therapeutic targets in neurodegeneration
Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
Ngày tải lên :
06/03/2014, 09:22
... effect in a telomere level should not be ruled out In vivo data on the recently described quadruplex-binding fluoroquinolone derivative Quarfloxin (CX-3543) is included It is currently in clinical ... selective inhibition of cell growth, with normal human cell lines being relatively unaffected; (d) senescence; (e) inhibition of telomerase activity in cells; (f) competitive inhibition of hPOT1 binding ... -(CH2)3- with a terminal cationic nitrogen-containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47],...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
Ngày tải lên :
30/03/2014, 09:20
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... mitogen activated protein kinase (MEK) inhibitor such as CI-1040 was used to test the potential therapeutic agent in in vitro ovarian cancer cell line (51) This cell lines containing KRAS or BRAF mutations, ... cancer, which will be discussed in details below a Chromosomal instability (CIN) Chromosomal instability lead to increase rate of losing or gaining chromosomes during cell division and accounts...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
Ngày tải lên :
09/08/2014, 03:24
... channels activation during beta(1) integrinmediated adhesion to fibronectin induces an up-regulation of alpha(v) beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1 J Biol Chem ... Maintain membrane potential and development of neurons of spinal cord and carotid glomus cells [92,93] GIT Regulate motility of gut [94] Endocrine system Secretion of insulin and modulating epinephrine ... exact role in carcinogenesis Role of Eag and HERG channels in cell proliferation and the cell cycle The indication of an erg like inward rectifier being involved in cell cycle came initially from...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
Ngày tải lên :
11/09/2015, 16:04
... antagonist, chemokines including IL-8 and MCP-1, and adhesion molecules including selectins and ICAM-1 are all involved in this response Production of some cytokines and chemokine results in the infiltration ... variety of inflammatory mediators in the pancreas The pro-inflammatory cytokines including Tumor necrosis factor- (TNF), Interleukin (IL)-1, IL-6, anti-inflammatory mediators including IL-10, ... discussed in greater detail 1.2 Literature review 1.2.1 Inflammation A lot of insults including mechanical injury, infectious pathogen, chemical injury, burn, radiation and tissue injury, shock, can induce...
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Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
Ngày tải lên :
09/08/2014, 01:22
... protein kinases Mitogen-activated protein (MAP) kinases are stress-activated serine/threonine kinases that include the p38, ERK (extracellular regulating kinase), and JNK (c-Jun-N-terminal kinase) ... N-terminal kinase; MAPKAPK, mitogen-activated protein kinase-activated protein kinase; MEK1/2, mitogen-activated protein kinase kinases types p38 inhibitors are effective in preclinical models ... extracellular regulating kinase; GPCR, G-protein coupled receptor; IL, interleukin; JAK, Janus kinase; LIGHT, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes...
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Báo cáo y học: " Therapeutic targets for HIV-1 infection in the host proteome" pot
Ngày tải lên :
13/08/2014, 09:21
... cycle in Tat expressing cells, including ribosome and actin/cytoskeleton genes dependence on efficient protein processing and intracellular transport These findings suggest an increase in Tatinduced ... close interplay between promoting and inhibiting factors induced by Tat These findings, coupled with the up-regulation of signaling receptors involved in cell growth and survival, illustrate an intrinsic ... containing (protein disulfide isomerase) calumenin protective protein for beta-galactosidase (galactosialidosis) pituitary tumor-transforming interacting protein FK506 binding protein 9, 63 kDa GRP58...
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Computational study of therapeutic targets and ADME associated proteins and application in drug design
Ngày tải lên :
15/09/2015, 22:19
... 38] Information about non-target proteins and natural small molecules involved in these pathways is also useful in the search of new therapeutic targets and in understanding how therapeutic targets ... Collection of therapeutic target information As indicated in previous section, three important information communities should be included in TTD: therapeutic target information, information about targets ... simultaneously affect many proteins in different pathways [55] For instance, in addition to interacting with its main target protein cyclooxygenase, anti-inflammatory drug aspirin is known to affect NF-kappa...
