theiler s virus infection as a model for ms
Báo cáo khoa học: Hematopoietic differentiation from human ESCs as a model for developmental studies and future clinical translations Invited review following the FEBS Anniversary Prize received on 5 July 2009 at the 34th FEBS Congress in Prague docx
... improve hiPSC technology as well as for a complete evaluation of the possible consequences of use of hiPSCs for drug screening, as disease models and for medical purposes Conclusions The use of stem ... engraftment was achieved using both methods as shown by expression of human CD45 3–6 months post-transplantation Additionally, secondary engraftment was achieved following intravenous transplantation ... mouse model of sickle cell anemia carrying the human mutant variant of the b-globin gene (bS) that is responsible for the disease Fibroblasts from a diseased animal were reprogrammed into iPSCs, and...
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Báo cáo y học: "Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes" ppsx
... collection phase and the start of assembly and analysis The end of this phase will be marked clearly on the snake genomics website [21], as will milestones of data analysis and release The maximum ... posted on the Ensembl [31], University of California Santa Cruz [32] and NCBI [33] genome browsers for public queries as soon as it is available and passes contamination analyses, and relevant ... the families Viperidae (for example, rattlesnakes, and adders) and Elapidae (for example, coral snakes, cobras, and mambas) In addition to these lineages that contain commonly used model research...
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Báo cáo y học: "Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials" ppsx
... expression of collagenase-3 in normal, differentiating rat osteoblasts J Cell Physiol 1999, 181:479-488 129 Yamashita T, Asano K, Takahashi N, Akatsu T, Udagawa N, Sasaki T, Martin TJ, Suda T: ... process as far as is feasible in order to conserve the greatest amounts of innate and biomechanically sufficient (albeit necrotic) epiphyseal bone for as long as possible, because accelerated ... intravascular coagulation and osteonecrosis in man He has suggested that the mediatory pathway of fat emboli, hypercoagulability, stasis and endothelial damage by free fatty acids induces osteonecrosis...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... for mouse sVCAM-1 (R & D Systems Inc., MN, USA), according to the manufacturer s instructions The assay sensitivity was 30 pg/ml Statistical analysis All results are presented as mean ± SEM For ... was used to examine the statistical significance of in vitro assays Repeated measure test and post hoc Duncan test was used to analyze the statistical significance of VCAM-1 and CD11b studies ... cerebral vasculature by anandamide provides a new mechanism that may explain the therapeutic action of increased anandamide tone in neuroinflammatory diseases like MS Additional material Additional...
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báo cáo hóa học: " TLR3 signaling is either protective or pathogenic for the development of Theiler''''s virus-induced demyelinating disease depending on the time of viral infection" docx
... encephalomyelitis virus (TMEV) is a positive sense single-stranded RNA (ssRNA) virus of the Picornaviridae family [12] TMEV establishes a persistent CNS infection in susceptible mouse strains that results ... sense and antisense primer sequences used for cytokines are as follows: TMEV (VP1), (5’TGACTAAGCAGGACTATGCCTTCC-3’ and 5’-CAACGAGCCACATATGCGGATTAC-3’); IL-1β, (5’-TCATGGGATGATAACCTGCT-3’ and ... severe hind limb paralysis; grade = severe hind limb paralysis and loss of righting reflex; and grade = death Plaque assay After cardiac perfusion with cold Hank s balanced salt solution (HBSS)...
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A non mouse adapted dengue virus strain as a new model of severe dengue infection in AG129 mice
... Summary vascular leakage was minimal; basal production of these cytokines was instead measured in the animals at moribund state, where tissue damage and vascular leakage were more severe This observation ... x Abbreviations ABBREVIATIONS ADE antibody-dependent enhancement AST aspartate aminotransferase ALB albumin ALT alanine aminotransferase BHK Baby Hamster Kidney bw body weight C capsid CD Cluster ... Sabin also revealed that DEN at an intermediate mouse passage level, beginning at the 17th passage for type virus and 18th passage for type virus, were satisfactorily attenuated and induced a...
