this is the stu that stars are made of

... perihelion is called the major axis of the ellipse and half that distance, the semi-major axis, gives the size of the ellipse It is approximately the average distance between the planet and the Sun, ... was that the distance of the Sun from Earth is much greater than the distance of the Moon so that the angle θ is only a little less than 90◦ This meant that, since small differences from 90◦ made ... Aristarchus tried to measure the angle θ shown in the figure This angle would not give the actual distances of the Sun and the Moon from Earth but it would give the ratio of the distances of the...

Ngày tải lên: 06/07/2014, 15:31

... perihelion is called the major axis of the ellipse and half that distance, the semi-major axis, gives the size of the ellipse It is approximately the average distance between the planet and the Sun, ... was that the distance of the Sun from Earth is much greater than the distance of the Moon so that the angle θ is only a little less than 90◦ This meant that, since small differences from 90◦ made ... Aristarchus tried to measure the angle θ shown in the figure This angle would not give the actual distances of the Sun and the Moon from Earth but it would give the ratio of the distances of the...

Ngày tải lên: 06/07/2014, 15:34

... characteristics are presented as mean (SD) or as otherwise specified Results The mean age of the 176 women included in the analysis was 52.3 (6.6) years Other participant characteristics are listed ... 7.04 0.009 The principal finding of this study was that in women at midlife, the level of hsCRP in serum made a significant independent contribution to the variation in the volume of total tibial ... analysis indicates that the impact of hsCRP is not purely mediated through BMI While increased hsCRP has been reported in the early phases of OA [22], this study provides the first evidence of an...

Ngày tải lên: 09/08/2014, 10:23

... years of experience in the area of HIV-1 replication fitness PLS has published key papers in this area that are cited in this manuscript HBC is a post doctoral associate and is working in the area ... selection of L74V is mainly associated with the use of didanosine This study showed that the selection of L74V and L74I is controlled by two independent pathways and it is speculated that the resistance ... DNA synthesis at low dNTP concentrations [36] RT codons 65 and 74 are parts of the highly flexible b3-b4 linkage group in the finger subdomain of the 66 kDa subunit of HIV RT [37] Analysis of HIV-1...

Ngày tải lên: 11/08/2014, 21:21

... each study, the OR is plotted on a logarithmic scale against the precision (the reciprocal of the SE) Discussion The GSTP1 gene, which encodes the GST π isoenzyme, is the most important form in the ... by the DSTPLAN4.2 software with MAF in controls as the frequency of risk factor, OR was selected 1.5 and 2.0 as the relative risk and а=0.05 as the significance † Table Characteristics of published ... homogenous, the fixed-effects model was then used; otherwise, the random-effects model was more appropriate We also computed the power of the selected studies by using the DSTPLAN4.2 software, in...

Ngày tải lên: 25/10/2012, 11:40

... to the model of action of TPO with its receptor on target cells It is well established that serum levels of TPO are regulated by the binding of the ligand to the receptor and the endocytosis of ... agents At this time this is not known; future longitudinal studies may give an answer However, the lack of correlation between TPO, on the one hand, and blood platelet counts, on the other, is in ... described for the opposite, viz the drop in TPO that occurs when immunologic thrombocytopenic purpura patients respond to therapy with raised platelet counts However, this hypothesis is not supported...

Ngày tải lên: 03/11/2012, 10:52

... inseparable In fact, there's this stupid joke going around, that we share the men, which of course, is absurd And to tell you the truth, despite the fact that we have been seeing each other for so many ... as racist as us Christians That, I couldn't stomach Mum's veto, that is You see, Daniel's, that' s Dani‟s name, Daniel's father is dead and his mother is a tough old bitch who controls the purse ... mother and I got to know him He is the designer of the clothes she produces The modéliste They say that domineering women tend to produce weak and sometimes abnormal sons Well, Moni's mother is...

Ngày tải lên: 06/11/2012, 17:33

... Y310F tau, this band was not apparent on western blots of lysates of Y394F tau (Fig 2A) The absence of this larger species could indicate that phosphorylation of tau by Fyn is reduced and therefore, ... The SH3 domain of Fyn binds to proline-rich motifs within the sequence PXXP in interacting proteins Seven such motifs are present in the proline-rich domain of the longest isoform of tau in the ... Fyn are important for the cellular distribution of these proteins For example, we have shown that the trafficking of tau to DRMs [9] and plasma membranes [5] is Fyn-dependent As we found that the...

Ngày tải lên: 14/02/2014, 14:20

... but not the PI3-Kc isoform contributes to platelet procoagulant activity following P2Y12 stimulation Discussion The results of the present study highlight the importance of the ‘weak’ agonist, ADP, ... platelets This suggests that it is not Ca2+ reuptake itself that is controlled by PI3-K, but a different process that is still dependent on normal Ca2+-ATPase function A remarkable finding is that the ... considerable amount of the PIP3 formed in platelets [21], this may suggest that the PIP3 produced by this isoform leads to plasma membrane binding and, hence, activation of PH domain-containing...

Ngày tải lên: 18/02/2014, 16:20

... region of Rac1b (dotted green line on the right), where the 19 amino acid insertion of Rac1b is found, is disordered in the crystal The mostly disordered structures of the switch II region are compatible ... The positions of the Lys147 residues are almost identical Lys147 of Rac1 is yellow, and the equivalent residue of Rac1b is shown in orange on top There is only a minor change in orientation of ... addition Therefore, the reason why Lys147 rather than Lys5 is the main acceptor site for ubiquitin in Rac1 remains to be elucidated Of note, however, is that recent studies on the role of the Rab-like...

