the role of the immune system and lessons from animal models
Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity of the insertion was validated by digesting the plasmid ... 641, 667, and 691 To construct the GST fusions of the tandem SH2 domains of each SHP-1 and SHP-2, the sequences corresponding to amino acids 2–232 of each SHP-1 and SHP-2 were amplified from a PHA-activated ... purified (< 820 bp) The insert was then ligated into the pSPORT vector and the resulting full-length siglec-10 clone was designated 995-2 and the sequence was verified against the other siglec-10 clones...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... axis of communication between the innate and adaptive parts of the immune system that might be an interesting target for the immunotherapy of inflammatory autoimmune diseases [26,27] Role of IL-17 ... (IL-17) in bone resorption The interrelationship of IL-17 with receptor activator of NF-κB ligand (RANKL), IL-1, tumor necrosis factor (TNF) and the modulatory role of IL-4 and osteoprotegerin (OPG) ... replace the proinflammatory/catabolic function of IL-1/ TNF, directly or through interplay with other macrophagedriven factors Role of IL-17 in other inflammatory/autoimmune diseases 34 Apart from the...
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Báo cáo y học: "Tumor microenvironments, the immune system and cancer survival" ppt
... cells their component cells, and their microenvironment Among the important advances that have derived from these technologies is the molecular classification of tumors on the basis of only their ... reinvigorated approach These studies highlight the importance of studying the genetics and phenotypes not only of cancer cells but also of the surrounding microenvironment The immune system has long ... expressed in the non-malignant cells Therefore, in this study, patient outcome was most directly associated with the type of immune response, not the expression profile of the cancer cells themselves...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
... to further our understanding of arthritic processes and concomitant cartilage and bone destruction, and have provided novel insights and treatment targets However, final proof of the use of data ... ACPAs are a key feature of RA and the recent success of treatment with an anti-B cell drug (Rituximab) supports the belief that they have a pathogenic role in it In some of the models, such as collagen-, ... any of the classic arthritis models and this holds as well for the more novel models such as KRN and SKG arthritis and passive GPI/KRN arthritis In fact, both T cell- and IC-driven murine models...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... injection of FGF8 causes degradation of the ECM of the articular cartilage and release of S-GAG into the synovial fluid In addition, the injection of FGF8 decreased the bone weight of the patella ... chondrocytes These studies suggest that the injury of synovia induces the expression of FGF8 in the joint, and this may promote degradation of cartilage via a paracrine system The bone weight of the patella ... Injection of FGF8 into the rat knee joints promoted the release of S-GAG from cartilage into the synovial fluid Following injection of FGF8, the weight of the patella was reduced Further study...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research is supported by grants from the Wellcome Trust, the Medical ... well recognized for the regulation of immune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression ... pathogens demanding conflicting response patterns, the fine-tuning effect of multiple allelic variants allows the immune system to be variably calibrated across the population In the absence of infection,...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the periphery The possibility ... inducing the local induction of Th3 or Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they ... activated, and will recruit other T cells and other inflammatory cells and mediators to the site As the response becomes mature, a group of regulatory T cells will develop locally as a result of the...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
... a major role in the regulation of the inflammatory process in experimental models of hepatitis and colitis in mice, emphasizing the critical role of adipose tissue-derived leptin in immune modulation ... leptin-deficiency The role of leptin in experimental models of arthritis A potential role of leptin has been recently investigated in several models of arthritis depending on acquired or innate immune responses ... proinflammatory state Effects of leptin on phagocytes The role of leptin in the regulation of important macrophage functions is further emphasized by alterations in the phenotype of those cells during...
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Báo cáo y học: " Mimicking microbial ‘education’ of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?" ppt
... mycobacteria might therefore have influenced the evolution of the immune system because they have been ubiquitous throughout mammalian phylogeny Consequently, the concrete paving of modern cities and food ... and professional antigen-presenting cells (dendritic cells) may be the target of a microbial bystander effect, that may dictate the pattern of accessory molecules and cytokines, and modulate the ... coming from animal studies in which DNA immunostimulatory sequences are used as adjuvants with allergen for allergen-specific immunotherapy, and from trials with Homeostasis of the immune system...
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Báo cáo y học: " Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system" pps
... have been observed in the functional structure of some key components of the innate immune response, such as the human TLRs system, and of the adaptive immune system, such as the TCR Even if microbial ... upon the system s dynamics and functionality Indeed, the architectural characteristics of a system and the features of individual components together play indispensable roles in forming the symbiotic ... challenge in network theory and systems biology [3] While the application of the network paradigm revealed the existence of structural complexity, many other layers of complexity in the system became...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
... unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor ... such as TGF-β and/ or (2) allow metastasis of tumor cells These functions vary depending on the type of tumor and the location of the TAMs in the tumor e.g TAMs in hypoxic areas of the tumor express ... immunity and cancer Tumors not consist of a homogeneous population of cells; rather they are a composite of the cancer cells, mesenchymal and endothelial cells, and immune cell populations The link...
