therapeutic models and clinical trials

Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx

Ngày tải lên : 09/08/2014, 06:22

... RA Animal models for RP have been described as those immunized with either collagen type II (CII) or matrilin-1 and as models that appear spontaneously [1–3] These models differ in clinical features ... arthritis models and spontaneous models Several other models for arthritis have been reported but these will not be discussed here We believe that they should be considered as alternative models ... confirmed the clinical signs (Fig 2) As measured by antibody response, all strains responded strongly to matrilin-1 and in some cases also to CII and CIX, but no correlation with clinical symptoms...

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Tài liệu SLEEP-RELATED BREATHING DISORDERS EXPERIMENTAL MODELS AND THERAPEUTIC POTENTIAL docx

Ngày tải lên : 14/02/2014, 17:20

... Zapol and K J Falke 25 Gas Mixing and Distribution in the Lung, edited by L A Engel and M Paiva 26 High-Frequency Ventilation in Intensive Care and During Surgery, edited by G Carlon and W S Howland ... Roussos and P T Macklem 30 The Pleura in Health and Disease, edited by J Chrétien, J Bignon, and A Hirsch 31 Drug Therapy for Asthma: Research and Clinical Practice, edited by J W Jenne and S Murphy ... Robertson and H W Taeusch 85 The Thorax: Second Edition, Revised and Expanded (in three parts), edited by C Roussos 86 Severe Asthma: Pathogenesis and Clinical Management, edited by S J Szefler and...

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Access to unapproved therapeutic goods Clinical trials in Australia pdf

Ngày tải lên : 07/03/2014, 08:20

... unapproved therapeutic goods Clinical trials - an overview Classification of clinical trials Clinical trials of medicines Medical device trials Regulation of medicine and medical device clinical trials ... Provisions in the Therapeutic Goods Act 1989 and Therapeutic Goods Regulations 1990 for Medicines and ‘Other Therapeutic Goods’ The CTN and CTX Schemes for clinical trials of medicines and OTGs have ... assessing a clinical trial application Regulation of Medicine and Medical Device Clinical Trials in Australia - An Introduction to the CTN and CTX Schemes Clinical trials of medicines and medical...

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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx

Ngày tải lên : 18/06/2014, 19:20

... approval (IRB-HSR# 10598, 10524, and1 1491) and review by the FDA (BB-IND# 9847 and 12191) Patients’ blood specimens from clinical trials (HSR# 1524(HSR# 10524 and 11491) were monitored during ... and Bill Goodwin Additional philanthropic support was provided by Frank and Jane Batten, the James and Rebecca Craig Foundation, George S Suddock, Richard and Sherry Sharp, and the Patients and ... handling before and after cryopreservation Some studies have defined optimal time intervals between venipuncture and cryopreservation [26-29] and optimal conditions for freezing [30] Also, handling...

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Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx

Ngày tải lên : 09/08/2014, 06:22

... the TCR transgenic K/B×N model and the situation in patients Some of the major clinical and immunological similarities and differences between CIA, the K/B×N model and G6PI-induced arthritis are ... response Although the two models exhibit clinical and pathophysiological differences, a complex interplay between cells and effector mechanisms of both the adaptive and innate immune system is ... affinity for G6PI Thus, unlike the CIA and K/B×N models, both CD4+ T cells and antibodies are necessary for the development of G6PI-induced arthritis, and neither transfer of T cells nor transfer...

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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx

Ngày tải lên : 09/08/2014, 06:22

... Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded adjudication in trials ... authors independently read each clinical trial report and scored the reports for reporting quality and validity Disagreements were discussed and consensus achieved Trials were scored for quality ... Arthritis Research & Therapy Vol No Moore et al Results Trials Clinical reports of 31 randomised trials – 21 in osteoarthritis, in rheumatoid arthritis, and in mixed osteoarthritis or rheumatoid arthritis...

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Báo cáo y học: " Correction: Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports" docx

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects" pptx

Ngày tải lên : 09/08/2014, 14:21

... clinical and serological activity of SLE [18] Improvement of the lupus disease in animal models with androgen administration led investigators to also consider dehydroepiandrosterone (Table and ... hopefully some of them represent interesting candidates for future clinical trials Two peptides and one peptide construct have reached advanced clinical trials in lupus patients The efficacy of the ... phase I and phase II clinical trials conducted by ImmuPharma (Mulhouse, France) Peptide P140 was found to be safe and well tolerated by subjects, and significantly improved the SLEDAI score and biological...

