therapeutic hypothermia in traumatic brain injury

... HQ, Jenkins LW, Marion DW, Dixon CE: Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats Brain Res ... global ischemia Brain Res Mol Brain Res 2001, 86:34-47 33 Lyeth BG, Jiang JY, Robinson SE, Guo H, Jenkins LW: Hypothermia blunts acetylcholine increase in CSF of traumatically brain injured rats ... trial in patients with raised intracranial pressure after traumatic brain injury Published: 15 February 2010 References European Brain Injury Society homepage [http://www.ebissociety.org/ head -injury. html]...

Ngày tải lên: 13/08/2014, 20:21

... JW, Stover JF, McIntosh TK: Pharmacology of traumatic brain injury Curr Opin Pharmacol 2003, 3(1):27-32 Doppenberg EM, Choi SC, Bullock R: Clinical trials in traumatic brain injury: lessons for ... receptor type 1-related protein y, IgG1-linked murine recombinant fusion protein; MBP, mannose-binding protein; rVCP, recombinant Vaccinia virus complement control protein; sCR1, soluble complement ... (in 0.1% milk in PBS containing 0.05% TWEEN) and murine recombinant mouse C5a at defined concentrations for establishing the standard curve After incubation and subsequent washing steps, biotinylated...

Ngày tải lên: 19/06/2014, 22:20

... clinical reality are vital to those of us seeking to expand our armamentarium of therapeutic options in the treatment of these injuries [6-8] Competing interests SMM is an investigator in the Traumatic ... Neuroprotection in traumatic brain injury: a complex struggle against the nature of biology Curr Opin Crit Care 2007, 13:134-142 Wang KK, Larner SF, Robinson G, Hayes RL: Neuroprotection targets after traumatic ... Traumatic Brain Injury Clinical Trials Network JDK is a Principal Investigator in the Resuscitation Outcomes Consortium References Xiao G, Wei J, Yan W, Wang W, Lu Z: Improved outcomes from the administration...

Ngày tải lên: 13/08/2014, 11:22

... and brain tissue pH after traumatic brain injury Neurosurgery 2004, 55:877-881 12 Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G: The effect of intensive insulin therapy on infection ... days after brain injury in the intensive glycemic control group This unexpected worsening of mortality is cause for great concern among those who advocate intensive glycemic control in brain trauma ... to mmol/l) in patients with severe traumatic brain injury Crit Care 2008, 12:R98 Lam AM, Winn HR, Cullen BF, Sundling N: Hyperglycemia and neurological outcome in patients with head injury J Neurosurg...

Ngày tải lên: 13/08/2014, 11:22

... integrated in the US into a much larger interagency initiative towards ‘an integrated approach to research in psychological health and traumatic brain injury This initiative included working groups ... towards ‘an integrated approach to research in Psychological Health and Traumatic Brain Injury References Maas AIR, Stocchetti N, Bullock R: Moderate and severe traumatic brain injury in adults ... Steyerberg EW: Prognosis and clinical trial design in traumatic brain injury: the IMPACT study J Neurotrauma 2007, 24:232-238 Brain Trauma Foundation [http://www.braintrauma.org/site/ PageServer]...

Ngày tải lên: 13/08/2014, 19:20

... improving the design and analysis of clinical trials in moderate to severe traumatic brain injury Neurotherapeutics 2010, 7:127-134 McHugh GS, Butcher I, Steyerberg EW, Marmarou A, Lu J, Lingsma ... simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project Clin Trials 2010, 7:44-57 ... in stroke trials Stroke 2007, 38:1911-1915 doi:10.1186/cc10240 Cite this article as: Roozenbeek et al.: The added value of ordinal analysis in clinical trials: an example in traumatic brain injury...

Ngày tải lên: 14/08/2014, 08:21

... McLaughlin, K A., Pavese, A., Heidrich, A., & Posner, M I (2000) Evaluation of attention process training and brain injury education in persons with acquired brain injury Journal of Clinical and ... demographics The following demographic information was taken: age at injury (in years), age at first assessment (in years), time since injury (in months), days of post -traumatic amnesia (PTA) ... The remainder of the time was dedicated to a psycho-education programme addressing common consequences of brain injury and introducing compensatory strategies 2.3 Statistical analysis Baseline comparisons...