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ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the experiment (6 weeks), τ is the duration of the cell cycle ... to the cubic root of the cell number Therefore the ratio between the diameters of tumors from control and depleted mice is given by: (3) 𝐷𝐷𝑐𝑐 � 𝐷𝐷 = {𝑒𝑒 ( 𝑑𝑑 } [𝑘𝑘 𝑐𝑐 −𝑘𝑘 𝑑𝑑 ]𝑡𝑡 ) 𝜏𝜏 k c and...
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Basic immunology functions and disorders of the immune system
... for immunotherapy of cancer FIGURE 1-1 The importance of the immune system in health and disease This table summarizes some of the physiologic functions of the immune system Note that immune responses ... microbes is the immune response Immunology is the study of the immune system and its responses to invading pathogens The physiologic function of the immune system is to prevent infections and to eradicate ... nomenclature of immunology, some of the important general properties of all immune responses, and the cells and tissues that are the principal components of the immune system In particular, the following...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... one of these studies collected data on the number of poultry kept by the sampled households in the study year and, in the case of Kenya, Nigeria, and Ghana, on the number of poultry sold and the ... income and wealth According to this method of matching, the two groups—which include the treatment group of households representing the result of the HPAI-induced supply -and- demand shocks and the ... Oparinde, and Maina 2008; Omiti and Okuthe 2008) Therefore, information regarding the role of poultry in the livelihoods of small-scale poultryproducing households and the livelihoods impacts of HPAI-induced...
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Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... confirms one of the most standard hypothesis on the microeconomy of transition: the adjustment and growth of enterprises require that they meet a growing demand for their goods and adjust to ... rather some exogenous characteristics of the sample 14 These phenomena are generated in a model of soft budget constraint in Berglof and Roland (1994) 22 Enterprise Adjustment and the Role of ... supply of credit Finally, the higher the co-ordinate on the f2 axis, e.g the more the enterprise is faced with financial limit, the higher the level of barter transactions and the higher supply of...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... determinants of the presence of Zn(II), and therefore of the Zn- or Cu-thionein character of the polypeptides Hence, the two full-length peptides, CeMT1 and CeMT2, give rise to mixtures of complexes, ... stoichiometry and the homogeneity of their preparations These differences are a result of the different coordination capacities of the respective C-terminal moieties and are attributable to the four ... reported for the native and recombinant Cd(II)–CeMT2 isoform [16,20] The slight blueshift of the spectrum of Cd6Zn1–CeMT1 in relation to that of Cd6–CeMT2 is attributable to the influence of the Zn(II)...
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Paradoxical roles of the immune system during cancer development docx
... On the basis of classical theories of immune surveillance and more recent awareness of the tumour-promoting properties of innate immune cells, researchers are now investigating the efficacy of ... increased when there is a previous history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed ... of defects in their natural immune defence mechanisms, and/ or because they fail to normalize their immune status following infection Some support for this hypothesis comes from experimental animal...
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The Role of Deployments in Competency Development - Experience from Prince Sultan Air Base and Eskan Village in Saudi Arabia potx
... 20 of the competencies and skills featured in the survey, the “best” responses of the officers differed significantly from those of the enlisted personnel For the remaining 26 competencies and ... differences between the total responses of the officers and those of enlisted personnel The results of this exercise are shown above and in the table that follows The table above shows the percentages ... designed and well executed; the data and assumptions are sound; the findings are useful and advance knowledge; the implications and recommendations follow logically from the findings and are explained...
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The role of health related, motivational and sociodemographic
... of food label use, the relationship between the perception of labels and the actual and meaningful use of the information in the labels is influenced by factors associated with understanding the ... representation of the Germanspeaking part of Switzerland Questionnaire The questionnaire contained questions about all of the variables and constructs listed in Fig Most of the predictor concepts and the ... may decrease understanding of the label(30) and on the other might cause people to not even look at the label if they think they will not understand the numbers on it anyway Furthermore, shopping...
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the role of neutrinos, strings, gravity, and variable cosmological constant in particle physics
... instant of Big Bang, of the order of 10114 ergs.cm-3 and it represents the energy density at the beginning of time when the size of the universe was of the order of r0 The entire evolution of the ... gravitation itself MATHEMATICAL BASIS OF THE THEORY The success of the geometrization of gravity by the general theory of relativity had led Einstein and others, ipso facto, to further extend the geometrical ... results: (1) The mass of everything from the elementary particles all the way to the mass of the universe, is given by (22) (2) In the limit of r0 = the field equations of the unified field theory...
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