Ngày tải lên: 18/02/2014, 16:20

... GC supports the hypothesis that ERK1/2 is an important signalization pathway in the regulation of steroidogenesis by LN in GC Conclusion The results of this study emphasize the role of cytoskeleton ... (percentage of labeled cells) and the pyknotic index (percentage of pyknotic cells) after 48 h of culture This has been shown to allow the be the optimal culture time for the study of the effects of various ... c and d) Overall analysis of results of this experiment showed the existence of significant correlations between the percentage of round cells and the proliferation rate of GC from small follicles...

Ngày tải lên: 05/03/2014, 17:20

... young The date the first egg was laid was used as the measure of the beginning of the breeding season for a female The ‘end of the breeding season’ was estimated as the date of failure or fledging of ... 1995) The trend for lower survival of yearling females in pairs compared to groups is inconsistent with this hypothesis, but it is possible that lower effort emphasizes a pre-existing effect of ... 4b) It is possible that there are differences in the quality of breeding locations unrelated to the ‘territory quality’ index To assess this possibility, pairwise comparisons were used of seasonal...

Ngày tải lên: 14/03/2014, 16:20

... Adherents of this argument often posit that the revolutionary origins of the regime predispose it toward the acquisition of nuclear weapons and other weapons of mass destruction Along these lines, ... and coherence Their comments significantly strengthened the substance of the report and its recommendations Of course, the content of this report is the sole responsibility of the authors Abbreviations ... of the hijab.42 It is important to note that bureaucratic politics may also be driving this juxtaposition of internal dissent and external interference The MOIS has been at the forefront of this...

Ngày tải lên: 15/03/2014, 21:20

... by Nd1, as is the case with other RNase A-like enzymes The orientation of the His97 ring in the deposited structure (PDB code 2i5s) was determined, on the basis of the B-factors of the imidazole ... on the constellation of all atoms within the unit cell In other words, the crystal structure is encoded in the diffracted X-rays – the shape and symmetry of the cell define the directions of the ... approximation of the true structure, depending on the accuracy of the calculated phases, that is, on how good the model is from which the phases were computed Another type of electron-density map, the...

Ngày tải lên: 16/03/2014, 06:20

... V8d ẳ V8r ẳ Together, the graphs depicted in Fig 6BF show that the inhibition in the rate of synthesis of ATP from ADP is accompanied by an increase in the rate of synthesis of Ino, without any ... these results would indicate that H2O2 diminishes the rate of synthesis of ATP, probably through inhibition of glycolysis It is worth noting that H2O2 has no appreciable effect on the level of ... Effect of H2O2 on glycolysis From the above, it seemed obvious to verify in our experimental conditions the eect of H2O2 on either the rate of glucose consumption or on the rate of synthesis of ethanol...

Ngày tải lên: 17/03/2014, 10:20

... ubiquitination of Ruk isoforms This hypothesis is currently under investigation The discovery of Ruk isoform ubiquitination in cells prompted us to investigate the importance of this modification, especially ... at the C-terminal region, which is common between them It is well established that ubiquitin is conjugated to target proteins through lysine residues Sequence analysis of Ruk isoforms showed that ... ubiquitination of Ruk isoforms in vivo In this experiment, EE-tagged versions of all three isoforms of Ruk were cotransfected into Hek293 cells together with HA-tagged Ub Two days after transfection, Ruk isoforms...

Ngày tải lên: 17/03/2014, 23:20

... structures and other oligomers is growing, given that the toxicity of these species appears to surpass that of mature fibrils [76] It is possible that the toxicity of aggregates is simply correlated ... indicating that the growth of type Bunagitated depends on the remaining nonfibrillated glucagon concentration rather than on the amount of type A fibrils formed before them [63] This is inconsistent ... In the case of glucagon, clues to the mechanism of this acceleration can be observed in the morphology of the resulting fibrils, with agitation generally producing type Bagitated fibrils, which are...

Ngày tải lên: 23/03/2014, 03:20

... time points of the incubation process The ratio of insulin to amylin was 10 : in each group The results of this assay (Fig 7) showed that the time of insulin addition was critical for the promotional ... after 72 h of incubation This result suggests that the enhanced aggregation could be due to the interaction between amylin and insulin rather than the self-assembly of insulin Considering the observation ... new mechanism is needed to explain the different behaviors of amylin in healthy individuals and T2D patients On the basis of our observations, we suggest a hypothetical mechanism for the amylin–insulin...

Ngày tải lên: 23/03/2014, 04:21

... yield is the ratio of the total activity of OGDHC in the eluate to the total activity of the OGDHC applied to the column ND, not determined Dissociation of E1o from OGDHC Dissociation of E3 from ... rates This is in accordance with published data on the rate-limiting role of the E1o component in Reaction (1) catalyzed by the complex [34] It is known that the binding of E3 to OGDHC is mediated ... substitution of this interaction for that with synaptic membrane interferes with the integrity of the complex This may explain the observed difference in the stability of brain and heart OGDHC over the...

Ngày tải lên: 23/03/2014, 06:20

... pH 6.8 (j) in the presence of coated G4–6 The interaction was monitored at 405 nm The model of the closed state of gelsolin shows that two segments of the G2 domain are located in the G2/G4–6 interface ... in which it is suggested that the C-terminal helix of gelsolin’s G6 domain binds G2 and that this contact is released upon the binding of calcium We have further shown that residues 203–225 and ... interaction in the presence of mM EGTA, which is similar to that found at pH 7.5 in the presence of calcium (Fig 1) Activation of gelsolin at low pH is expected to involve an opening of the molecule...

Ngày tải lên: 23/03/2014, 21:20