the role of radiation therapy in renal cell carcinoma

... contributes to the tissues of the developing animal including the germ line Successful microinjection of ES cells into the blastocysts results in an embryo comprised of cells from the original blastula ... mouse B lymphoma cell line or the DT40 chicken B cell line Although these studies indicate a role for Dok-3 in negative signaling of the BCR, a definitive role of Dok-3 in primary B cells has yet ... effector protein of Dok-3/Grb2 signaling module Most of the work prior to the completion of this PhD thesis project had been focused on studying the role of Dok-3 in BCR signaling using either A20...

Ngày tải lên: 14/09/2015, 09:08

... from the Biological Resource Centre who had help in the microinjection of Dok-3 ES cells, maintaining and changing the many cages of mice, and the staffs from DNA Sequencing Facility for their ... SH3 domain binding protein Geneticin Gancyclovir Growth factor receptor-bound protein Haemagglutinin 1,3,4,5-tetrakisphosphates Immunoglobulin Interleukin Inositol 3,4,5-triphosphate Insulin receptor ... chromosome 10 Protein tyrosine kinase Ras GTPase activating protein Src-homology Src-homology SH2-containing inositol 5’-phosphatase-1 SH2-domain containing protein tyrosine phosphatase-1 Son of sevenless...

Ngày tải lên: 14/09/2015, 10:44

... differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule [10,11] Since ... play a fundamental role in the mechanisms controlling the protein turnover of the kidney There exists conflicting evidence concerning the role of UCHL1 in tumorigenesis varying from anti-tumor ... However, in this study it is demonstrated that the silencing of UCHL1 in both RCC cell lines as well as in primary RCC lesions mostly of clear cell subtype is rather linked to the methylation of the...

Ngày tải lên: 18/06/2014, 15:20

... pro15 form These enzymes are in an inactive state due to the thiol (SH-) group of the cysteine residue within the pro-domain interacting with the Zn2+ ion in the catalytic domain Disruption of this ... domain situated in the hinge region which is ~75 amino acid residues in length (23-26) It is of interest to point out that in the gelatinases, collagen binding is conferred by the fibronectin ... IL-10 Interleukin-10 IL-1β Interleukin-1 beta IL-12 Interleukin-12 IL-13 Interleukin-13 xxii IL-21 Interleukin-21 IL-22 Interleukin-22 IL-23 Interleukin-23 IFN-γ Interferon gamma ITK IL-2 inducible...

Ngày tải lên: 24/08/2014, 11:37

Ngày tải lên: 13/11/2014, 10:36

... The role of FGFR3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice Mona Foth Submitted in fulfilment of the requirements for the Degree of PhD ... node invasion; N1 indicates cells in one lymph node in the pelvic area; N2 in more than one lymph node in the pelvis; and N3 in one or more lymph nodes in the groin or other parts of the body The ... mutations in urothelial cell carcinoma can occur at different codons in the extracellular domain, the transmembrane domain, or the cytoplasmic tyrosine kinase domain, which can cause various changes in...

Ngày tải lên: 22/12/2014, 20:56

... and the NA are the two large spike-like glycoproteins on the surface of the virus HA is a lectin that mediates the binding of the virus to target cells and facilitates the entry of the virus into ... secretions and the lung epithelium   In the lung, the first line of protection against the influenza virus is provided by the mucus lining of the respiratory tract which contains sialic-acid bearing glycoproteins ... with an increased fraction of influenza-specific CD8+ T cells expressing the interleukin-7 receptor at the peak of the response, resulting in enhanced numbers of memory precursor cells in IFN-γ-/-...

Ngày tải lên: 10/09/2015, 09:25

... regulators of the cell cycle, including Cdc2/cyclinB complex, now known CDK1 (100) The main goal of cells in the G1 phase of the cell cycle is to prepare for DNA synthesis in the ensuing S phase The ... examined the role of Chk1, a canonical member of the ATM/ATR pathway, in DNA damage-induced G2 checkpoint control While examining the role of p38 in the G2 checkpoint pathway, we found that inhibition ... onto to the start of cytokinesis (389) Some of the key signaling proteins that feed into the spindle checkpoint include the polo-like kinases Plk1 and Plk2, and the aurora kinases (401,455) These...

Ngày tải lên: 11/09/2015, 09:02

... Overexpression of PrP in human embryonic kidney 293 cell lines, rabbit epithelial Rov9 cell lines, and murine cortical TSM1 cell line resulted in cells sensitive to the apoptotic inducer, stauroporine, ... aspects of PrP In humans, PrP is initially synthesized as a pre-pro-PrP of 253 amino acids in the cytosol PrP contains a hydrophobic N-terminal signal peptide of 22 amino acids while the last 22 amino ... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer...

