domains caused either by the occupancy by other calcium ions, or by the presence of protons We have shown that the helix latch and the G2 to G4–6 interaction in general is not...
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Social capital and Health status: a protective impact among elderly or inactive but not among active ? doc
Ngày tải lên :
28/03/2014, 20:20
... to examine the association and the causal influence of social capital and health status, we restrict our analysis to the key informants aged between 25 and 85 years old, who are not student and ... sub-populations using the individuals’ age and occupational status People in employment, unemployed and homemakers aged less or equal to 55 years old are gathered together and constitute the first sub-population ... speaking?” The following responses are: to have spoken in French”, to have spoken in French and another language” or to have spoken only in language other than French” This indicator enables to consider...
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Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
Ngày tải lên :
31/03/2014, 08:20
... involved in the high-affinity binding of these toxins to R25 and CaM In contrast to AtnI2, both AtnI2/ AtxA(K108N) chimeric proteins were able to bind to these AtxA-binding proteins, but were not toxic ... that F24 and the last 26 amino acid residues of potently neurotoxic AtxA are not enough to transform a nontoxic sPLA2 into a neurotoxic one It is evident that some other residues on the toxin molecule ... demonstrated that Atxs, the presynaptically neurotoxic sPLA2s from venom of the long-nosed viper, strongly and specifically bind to neuronal receptor R25 and CaM [18,19] No binding to these proteins was...
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