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Báo cáo y học: " Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed " potx

Ngày tải lên : 12/08/2014, 11:22

... http://respiratory-research.com/content/11/1/136 randomised clinical trials of augmentation therapy with alpha-1 antitrypsin that are integrated in the manuscript, has received grant monies from Bayer and Talecris Biotherapeutics, and has ... powered double-blind randomised trial of the clinical effectiveness of AAT augmentation therapy has been lacking The individual and combined analysis of the Danish-Dutch and EXACTLE trials confirms ... of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996, 17:1-12 Olivo SA, Macedo LG, Gadotti IC, Fuentes J, Stanton T, Magee DJ: Scales to assess the quality of randomized...

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Báo cáo y học: "Clinical review: Balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use" ppt

Ngày tải lên : 13/08/2014, 11:22

... aeruginosa [59] and 3.2% for Acinetobacter spp [60] have been reported Between 1997 and 1999 and 2004 and 2006, imipenem nonsusceptibility in P aeruginosa increased from 23.6% to 29.3% and from 33.3% ... 0.5 and Reproduced with permission from Kuti et al [42] For 2004 and 2005, meropenem nonsusceptibility for P aeruginosa was 9.7% and 12.4%, respectively, and for Acinetobacter spp was 23.9% and ... MIC > 30%, 50%, and 100%) as a function of MIC for imipenem and meropenem at a dosage of 500 mg q6h The 30% and 50% targets represent conservative estimates for bacteriostatic and bactericidal...

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Báo cáo y học: "Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment" pdf

Ngày tải lên : 13/08/2014, 13:20

... mediator Fas ligand was severely inhibited in both dogs with CPSS and in dogs with PPVH (1 4and 8-fold, respectively) Moreover, caspase-3 was halved in both CPSS and PPVH On the other hand, no induction ... apoptosis-related signaling proteins and hypoxia induced factor We measured three well-known basic apoptotic components of which two are pro-apoptotic (caspase-3 and Fas ligand) and one is anti-apoptotic ... proliferation, and growth-arrest Therefore we investigated expression levels of pro-apoptotic Fas ligand and caspase-3, anti-apoptotic Bcl-2 [17], cell-cycle stimulating TGFα, and cell-cycle...

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Báo cáo y học: "Moxibustion and other acupuncture point stimulation methods to treat breech presentation: a systematic review of clinical trials" pptx

Ngày tải lên : 13/08/2014, 15:21

... studies and reviews in the electronic databases http://www.cmjournal.org/content/4/1/4 Inclusion criteria We included randomized controlled trials (RCTs) and non-randomized controlled clinical trials ... the trials with similar study designs [13,16] in our meta-analysis We included in the present review both randomized and non-randomized trials because many trials carried out in China are non-randomized ... remaining 13 in China Six trials were published in English [6,14,15,17,22,24] and three trials had more than two arms Among the included trials, ten RCTs and seven CCTs involved 2090 and 1409 pregnant...

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Báo cáo y học: "Systematic review of clinical trials of cervical manipulation: control group procedures and pain outcomes" pptx

Ngày tải lên : 13/08/2014, 15:21

... single and 2) multiple intervention session trials Methods Search Strategy Data extraction and analyses A search for randomized controlled clinical trials was performed in PubMed 1966-May 2010 ... Spinal"[Mesh]) AND Clinical Trial “[Publication Type] Reference lists from these selected trials were searched for any additional trials The reference lists of two prior studies, one review [4] and one ... areas for improvement in future controlled clinical trials Twenty-one (21) trials were identified, multi-session trials and 12 singlesession trials The most commonly employed control group procedure...

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Báo cáo y học: "because I am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials – assessment of understanding, appreciation and reasoning'''' pot

Ngày tải lên : 13/08/2014, 18:21

... and adolescents with ADHD and/ or ODD and their parents, we examined both the feasibility of providing information about clinical trials according to informed consent criteria and the understanding ... information related to clinical trials The appreciation of children and adolescents and their parents of what a clinical trial involved and their reasoning about participation in a clinical trial were ... not well understood and appreciation was low – by both children and adolescents and often by parents The capacity to understand the nature of placebo was low and children and adolescents had...

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