... reduce the levels of anti-apoptotic Mcl-1 The rather low levels of Bcl-2 in the PC3 cells may explain why the radiation-induced down-modulation of Bcl-2 was of minor importance for the response of ... indicate whether the therapy effects observed are due to inhibition of proliferation, cell death induction, or both Therefore, in a next step, we examined whether the anti-neoplastic effectsof ErPC3 ... cells the down-regulation ofthe two anti-apoptotic Bcl-2 proteins may contribute to the antineoplastic effectsof ErPC3 and radiotherapy In contrast, the radiation-induced down-modulation of the...
... that while implantation ofthe beads alone does not impair the steady growth ofthe cells in the vicinity ofthe beads, the addition of A+4 or A-4 initially stimulates the cell growth rate, albeit ... day 7, and then only to a limited extent in small groups of cells Discussion Potential biological effectsof agarose beads The present results shed light on the short- termeffectsof agarose ... Markers The experiments were designed to discriminate between the in vivo effects due to the surgery and implantation ofthe untreated beads and the cascade of events resulting from the implantation...
... myocardial injury The lack of worsening ofthe TnI leak suggests that milrinone does not exacerbate the underlying pathologic process in these patients, at least in theshortterm This should ... is the case, it is also possible that this potential benefit may outweigh the possible adverse effectsof inotropic agents in theshortterm An additional complexity is that the witnessed effects ... practical Another related concern is whether standard therapy, particularly increased loop diuretic dosing, could explain the findings and confound the milrinone effects In terms of TnI levels, there...
... (increasing or decreasing), the subsequent effectsof fire [5] The classification ofthe severity of a fire based only on function ofthe remaining surviving trees could be then insufficient to classify ... restrained by the distance to the mother tree because of its low dispersal capacity [14, 49], and a transient seed bank [47], the occurrence of favorable weather periods [51], and the presence of a propitious ... prevailing at the time ofthe fire, after it, and to the specific conditions ofthe site considered In burned areas, the consumption of biomass and reduction of vegetation cover by the actual fire increased...
... study we focused on short- term rather than on long -term effects From a theoretical point of view, the shortterm responses seen here might simply be offset by a subseR412 duration Effects on breathing ... preserved over time or whether they are offset by slowly adapting reflexes or behavioural responses over a longer period of observation On the other hand, the PEEP-related short- term effect is sufficiently ... Switzerland), which was placed at the proximal end ofthe ETT Airway pressure was measured between the pneumotachograph and the outer end ofthe ETT Spot-check measurement of tracheal pressure were taken...
... regulating the level of ammonium assimilation upon an ammonium pulse Analysis of regulation ofthe transient response ofthe GS rate The decrease in the rate of GS upon the sudden addition of ammonium ... determines the relative importance ofthe various regulators during transient regulation ofthe rate of GS Finally, we alter gene expression of GDH, GOGAT, and GS and calculate theeffects on the ... mechanistically in terms ofthe network topology and the kinetic properties ofthe molecular components ofthe network One possible approach to finding these explanations is through calculation ofthe properties...
... vulnerable, population of patients Chemotherapy-induced cognitive decline in the absence of radiation The best data on the cognitive effectsof chemotherapy alone have come from studies of children with ... are planned that further reduce the dose of craniospinal radiation to 1,800 cGy, virtually no attention has been paid to the possible contribution ofthe chemotherapy to the cognitive decline ... support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity associated with very high doses of chemotherapy is...
... brothels’ or in private homes of their pimps or agents Figure 2 Brothels in Singapore Front of a brothel The interior of a brothel Back alley of a brothel where clients gather A room in the brothel ... been evaluated The majority of studies that used rigorous evaluation designs evaluated the short- termeffectsofthe program Of those few studies that evaluated the long -term effects over a period ... and these programs have been found to be effective with regard to their short- term effects, that is, the change within to months ofthe intervention It is not known, however whether these effects...
... of generating substantial short- and long -term effects upon subjects’ HRQoL At the early measurement, a limitation ofthe capability to perform usual activities (EQ-5D) and deterioration ofthe ... short- term and long -term effectsof VABB (11G) on HRQoL remain an open field The particularities in VABB are worth investigating systematically, as the special features of VABB together with the larger ... should be born in mind for the extrapolation of these findings to other settings Nevertheless the exact nature of differences between Domeyer et al Health and Quality of Life Outcomes 2010, 8:11...
... analysis of changes in the consequent series of samples obtained the same patient was analysed using the paired t-test For the analysis ofthe long -term changes the Mann-Whitney test was used The ... Here they change/switch the expression pattern of Ig from IgD and IgM to IgG, IgA and IgE The switch of Ig classes indicates the formation of antigen-specific memory B cells By the expression of ... from the same patients analysed at the same time points retained up to 30% of B cells, which gave a possibility to follow the ontogeny of B cells in the paired samples of BM obtained prior and shortly...
