tissue engineering of organs

... for the degree of Doctor of Philosophy in the Division of Bioengineering at the National University of Singapore under the supervision of Associate Professor Toh Siew Lok and Professor James Goh ... potential of regenerating functional tissues of autologous origin [1, 3, 11, 20-22] For the purpose of tissue engineering ligament tissues, the goal will be to generate neotissue from autologous cells ... lack of vasculature at the tissue, causing inadequate supply of essential reparative factors or agents should the tissue be torn [13] Consequently, the disruption of the ACL remains one of the...

Ngày tải lên: 10/09/2015, 15:52

... 2.2.1 Bone tissue engineering 13 2.2.2 Skin tissue engineering 15 v 2.2.3 Genito-urinary tissue engineering 16 2.2.4 Limitations of current status of tissue engineering ... importance of presence of an intact vasculature is understood recently in the success of genitourinary tissue engineering 2.2.4 Limitations of current status of tissue engineering There are a lot of ... injured tissue stimulates the body’s own cells to promote local tissue repair 1.2.1 Importance of vascularization in tissue engineering Several tissues have shown encouraging results for tissue engineering, ...

Ngày tải lên: 14/09/2015, 08:48

... tissue engineering strategies, as detailed in the next section 1.3 Tissue engineering as a potential regenerative strategy Tissue engineering is the application of principles and methods of engineering ... Choice of scaffolds for periodontal tissue engineering As discussed in Chapter 1, limitations in current therapeutic procedures open up new revenues for tissue engineering The term tissue engineering ... process of maturation 6.4 Discussion 114 117 6.4.1 Cytocompatibility of alkali-treated PCL membranes 117 6.4.2 Evaluation of hPDLF-membrane constructs 119 CHAPTER TISSUE ENGINEERING OF A hPDLF...

Ngày tải lên: 14/09/2015, 12:07

... degree of Doctorate of Philosophy in the Graduate Program of Bioengineering (NUS Graduate School for Integrative Sciences and Engineering) at the National University of Singapore No part of this ... DW Tissue engineering of an osteochondral transplant by using a cell / scaffold construct Poster presentation Joint meeting of the Tissue Engineering Society International and the European Tissue ... 1.2 Tissue Engineering The advent of tissue engineering has generated much excitement in medicine and science, attracting the attention of clinicians, researchers and even the general public Tissue...

Ngày tải lên: 14/09/2015, 14:07

... advanced courses of cell culture and tissue engineering To limit the volume of the book, we selected a limited number of cells and tissues that are representative of the state of the art in the ... limited number of interesting viii Preface and distinctly different tissue engineering applications, will be of interest for the further growth of the exciting field of tissue engineering We also ... CULTURE OF CELLS FOR TISSUE ENGINEERING Culture of Specialized Cells Series Editor R Ian Freshney CULTURE OF CELLS FOR TISSUE ENGINEERING Gordana Vunjak-Novakovic...

Ngày tải lên: 22/03/2014, 15:20

... the field of tissue engineering as the result of Page 10 of 16 (page number not for citation purposes) Journal of NeuroEngineering and Rehabilitation 2007, 4:15 advances made in areas of cell biology ... growth of corticospinal tract fibers into the implant and led to significant recovery of function of rats under investigation despite absence of regrowth of these fibers into the host tissue ... for review) The core approach of tissue engineering consists of provision of an interactive environment between cells, scaffolds and bioactive molecules to promote tissue repair To achieve this...

Ngày tải lên: 19/06/2014, 10:20

... Tissue Engineering II Basics of Tissue Engineering and Tissue Applications Volume Editors: Lee, K., Kaplan, D Vol 103, 2007 Tissue Engineering I Scaffold Systems for Tissue Engineering Volume Editors: ... on tissue engineering in the series Advances in Biochemical Engineering and Biotechnology This volume reflects the emergence of tissue engineering as a core discipline of modern biomedical engineering, ... appreciation of cellular function in vivo Knowledge of the tissue microenvironment and communication with other organs is essential, since the key questions of tissue engineering are: how can tissue...

Ngày tải lên: 27/06/2014, 10:20

... the advent of human embryonic stem cells has brought forth new sources of cells that may be useful in a variety of areas of tissue engineering This third edition of Principles of Tissue Engineering ... aspects of gene therapy as well as intracellular delivery of genes and drugs to cells and tissues are discussed Various important engineered tissues, including breast -tissue engineering, tissues of ... are examined In sum, the 86 chapters of this third edition of Principles of Tissue Engineering examine the important advances in the burgeoning field of tissue engineering This volume will be very...

Ngày tải lên: 29/06/2014, 09:21

... of insulin, but insulin production subsequently fell to undetectable levels as a result of the loss of expression of key insulin gene transcription factors A combination of the introduction of ... consideration of patch size, in which a patch is described as the number of cells of a single genotype within an area of tissue that is derived either from a single clone or from the coalescence of multiple ... considered an epidemic of the 21st century Blood glucose homeostasis is controlled by endocrine beta-cells, located in the islets of Langerhans in Principles of Tissue Engineering, 3rd Edition...

Ngày tải lên: 29/06/2014, 09:21

... craniofacial remodeling and other therapeutic procedures of skeletal regeneration To be considered for tissue engineering applications, the architecture of the scaffold should ideally mimic that of ... repair of osteochondral lesions, such a complex construct would have the advantage of promoting ingrowth of native bone tissue, while optimizing the transition zone to prevent delamination of tissues ... studies to assess repair of osteochondral lesions The promise of mesenchymal progenitor or stem cells Although the use of chondrocytes for applications of cartilage tissue engineering is prevalent,...

