... terms of surface coverage per area of electrode, C H + denotes the concentration of protons, and C GLY denotes the concentration of glyoxylic acid The conversion of bulk concentration of oxalic acid ... is the ratio of volume of the cell to electrode area (cm /cm ) By the use of the rate of change of species θ1 and θ2 given in Eqs (8)–(12), the faradaic current density of oxalic acid reduction ... if the electroreduction of adsorbed oxalic acid becomes the rate limiting step Key words: Oxalic acid, glyoxylic acid, electroreduction, impedance Introduction Glyoxylic acid is known to be an
Ngày tải lên: 12/01/2022, 23:02
... role of s uch amino -acid replace- ments in the development of essential h ypertension. Furthermore, the results indicate the possibility of a differ- ential as well as independent modification of ... CYP11B2 reaction steps. The combination of functional data and computer modelling of CYP11B2 suggests an indirect involvement of r esidue 147 in the regulation of CYP11B isoform specific substrate conversion ... tures are mainly located in the C-terminal regions of CYP11B1 and CYP11B2. So far, the role of distinct amino acids of the N-terminal regions of human C YP11B isozymes h as n ot been studied extensively,
Ngày tải lên: 24/03/2014, 03:21
Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf
... presence of 100 nM ÔcoldÕ leptin (data of the ÔcoldÕ leptin experiment with CHP100 cells were superimposable to those of U937 cells, and were omitted for the sake of clarity) Western blot analysis of ... were increased by treatment of U937 cells, but not of CHP100 cells, for 24 h with lM progesterone (Fig 3B) Quantitative analysis of phospho-STAT3 and of total Ikaros isoforms by ELISA corroborated ... levels of Ikaros For the analysis of total STAT3 and of the corresponding phosphorylated (activated) form, whole cell extracts were prepared as reported previously [8] For the determination of Ikaros
Ngày tải lên: 30/03/2014, 15:20
Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... side-chain of E139 might influence the properties of the flavin, assuming some of the functions carried out by E301 in the wild-type enzyme [22]. In this context, a special reactivity of the side-chain of ... analyse the function of the glutamic acid residue at position 139. A previous characterization of the reduction of several E139 FNR mutants by Fd suggested the formation of less productive complexes ... instead of Fd and replaces it in the ET from photosystem I to FNR [1,2]. Three-dimensional structures of free FNRs from different organisms have been reported [3–6], as well of those of nonproductive
Ngày tải lên: 31/03/2014, 08:20
Analysis and practical implementation of a model for combined growth and metabolite production of lactic acid bacteria
... amount of lactic acid in the medium and the buffering ca pacity of the medium are known. The amount of undissociated lactic acid is then further related to the total amount of lactic acid LaH ... ingredients, e.g., acid- ification, curdling and production of flavour com- pounds, and (ii) inhibition of the outgrowth of microbial pathogens and spoilage organisms. The antimicrobial potential of LAB ... lected. Application of the adapted model of Nicolaı¨ et al. to the experimental data set of cell concentration N, total lactic acid concentration LaH tot and pH consists out of two major steps,
Ngày tải lên: 05/05/2014, 08:44
báo cáo hóa học:" Anti-angiogenic effect of high doses of ascorbic acid" pptx
... the effects of the high concentrations of ascorbic acid on energy metabolism and capillary tube formation. 2. Effects of high dose ascorbic acid on angiogenesis The effect of ascorbic acid on capillary ... high-concentrations of AA (post intravenous administration of 15 g, 30 g, and 60 g) and time of expo- sure were established. The infusion of 15 g of ascorbic acid in 45 min raised the plasma level of AA to ... of closed loops. The pres- ence of the EPCs increased the number of closed loops, but the sum of the cells did produce the same count of ves- sels. The addition of EPCs increased the number of
Ngày tải lên: 18/06/2014, 15:20
Structure, Properties, and Preparation Of Boronic Acid Derivatives Overview of Their Reactions and Applications
... the presence of two hydroxyl groups, the acidic character of most boronic acids is not that of a Brønsted acid (i.e., oxyacid) (Equa- tion 1, Figure 1.6), but usually that of a Lewis acid (Equation ... presumably due to internal coordination of one of the ni- tro oxygens [52]. One of the most acidic of known boronic acids, with a pK a of ca. 4.0, is 3-pyridylboronic acid (14), which exists mainly as ... (Table 1.2). It is slightly more acidic than boric acid (pK a 9.2). The pK a s of Table 1.2 show that the rel- ative order of acidity for different types of boronic acids is aryl > alkyl. Bulky
Ngày tải lên: 02/07/2014, 12:53
Studies on electrolyte formulations to improve life of lead acid batteries working under partial state of charge conditions potx
... comparison of several gel composition and acid electrolytes. No additional peaks appear in the voltam- mograms of any of the new gel compositions due to secondary redox reactions of the silica ... 2 evolution) of some gel formulations (examples of sulphuric acid, fumed silica and colloidal silica) compared to a standard acid elec- trolyte whereas Table 2 shows the values of the Tafel slope, ... Journal of Power Sources 162 (2006) 851–863 Studies on electrolyte formulations to improve life of lead acid batteries working under partial state of charge conditions J.C.
