... metabo-lism ofthe allergen was altered as a result of the in ammation inthe lungs of sensitized animals.Up to now there are few data available on the fate of an allergen after inhalation. In this ... to the allerge-nicity of HDM by favouring a pro -in ammatory envi-ronment inthe airways. Inthe case of most allergensthough, including other dust mite allergens such asDer p 2, detailed investigations ... we could track the fate of an inhaled aller-gen in vivo. Based upon our findings, we conclude that thein ammatorystate ofthe lung in uences the rate of metabolism and clearance of Der p 2. Thus,...
... recorded the acidity inthe rain water in April, May yearly. No using of rain water in early rainy season is recommended as way to treat the air-dust and other pollutants deposited in the house-roofs ... inthe coastal lands ofthe delta. Saline encroachment effects almost half ofthe MD. The salinity is caused by sea water intrusion in open mouths and estuaries. The phenomenon of salinity ... bars inthe sea in front ofthe estuaries. Otherwise, in early rainy season, nearly 1,6 million hectares ofthe delta are infected by the acidity water due to the washing out aluminium and iron...
... political economies of cheap food increases, outpost agriculture is finding a renewed niche in emerging indigenous movements against the vulnerabilities embedded within participation inthe cheap food ... high-frequency of forest fires collects within the basin ofthe Alaskan interior, and during 8 Whether real or perceived, the coldness of river water is mentioned often in BIA reports from schoolteachers ... vulnerability as they manifest inthe past and present of Alaska Native foodways. The first paper, ‘Outpost Gardening in Interior Alaska’ examines the historical dimensions of cropping by Athabascan...
... 1995). In the past few years, there has beenan increase inthe reported inci-dence of torture — cruelty by the husband and the husband’s rela-tives. The reported number of incidents of torture increased ... compo-nents ofthe spread of HIV. Sur-veys in some areas show 5 to 10percent of truck drivers in the country are HIV infected (AIDSAnalysis, 1996).Despite the alarming growth of the epidemic, ... Only7 ofthe 15 major states in Indiahave higher male infant mortality(Figure 6). Inthe remaining states,equal or higher female ratessuggest that girls suffer greaterneglect.One ofthe most...
... graph obtained from G by contracting the edges in E1and delet-ing the edges in E2. Let H be the graph obtained from Zdby contracting the edges in K1and deleting the edges in K2. By ... U(W; x, y) the intersection of U(W) with the event that the path connecting x, y inthe USFis edge-disjoint from the oriented USF paths connecting the vertices in V :=W \{x, y} to in nity. By ... ΥR, the paths in F to ΥRfrom the vertices in the complement of ΥR∪ B(x, R) are conditionally independent of γR. Therefore the conditional distribution of ζRgiven ΥRis just the harmonic...
... insulinreceptor-interacting region (PIR) [6] and inhibits the tyrosine kinase activity ofthe IR [7]. On the basis of the crystal structure ofthe tyrosine kinase domain of the IR in complex with the PIR ⁄ BPS domain ... residues of the IR kinase loop, which help position the PIR–BPS andincrease binding affinity [8]. Although the interaction of Grb14 with the IR is probably themajor determi-nant ofthe insulin-induced ... question, we first assessed the ability of insulin administered in vivo to increase the level of RCAM-lysozyme in cell fractions, and thenassayed the fractions of insulin-injected rats for Grb14,IR...
... cells were incubated for 24 heither inthe absence or in prese nce of FSH, dbcAMP,cholera toxin or bFGF, either in combination with FSH ordbcAMP or cholera toxin and bFGF.Extraction of total ... [5154]. Inhibitory transcription factorsthat bind to AP-1 or FIN-1 o r that inactive b inding ortransactivation capacity of, for example, FIN-1 and USF-1,could explain activation or inhibition of ... partners of bFGF (Eur. J. Biochem. 269) 509 The bFGF binding requires speciđc motifs on highlysulfated HS chains. Sodium chlorate, in inducing structuralalteration of HS chains, prevents the bFGF...