Ngày tải lên: 09/08/2014, 01:23

... curve from the acquisition of fragmented, but detailed information, to the ability to critically overview over the complex field of tissue engineering is a vision of Head & Face Medicine We hope ... the head and neck area By publishing the various aspects of, for example tissue engineering in one journal the reader can gain an overview of the whole field Research papers are intended to provide ... scientific branches To overcome this problem, the demanding, complex and interdisciplinary aspects of tissue engineering has to be approached from new ways We have conceptualised Head & Face Medicine...

Ngày tải lên: 11/08/2014, 23:22

... by the density of the condensation [19] Technical aspects of the micromass technology In the context of tissue engineering, ex vivo tissue generation may be optimised by the use of cell re-aggregation ... suggested that after in vivo transfer of such reaggregates, tissue healing is improved in sense of a repair tissue that mimics the features of the original skeletal tissue [1,24] Especially preclinical ... as most promising in skeletal tissue engineering by some researchers A recently elaborated approach in extracorporal tissue engineering is therefore the avoidance of non-degradable scaffolds,...

Ngày tải lên: 11/08/2014, 23:22

... bone tissue engineering approches Moreover, there are some reports using totipotent embryonic stem cells for tissue engineering of bone [49,50] Another group of cells, which is a special focus of ... repair of cartilage is critically dependent on the extent of tissue destruction Based on the extent of tissue damage, articular defects can be classified into three types: - mechanical disruption of ... review of the literature Part Int J Oral Maxillofac Surg 2005, 34:107-113 Dimitroulis T: The role of surgery in the management of disorders of the Temporomandibular Joint: a critical review of the...

Ngày tải lên: 12/08/2014, 00:20

... 1.4 Bone Tissue Engineering 1.4.1 Limitations in Bone Tissue Engineering 1.5 Importance of Vascularisation 1.5.1 Vascularisation in Bone Tissue Engineering ... Choolani, SH Teoh The importance of continuous hypoxic exposure for the culture of human fetal mesenchymal stem cells in bone tissue engineering applications 3rd Tissue Engineering and Regenerative ... Tissue Engineering Strategies: Focus on Coculture Systems Journal of Tissue Engineering and Regenerative Medicine 2012 Nov 19 doi: 10.1002/term.1617 Yuchun Liu and Swee-Hin Teoh Development of...

Ngày tải lên: 09/09/2015, 10:16

... branch of this work Special thanks go to my lovely friends and wonderful colleagues from the Tissue Modulation Laboratory, the Department of Biomedical Engineering and the NUS Tissue Engineering ... 28 2.4 Potential applications of PHIs in tissue engineering 31 Chapter Incorporation of a PHI into Scaffolds: A Vascularization Strategy for Tissue Engineering Applications 33 3.1 Introduction ... regeneration and tissue engineering 113 6.3 Conclusions 114 References 115 vi Summary Clinical applications of tissue engineering are constrained by the ability of the implanted...

Ngày tải lên: 09/09/2015, 11:11

... function and patency of the vascular grafts, the concept of vascular tissue engineering (VTE) that involves the principles of engineering and life sciences in the development of vascular substitutes ... RELEASE SYSTEM OF NITRIC OXIDE FOR CARDIOVASCULAR TISSUE ENGINEERING APPLICATION ZHANG QINYUAN B.Eng (Hons), National University of Singapore A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... viii - List of Figures Figure 1-1 Schematic illustration of the proposed work Figure 2-1 Anatomy of the coronary arteries of the heart [41]……… 10 Figure 2-2 Layered structure of a coronary...

Ngày tải lên: 10/09/2015, 09:08

... PERFORMANCE OF EXTRUSION-BASED ADDITIVE MANUFACTURED SCAFFOLDS FOR BONE TISSUE ENGINEERING MUHAMMAD TARIK ARAFAT (B.Sc in Mechanical Engineering, BUET) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... basis of life sciences and medicine with the methods of engineering The purpose of TE is to develop a biological substitute that can replace, repair and/or improve tissue function Scaffold-based tissue ... of the research 05 1.5 Structure of thesis 06 Chapter Literature review 08 1.1 Background 08 2.2 Background of scaffold technology 09 2.3 Design of scaffolds 11 2.3.1 Porosity and pore size of...

Ngày tải lên: 10/09/2015, 15:51

... number of patients needing an organ transplant far exceeds the supply of donor organs and tissues available This severe organ shortage led to the inception of Tissue Engineering Tissue Engineering ... proteins and new tissue formation Hence, the properties of the scaffolding materials are crucial in determining the success of many tissue engineering applications The general tissue engineering paradigm ... Chapter 1: Introduction The design of biomaterials is important in the field of tissue engineering and regenerative medicine Since the development of tissue engineering scaffolds, there is a need...

Ngày tải lên: 11/09/2015, 09:10

... conducted under the control of the supervisory unit of the software The system has successfully demonstrated fully automated construction of a tissue engineering scaffold composing of 50 microparts whose ... attentions since its advent in the 1980s Most tissue engineering strategies for creating functional replacement tissues of organs rely on the application of an engineered extracellular matrix or scaffold, ... cells, and guide the tissue regeneration, especially during the degrading period of the scaffold [4] Methods for the fabrication of tissue engineering scaffolds include nanofiber selfassembly,...

Ngày tải lên: 11/09/2015, 09:17