the sky is falling queens of the stone age

... close to the twofold axis of E3 preventing the association of a second PSBD [28,29]. The interaction occurs at the C 2 -axis of symmetry in the E3 dimer, chiefly with the interface domain of E3, which ... representing the PSBD of the dihydrosuccinyltransferase chain of the 2-oxoglutarate dehydrogenase complex of E. coli [12] and of the dihydroacetyltransferase chain of the PDH complex of B. stearothermophilus ... of Biochemistry, University of Cambridge, UK The 2-oxo acid dehydrogenase complexes consist of multiple copies of three distinct enzymes that together catalyse the oxidative decarboxylation of...

Ngày tải lên: 16/03/2014, 18:20

... fighting the fantasies of his mind, and took another breath of air. This time it burned less, and he could force an awareness of the smells around him. But there was none of the pungent odor of the ... was supervising the supervisors, making an inspection tour of all this. Of all what? Apparently then this must be another of their frenzied ef- forts to find a way to put back the sky. He'd ... the warlocks of this world had discovered that they could not solve the problem of the sky, they must have gone into a state of pure hysteria, like a chicken dashing back and forth in front of...

Ngày tải lên: 15/03/2014, 17:20

... response. The girls will think that if they do it just right, they’ll get the reaction they expect. It’s the same kind of instinct that keeps a grown woman going after a narcissistic or other - wise ... morning the sisters climbed on each other’s dressers to get to the clothes hanging in their closets. One girl had a pink two-piece outfit, and the other had a green two-piece outfit. Their mother ... adjoined each other. The sandbox was in our yard, and the swing set straddled the invisible line that divided our properties. Our mothers, who soon became friends, saw the advantage of their two...

Ngày tải lên: 08/03/2014, 23:20

... levels altered the ratio of APPsa to APPsb, but did not substantially modify the total levels of APPs or of APP CTFs. This suggests that there is a discrete pool of FLAPP that is directed towards processing, ... that is essential for generation of the amyloid b-protein is the b-site APP-cleaving enzyme 1 (BACE1). Here, we investigated the effects of genetic manipulation of BACE1 on the processing of the ... signaling role of the ICDs released by the APP family of proteins, but may impact on other functions of this family of proteins. Experimental procedures Reagents Unless otherwise specified, chemicals...

Ngày tải lên: 15/03/2014, 10:20

... into his foreign dominions was the readiest way of converting them to the principles of the Christian religion. These, then, were the first forerunners in the great cause of the abolition of the ... awakened? What is the meaning of the noise around us, of the trampling of people's feet, of the rustling of the bow, the quiver, and the lance? Let us rise up and inquire. Behold! the inhabitants ... nature of it; and of the extent of it; and of the difficulty of subduing it.—Usefulness also of the contemplation of this subject. I scarcely know of any subject, the contemplation of which is...

Ngày tải lên: 15/02/2014, 09:20

... ρ n,d k throughout the rest of the paper. Our key idea in the proof of Theorem 1 is the use of the endomorphism bundle End(V k ) and the construction of sections of this bundle via Toeplitz operators ... from the rest of the mapping tori as a purely TQFT consequence of Corollary 1. In this paper we have initiated the program of using of the theory of Toeplitz operators on the moduli spaces in the ... that − 1 6 {ϑ∧[ϑ∧ϑ]} is a generator of the image of the integer cohomology Annals of Mathematics Asymptotic faithfulness of the quantum SU(n) representations of the mapping class groups...

Ngày tải lên: 16/02/2014, 05:20

... translocation of the periplasmic loops of KdpD in the absence and in the presence of CCCP. These results demonstrate that the pmf is required for efficient membrane insertion of KdpD with the tags. This is ... loop is cleaved by the protease, only a small shift of the molecular mass of the protein is expected because the antibody recognizes the remaining C-terminal domain. In the presence of YidC, the ... that of the YidC-containing cells (Fig. 8B, compare lanes 2 and 5). Taken together, these results suggest that the presence of the epitope tag is the reason why KdpD-C requires the assistance of...

Ngày tải lên: 20/02/2014, 11:20

Ngày tải lên: 23/02/2014, 19:20

... S 2 and the location of structural elements (Fig. 4). Furthermore, the R ex terms are distributed throughout the 3D structure of the protein, and most of them are large (Fig. 4); the exception is ... responsible, from a thermodynamic point of view, for the binding of the monomeric species of CAC? We have previously discussed the variation in the free energy of binding as a function of the changes ... (i.e. the internal motions of the bond vectors are independent of the overall rotational movement of the molecule). Furthermore, the internal motions of each bond vector are independent of each other,...

Ngày tải lên: 07/03/2014, 06:20

... system of His15 and a distortion of the N-terminus of the first helix, which supports the histidine ring. In ad dition, the C -terminal helix is bent because the side chain of Leu86 located at the ... orientation, is arranged almost parallel to the a-helices and the b-sheet of the protein. As the 1 H N - 15 N bond vectors in the a-helices are therefore almost parallel to the z-axis, their size is mainly ... 69–82). The active site of the HPr molecule containing the residue His15 is formed by loop L1. Recalculation of the 3D-structure of wild-type HPr and comparison with the mutant protein It is known...

Ngày tải lên: 07/03/2014, 16:20

... water, of the very colour of the ocean itself, buoyed up their hopes of the discovery of the Western Passage. Davis turned his ships to the south, coasting the shore. Here and there signs of man ... for his discovery of the Hudson river, was sent out by Sir John Wolstenholme and Sir Dudley Digges to find the North-West Passage. The story of his passage of the strait, his discovery of the ... progress of physical science, the rapid advance in the knowledge of electricity and magnetism, and the rise of the science of biology were profoundly altering the whole outlook of the existing...

Ngày tải lên: 08/03/2014, 15:20

... regions of dis- order in the ABDs of spinophilin and neurabin. As shown in Fig. 1, these programs also predicted a high degree of disorder in the ABDs of spinophilin and neurabin. On the basis of these ... activity of spinophilin. The histo- grams on the right show a quantitative anal- ysis of the polymer length distributions of actin alone (control, top histogram) or in the presence of an equimolar ... National Institute of Neurological Disorders and Stroke to WP. The content is solely the responsibility of the authors and does not necessarily represent the of cial views of the National Institute of Neurological...

Ngày tải lên: 16/03/2014, 06:20

... used for the disintegration of the cells (data not shown). Because of the high expression levels of the transiently transfected receptors in COS7 cells, they were used for the analysis of dimerization ... membrane-proximal domains of gp130 is limited to ensure the correct spacing between the CBM and the membrane, each of the domains was replaced by the corresponding domain of the GCSFR. The replacement is assumed ... II of the ligand contacts the CBM of gp130 [14,15], while site III contacts the Ig-like domain of the LIFR [13]. In the resulting complex, D3 of gp130 and D5 of the LIFR show the greatest distance...

Ngày tải lên: 18/03/2014, 01:20

... and promiscuous sex. There was more to rock music than this, much more. In the musician's lyrics, from the classic rock music era of the seventies to the more modern forms of rock music of the ... the essentials of music. Although there are modified forms of instruments and there are even new types of instruments, music still manages to convey a message of one type or another to all that listen. ... Social issues also played a major role in the developing culture of the seventies. Bands often used their popularity to spread their feelings on such topics. They were, and still are, the central of...

Ngày tải lên: 21/03/2014, 22:50

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Ngày tải lên: 29/03/2014, 03:21

Ngày tải lên: 30/03/2014, 05:20