the structure of the solution
báo cáo hóa học:" Research Article Global Structure of Nodal Solutions for Second-Order m-Point Boundary Value Problems with Superlinear Nonlinearities" pot
... discussed the global structure of positive solutions of 1.1 , 1.2 with f0 ∞ However, to the best of our knowledge, there is no paper to discuss the global structure of nodal solutions of 1.1 , ... Σν denote the closure of set of those solutions of 1.1 , k k ν 1.2 which belong to Φk The main results of this paper are the following Theorem 1.5 Let (A1)–(A4) hold a If f∞ 0, then there exists ... at the right end of the interval 0, , with the following properties ignoring the truncated bump see, : i all the positive resp., negative bumps have the same shape the shapes of the positive and...
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... mechanism of transphosphorylation, which implies the A Fig Stereo diagram of the active center of HtA (A) Superposition of the active-site residues of the 20 conformers of the solution structure of ... 2009 The Authors Journal compilation ª 2009 FEBS 2383 Solution structure of hirsutellin A A Viegas et al A B C Fig Representation of the 3D structure of HtA in solution (A) Superposition of the ... with the other charged groups In the NMR structures, this side ˚ chain of D40 is a short distance (£ A) from the side chains of H42 and R95 Finally, the aromatic ring of F126, placed close to the...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... superimposed on the X-ray structure (dark blue colour) and (B) structure alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII Residue ... sequence and structure alignment Residue number range in the X-ray structure of AII Fig (A) Sequence alignment of the fragment 4–7 of the backbone of the 13 ensemble solution structures of AII (brown ... after the sequence and structure alignment of the two structures by using the program Profit1.8 Remarkably, the superposition of the solution state and the bound structure of AII exhibits small...
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
... (c)MeCP2] [15] The solution structure of the MBD of rat (r)MeCP2 has recently been determined [17] The MBD adopts a wedgeshaped structure, composed of an antiparallel b-sheet on one face of the wedge ... [18] The structure of the helical coil a2/a3 allows us to interpret the consequences of the six mutations As P153(152) and G162(161) are buried in the protein core, replacement of each of these ... cluster in these two regions Knowledge of the structure of a larger portion of MeCP2 including the transcriptional repression domain would resolve these speculations and clarify the role of the helical...
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Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... reported X-ray structure of bovine SOD [32] The structure is also similar to the solution structure of the monomeric mutants with the exception of the significantly better definition of the first part ... solve the solution structure of the reduced dimeric protein (by using a classical NMR approach) in order to compare the solution structures of the monomeric and dimeric species as well as the solution ... percent of the backbone 13C resonances were assigned and about 86% of the 13C side-chain resonances All the ring protons of the histidines of the active site and of His43 were assigned through the...
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Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc
... mobility with respect to the rest of the structure Further studies of the receptor bound forms of the chimera and other related ligands will be necessary to define the nature of the interactions leading ... the calculation of the chimera structure, this provides strong evidence that the overall structure is unchanged by the modification of the sequence Given that the solution structure of mEGF/TGFa44250 ... Several of these were identified in previous studies of EGF, and the backbone fold of the chimera is clearly similar to those of the EGF structures The presence of a backbone hydrogen bond from the...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... scattering from the grey structure, while the solid curve represents scattering from the black, structure The difference between scattering from the two structures is given in the top of the graph, ... disordered elements in the crystal structure will also be disordered in solution, but they will contribute Fig Models of the arrestin dimer in solution Models of the arrestin dimer in solution Structural ... us Neither of these parameters are within the range of our experimental observations, and therefore the predominant species in solution are the monomer and dimer Additional evidence that the crystallographic...
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Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot
... FEBS 1601 Solution structure of the RICH catalytic domain G Kozlov et al Results Structure of the RICH catalytic domain We determined the structure of the 24 kDa catalytic fragment of goldfish ... (B) Representation of flexibility in the solution structure of the RICH catalytic domain The width of the sausage is reversely proportional to the heteronuclear NOE values The figure was generated ... structures The lowest-energy structure from the RICH NMR ensemble is used for the overlay (D) The surface of the RICH catalytic domain shows several negatively charged patches of residues The catalytic...
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Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity pdf
... establish the preferred geometry of the precursor We now report the chemical synthesis, biochemical production, and solution structure of preCbnB2, and compare it with the structure of the mature ... help determine the structural basis of the inhibition of the antimicrobial activity of CbnB2 by the leader and to assist future analysis of the interaction of preCbnB2 with its ABC transporter ... for cleavage of the leader peptide after the double glycine motif [16,17] This cleavage occurs on the cytoplasmic side of the membrane during export of the bioactive peptide [18] The leader peptide...
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Báo cáo khoa học: Solution structure of the active-centre mutant I14A of the histidinecontaining phosphocarrier protein from Staphylococcus carnosus ppt
... regions Fig Structure ensemble of HPr(I14A) The average structure of the 10 lowest-energy structures out of 300 calculated with CNS is shown The radius of the spline reflects the RMSD values of the Ca ... computed as the ratio of the standard deviations of the chemical shifts of the amide nitrogen and proton nuclei Results Determination of the three-dimensional structure of HPr(I14A) To allow the comparison ... atoms of Ala19 In addition, the C-terminus folds back onto the core of the protein thereby allowing the side chain of Leu86 to partly fill the hole created by the removal of Ile14 Due to these...
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... to those of the lipid phase of the membrane, which promotes the formation of short-range H-bonds inducing helical structures The structural characterization of a monomeric, soluble form of Ab-(1–42) ... only to shed some light on the steps involved in the fibrillogenesis, but, most of all, to evaluate the role of Ab-(1–42) in the interaction with the membrane The structure of Ab-(1–42) found in aqueous ... correspond to the portion of the peptide crossing the membrane, whereas Shao et al [13] reported evidence that the peptide is located entirely on the outside of the micelles, in contact with the negatively...
