the value of drug delivery

... Frequencies of dosing A1, A2, A3, A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of ... concentration at the site of drug action Roles: Carry Transport Protect Distribute Enhance body retention, the efficacy of the treatment ROUTES OF DRUG ADMINISTRATION Topical delivery ORAL DELIVERY (GASTROINTESTINAL ... enhancers: SELECTION OF ROUTE OF DRUG ADMINISTRATION  Affects the onset and duration of drug action Ex: Administration of nitroglycerin  Depends on the desired drug concentration profiles to be achieve,...

Ngày tải lên: 18/04/2014, 15:37

... since none of them alone is useful for the majority of the BC and none of them is specific for cancer or breast tissues No biomarker has been suggested to date for the early diagnosis of BC (24) ... Med Sci 2011, The results of the present study and the other three studies did not fully confirm each other Several hypotheses may be suggested to explain these differences First of all, Li’s ... subjects, the comparison of the benign and control groups did not yield a statistically significant difference None of the proteomics reach 154 reasonable AUC values for the discrimination of the BC...

Ngày tải lên: 25/10/2012, 11:15

Ngày tải lên: 25/10/2013, 06:20

... of perceiving, of thinking, of understanding and of interacting spring out of the boundaries of ”humanity,” spring out of the boundaries of ”nationhood,” and spring out of the boundaries of the ... strength) of the wave length According to survivors of near-death experiences, the higher the level of the spirit the brighter the light shines, and the lower the level the darker the light seems ... were of Old Norse, the language of the Vikings and the precursor of modern Icelandic, and these words were actually used by the Vikings The other twelve words were all related to seafaring, and of...

Ngày tải lên: 24/12/2013, 13:15

... aggregating the average WTP over the population of the municipality and comparing this figure to the operating and upgrading costs of the STP The result of this revealed that the annual taxes the residents ... reduce the amount of untreated raw sewage deposited in the Ganga The most noteworthy of these is the Ganga Action Plan (GAP) Initiated in 1984 by the Indian Government, and supported by the Netherlands, ... the meanwhile the results of this study disclose that, despite their tight budget constraints the local public value improvements in the quality of the water in the Ganga and if the local government...

Ngày tải lên: 18/02/2014, 01:20

... not as remarkable as the revelation of the techniques used to manipulate the process and the data These two design parameters, the number of sources of data, and the number of cases studied, provide ... empiricist/subjective theory of being, the views of actors, as communicated through case studies, is the empirical point of departure Of course, there are very few who occupy either of these polar positions, ... the epistemological basis of the case study Many of the criticisms of the case study method relate to the highly labour intensive nature of this research strategy Miles (1979) suggests that the...

Ngày tải lên: 20/02/2014, 11:20

... Predictors of success in the treatment of MDR TB are the use of pyrazinamide and ethambutol if the strain of TB is susceptible to these drugs, the use of a fluoroquinolone, the use of more than five drugs, ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... forecasting One of the most urgent needs is to obtain accurate data on the existence of totally drugresistant (TDR) TB, said Cassell, because only then will the rest of the world take notice of the problem...

Ngày tải lên: 05/03/2014, 11:20

... some of the gains of service delivery, the ideology and practice of cost recovery became more dominant in a number of ways First, there is the question of how cost recovery influenced the then-Department ... not simply the result of historical factors Much of what the authors of this book refer to as the “crisis of service delivery is actually a result of the pro-market policies adopted by the South ... boundaries, or the national mobility of goods, services, capital or labour The Minister, with the concurrence of the Minister of Finance, may by notice in the Gazette, set a limit on the amount of the rate...

Ngày tải lên: 06/03/2014, 04:20

... Understanding the Value of the MBA, Bruce Figure shows the distribution of values for the MBA Degree scale and Figure 3, the distribution of values for the School/Program scale Figure Distribution of MBA ... quickly the investment is recouped, the higher the rating of the overall value of the MBA The overall value of the MBA is also related to the job satisfaction of alumni In MBA Alumni Perspectives ... of the multiple regression analysis show that both the MBA Degree and School/Program variables contribute significantly to prediction of the overall value of the MBA, regardless of the type of...

Ngày tải lên: 08/03/2014, 02:21

... and professional skepticism about the value of the guidelines was profound 11 The guidelines in question, published in 2006, were written under the aegis of the National Kidney Foundation.19 The ... whether or not to include an indication in their drug summaries Compendia face the objective task of evaluating the evidence for the novel use of a drug or device, amid the competing pressures of: ... allowing for the introduction of competing interests Factors that affect the usability of an abstract include issues such as the extent of the analysis, the degree of completeness of the study (clinical...

Ngày tải lên: 09/03/2014, 00:20

... prevails q is the probability of the high price prevailing (1-q) is the probability of the low price prevailing r is the rate of interest The expected value of information is: The expected project ... return of $50r* The present value of this return (at the market rate of interest) is $50(r*/r) = $50*1.5 = $75 The cost to the economy of raising $100 of public funds by borrowing from the public ... immediately from the expected NPV if the project is delayed for one year, we get an estimate of the value of information The value of information rises as: • the initial capital cost, K, rises; • the return...