Ngày tải lên: 25/04/2016, 07:31

... Injury 69 David E Tannehill Section Therapeutic Hypothermia- Traumatic Brain Injury/ Intracranial Hypertension 77 Chapter Therapeutic Hypothermia in Traumatic Brain Injury 79 Farid Sadaka, Christopher ... resuscitation Traumatic brain injury (ICP CONTROL) Traumatic brain injury ( outcome) Stroke Fever in patients with neurological injury Subarachnoid hemorrhage- vasospasm prevention Intraoperative hypothermia ... problem with surface cooling is cold injury, causing pressure ulcers and Therapeutic Hypothermia in Brain Injury skin breakdown Surface cooling is less efficient in reducing the temperature of...

Ngày tải lên: 06/03/2014, 23:20

... Surgeons The Joint Section on Neurotrauma and Critical Care Management and prognosis of severe traumatic brain injury, part 1: Guidelines for the management of severe traumatic brain injury J Neurotrauma ... of interest exists References 10 11 12 13 14 15 16 17 18 Timofeev I., Hutchinson PJ Outcome after surgical decompression of severe traumatic brain injury Injury 2006;37:1125-1132 Coplin WM Intracranial ... hemicraniectomy in normal brain An experimental PET-study in cats Brain Res 2003;982:31-37 37 Sakamoto S, Eguchi K, Kiura Y, et al CT perfusion imaging in the syndrome of the sinking skin flap before...

Ngày tải lên: 25/10/2012, 11:40

... Post -Injury (hours) E * D Brain IL-2 (pg/mg protein) Brain TNF (pg/mg protein) B Time Post -Injury (hours) C Brain IL-4 (pg/mg protein) * Brain IL-1 (pg/mg protein) Brain IL-6 (pg/mg protein) A Page of 16 ... severe traumatic brain injury in adults Lancet Neurol 2008, 7:728-741 Gaetz M: The neurophysiology of brain injury Clin Neurophysiol 2004, 115:4-18 Masel BE, DeWitt DS: Traumatic brain injury: ... Post -Injury (hours) Figure Increase in brain edema does not differ in traumatic axonal injury rats with or without hypoxia Brain water content was determined at 2, 24, 48, 72 and 96 h post -injury, ...

Ngày tải lên: 19/06/2014, 22:20

... in an incomplete understanding of their contribution to injury- induced pathology, but have indicated that the receptor is affected by injury Sihver et al [12] found a decrease in GABAAR binding ... the injuryinduced decrease in expression (M = 74.93) [F(3,9) = 14.907, p < 01], indicating DZ decreased α3 expression, regardless of injury condition DZ normalized γ2 injuryinduced decreases in ... ME, McIntosh TK: Workshop of animal models of traumatic brain injury J Neurotrauma 1994, 11:723-732 30 Hamm RJ, O'Dell DM, Pike BR, Lyeth BG: Cognitive impairment following traumatic brain injury: ...

Ngày tải lên: 10/08/2014, 05:21

... of mind after traumatic brain injury Neuropsychologia 2005, 43:99-114 Havet-Thomassin V, Allain P, Etcharry-Bouyx F, Le Gall D: What about theory of mind after severe brain injury? Brain Injury ... factors in brain injury- associated personality change Brain Injury 1994, 8(3):265-276 Turkstra LS, Dixon TM, Baker KK: Theory of Mind and social beliefs in adolescents with traumatic brain injury ... traumatic brain injury Brain Injury 1996, 10:319-327 Ashman TA, Spielman SA, Hibbard MR, Silver JM, Chandna T, Gordon WA: Psychiatric challenges in the first years after traumatic brain injury: ...

Ngày tải lên: 11/08/2014, 15:22

... mediator production following traumatic brain injury In Shock, Sepsis, and Organ Failure -Brain Damage Secondary to Hemorrhagic -Traumatic Shock, Sepsis, and Traumatic Brain Injury: Fifth Wiggers Bernard ... in severe traumatic brain injury Crit Care Med 2005, 33:654-660 Zygun DA, Doig CJ: Measuring organ dysfunction In Yearbook of Intensive Care and Emergency Medicine Edited by: Vincent JL Berlin, ... mmHg Dopamine ≤5a, dobutamine (any dose) Dopamine >5a or epinephrine ≤0.1a or norepinephrine ≤0.1a Dopamine >15a or epinephrine >0.1a or norepinephrine >0.1a Hematologic: platelet count >150 ≤150...