Ngày tải lên: 12/10/2015, 17:36

... of potassium from the cell (step 5a) resulting in a fall in intracellular levels of potassium (step 5b) The fall in intracellular potassium levels triggers the assembly of the components of the ... immunopathology of influenza infection of the lung in an in vivo murine model A detailed understanding of the mechanisms that undermine pathogenicity and the host-virus interactions that influence the outcome ... C-terminal CARD (ASC) is required together with CARDINAL for oligomerization The assembled components of the inflammasome initiate the processing of procaspase-1, resulting in the formation of the...

Ngày tải lên: 13/10/2015, 16:41

... raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of a concern for people in the behavioural theories as being ... anything towards raising the profile of women in management, as the theory was constructed as a male model at a time when women were not visible in paid employment One of the off shoots of the ... enabling of others to help achieve the goals of the organisation Furthermore, the ability to control others is given no prominence in this recent definition of leadership A brief review of early...

Ngày tải lên: 08/10/2013, 15:56

... relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national inter-bank lending centre provides pricing information, ... source of financing for enterprises, if their own capital is excluded In summary, the deepening process of the financial markets has rendered the dominance of the banking sector in the financial ... in turn contributed to the financial stability not only in Asia but also in the whole world Role of the international financial institutions ( IFIs ) The IFIs have played an active role in financial...

Ngày tải lên: 18/10/2013, 07:15

... adults (39 ) The renewed interest in examining the indications for BCG vaccination in the United States included consideration of the wide range of vaccine efficacies determined by clinical trials ... explore the sources of the heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data ... efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination The protective efficacy of BCG...

Ngày tải lên: 15/02/2014, 13:20

... understanding issues facing community banks I THE CURRENT ROLE OF COMMUNITY BANKS The banking system in the United States has always been unique in the sense of containing large numbers of small ... were not there, other financial services providers might readily step in to take their place This article examines the role of community banks in the U.S economy The first section of the article ... While community banks still comprise the vast majority of banks, the question arises whether their role in the banking system has declined to the point of insignificance This section shows that...

Ngày tải lên: 16/02/2014, 11:20

... geometry of the hinge loop after ligation Also in this case no clashes were detected at Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the ... Nter are the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase The black circle between the monomers indicates the mass center of the dimer ... electrostatic field of different Fig Plot of the EIE values as function of rotation (r) and inclination (i) angles of RNases The hatched axis at the bottom and right of the plots show schemes of some conformations...

Ngày tải lên: 19/02/2014, 06:20

... 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal structures of the N-glycans of GAT1, N-glycosylation processing of NNN was inhibited ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation ... for the immunostaining The protein bands obtained in western blotting were analyzed by phosphoimager scanning The total protein of the cell surface and intracellular bands of each wild type or...

Ngày tải lên: 19/02/2014, 17:20

... t is the in interaction of the results of these asynchronous processes that the process of comprehension is defined 4.1 The processes are independent of the knowledge representations defined ... activation of a l l meanings of each recognized word in HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon meanings for ... defined than through other methods, because i t enables one to develop a broader perspective of the questions within an analysis of the hypothesis in the cont e x t of a characterization of the...

Ngày tải lên: 21/02/2014, 20:20

... evolution of the same type of variables; their judgement on their actual and future behavior, including the type of constraints they face Some sets of answers are strongly cardinal, as for the current ... access-to-input for the worst in this sub-pool Conversely, the overbearing influence of the financial constraints in the lower half is statistically associated with a rather low occurrence of real ... Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm's Qualitative Survey The main underlying question in the above-mentioned conclusions rather brings back to the issue of the adjustment...

Ngày tải lên: 06/03/2014, 08:20

... many of them have been pioneers in the Latin American microfinance industry As of today, out of 15 Latin American members are active in microfinance These members are involved in different ways in ... unrivalled in scale, and outreach continues to grow in terms of the number of microborrowers Institutions providing microfinance in Asia play a critical role in increasing the access to finance for ... very helpful in bringing microfinance into the spotlight not only in developing countries but also in the developed world The awareness by policy makers about the role of microfinance as a major...

Ngày tải lên: 06/03/2014, 10:20

... cholinergic responses The origin of pRCC in the tubular epithelium [54] and the presence in it of muscarinic and nicotinic receptors [34,55] support a role for ACh in renal tubules The increase in ... of binding with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported the renal cells themselves ... butyrylcholinesterase The incomplete binding of renal butyrylcholinesterase to the lectin LCA, which fully reacts with the enzyme of plasma (Fig 3), strongly supports the renal origin of the butyrylcholinesterase...

Ngày tải lên: 06/03/2014, 22:21