thymoquinone as an apoptosis inducing agent for follicular lymphoma

... permeability which releases cytochrome c that binds to Apaf-1 in the cytosol, and this complex activates caspase-9 [10] Caspases-8 and -9 are initiator caspase enzymes After an initiator caspase is cleaved ... ligands, cross-link, and provide a binding site for an adapter protein with a death domain (FADD) FADD binds an inactive form of caspase-8 and -10 in humans [8] Multiple procaspase-8 molecules are ... shown that ApoG2 can activate the initiator caspase-9, and the effector caspase-3, and induce caspase cleavage at nanomolar concentrations In addition, ApoG2 activates PARP and AIF which have...

Ngày tải lên: 10/08/2014, 22:20

... increases in the probability of success Performance management experts cite two well-known adages: “When performance is measured, performance improves,” and “When performance is measured and reported, ... support and research assistance) However, once you’re a trained agent, the 50/50 arrangement doesn’t change as drastically as it can in the residential arena ߜ You construct your own database Commercial ... • As you earn more, your commission splits increase, as well In your early years as an agent, expect an agent/ company commission split arrangement somewhere in the neighborhood of 50/50, based...

Ngày tải lên: 27/03/2014, 01:27

... concentration and hence enhance the cytotoxicity of anticancer agents Meanwhile, it is observed that the inhibition effect for drug-resistant K562/AO2 cancer cells was relatively significant than that for ... into the nanocomposites and stored in the dark at 4°C for more than 12 h to form the PLA/Au nanocomposites conjugated with dauborubicin Atomic Force Microscopy Study In a relevant atomic force microscopy ... color did not change Ultrapure water was added in which the final volume was 100 mL and the diameter of Au nanoparticle was about 15 nm The other reagents were analytical grade For the following...

Ngày tải lên: 21/06/2014, 08:20

... decreasing noise variance) It can also be seen that the gain is indeed higher than for reasonable cases: it does not seem reasonable to allow the interference, which is due to changes in the channel, ... significantly above the noise as it would unacceptably decrease the performance So this shows that for a given bit rate usage, a well- EVALUATION OF PERFORMANCE Relation between estimation variance and ... able to perform this coarse estimation However, for reasons explained later, it might not be as efficient in the initialization phase The precoder can then be computed and transmission can start...

Ngày tải lên: 22/06/2014, 23:20

... lesions mean tumor ADC values decreased significantly A slight increase in TV accompanied the decrease in ADC (compare Figures and 6) How may this decrease in mean tumor ADC and increase in TV ... design and coordination of the study, data acquisition and analysis and drafted the manuscript MZ and DL participated in data acquisition and analysis as well as literature review MP, FF and JR ... colorectal liver metastases was 62.2 cm3 (range: 0.5 - 786.2 cm3) while mean tumor ADC was 1.75 × 10-3mm2s-1 (range: 0.65 3.22 × 10 -3 mm s -1 ) In non-treated lesions mean TV was 50.0 cm (range: 2.3 -...

Ngày tải lên: 09/08/2014, 09:20

... concern for resistance development Also, employment of antimicrobial agents for uses other than therapeutic reasons is hastening the emergence of antimicrobial resistance Resistance can appear ... ACKNOWLEDGEMENT First and foremost, I would like to thank both my supervisors, Dr Yen Wah Tong and Dr Yi Yan Yang, for their constant support and encouragement even during the tough phases of my Master’s program ... concentration assay was performed against pathogenic organisms like Staphylococcus aureus and Candida albicans The cytotoxicity of the two amphiphilic peptides was also tested by means of the haemolysis assay...

Ngày tải lên: 04/10/2015, 15:58

Ngày tải lên: 08/08/2012, 17:20

... comfort area defined by ASHRAE (Figure 30) As well as the other two cases, cooling is performed as a consequence of an increase in the humidity level, though in this case it is more effective for ... economic solution than installing an only system In 1986, Anderson tested an air conditioning system using a direct and an indirect evaporative cooler combined with an expansion battery, and compared ... advantages and disadvantages and indicating and establishing some basis about their design, was developed by Dr John R Watt, who worked for the Research Laboratory of the U.S Navy He built and...

Ngày tải lên: 05/09/2013, 16:10

... resulting proteins were assessed by SDS, nondenaturing and transverse urea gradient PAGE, and activity was assessed against tPA [6] Complex formation assays Wild-type and Ser52Arg neuroserpin ... neuroserpin and tPA Ser52Arg neuroserpin is inactive as an inhibitor of tPA Wild-type neuroserpin forms complexes with tPA with a stoichiometry of inhibition of and an association rate constant (kass) ... polymer formation and Tm [19], and thus it was unusual to find that the Tm was higher than that of the less severe Ser49Pro neuroserpin The overall structure of Ser52Arg neuroserpin was therefore assessed...

Ngày tải lên: 07/03/2014, 16:20

... Glaubitz and Andreas Engel for valuable discussions, and we thank Walter Rosenthal for the cDNA of human ETB We further ´ thank Robert Tampe and Katrin Schulze for their help with SPR analysis ... Switzerland), and 0.1% (w ⁄ v) Triton X-100 Horseradish peroxidase-conjugated T7-tag antibody (Merck Biosciences) was diluted : 5000 and incubated for h with the membrane Washed blots were analyzed ... Homo-oligomerization of rhodopsin-like GPCRs is an increasingly recognized mechanism, and might represent an important platform for the modulation of GPCR activities such as ligand binding, signaling or trafficking...