Ngày tải lên: 05/07/2014, 20:21
Báo cáo vật lý: "Synthesis, Characterisation and Catalytic Performance of Porous Nafion Resin/Silica Nanocomposites for Esterification of Lauric Acid and Methanol" potx
... pores because of. .. nature of the acid greatly influenced the activity of the catalyst The esterification reaction was more rapid with lauric acid (C12) than with stearic acid (C18) ... Influence of the molar ratio of methanol :lauric acid, R, on the esterification reaction Molar ratio of methanol :lauric acid, R Conversion... nanocomposite and time = 24 h Maximum acid ... (▼) of methyl laurate from the esterification of lauric acid and methanol as a function of (a) Nafion resin and (b) Nafion resin load in the NR/S nanocomposite. Nafio resin (wt%) Amount of
Ngày tải lên: 07/08/2014, 14:20
Báo cáo khoa học: " Effects of liming and gypsum regimes on chemical characteristics of an acid forest soil and its leachates" ppsx
... field profile was reconstituted in containers of rigid polyethylene (30 cm deep and 20 cm diameter) using 6 cm of A1 and 15 cm of (B) with bulk densities of 0.65 ... contributes to the acidification of the soil leachate and release of Al and K by weathering An exchange of Al by K may have occurred at low pH due to the specific adsorption of K onto ... of aluminum and calcium in the soil solution of acid soils on root elongation of glycine max cv Forrest Aust J Agri Res 39, 319-338 Brunner W, Blaser P (1989) Mineralization of
Ngày tải lên: 08/08/2014, 18:21
Báo cáo y học: "Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus" doc
... characterized the role of the IFNAR2 chain of the type I IFN (IFN-I) receptor in the targeting of nucleic acid- associated autoantigens and in B-cell expression of the nucleic acid- sensing Toll-like ... development of proteinuria in the mice, a measure of kidney disease, was therefore assessed. Over the course of 12 months, 5 of 10 (50%) pristane-treated WT mice developed proteinuria, whereas none of ... Autoantibody profiling of pristane-treated mice using autoantigen microarraysAutoantibody profiling of pristane-treated mice using autoantigen microarrays. Individual arrays composed of over 50
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesi" pps
... profiling the binding of active RAR isoforms in both the presence and absence of retinoid signaling, we observe that only a small subset of sites are constitutively bound. An addi- tional set of ... activated receptor; RA: retinoic acid; RAR: retinoic acid receptor; RARE: retinoic acid response element;... Ligand-dependent dynamics of retinoic acid receptor binding during ... differentiation of embryonic stem cells into motor neurons Cell 2002, 110:385-397 Balmer JE, Blomhoff R: A robust characterization of retinoic acid response elements based on a comparison of sites...