Ngày tải lên: 16/03/2014, 01:20

... some of the gains of service delivery, the ideology and practice of cost recovery became more dominant in a number of ways First, there is the question of how cost recovery influenced the then-Department ... not simply the result of historical factors Much of what the authors of this book refer to as the “crisis of service delivery is actually a result of the pro-market policies adopted by the South ... boundaries, or the national mobility of goods, services, capital or labour The Minister, with the concurrence of the Minister of Finance, may by notice in the Gazette, set a limit on the amount of the rate...

Ngày tải lên: 16/03/2014, 11:20

... glimpse of the universality inherent in the exclusivity of aesthetic experience the fact, that all of us is limited to our own Like for the dying Lester, very often the experiences that mean the ... favour of objects over their subjective reception; this is a bypassing of the dilemma of aesthetic experience altogether That is, Beardsley's notion of aesthetic experience is indeed the 'phantom' ... traded the fervour of a Vienna at the turn of the century for a retreat into insitutions on the model of the Tate museums in London And even though these institutions eschew elitism and pride themselves...

Ngày tải lên: 16/03/2014, 18:20

... ineffective because of the development of resistance Thus a minimum of three to four new drugs are needed immediately to avert the escalation of drug- resistant TB The delivery of drugs to the populations ... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute acts under the responsibility given to the ... of This Report, 18 THE GLOBAL SPREAD OF MULTIDRUG-RESISTANT AND EXTENSIVELY DRUG- RESISTANT TUBERCULOSIS Scope of the Problem, 19 Underreporting of MDR TB in Africa, 25 The Threat of Totally Drug- Resistant...

Ngày tải lên: 23/03/2014, 11:20

... (the joint Group of the Royal Society of Chemistry and the Society of Chemical Industry), covers some of the advances in the Chemical Aspects of Drug Delivery Systems New materials for drug delivery ... intramuscular drug delivery The types of carrier materials used, the drug substance and the biological environment for drug delivery all influence the mechanisms of drug release Table highlights the principal ... clearance, and the constraints imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY SYSTEMS The principal...

Ngày tải lên: 28/03/2014, 10:20

... either the likelihood a loan is repaid (and thus, the cost of a loan) or the availability of credit These results highlight the distinct tradeoff between 1) limiting the collection and use of ... models explain the evolution of credit bureaus and the lending markets they support? Japelli and Pagano (1999) provide one of the very few attempts to test the predictions of the theoretical models ... not the experience of other financial institutions Tables and display the results of the retail-only simulations As in the previous discussion of the negative-only simulation, suppose we use the...

Ngày tải lên: 29/03/2014, 07:20

... linking the organisational beneficiaries of ABIs 3.3 The Arts Value Matrix 3.4 The four value zones of the arts 3.5 Overlapping the four value zones of the arts with the Arts Value Matrix 4.1 The ... viii The value of Arts-based Initiatives in business Introduction The benefits of ABIs for organisations The Arts Value Matrix: mapping the value of ABIs The polyvalent nature of the impact of ABIs ... business benefits The beneficiaries and the characteristics of the benefits of ABIs are illustrated This defines the basis of the ‘Arts Value Matrix’ as a framework to map the value of ABIs and to...

Ngày tải lên: 30/03/2014, 04:21

... companies and the market around the date of each acquisition In fact, when the team calculated the impact of these declines on the total value of EG, they realized that the decline in EG's total value ... than they now of communicating with the market and other players about the value of their plans and strategies But first they need to become value managers themselves, and to understand what value ... this case, they chose the last three years They used these projections to estimate the value of each EG business, as well as the cost of corporate headquarters activities and the value of nonoperating...

Ngày tải lên: 08/05/2014, 10:11

... about the theme of Kant’s conception of value, and how it is central to this book Chapter 6, the first chapter of Part II, offers an answer to one of the most basic questions about the imperative of ... at least some weight to the ends of the other members Taking into account these facts about the members of the kingdom of ends, plus the sorts of ends that we can predict they would have, will ... itself Part II of the book goes beyond arguing for a particular reading of ‘humanity’ in the humanity formulation There are two main goals of the second half of the book The first is to fit the humanity...

Ngày tải lên: 10/06/2014, 22:33

... staining, in collaboration with the CIC executive office and the steering committee of the CIC Immunoassay working group The authors of this group acknowledge the concept of the Minimal Information About ... did the final approval of the manuscript MK, MP, LMcN, TC, JY, KO and AH were driving the conception and design of the study, selected the donors for the study, interpreted the data and wrote the ... any of the four donors were similar (Table 2) Introduction of a DUMP channel decreases the amount of non-specific events observed in the CD8-positive cell fraction The main aim of this proficiency...

Ngày tải lên: 18/06/2014, 22:20