... parameters Given the diversity in improvement topics ofthe sites, the aim of this study was to measure the possible impact ofthe QIC on a wide variety of patient outcomes, professional performance, ... about the goals and structure ofthe project The participating teams each had to pay a fee of €23.750 Euro to cover project management costs Start Kick-off Before the kick-off meeting, the participating ... divided by the number of items within that section The overall score was derived linearly: the average scores of each section were summed, and then divided by the number of sections Page of 10 follow...
... family size [22] A model of how balance is maintained through proper positioning ofthe CoM and momentum ofthe CoM over the base of support has been established as a measure of dynamic balance control ... motion They had reduced mediolateral peak velocities ofthe CoM by day 14 and also reduced mediolateral separation ofthe CoM and CoP on day 28 Both of these indicate a conservative control of mediolateral ... participating in their particular activity at the time of injury at either the college or professional level, or have since graduated and are no longer active Recently, tests of balance control...
... N content Therefore, the highest variability of N content within the current needles occurs during the months of May and June (Fig 3) In August, when the shoot growth was completed, the lowest ... burst and acceleration of bud phenology result in prolongation ofthe shoot growth period and in a subsequent enhancement of wood production (Beuker 1994) The effect of long -term (months and years) ... differences between the treatments in the shoot length were observed at the end of growing seasons The influence of elevated CO2 on Norway spruce phenology was recorded during the first spring as...
... To evaluate theeffectsofthe different competition regimes created by each of these treatments on the performance of spruce seedlings; (iii) To understand the long -term impacts of vegetation ... there are few, if any, environmental constraints However, these treatments generally provide only short- term relief from competing vegetation The control often lasts only for the balance ofthe ... VI) DISCUSSION Responses of vegetation communities to brushing treatments depend on the type of treatment, the ecosystem, the type of plant community, and the abundance of component species In...
... role in the in vitro control ofthe expression ofthe episodic growth pattern ofthe species, these factors therefore have a major influence (Favre and Juncker, 1989) An alternation of culture ... the long term, the management ofthe culture media, together with the clonal effects (Juncker and Favre, 1989), appeared to be the main factors Chalupa V (1988) Large-scale micropropagation of ... approaching DISCUSSION These results generally confirm the potential of shoot-tip explants in the advantages decontamination of infected stocks and in the stimulation ofthe growth capacity of plant material...
... clamping ofthe aorta The difference in stroke between the two OPCAB subgroups fell shortofthe statistically significant level (P = 0.69) There were no significant differences between the both ... revascularization, the whole heart depends on the left internal mammary for its blood supply Concerns regarding the inability ofthe left internal mammary to supply the whole heart are only theoretical These ... insufficiency • Off-pump (OPCAB) The goodness of model was evaluated using the Hosmer and Lemeshow goodness -of- fit statistic and residual analysis The propensity score model C-statistics (area under the...
... studies of short- term prediction of violence The weaknesses in most designs are underreporting of incidents, lack of correction for therapeutic interventions, and a disregard ofthe influence from the ... entering the PICU area and admitted to the other ward The study ward consists of an ordinary closed acute ward area (310 m2) and a PICU area (190 m2) The main entrance leads to the ordinary area ofthe ... In the end ofthe corridor a locked door separates the PICU area from the ordinary area The PICU area consists of two wings with two single patient rooms in each The patients stay mostly in the...
... evaluate the effect of drugs on the level of these biomarkers [15] The key question about all three of our assays is whether they only reflect matrix degradation present in lung interstitium or whether ... altered processing ofthe heparan sulfate molecule in the lungs of patients with emphysema In view ofthe biological functions of heparan sulfate, this could lead to destabilisation ofthe extracellular ... FEV1, Kco and baseline value of each ofthe biomarkers was assessed by the Spearman's rank correlation coefficient Results Analysis of change over time of any ofthe three biomarkers for a given...
... risk ofthe development of microalbuminuria and clinical albuminuria (17-19) The expected beneficial effect ofthe intensive therapy is to prevent the onset or at least delay the progression of ... to poor compliance At the end ofthe 18th month when compared with the pretreatment levels, the mean HbA1c of these eight patients had decreased, to 7.5±1.01 (p
... on the day (up to 24 hours) before the diagnosis of each episode of sepsis Quality ofthe database The data-capture software automatically conducted multiple checks for internal consistency of ... and others), and multiple sites Early effective antibiotic therapy was defined as effectiveness on the causative agent of at least one ofthe empirically selected antibiotics on the day ofthe ... admission to the ICU We excluded patients with treatment-limitation decisions taken before or on the day ofthe diagnosis of severe sepsis At least two ofthe following criteria were required for the...