... results in blocking ofthe binding ofthe SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For active n-Src in which the C-tail tyrosine was ... demonstrated that intra-domain interactions betweenSrc family kinases (SFKs), stabilized by binding ofthe phosphorylatedC-terminus to the SH2 domain and ⁄ or binding ofthe SH2 kinase linker to the SH3 ... studies of inactive andactive Src, the SH2 and SH3 domains are believed toform a ‘regulatory apparatus’. Binding ofthe phos-phorylated C-terminus to the SH2 domain and ⁄ orbinding ofthe SH2-kinase...
... ∞ THE FINANCIAL CRISISINQUIRY REPORTFINAL REPORT OFTHE NATIONAL COMMISSION ON THE CAUSES OFTHE FINANCIAL AND ECONOMIC CRISIS INTHE UNITED STATESOFFICIAL GOVERNMENT EDITION THE FINANCIAL ... Oce ofthe Comptroller ofthe Cur-rency and the Oce of Thrift Supervision, caught up in turf wars, preempted stateregulators from reining in abuses. CONCLUSIONS OFTHE FINANCIAL CRISIS INQUIRY ... in action being taken. It was kind of quaint.” In , when Cleveland was looking for help from the federal government, othercities around the country were doing the same. John Taylor, the...
... titration. Inthe fits, the protein concentrationwas left free, to serve as an indicator of stoichiometry. In the case of 1IR, the fit resulted in a binding stoichi-ometry of 2 : 1, i.e. dimer binding. ... S1),indicating that it is static in nature. We do not havean unequivocal interpretation ofthe origin ofthe staticquenching. However, judging from the binding stoichi-ometry together with the ... available, indicating secondary struc-tural changes inthe linker connecting the dimerizationand DNA-binding domains, and rearrangement of the relative orientation ofthe two domains [7,9]. The con-formational...
... However, the amino acidsforming the catalytically active center ofthe A-chains of the MLp toxins are fully conserved and retained in corresponding positions, as inthe A-chain of ricin [27] ... B-chain andposition ofthe carbohydrate-binding sites areindicated. Each B-chain domain is composed of three homologous subdomains a, b, c andlinking k subdomain which joins the B-chainto the ... Gln256 ofthe ricin B-chain in the second sugar binding site [28]. The exceptions are the replacement of Trp38 fi Ser inthe ML2p B-chain andTyr252 fi Phe inthe ML3p B-chain (Fig. 2). The highly...
... of all classes, the hatred ofthe Commons, the defection of the Lords, the alarm ofthe Church, and the wavering loyalty ofthe army.William, however, was already informed of these facts, and ... dispute being the succession to the crown of Spain, England's feelings inthe matterbeing further imbittered by the recognition by Louis XIV ofthe Pretender as King of England. Therefore,although ... Had these rights notbeen renounced Philip would have had the best claim to the Spanish throne, the next of kin after him beingCharles of Austria.During the later days ofthe King of Spain all...
... interest in improving working and living conditions inthe shipping industry. The Office’s programme on decent work in the maritime industry played a major role in improving the promotion of ... relating to the health of seafarers, often through the Joint ILO/WHO Committee on the Health of Seafarers. Since the Committee’s last meeting in 1993, 3 the two Organizations held, in 1997, the ... programme. The Government ofthe Republic of Korea has continued to support the ILO maritime programme by seconding staff for a period ofthree years. 47. The following are examples ofthe kinds of...
... is the shift ofthe pH optimumfrom near neutral inthe wild-type to pH 9.2 inthe R389Amutant, which is in accord with an increase inthe pK of Y229 if the stabilizing R389 residue is lacking. ... coordination to the otherligands ofthe binding site (center I), but the bindingbecomes much weaker as emphasized by the dramaticincrease ofthe Na+ion concentration required to saturate the enzyme. ... carboxybiotin, or slow Na+move-ment through the channel to its binding site.Following the decarboxylation of carboxybiotin in the reaction cycle (Fig. 4B,C), the biotin prosthetic group leavesthe...