Ngày tải lên: 09/08/2014, 22:23
Báo cáo y học: "Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines" ppsx
... Page 1 of 18 (page number not for citation purposes) Journal of Inflammation Open Access Research Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins ... ability of TMP to interfere with the binding of Sp1 to DNA. TMP has been found to arrest the growth of certain tumor-derived cell lines in the G 2 phase of the cell cycle by inhibiting production of ... activ- ity of COX-2 was inhibited by 40–50% in the presence of 25 μM TMP while inhibition of COX-2 activity was essen- tially complete in the presence 50 μM TMP. The level of inhibition of COX-2
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: "The significance of glucose, insulin and potassium for immunology and oncology: a new model of immunity" ppt
... of infection. That suggestion is based on a new model of immunity that describes the effect of hormones on lymphocytes. We hypothesized that the application of glucose, insulin, thyroid and potassium ... effect of a thyroxine, glucose, insulin, and potassium (TGIK) combination was studied in a series of controlled experiments in murine models of tumor progression to assess the biologic activity of ... effect of insulin on lymphocytes becomes significant when seen as part of the profile of events when a body is challenged by infection. More than twenty years ago Bei- sel mapped the response of
Ngày tải lên: 11/08/2014, 10:23
báo cáo khoa học: " Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach" pptx
... Red Orange Residue (FatA vs FatB) S/A vs G (96) P vs T/S (209) Y/D vs E (249) D vs E (259) A vs M (74) T vs V/L (110) T vs M/R (141) E/Q vs S (174) Q/R vs W (221) Q vs K (86) Number given is ... analysis Fatty acid content of the medium from various cell cultures was determined by the production and measurement of fatty acid methyl esters Briefly, 22 μl of glacial acetic acid and ml of 1:1 (vol:vol) ... listed as determined by GCMS of FAMEs (B) Quantity of each fatty acid present in each of the variants Error bars represent the standard error for five independent clones of each variant group, the
Ngày tải lên: 12/08/2014, 05:20
Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx
... production, indices of degree of inflammation, are hallmarks of asthma Goblet cell metaplasia and mucus production were determined by PAS staining of histological sections of lung tissues from ... and challenge of wild type, which supports the notion of LPA as a chemotaxis factor of inflammatory cells in allergic inflammation The source of LPA accumulation and mechanism(s) of LPA generation ... and mediates multiple cellular responses to lysophosphatidic acid Proceedings of the National Academy of Sciences of the United States of America 1998, 95(11):6151-6156 Im DS, Heise CE, Harding
Ngày tải lên: 12/08/2014, 14:20
Báo cáo khoa học: " Science review: Carnitine in the treatment of valproic acid-induced toxicity – what is the evidence" pot
... treatment of migraine headache. VPA is a branched chain carboxylic acid (2-propylpentanoic acid or di-n-propylacetic acid) , with a chemical structure very similar to that of short chain fatty acids ... use of carnitine supplementation in the management of VHT, VHE and acute VPA poisoning. The potential benefit of carnitine supplementation in the prevention of VHT of VHE in the setting of chronic ... the ratio of acyl-CoA to free CoA in the mitochondria [32]. Transport of long-chain fatty acids Carnitine facilitates transport of long-chain fatty acids from the cytosol compartment of the muscle
Ngày tải lên: 12/08/2014, 22:22
Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets" ppt
... GLY,, ,, equaation 3 () Simulation of the effect of inhibition of both ICL1 and ICL2 by 3-nitropropionate (3-NP)Figure 5 Simulation of the effect of inhibition of both ICL1 and ICL2 by 3-nitropropionate ... expression profile could be connected to the metabolic profile via simulation of the pathway under study. In E. coli, the in vivo kinetic parameters required for estimating the metabolic profile of most ... expression profile can be connected with the metabolic profile via simulation of the pathway under study. In this communication, we describe the construction of a kinetic model of the TCA cycle
Ngày tải lên: 13/08/2014, 23:20
Báo cáo y học: "The AID/APOBEC family of nucleic acid mutators" pot
... in lipid transport. A detailed understanding of the biological roles of the family is still some way off, however, and the functions of some members of the family are completely unknown. Given ... identification of AID that a number of genes were mutated as a byproduct of antibody diversification processes and that mutations and aberrations in some of these genes were specific to cancers of the ... The rise of the AID/APOBEC gene family appears to have been concurrent with the appearance of the vertebrate lineage and the evolution of adaptive immunity and AID is thought to be one of the ancestral
Ngày tải lên: 14/08/2014, 08:21
Báo cáo y học: " The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution" pptx
... the evolution of amino acid biosynthesis in diverse species. Results and discussion Biological distribution of amino acid biosynthetic networks The origins and evolution of amino acid biosynthesis ... an event of retention of duplicated genes as groups, instead of single entities. The retention of groups of dupli- cates has been suggested to play a significant role in the evo- lution of metabolism ... acid biosynthesis universal branches show a maximum of around 45% of reactions (y- axis) in 70% of sampled genomes (x-axis) when all MetaCyc enzymes have a maximum of 24% of
Ngày tải lên: 14/08/2014, 08:21