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Báo cáo Y học: Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system docx

Báo cáo Y học: Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system docx

Báo cáo khoa học

... ligase). The multiubiquitinatedtarget proteins thus produced are degraded by the 26Sproteasome. On the other hand, some proteins, such asornithine decarboxylase, are degraded by the proteasomewithout ... Tob was the same as that in the case of endogenous Tob (data not shown). Takentogether, the results suggest that the BTG/Tob familymembers BTG1, BTG2, Tob, and Tob2 are degraded by the 26S ... degradation by the ubiquitin–proteasome system. The life spans of the C-terminal truncated mutants were muchlonger than those of the full-length and the N-terminalmutants with truncation of the BTG/Tob...
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Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt

Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt

Báo cáo khoa học

... In the RAD50 homodimer, the signature motifs are adjacent to the opposing Walker A sitesand the serines of each signature motif form hydrogenbonds with the c-phosphate of the ATP bound by the opposing ... model for the transport cycle of the active TAP variant 2–1C2. The initiation step and the progress of the transport cycle are similar to the hypothesized peptide translocation model of the wild-type ... binding pocket by othersequence elements than the b11region. Crystal structureanalysis of the human TAP-NBD1 shows that the end partof the a6region points structurally into the nucleotidebinding...
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Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx

Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx

Báo cáo khoa học

... where the authors have identified the reverse productsand shown that the CMP activation of the reverse ofsynthesis is by a different mechanism from base exchange[20]. Further analysis of the ... showing that the endogenous levelof CDP-DAG is too low to allow detectable synthesis. The level of PtdIns in the membranes does not allow synthesis ofdetectable PtdIns by exchange of the polar ... that placed in the appropriate conditions, the enzyme is able to catalyse the reaction reverse of synthesis. The substrates for exchangecan be PtdIns molecular species made by the enzyme orexogenous...
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The Neighbors Are Watching by Debra Ginsberg pot

The Neighbors Are Watching by Debra Ginsberg pot

Tiếp thị - Bán hàng

... didn’t get out of the car, just turned the car off and sat there. They stared at her through the windshield, this stranger in their driveway, and she stared back at them. The cooling engine ... reaction time was slowed by the heat, so it took the baby giving her another hard kick for her to break the stare and look away.“Sshh,” she said again. “Quit it.” But by then she was talking to ... either help or hinder, several of the Fuller Court residents poke their noses into the business of their neighbors. On the other hand, just as many turn a blind eye to behavior or events they’d...
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Default Risk Cannot Explain the Muni Puzzle: Evidence from Municipal Bonds That Are Secured by U.S. Treasury Obligations ppt

Default Risk Cannot Explain the Muni Puzzle: Evidence from Municipal Bonds That Are Secured by U.S. Treasury Obligations ppt

Ngân hàng - Tín dụng

... indexed by t. The estimates are compared across maturities and ratings. Trzcinka findsthat none of the estimated β’s are significantly different from (1 − τc)at the 5% significance level. Furthermore, ... whenthey are issued. Another advantage of studying prerefunded bonds isthat they are effectively noncallable bonds. This is because the optioncomponent of the call is extinguished at the refunding ... onaverage there are about 160 bonds from which to estimate the termstructure in each month. Panel B describes the prices of the bonds in the sample. In 6 of the 8 years, at least 56% of the sample...
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No Safer Place in the World for Your Money - How to Make Sure All Your Deposits Are Protected by FDIC Insurance docx

No Safer Place in the World for Your Money - How to Make Sure All Your Deposits Are Protected by FDIC Insurance docx

Ngân hàng - Tín dụng

... accounts on the next business day by arranging with a healthy institution to assume the insured deposits. The account owners can then decide whether to remain as customers of the other bank ... coverage. But if the joint account is not restructured by the end of the grace period, the $400,000 balance will only be insured up to $250,000 as the surviving co-owner’s funds in the single account ... investigate, but they generally have to credit the consumer’s account for the amount of the alleged error on a “provisional” (temporary) basis pending the outcome of the review.“Until the bank provides...
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Báo cáo khoa học: The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain pptx

Báo cáo khoa học: The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain pptx