Ngày tải lên: 13/08/2014, 02:24

... Marwaha N, Singh D, Varma N, Mathuriya SN: Change in tissue thromboplastin content of brain following trauma Neurol India 2005, 53:178-182 Stein SC, Smith DH: Coagulopathy in traumatic brain injury ... drug was administered in addition to standard treatment for injuries and bleeding at the participating hospitals Traumatic brain injury post hoc subanalysis In accordance with protocol inclusion ... clotting system with rFVIIa in such injuries, due to the release of tissue factor (TF) in the brain and the prevalence of consumption coagulopathy or disseminated intravascular coagulation in brain...

Ngày tải lên: 13/08/2014, 08:20

... year after traumatic brain injury: A multicenter analysis Arch Phys Med Rehabil 1997, 78:125-31 Ruffolo CF, Friedland JF, Dawson DR, Colantonio A, Lindsay PH: Mild traumatic brain injury from ... possible, households were strategic in minimizing the loss of household income by selecting Table 1: One-year costs associated with treatment by level of traumatic brain injury (Unit: USD, 1USD = 15,850 ... road traffic injuries, a rate of 734 per 100,000 population [2] According to the World Health Organization, traumatic brain injury (TBI) is the main cause of fatal and non-fatal injury for motorcycle...

Ngày tải lên: 13/08/2014, 11:22

... less than 2% severe traumatic brain of surface P-selectin in with healthy controls Changes in expressioninjury patients comparedplatelets isolated from severe traumatic brain injury patients compared ... Figure Relative increases in norepinephrine-induced expression of P-selectin in arterial (blackhealthy controls (white bars) expressed as a percentage of severe traumatic brain injury (TBI) patients ... correlated with the rate of norepinephrine infusion during steady-state conditions of the norepinephrine infusion period The average norepinephrine dose infused in the presently investigated patients ranged...

Ngày tải lên: 13/08/2014, 11:22

... we investigated the impact of maintaining blood glucose levels within low and tight limits on fluctuations in blood glucose values, insulin and norepinephrine requirements, alterations in intracranial ... Changes in arterial blood glucose, insulin and norepinephrine dose, and ICP Shown are changes in arterial blood glucose, insulin and norepineICP phrine dose, and intracranial pressure (ICP) in surviving ... metabolic reduction in gray matter acutely following human traumatic brain injury J Neurotrauma 2004, 21:149-161 Bartnik BL, Hovda DA, Lee PW: Glucose metabolism after traumatic brain injury: estimation...

Ngày tải lên: 13/08/2014, 11:22

... Thoracic injury 0.13 Abdominal injury 0.34 Extremities injury 0.20 Diffuse injury without brain swelling 12 0.046 Diffuse bilateral brain swelling 12 Diffuse unilateral brain swelling with midline ... reactivity (n)a One reacting Both reactingb 12 14 Diffuse injury without brain swelling Diffuse bilateral brain swelling Diffuse injury unilateral brain swelling with midline shift Any mass lesion ... findings of CTs conducted before inclusion of the patients in the study The CT findings on inclusion were regarded to be the worst of the hospital stay; the prognostic value of such CT findings...

Ngày tải lên: 13/08/2014, 11:22

... Glenn T, Martin N, Hovda D: Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving lactate/pyruvate ratio after traumatic brain injury Crit ... 34:850-856 Hamlin GP, Cernak I, Wixey JA, Vink R: Increased expression of neuronal glucose transporter but not glial glucose transporter following severe diffuse traumatic brain injury in rats J Neurotrauma ... Holbein M, Béchir M, Ludwig S, Sommerfeld J, Cottini SR, Keel M, Stocker R, Stover JF: Differential influence of arterial blood glucose on cerebral metabolism following severe traumatic brain injury...

Ngày tải lên: 13/08/2014, 16:20

... tissue injury was maintained in all slices prior to inclusion in the study groups This initial injury could be observed in all slices and is attributable to minimal cell death originating from ... cell injury in the slices The normalised integral was defined as the trauma intensity This analysis was performed for each slice in every group Two types of tissue injury were defined: 'Total injury' ... before final fluorescence imaging Microscopy and staining PI is a nucleic acid intercalating agent that is membrane-impermeable in vital cells with intact cell membranes In damaged cells gaps in the...

Ngày tải lên: 13/08/2014, 16:20