Ngày tải lên: 16/03/2014, 10:20

... or mouse anti-Hsp70 Ig (Sigma) at room temperature for h After a wash with TTBS, the membrane was further incubated with horseradish peroxidase-conjugated antirabbit or anti-mouse IgG (Santa Cruz ... 37 °C for h and further incubated for h at 37 °C The levels of Hsp105a and Hsp70 significantly increased in cells treated with 45 and 60 mM SA However, the levels remained unchanged or decreased, ... nitrocellulose membranes, and immunostained using antiHsp105 or anti-Hsp70 Ig (upper panels) Bands were quantified by densitometry, and relative levels of Hsp105a or Hsp70 are shown as ratios to that...

Ngày tải lên: 17/03/2014, 10:20

... care, and health care, and other services other services Local Local Transportation Transportation Souvenirs, Souvenirs, Duty Free Duty Free Banks, Banks, Foreign Foreign Exchange Exchange Government ... 35,000 Kuwait Greece Italy 30,000 Bahrain Hong Kong Iceland Switzerland Australia Denmark Ireland Canada Finland France Sweden Taiwan Japan Germany Spain Israel Slovenia Portugal Cyprus Czech Republic ... Economic cities have an unclear relation to clusters and the surrounding regional economy Eastern Province Makkah AlBaha Asir Najran Jizan Jizan Economic City • They ask for private sector action...

Ngày tải lên: 23/03/2014, 19:20

... reorganization The EspB (or EarB) gene product was first identified as an important factor in EPEC attachment [14] and later characterized as a T3SS-secreted protein required for signal transduction ... Acknowledgements This work was supported by Grants-in-Aid for the Global COE program A08 from the MEXT, Japan, and Grant-in-Aid for Young Scientists (B) from Japan Society for the Promotion of Science ... 6, 313–318 Batchelor M, Prasannan S, Daniell S, Reece S, Connerton I, Bloomberg G, Dougan G, Frankel G & Matthews S (2000) Structural basis for recognition of the translocated intimin receptor...

Ngày tải lên: 29/03/2014, 09:20

... selectivity can be increased through ligand dimerization or by screening for conformational-sensitive targeting agents such as affibodies, avimers and nanobodies, as well as intact antibodies and their fragments ... reduced toxicity and enhanced anti-metastatic effects in two different mouse tumour models, emphasizing the advantages of a mechanism-based design for targeted nanocarriers84 Organic nanoparticles ... Box Rational design of nanocarriers for cancer therapy Nanocarriers can offer many advantages over free drugs They: For rapid and effective clinical translation, the nanocarrier should: • • •...

Ngày tải lên: 28/05/2014, 15:07

... APC anti-CD45 (BD Pharmingen, San Diego, CA) and PEmouse anti-human CD144 antibody (eBioscience, San Diego, CA) CD52 expression was confirmed with using FITC-anti-human CD52 (GeneTex San Antonio, ... breast, gastric, pancreatic, and lung carcinomas[20] Consistent with this finding, we observed VLC in http://www.translational-medicine.com/content/7/1/49 melanoma, breast, lung, and ovarian cancer ... tissue using an anti-CD52 antibody (1:100 GeneTex, Inc) and anti-VE-Cadherin FITC antibody (1:200 Bender MedSystems) Immunohistochemistry was performed on murine tumors with anti-CD31 antibody (1:800...

Ngày tải lên: 18/06/2014, 15:20

... placement This participant had an awkward position in his wheelchair (See Figure 3(b)) which forced us to position the thermal camera at an angle and distance from the participant that was not consistent ... Kiguchi M, Kanazawa T: A communication means for totally locked-in ALS patients based on changes in cerebral blood volume measured with near-infrared light IEICE Transactions on Information and Systems, ... face region If one can voluntary control mouth open and close action, sip and puff technology, EMG based switches, and computer vision based switches can also be used The advantage of the proposed...

Ngày tải lên: 19/06/2014, 08:20

... the data and wrote the manuscript; XL performed cell culture, western blot analysis, ELISA assay and NO measurements; RL and LS helped in performing NO measurements All authors read and approved ... disease: different molecular targets and potential therapeutic agents including curcumin Curr Opin Pharmacol 2009, 9:434-444 Zhang D, Liu R, Sun L, Huang C, Wang C, Zhang DM, Zhang TT, Du GH: Anti-inflammatory ... JD: Mechanisms of Disease: astrocytes in neurodegenerative disease Nat Clin Pract Neurol 2006, 2:679-689 Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J:...

Ngày tải lên: 19/06/2014, 22:20

... GHQ-12 and MBI-EE was associated with participation in the coaching program and this was accompanied by stronger effects for GHQ-12 than for MBI-EE The regression analysis applied to model and model ... regression analysis at t-1 was used as additional covariate The last analysis was focused on the association between health factors and participation This result has to be taken into account for the ... decreased Thus, for reasons of stability and efficiency there are good reasons for disregarding other covariates and suppressor effects and to rely primarily on intention as the main variable for...

Ngày tải lên: 20/06/2014, 00:20

... benefit and the aim of our study was to determine whether IL-6 was such a marker An animal model using Sprague Dawley rats was used for this study Many studies have utilized rats as a model for fat ... litter The animals were induced using inhalational halothane anesthesia with a mixture of oxygen Depth of anesthesia was assessed by pedal reflex After each animal was anaesthetized, it was placed ... drill was advanced well into the medullary canal A mm Kirchner wire (2.5 cm long) was then advanced (Figure 1) until it was flush with the joint surface The wound was closed in the same manner as...

Ngày tải lên: 20/06/2014, 01:20