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INFLUENZA VIRUS a model for learning about disease
... 189 0s Ivanovski and Beijerinck showed that a disease in tobacco was caused by a virus Loeffler and Frosch discovered an animal virus that causes foot –and-mouth disease in cattle Many years ... RNA DNA Viruses ssDNA dsDNA linear circular RNA Viruses Mostly single-stranded Positive-sense RNA: genomes that are ready for immediate translation into proteins Negative-sense ... synthesizing viral proteins (translation) New DNA is synthesized using host nucleotides RNA viruses- replicated and assembled in the cytoplasm Assembly Mature virus particles are constructed...
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Báo cáo sinh học: " The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World" pdf
... necrosis In contrast, astrocytes were mainly resistant to WNV infection This is consistent with in vivo data showing a massive infection of brain structures such as brain stem, hippocampus and cortex ... (GenBank accession number AF481864) Virus titration was performed on AP61 cells by focus immunodetection assay as previously described [9] Infectivity titers were expressed as focus forming units ... 77:2578-2586 Xiao SY, Guzman H, Zhang H, Travassos da Rosa AP, Tesh RB: West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis Emerg Infect Dis 2001,...
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Báo cáo y học: "Chiropractic as spine care: a model for the profession" pptx
... arbitrary obstacles?" To answer this question, we should step back and take a dispassionate assessment of how society invests its trust in professionals The trivial answer identifies institutional ... The essence of the IOM definition, as well as others, is of a primary care physician as a generalist and not a specialist This is most easily illustrated by the prototypical examples of PCPs as ... dental profession is a practical and successful parallel Consider the advantages of the dental model: • Dentists and dental surgeons have established themselves as the absolute, undisputed authorities...
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Flavor enhancement as a tool for increasing pleasantness and intakeof a snack product among the elderly
... first The subjects were asked to rate one sample a day at any time of the day they wanted Similarly to the tasting sessions, As the final task in the second tasting session, most of the subjects ... sample The scales used were the same as in the tasting sessions Subjects were also asked to evaluate the amount of eaten snack product using a 5-point visual scale with simple boxes black and white ... evaluation sessions lasting approximately 30 each In addition to the tasting sessions, the subjects participated in a six-day home-use test Subjects received a small food reward after the last...
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Knowledge Management as a Catalyst for Innovation within Organizations: A Qualitative Study
... from successful past teams into new teams in other areas, by job rotation and by using experienced mentors for teams (Madhaven, 1998) As interaction with customers and suppliers increase, the knowledge ... regard to key trends The survey data was not used to establish reasons and meanings The survey ®ndings are fully discussed in McAdam and McCreedy (1999) Participative workshops The survey data showed ... organisation].' `Take catering, a new menu in California is in the best restaurants in Paris a fortnight later because you have chefs who travel the world.' Collaboration was seen as important for...
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Module 7: Microsoft Proxy Server 2.0 as a Solution for Internet Connectivity
... partners have mandated that the legal assistants have Internet access 24hours -a- day, 7-days -a- week What design changes would you make to ensure that the legal assistants would always have Internet access? ... mission-critical Web-based application that manages customer reservations, ticketing, baggage handling, and baggage tracking Support for a mission-critical Web-based application that allows customers ... discuss your answers with the class Scenario A legal firm specializes in patent and copyright law At each geographic location, legal assistants within the firm conduct research for the firm’s...
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Module 8: Routing as a Solution for Private Network Connectivity
... of applications that can take advantage of multicast transmissions RIP -for- IP version is an example of a protocol that can take advantage of multicast transmissions to update routing information ... initially created for the market research company Washington DC Kansas City Los Angeles Atlanta Dallas Delivery Tip Read the scenario to the students and review the questions as a group Give the students ... Access is not an appropriate solution for all locations As a result, you would need to use routers that support full-multicast routing at Kansas City, Los Angeles, and New York All other locations...