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THERAPEUTIC HYPOTHERMIA IN BRAIN INJURY pdf
Ngày tải lên :
06/03/2014, 23:20
... problem with surface cooling is cold injury, causing pressure ulcers and Therapeutic Hypothermia in Brain Injury skin breakdown Surface cooling is less efficient in reducing the temperature of ... can be initiated in the prehospital or in hospital setting There are ongoing studies involving prehospital cooling One should be mindful that if prehospital cooling is not followed by in hospital ... ischemia-reperfusion injury leading to intravascular clot formation resulting in microvascular thrombosis in the brain [42,43] Therapeutic Hypothermia could be beneficial in this instance since platelets...
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Báo cáo khoa học: "Identifying Repair Targets in Action Control Dialogue" pdf
Ngày tải lên :
08/03/2014, 21:20
... extend the grounding act model by introducing degree of groundedness that have a quaternary distinction instead of the original binary distinction The notions of partial grounding and mid-discourse ... grounding in a dialogue from the viewpoint of Description Initial state Ongoing Requested a repair by a responder Repaired by a responder Requested a repair by the initiator Finished Canceled DU1 Init-I ... responder succeeded in interpretation E.g., turning to the right as the speaker intended in response to the request “turn to the right.” 3.3 Partial and mid-DU Grounding In Traum’s grounding model, the...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
Ngày tải lên :
16/03/2014, 01:20
... particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in various cancer types, including CLL, breast cancer, ... of essential proteins responsible for accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes ... RNA-binding-domain protein that is a homologue of the HIV transactivating response RNA-binding protein (TRBP) The functional strand of the miRNA duplex guides the RNA-induced silencing complex (RISC)...
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CONSOLIDATED LIST OF FINANCIAL SANCTIONS TARGETS IN THE UK pdf
Ngày tải lên :
23/03/2014, 02:20
... AWDH, Bin Laden, Osama, Mohamed (3) BIN LADEN, Usama (4) BIN LADIN, Osama (5) BIN LADIN, Osama, bin Muhammad, bin Awad (6) BIN LADIN, Shaykh, Usama (7) BIN LADIN, Usama (8) BIN LADIN, Usama, bin ... moving recruits to Al-Qaida training camps in South Asia In Jan 2008, convicted in absentia by the Bahraini High Criminal Court for financing terrorism, undergoing terrorist training, facilitating ... Bahraini Other Information: UN Ref QI.A.254.08 Bahrain-based financier and facilitator for Al-Qaida In Jan 2008, convicted by the Bahraini High Criminal Court for financing terrorism, undergoing...
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Novel Therapeutic Concepts in Targeting Glioma Edited by Faris Farassati potx
Ngày tải lên :
23/03/2014, 15:20
... re-entered clinical trial 5.2 Tyrosine kinase inhibitors that target the EGFR TKIs are small molecules that specifically target the kinase domain of tyrosine kinases, preventing binding of ATP ... targeting wtEGFR are have been tested in GBM using systemic administration, including mAb 425 131I-mAb 425 has been used in several clinical trials and clearly demonstrates targeting to GBM following ... 12 Novel Therapeutic Concepts in Targeting Glioma complete excision in the placebo group27 In 2007 Stepp and colleagues reported similar findings with GTR in 65% of patients undergoing FIGS compared...
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Impact of Molecular Biology on Cancer Treatment: I Therapeutic Targets potx
Ngày tải lên :
29/03/2014, 01:20
... (HER4)[4] Prevention or inhibition of RTK signalling includes selective targeting of the extracellular ligandbinding domain, the intracellular tyrosine kinase or the substrate-binding region Pharmacological ... in maintaining bone density and in lowering circulating cholesterol, but antiestrogenic actions in the breast It has proved to be valuable in the treatment of ER-positive breast cancer The finding ... endogenous p53 gene in the tumour) - including inhibiting MDM2, blocking the p53-MDM2 interaction, inhibiting nuclear export and mimicking p14ARF which is a small protein-activator of the p53 response[14]...