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Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx
... elbowÕ of C5 is located at the upper left corner of the figure when C5 is in the presence of the cosolvents trifluoroethanol or hexafluoroisopropanol The high-resolution solution structure of HIV ... the model structure [33], which is based on the NMR structure of the SIV gp41 ectodomain [18] The gp120 C5 structure is shown in red and is taken from the present work The structure of the core ... in the gp120 X-ray structure; thus, the C5 domain can be overlaid with the C terminus of the gp120 X-ray structure (the RMSD of the NMR VKI backbone to the X-ray VKI backbone is ˚ 0.4 A) The...
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Báo cáo khoa học: Solution structure of the bb¢ domains of human protein disulfide isomerase docx
... Superimposition of the solution structure of the human PDI-b¢ (blue) with the crystal structure of yeast PDI-b¢ (red, Protein Data Bank entry code 2B5E) (C) Superimposition of the solution structure of human ... mm of monomers at 30 °C Most of the 1H-15N HSQC signals of the dimeric form of PDI-bb¢ coincide with the signals of the monomeric form or are weak as a result of the high molecular weight of the ... one structure, the catalytic cysteines face each other; in the other, the catalytic residues of the a domain face away from the a¢ domain The crystal structures also revealed the presence of a...
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Báo cáo khoa học: Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase pdf
... helices and of P16 (Fig 1) Helices 5002 Fig Stereo views of the solution and crystal structures of DnaG-C (A) Superposition of the backbone atoms of residues 447–581 of the 20 NMR conformers of DnaG-C ... boundaries of helix (Fig 3D,E), showing that this helix can be separated from the core of the structure The solution structure of DnaG-C identifies the crystal FEBS Journal 273 (2006) 4997–5009 ª 2006 The ... binds to the core of the structure in the monomeric solution structure (Figs 3A and 4) The two conformers in the crystal structure vary not only with regard to helix (Fig 3D,E) but also in the part...
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Báo cáo khóa học: Structural characterization of the human Nogo-A functional domains Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration ppt
... undetectable in five of the 10 selected structures Figure 8E shows a representation of the electrostatic potential associated with the contact surface of the Nogo-40 structure The most interesting ... for the use of TFE, which represents a common practice in stabilizing the structure of a polypeptide with intrinsic helical propensity to enable their further analysis [29] The NMR structure of ... partially structured but can be induced to form a helical structure via interaction with Zn2+ Furthermore, the determination of the Nogo-40 solution structure offers a starting point for further understanding...
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Báo cáo Y học: The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider pptx
... twist of the b sheet of androctonin compared to the two other peptides Despite such differences, the rmsd of the coordinates of the b strands of the three peptides when superimposed on the backbone ... on each side of the sheet reduces considerably the hydrophobicity of the surface of androctonin when compared to the two other peptides (Fig 5) Mode of action The mode of action of the three peptides ... in the headgroup region of the membrane, leading to a decrease of the thickness of the lipid bilayer, and then to (b) an active state, when the peptide penetrates the hydrocarbon core of the...
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Báo cáo khoa học: NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a-like physiological activity doc
... )65) To determine the amplitude of the toxin-induced slow inactivation, we subtracted the control traces from the traces recorded in the presence of the toxin The amplitude of these toxin-induced ... separation of all the b Na-ScTxs from all the a Na-ScTxs The a Na-ScTxs have identities of the order of 50% among themselves, the same being true for all the b Na-ScTxs (data not shown) However, when the ... capable of discriminating between Na+-channel isoforms of the same organism (e.g the rat brain isoform rNaV1.1 is 10-fold more sensitive to the action of the a Na-ScTx Lqq5 than the cardiac isoform...
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Báo cáo khoa học: Solution structure of Cu6 metallothionein from the fungus Neurospora crassa pptx
... had inhibited its structure elucidation A hallmark of the MT structures is the dependence on the sequential position of the cysteine in the primary sequence, the identity of the coordinated metal ... positioning of the seven cysteine residues with other members of the MT family of proteins, none of the other structurally characterized MTs show the same fold This is reflected in the r.m.s.d ... derived structure of the yeast MT without the 13 C-terminal residues and the small angle X-ray scattering pattern of the full length protein which has been attributed to the core of the NMR structure...
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Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot
... the length of loop I is longer in short neurotoxins The NMR structure of NTX-1 is closest to that of the a-cobratoxin crystal The superposition of these two ˚ structures shows an RMSD value of ... between the two structures in this region For example, the side chain of Arg35 is in proximity to Trp31 in the crystal structure, whereas the solution structure shows that the aromatic side chains of ... the X-ray structure can be observed in the NMR structures but the length of the b-strand in loop I in solution is somewhat shorter than that of the crystal one (Fig 6A,B) The presence of an additional...
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Báo cáo khoa học: Functional aspects of the solution structure and dynamics of PAF – a highly-stable antifungal protein from Penicillium chrysogenum pdf
... mass of PAF) as a result of the presence of three disulfide bonds Importantly, the MS data yielded evidence demonstrating the lack of any post-translational modification of native PAF other than the ... mPAF at the respective concentrations of and 100 lgÆmL)1 Fig Ribbon diagram of the mean PAF structure without disulfide bond constraints the core of the protein (Fig 9) As a consequence of the highly-twisted ... positioned in the space between b4 and loop and create a welldefined aromatic region of the protein The topology of the disulfide pairs and the function of the cysteines According to the biochemical...
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