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Module 10: RADIUS as a Solution for Remote Access
... prepared to clarify if necessary Lead a class discussion on the students’ responses Module 10: RADIUS as a Solution for Remote Access v Securing a RADIUS Solution A secure RADIUS solution ensures ... the RADIUS client is a remote access server If Remote Access Clients Must • Administer Windows 2000–based servers • Access Web-based applications and FTP servers • Run applications that are based ... clarify if necessary Lead a class discussion on the students’ responses vi Module 10: RADIUS as a Solution for Remote Access Lab Strategy Use the following strategy to present this lab Lab A: ...
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Social factors as a basis for treatment
... effective and which standards are necessary for success 175 Social factors as a basis for treatment Conclusion Social factors can affect the course and outcome of mental illness Programmes that attempt ... mental health system at standard rates of pay As case manager aides they helped their clients with a variety of tasks, such as applying for welfare entitlements and finding housing, and counselling ... replicated in other areas of the United States 173 Social factors as a basis for treatment A jail diversion programme People suffering from both substance abuse disorder and serious mental illness...
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Tài liệu Module 2: TCP/IP as a Solution for Networking pdf
... mask, and neighbor or gateway addresses Server applications that assign IP addresses and resolve symbolic names to IP addresses require a fixed IP address, subnet mask, and default gateway Addresses ... advanced interior routing protocols such as RIP version and Open Shortest Path First (OSPF) The following table lists the class-based addresses Address Class Address Range Default Mask Purpose ... default mask Classes with variable length subnet masks (VLSM) Classless Inter-Domain Routing (CIDR) with a specified prefix length Class-based networks support a single subnet mask, and are suitable...
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Tài liệu Module 3: DHCP as a Solution for IP Configuration pptx
... clients and BOOTP clients When IP addresses are issued, DHCP Clients retain the address for a lease period BOOTP clients, as used in many diskless workstations, not support IP address leases Note ... To describe how modifying lease length influences address reclamation As Lease Length Network Traffic IP Addresses Release As Lease Length Network Traffic IP Addresses Release Lead-in You can modify ... questions Be prepared to discuss your answers with the class Scenario An organization has decided to restructure an existing DHCP-based network You are assigned the task of evaluating how to enhance...
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Tài liệu Module 4: DNS as a Solution for Name Resolution docx
... records For organizations that have a separate private and public namespace, create the subdomain for WINS under the private namespace For organizations that have the same namespace for private and ... updated DNS servers by using secured dynamic updates For example, a server hosting a Web site has a Host (A) record in a dynamically updated DNS zone A second server is installed that has the same ... increases as well Similarly, as the DNS zone database size increases, the length of time to resolve DNS queries increases Delegated zones divide a DNS zone database into smaller parts, thereby...
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Tài liệu Learning Networks as a Means for Work Organization Development pptx
... this case, however, does not refer to ready-made, transferable solutions; it refers to practices as generative ideas, which serve as sources of inspiration for companies Universities as Partners ... effectiveness in purchases and more reliable deliveries The core company has a special VAVE team and each supplier company has a VAVE coordinator External support for the Network s discussions, training ... which researchers are supposed to have an advantage over consultants as development partners of companies, owing to their basically critical scientific approach towards the ‘reality’ It is an open...
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Tài liệu Module 5: WINS as a Solution for NetBIOS Name Resolution doc
... builds and maintains a database of available NetBIOS resources and resolves NetBIOS names to IP addresses based on client requests WINS accomplishes name resolution in four distinct phases: Registers ... broadcast domain is small, broadcast traffic is acceptable, and hosts are configured as b-node (broadcast nodes) Identifying the Design Decisions After you have established the network infrastructure ... WINS database replication As the length of time for synchronizing redundant WINS databases increases, the probability increases that a WINS server failure will result in the use of an outdated...
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