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báo cáo hóa học:" Nutrition outcomes of HIV-infected malnourished adults treated with ready-to-use therapeutic food in sub-Saharan Africa: a longitudinal study" ppt
Ngày tải lên :
20/06/2014, 08:20
... on our first experience in treating severely malnourished HIV-infected adults with RUTF in three routine, home-based therapeutic feeding programmes in sub-Saharan Africa In these programmes, 15% ... criteria for starting combination antiretroviral therapy (ART) were those recommended in the 2006 WHO guidelines for scaling up ART in resourcepoor settings: all patients with WHO clinical stage 4, ... Megazzini KM, Heimburger DC, Stringer JS: Macronutrient supplementation for malnourished HIV-infected adults: a review of the evidence in resource-adequate and resource-constrained settings Clin Infect...
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báo cáo hóa học:" Patient-recorded outcome to assess therapeutic efficacy in protoporphyria-induced dermal phototoxicity: a proposal" docx
Ngày tải lên :
20/06/2014, 16:20
... the 35 lines in the questionnaire, resulting in a total of 490 estimates Using an 11-point Lickert scale as a reference, pain intensities were converted into pain scores so that no pain equaled ... Rational for choosing endpoints As stated in the Introduction, skin pain of variable intensity is the main symptom of PP-related phototoxicity Conditioned by their immediate pain reaction upon ... product The following conversions were performed: 'freedom from pain' was defined as 10 minus pain score, 'sun avoidance' was defined as 13 hours minus sun exposure time in 15-min blocks The scale...
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Báo cáo hóa học: " Research Article Detecting and Georegistering Moving Ground Targets in Airborne QuickSAR via Keystoning and Multiple-Phase Center Interferometry" doc
Ngày tải lên :
22/06/2014, 00:20
... for detecting and georegistering surface moving targets in multichannel SAR The interferometric scheme described here is able to detect moving targets well within the ground clutter Since the ... D M Zasada, “Detecting moving targets in SAR via keystoning and phase interferometry,” in Proceedings of the 5th International Radar Symposium (IRSI ’05), Bangalore, India, December 2005 [6] P ... “Detecting moving targets in clutter in airborne SAR via keystoning and multiple phase center interferometry,” in Algorithms for Synthetic Aperture Radar Imagery XIII, vol 6237 of Proceedings of...
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Báo cáo hóa học: "Research Article Detecting and Georegistering Moving Ground Targets in Airborne QuickSAR via Keystoning and Multiple-Phase Center Interferometry" pdf
Ngày tải lên :
22/06/2014, 06:20
... for detecting and georegistering surface moving targets in multichannel SAR The interferometric scheme described here is able to detect moving targets well within the ground clutter Since the ... D M Zasada, “Detecting moving targets in SAR via keystoning and phase interferometry,” in Proceedings of the 5th International Radar Symposium (IRSI ’05), Bangalore, India, December 2005 [6] P ... “Detecting moving targets in clutter in airborne SAR via keystoning and multiple phase center interferometry,” in Algorithms for Synthetic Aperture Radar Imagery XIII, vol 6237 of Proceedings of...
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Báo cáo hóa học: " Research Article Sequential Monte Carlo Methods for Joint Detection and Tracking of Multiaspect Targets in Infrared Radar Images" pptx
Ngày tải lên :
22/06/2014, 19:20
... of the joint detection/tracking algorithms in this paper unfeasible in a multitarget scenario The basic tracking routines discussed in the paper may be still viable though when used in conjunction ... Likewise, a change in target configuration hypotheses would result in new targets appearing in uniformly random locations as in (5) The main difficulty associated with the approach described in the previous ... simulations in Section in the sense that, rather than performing joint detection and tracking of the two targets, the algorithm assumes a priori that two targets are always present in the scene...
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ALZHEIMER’S DISEASE PATHOGENESIS-CORE CONCEPTS, SHIFTING PARADIGMS AND THERAPEUTIC TARGETS pot
Ngày tải lên :
28/06/2014, 05:20
... a sustained increase in CBF in basal ganglion and Cortex, particularly in fronto parietal regions 4.5 Cerebral insulin resistance Insulin in the brain plays an important role in regulating metabolism, ... times increased in vessels, microglia and neurons The binding of A to RAGE in the luminal membrane of the BBB leads to the peripheral A input in to the brain followed by binding to neurons Increased ... understanding of the role of vascular factors, inflammation, brain resistance to insulin and the recent and intriguing findings about the role of the prion receptors and prion like mechanisms in the...
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