the year britain became master of the world

... irth of the F emale B rain glanced at their mothers’ faces. They frequently touched the forbid- den toy cow, even though their mothers shouted, “No!” The one -year- old boys, driven by their ... to get to the clothes hanging in their closets. One girl had a pink two-piece outfit, and the other had a green two-piece outfit. Their mother giggled every time she’d see them switch the tops—pink ... adjoined each other. The sandbox was in our yard, and the swing set straddled the invisible line that divided our properties. Our mothers, who soon became friends, saw the advantage of their two...

Ngày tải lên: 08/03/2014, 23:20

... representing the PSBD of the dihydrosuccinyltransferase chain of the 2-oxoglutarate dehydrogenase complex of E. coli [12] and of the dihydroacetyltransferase chain of the PDH complex of B. stearothermophilus ... 119–171) of the B. stearothermophilus E2p polypeptide chain with the dimer of a protein domain (E3int) representing the interface domain (resi- dues 343–470) of B. stearothermophilus E3. The use of the ... close to the twofold axis of E3 preventing the association of a second PSBD [28,29]. The interaction occurs at the C 2 -axis of symmetry in the E3 dimer, chiefly with the interface domain of E3, which...

Ngày tải lên: 16/03/2014, 18:20

... was the readiest way of converting them to the principles of the Christian religion. These, then, were the first forerunners in the great cause of the abolition of the Slave Trade: nor have their ... held the reigns of the government of Spain till Charles the Fifth came to the throne, for the establishment of a regular system of commerce in the persons of the native Africans. The object of ... nature of it; and of the extent of it; and of the difficulty of subduing it.—Usefulness also of the contemplation of this subject. I scarcely know of any subject, the contemplation of which...

Ngày tải lên: 15/02/2014, 09:20

... from the rest of the mapping tori as a purely TQFT consequence of Corollary 1. In this paper we have initiated the program of using of the theory of Toeplitz operators on the moduli spaces in the ... multiple of the identity. We will suppress the superscript on the quantum representations and simply write ρ k = ρ n,d k throughout the rest of the paper. Our key idea in the proof of Theorem 1 is the ... (see the proof of Theorem 7). Theorem 1 now follows directly from knowing which elements of the mapping class group act trivially on the moduli space M. The assumptions on the pair (n, d) in Theorem...

Ngày tải lên: 16/02/2014, 05:20

... by the protease, only a small shift of the molecular mass of the protein is expected because the antibody recognizes the remaining C-terminal domain. In the presence of YidC, the shift of the ... before labelling the cells with [ 35 S]methionine. CCCP reduced the efficiency of the translocation of the second periplasmic loop of KdpD as indicated by the reduced appearance of the C-terminal ... follow the translocation of the second periplasmic loop. The results show that neither the Sec translocase nor the YidC protein are required for membrane insertion of the second loop of KdpD....

Ngày tải lên: 20/02/2014, 11:20

Ngày tải lên: 23/02/2014, 19:20

... responsible, from a thermodynamic point of view, for the binding of the monomeric species of CAC? We have previously discussed the variation in the free energy of binding as a function of the changes ... relationship between S 2 and the location of structural elements (Fig. 4). Furthermore, the R ex terms are distributed throughout the 3D structure of the protein, and most of them are large (Fig. 4); the exception ... (i.e. the spectral density function at the Larmor frequency of the 15 N) and J(0.87x H ) (i.e. the spectral density function at the 0.87 times the Lar- mor frequency of the 1 H) are independent of...

Ngày tải lên: 07/03/2014, 06:20

... was computed as the ratio of the s tandard deviations of the chemical shifts of the amide nitrogen and p roton nuclei. Results Determination of the three-dimensional structure of HPr(I14A) To allow the comparison ... system of His15 and a distortion of the N-terminus of the first helix, which supports the histidine ring. In ad dition, the C -terminal helix is bent because the side chain of Leu86 located at the ... parallel to the a-helices and the b-sheet of the protein. As the 1 H N - 15 N bond vectors in the a-helices are therefore almost parallel to the z-axis, their size is mainly determined by the positive eigenvalue...

Ngày tải lên: 07/03/2014, 16:20

... with one another the weapons of their common stock. The advance was made in the middle of the night, but at this season of the year the whole {60} scene was brilliant with the light of the midnight ... land offered nothing to their search, the air was moderate and the weather singularly mild. The broad sheet of open water, of the very colour of the ocean itself, buoyed up their hopes of the ... opportunity of alleviating the extreme hunger that I suffered with the refuse of the table of one of my acquaintances. At the end of the month (December 1770), they reached the woods, a thick growth of...

Ngày tải lên: 08/03/2014, 15:20

... is the b-site APP-cleaving enzyme 1 (BACE1). Here, we investigated the effects of genetic manipulation of BACE1 on the processing of the APP family of proteins. BACE1 expression regulated the ... charac- terize the impact of BACE1 inhibition as a putative therapy for the treatment of AD. We found that the de novo production and the endogenous levels of ICDs were not reduced by deletion of BACE1. ... inhibition of BACE1 will not adversely affect the potentially important signaling role of the ICDs released by the APP family of proteins, but may impact on other functions of this family of proteins. Experimental...

Ngày tải lên: 15/03/2014, 10:20

... (Fig. 2A,B). The NMR spectra of these constructs perfectly resembled the spectra of unfolded proteins: they showed no signs of either amide proton dispersion, which is indicative of hydrogen bonding ... description of the molecular components involved in the regulation and maintenance of dendritic spine morphology is funda- mental to our understanding of the functions of the central nervous system. The ... [38]. In the presence of these ABD constructs, the concentrations of fluorescent actin polymers appeared to be higher because of the precipitation of crosslinked actin polymer networks onto the glass...

Ngày tải lên: 16/03/2014, 06:20

... to the CBM that play specific roles in activation of the receptor by these two cytokines. The ligand independent activation of the D5-GCSFR chimera occurs in both the absence and the presence of LIFR ... a copre- cipitation of gp130 with LIFR independently of the lysis buffer used for the disintegration of the cells (data not shown). Because of the high expression levels of the transiently transfected ... membrane-proximal domains of gp130 is limited to ensure the correct spacing between the CBM and the membrane, each of the domains was replaced by the corresponding domain of the GCSFR. The replacement...

Ngày tải lên: 18/03/2014, 01:20

... came the dawn of new instruments such as drums, pianos, flutes, and guitars (Romeu 1). Both eras of rock used these types of musical instruments in one way or the other. They are the essentials of ... the developing culture of the seventies. Bands often used their popularity to spread their feelings on such topics. They were, and still are, the central of communication between all genres of ... the type of lyrical content used in the seventies compared to that of the nineties goes without question. The musicians today are much more liberal in what they say and what they present to the...

Ngày tải lên: 21/03/2014, 22:50

... activity of the peptides. A better under- standing of the mode of action of these peptides is crucial for the development of a new generation of antibiotics. It is known that, in the absence of both ... reduce the cost of synthesis (arginine is very expensive). The second analogue, BM-2, was designed in such a way that the relative importance of the rigidity and charge at the turn of the b-hairpin ... and the other at the C-terminus; this is sufficient to ensure the cationic nature of the peptide at its terminus. The structure of BM-1 is very compact, like the PG-1 structure, whereas that of...

Ngày tải lên: 22/03/2014, 21:20

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Ngày tải lên: 23/03/2014, 12:21

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Ngày tải lên: 30/03/2014, 05:20

Ngày tải lên: 30/03/2014, 10:20