Báo cáo khoa học

... compared with 72.5 lmin the non-mutated chimera. Therefore, as in PDE5,phosphorylation at the N-terminus of the PDE11A4GAF tandem may constitute a mechanism regulating the cGMP affinity of the ... stimulation dependson the presence of the hPDE11A4 N-terminus becausea construct in which the N-terminus is replaced by thatof the cyaB1 AC, is not stimulated [12]. In anotherstudy with the PDE5 tandem ... allosterically affect PDE11 activity. The role of the N-terminus of the PDE11A4 GAFtandem domain The N-termini that precede the GAF domains inmammalian PDEs are of significant length, 221 aminoacids...
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Madonna of the Seven Hills by Jean Plaidy ppt

Madonna of the Seven Hills by Jean Plaidy ppt

Tiếp thị - Bán hàng

... Lucrezia but they were soon to leave their mother’s house for that of a kinswoman of their father’s; therein they would be brought up as fi tted their father’s children.MADONNA OF THE SEVEN HILLS ... later there was added to this the offi ce of Vice- Chancellor of the Church of Rome. Indeed, the Lanzols had no need to regret the adop-tion of their sons by the Pope.It had been clear from the ... would treat them as his own sons if they would discard their father’s name of Lanzol and called themselves Borgia.Their parents had been anxious that the adoption should take place. They had...
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The People of Forever Are Not Afraid by Shani Boianjiu doc

The People of Forever Are Not Afraid by Shani Boianjiu doc

Tiếp thị - Bán hàng

... with their boot- camp soldiers. They ask them the same four questions:Do you love the army?Do you love the country?Who do you love more, your mother or father? Are you afraid to die? The commanders ... first they ask these questions when the soldier has her mask on, but then they get to ask them when the soldier is in the tear- gas tent, without the mask, and watch her panic. That is the goal ... Ushuaia, Argentina, the closest city to Antarctica, the end of the world. The bookstores are all in Spanish. The lakes are too cold for a swim. At the bars, all the clients are middle- aged Frenchmen,...
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Báo cáo khoa học: The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain ppt

Báo cáo khoa học: The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain ppt

Báo cáo khoa học

... these curves are usually > 0.9. The initial rates for all the proteins are expressed as a proportion of their standard activity, and the number following in paren-theses is the relative activities ... third helix of the R domain (EXPASY: HELIXWHEEL). The respective amino acids and their relative positions in the helix are indicated on the helical wheel. The hydrophobic residues [32] are italicized ... and 507 in the N-terminal region of the cen-tral R domain. Whether the two forms of PII are binding at exactly the same site or not cannot beShift in AT activity with addition of either R domain...
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Most cases of STEMI are caused by a thrombotic occlusion of a larger coronary artery (5). The pptx

Most cases of STEMI are caused by a thrombotic occlusion of a larger coronary artery (5). The pptx

Sức khỏe giới tính

... it was proposed very early on to advance the start of treatment to prehospital care by the EMS (50). The GISSI I trial was the rst mega trial to test the standard dose of 1.5 Mill U streptokinase ... platelets by brin and the nal formation of a stable thrombus. ASA has been shown to reduce the case fatality rate by 1/4 in the ISIS II trial (19). Since then, ASA has become routine in the treatment ... (ASA)ASA is the mainstay of antiplatelet therapy, inhibiting the COX1 pathway of thromboxane formation (Fig 3). Thus ASA blocks one of the routes to the com-mon nal step of activation of the GP...
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ISSAI 1500The International Standards of Supreme Audit Institutions, ISSAI, are issued by the pdf

ISSAI 1500The International Standards of Supreme Audit Institutions, ISSAI, are issued by the pdf

Kế toán - Kiểm toán

... The objective stated in the Standard is unlikely to have been met by the requirements of other Standards. In determining the requirements of a Standard, the IAASB will consider whether the ... requirements are proportionate to the importance of the subject matter of the Standard in relation to the overall objective of the engagement. The criteria, which are intended only to assist the IAASB ... demonstrates how the material in the extant ISA has been reflected in the proposed redrafted ISA. In particular, the analysis: Identifies existing sentences in the present tense and whether they are now...
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